Investigating the Relationship Between HBV DNA Levels and HBV Serological Markers

Basit Öğe Kaydı
dc.contributor.authorKocoglu, Esra
dc.contributor.authorTas, Tekin
dc.contributor.authorMengeloglu, Firat Zafer
dc.contributor.authorKarabork, Seyda
dc.contributor.authorCeylan, Kubra
dc.date.accessioned2024-09-25T19:58:37Z
dc.date.available2024-09-25T19:58:37Z
dc.date.issued2013
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractObjective: In this study, it is aimed to investigate the relationship between the HBV DNA positivity and serological markers such as HBsAg, HBeAg and anti-HBe in patients with acute or chronic hepatitis. Materials and Methods: Data of 574 patients whose serum specimens were processed in microbiology laboratory between march 2010 and july 2012 were retrospectively analysed. Results: In the study, HBV DNA was detected in 44.8% of HBsAg-positive, in 67.1% of HBeAg-positive and in 35.9% of anti-HBE-positive patients. HBV DNA was detected in 61.2% of the patients both of whose HBsAg and HBeAg were positive. However, HBV DNA was positive in one of 29 patients (3.4%) who had negativity of both HBsAg and HBeAg. DNA positivity was 6.3% in HBsAg-negative patients and 37.7% in HBeAg-negative ones. In the study, HBeAg was negative in 79.4% of HBV DNA-positive patients; anti-HBeAg was negative in 17.7% of DNA-positive patients. DNA levels were found significantly high in HBeAg-positive patients (p<0.001) as well as DNA levels were significantly high in anti-HBenegative ones (p<0.001). Conclusion: In conclusion, serological markers may be insufficient either in diagnosis of HBV infection or in determining the viral replication. In this study, it is observed that evaluating those tests together is useful in laboratory diagnosis.en_US
dc.identifier.doi10.4274/Vhd.02486
dc.identifier.endpage57en_US
dc.identifier.issn1307-9441
dc.identifier.issn2147-2939
dc.identifier.issue2en_US
dc.identifier.startpage54en_US
dc.identifier.urihttps://doi.org/10.4274/Vhd.02486
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13658
dc.identifier.volume19en_US
dc.identifier.wosWOS:000217220900005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofViral Hepatit Dergisi-Viral Hepatitis Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.subjectHBV DNAen_US
dc.subjectHBsAgen_US
dc.subjectHBeAgen_US
dc.subjectAnti-HBeen_US
dc.subjectHepatitis Ben_US
dc.titleInvestigating the Relationship Between HBV DNA Levels and HBV Serological Markersen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu