Objective Laboratory Parameters in Assessment of Asthma Control in Children

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dc.authoridYorgun Altunbas, Melek/0000-0002-4832-2928
dc.contributor.authorAltunbas, Melek Yorgun
dc.contributor.authorErkocoglu, Mustafa
dc.contributor.authorKarabork, Seyda Ozsoy
dc.date.accessioned2024-09-25T19:56:23Z
dc.date.available2024-09-25T19:56:23Z
dc.date.issued2024
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractObjective: Accurate decisions regarding the asthma control level are critical in asthma management. However, an objective laboratory parameter has not yet been defined for detecting asthma control levels in children. Materials and Methods: We aimed to determine objective laboratory parameters that can be used in evaluating the asthma control level. To achieve this, we compared the Global Initiative for Asthma (GINA)-defined asthma control scale with the Pediatric Asthma Control Test and laboratory parameters including serum periostin, tryptase, urinary leukotriene E4, and fractional exhaled nitric oxide levels in determining the control level of asthma in 160 children with asthma. Results: The serum periostin level and FeNO level were significantly high and the median Pediatric Asthma Control Test score was significantly low in uncontrolled patients (p<0.001, p=0.003, p<0.001, respectively). After ROC analysis, p -ACT (AUC:0.914, %95CI:0.86-0.97, p<0.001), serum periostin (AUC:0,669, %95CI:0.59-0.75, p=0.001) and FeNO (AUC:0.755, %95CI:0.67-0.84, p<0.001) were found to be predictive in the assessment of asthma control. There was inconsistency between the GINA-defined asthma control scale and the Pediatric Asthma Control Test in 28.7% of the study group. Within the patients having controlled asthma according to both the GINA-defined asthma control scale and Pediatric Asthma Control Test, 8.7% had high levels of periostin and FeNO. Besides, serum periostin levels and FeNO levels were both normal in 25.0% of the patients with uncontrolled asthma according to the GINA-defined asthma control scale and the Pediatric Asthma Control Test. Conclusion: The asthma control status demonstrated a correlation with FeNO and serum periostin levels. We hold the belief that incorporating objective laboratory parameters, such as FeNO and serum periostin, for the assessment of asthma control levels may have the potential to mitigate both overtreatment and undertreatment in the management of asthma.en_US
dc.description.sponsorshipAbant Izzet Baysal University Scientific Research Projects, Bolu, Turkey [2016.8.10.991]en_US
dc.description.sponsorshipThe study was funded by the Abant Izzet Baysal University Scientific Research Projects, Bolu, Turkey (Project No: 2016.8.10.991) .en_US
dc.identifier.doi10.21911/aai.2024.374
dc.identifier.endpage129en_US
dc.identifier.issn1308-9234
dc.identifier.issue2en_US
dc.identifier.startpage120en_US
dc.identifier.urihttps://doi.org/10.21911/aai.2024.374
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13268
dc.identifier.volume22en_US
dc.identifier.wosWOS:001158050000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherTurkish Natl Soc Allergy And Clinical Immunologyen_US
dc.relation.ispartofAsthma Allergy Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectAsthma controlen_US
dc.subjectfractional exhaled nitric oxideen_US
dc.subjecturinary leukotriene E4en_US
dc.subjectperiostinen_US
dc.subjecttryptaseen_US
dc.titleObjective Laboratory Parameters in Assessment of Asthma Control in Childrenen_US
dc.typeArticleen_US

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