Astımlı hastalarda obezite ile demografik özellikler, hastalık şiddeti ve atopi arasındaki ilişki
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Tarih
2008
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info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışmada astımlı hastalarda obezite ile cinsiyet, yaş, eğitim durumu, atopi ve hastalık şiddeti arasındaki ilişkiyi incelemeyi amaçladık. Gereç ve yöntem: Göğüs Hastalıkları polikliniğimizde astım tanısı konulan 261 hasta çalışmaya alındı. Hastaların vücut kitle indeksi (VKİ) (kg/m2) hesaplandı. Bulgular: Bu çalışmadaki astımlıların (195 kadın, 66 erkek) yaş ortalaması 48.4 ± 16.2 idi. Kadın hastalarda erkek hastalara göre obezite sıklığı daha fazla idi (kadınlarda %44, erkeklerde %23, p=0.003). Elli yaşın üzerinde ve ilkokul ve daha düşük eğitimli kadın astımlılarda obezite sıklığı daha fazla idi (p<0.001). Astımlılarda obezite ile atopi arasında bir ilişki bulunmadı (p>0.05). Hastalık şiddeti arttıkça obezite sıklığının arttığı saptandı (p<0.001). Astımlı hastalarda spearman korelasyon katsayısında VKİ ile astım şiddeti (r=0.326, p<0.001) ve yaş (r=0.361, p<0.001) arasında doğrusal ilişki saptandı. VKİ ile FVC de¤eri aras›nda ise negatif ilişki (r=-0.325, p<0.001) saptandı. Multivariate lojistik regresyon analizinde obezite için risk faktörleri şu şekilde bulundu. Elli yaşın üzerinde [odds ratio (OR)=2.2, 95% confidence interval (CI)=1.2-4.0], ilkokul ve daha düşük seviyede eğitimli (OR = 2.8, 95% CI=1.4–5.5), orta persistan astımlı (OR=5.1, 95% CI=1.3–19.4) ve ileri persistan astımlı olmak (OR=5.1, 95% CI=1.3–21.6). Sonuç: Bu çalışmada özellikle düşük eğitimli ve 50 yaş üzerindeki kadın astımlılarda obezite sıklığı daha fazla saptandı. Astım şiddeti arttıkça obezite sıklığı da artmaktaydı. Astım şiddeti ile obezite arasındaki nedensel ilişkinin açıklanabilmesi için daha detaylı çalışmalar yararlı olacaktır.
Aim: In this study we aimed to evaluate the relationship between obesity and gender, age, education status, atopy and severity of disease in asthma patients. Materials and method: Two hundred and sixty one patients diagnosed as asthma in our chest diseases clinic were enrolled in this study, and their BMI (kg/m2) were analyzed. Results: The mean age of asthmatic patients (195 female, 66 male) was 48.4±16.2 years. Frequency of obesity in female asthmatics was higher than in male asthmatics (in females 44%, in males 23%; p<0.05). In female asthmatics older than 50 years, and in those whose education level was primary school or lower, frequency of obesity was higher (p<0.001). There was no relationship between obesity and atopy (p>0.05). Severity of disease was found to be correlated with the increase in the frequency of obesity (p<0.001). Also in all patients there was a linear relationship in spearman correlation between BMI and asthma severity (r=0.326, p<0.001) and age (r=0.361, p<0.001). A negative correlation between BMI and FVC value (r=-0.325, p<0.001) was detected. In the multivariate logistic regression analysis, risk factors for obesity were found to be as follows: female asthmatics older than 50 years [odds ratio (OR)=2.2, 95% confidence interval (CI)=1.2–4.0], education level of primary school or lower (OR=2.8, 95% CI=1.4–5.5), moderate persistent asthma (OR=5.1, 95% CI=1.3–19.4), and severe persistent asthma (OR=5.1, 95% CI=1.3–21.6). Conclusion: In this study, frequency of obesity in female asthmatics was higher in patients with lower educational level and in patients older than 50 years. Severity of disease correlated with frequency of obesity. The causative relation between obesity and severity of asthma needs to be clarified with new and more detailed studies.
Aim: In this study we aimed to evaluate the relationship between obesity and gender, age, education status, atopy and severity of disease in asthma patients. Materials and method: Two hundred and sixty one patients diagnosed as asthma in our chest diseases clinic were enrolled in this study, and their BMI (kg/m2) were analyzed. Results: The mean age of asthmatic patients (195 female, 66 male) was 48.4±16.2 years. Frequency of obesity in female asthmatics was higher than in male asthmatics (in females 44%, in males 23%; p<0.05). In female asthmatics older than 50 years, and in those whose education level was primary school or lower, frequency of obesity was higher (p<0.001). There was no relationship between obesity and atopy (p>0.05). Severity of disease was found to be correlated with the increase in the frequency of obesity (p<0.001). Also in all patients there was a linear relationship in spearman correlation between BMI and asthma severity (r=0.326, p<0.001) and age (r=0.361, p<0.001). A negative correlation between BMI and FVC value (r=-0.325, p<0.001) was detected. In the multivariate logistic regression analysis, risk factors for obesity were found to be as follows: female asthmatics older than 50 years [odds ratio (OR)=2.2, 95% confidence interval (CI)=1.2–4.0], education level of primary school or lower (OR=2.8, 95% CI=1.4–5.5), moderate persistent asthma (OR=5.1, 95% CI=1.3–19.4), and severe persistent asthma (OR=5.1, 95% CI=1.3–21.6). Conclusion: In this study, frequency of obesity in female asthmatics was higher in patients with lower educational level and in patients older than 50 years. Severity of disease correlated with frequency of obesity. The causative relation between obesity and severity of asthma needs to be clarified with new and more detailed studies.
Açıklama
Anahtar Kelimeler
Astım, Atopi, Hastalık Şiddeti, Obezite, Asthma, Atopy, Obesity, Severity of Disease
Kaynak
Solunum
Eurasian Journal of Pulmonology
Eurasian Journal of Pulmonology
WoS Q Değeri
Scopus Q Değeri
Cilt
10
Sayı
3
