Klinik örneklerden izole edilen Kandida türleri ve antifungal duyarlılıkları
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Dosyalar
Tarih
2005
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Antifungallerin yaygın kullanımı sonucu antifungallere dirençli Kandida türleri ortaya çıkmaktadır. Bu çalışmada, klinik örneklerden izole edilen kandida türlerinin araştırılması ve antifungal duyarlılıklarının belirlenmesi amaçlanmıştır. Metod: Ocak 2004- Aralık 2004 tarihleri arasında Gaziantep Üniversitesi Tıp Fakültesi Mikrobiyoloji laboratuvarına gönderilen klinik örneklerden izole edilen kandida türleri ve antifungal duyarlılıkları araştırıldı. Bulgular: Kandida izole edilen toplam 102 örneğin 26'sı (%25.6) kan, 33'ü (%32.4) idrar, 4'ü (%3.9) yara sürüntüsü, 9'u (%8.8) balgam, 2'si (%1.9) dışkı, 6'sı (%5.9) açlık mide sıvısı, 18'i (%17.6) vajen salgısı, 4'ü (%3.9) dren sıvısı idi. En sık Candida albicans (%56.8), ikinci sıklıkla (% 7.7) C. tropicalis, üçüncü sıklıkla da (%6.8) C. sake izole edildi. Kanda ikinci sıklıkla (%19) C. parapsilosis izole edildi. Antifungal duyarlılık testi sonucunda, C. albicans'm flusitozine duyarlılık oranı %100 olarak bulundu. Bütün türler ele alındığında kandida türlerinin en duyarlı olduğu antifungal Amfoterisin B idi (%97,6). Bütün türlerin en fazla direnç gösterdiği (%8.4) antifungal mikonazol idi. Vajen sıvısı örneklerinde izole edilen C. albicans türlerinin en fazla nistatine duyarlı oldukları (%60) saptandı. Sonuç: Çalışmamız sonucunda, Candida infeksiyonlarında non-albicans türlerin artış gösterdiği ve bu türlerin antifungal ilaçlara direncinin yüksek olduğu, bu nedenle kandida infeksiyonlarında etkenin tür düzeyinde saptanıp antifungal duyarlılığının araştırılmasının tedavinin etkinliği ve direnç gelişiminin önlenmesi açısından yararlı olacağı kanısına varıldı.
Abstract: Aim: Candida species that are resistant to antifungal drugs grow up due to the widespread use of antifungal agents. In this study, it was aimed to determine the types of candida species isolated from various clinical samples, and to investigate the antifungal susceptibility of these isolates. Methods: Distribution of candida species, isolated from clinical samples that have been received between January 2004 and December 2004 in the Laboratory of the Microbiology Department of Gaziantep University Medical School were investigated together with antifungal susceptibility of these isolates. Results: Candida species were isolated from 102 clinical samples that included 26 (25.6%) blood, 33 (32.4%) urine, 4 (3.9%) wound swab, 9 (8.8%) sputum, 2 (1.9%) feces, 6 (5.9%) stomach fluid, 18 (17.6%) vaginal secretion, and 4 (3.9%) drain fluid. Candida albicans was the most commonly isolated species (56.8%), followed by C. tropicalis (7.7%) and C. sake (6.8%). C. parapsilosis was the second most common isolate (19%) in blood. C. albicans was found to be 100% sensitive to flucytosine. Amphotericin B was the antifungal agent that all species were most sensitive (97,6%). Isolates had the highest resistance rate to miconazole (8.4%) than those of others. C. albicans isolated from vaginal samples were most sensitive to nystatine (60%). Conclusion: We found an increased rate of non-albicans isolates in candida infections, and a relatively higher resistance in these species. We conclude that the isolation of candida species in candida infections may be helpful for the efficacy of the antifungal treatment and for prevention of the development of antifungal resistance.
Abstract: Aim: Candida species that are resistant to antifungal drugs grow up due to the widespread use of antifungal agents. In this study, it was aimed to determine the types of candida species isolated from various clinical samples, and to investigate the antifungal susceptibility of these isolates. Methods: Distribution of candida species, isolated from clinical samples that have been received between January 2004 and December 2004 in the Laboratory of the Microbiology Department of Gaziantep University Medical School were investigated together with antifungal susceptibility of these isolates. Results: Candida species were isolated from 102 clinical samples that included 26 (25.6%) blood, 33 (32.4%) urine, 4 (3.9%) wound swab, 9 (8.8%) sputum, 2 (1.9%) feces, 6 (5.9%) stomach fluid, 18 (17.6%) vaginal secretion, and 4 (3.9%) drain fluid. Candida albicans was the most commonly isolated species (56.8%), followed by C. tropicalis (7.7%) and C. sake (6.8%). C. parapsilosis was the second most common isolate (19%) in blood. C. albicans was found to be 100% sensitive to flucytosine. Amphotericin B was the antifungal agent that all species were most sensitive (97,6%). Isolates had the highest resistance rate to miconazole (8.4%) than those of others. C. albicans isolated from vaginal samples were most sensitive to nystatine (60%). Conclusion: We found an increased rate of non-albicans isolates in candida infections, and a relatively higher resistance in these species. We conclude that the isolation of candida species in candida infections may be helpful for the efficacy of the antifungal treatment and for prevention of the development of antifungal resistance.
Açıklama
Anahtar Kelimeler
Kandida Türleri, Kandida İnfeksiyonu, Antifungal Duyarlılık, Candida Spp, Candidal Infection, Antifungal Susceptibility
Kaynak
Van Tıp Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
12
Sayı
3
