Antiepileptic effects of Allium schoenoprasum L. in the acute epilepsy model in rats

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dc.authorid/0000-0002-0530-5394
dc.contributor.authorZaqzouq, Dana
dc.contributor.authorHim, Aydin
dc.contributor.authorGuneser, Ramazan
dc.contributor.authorTurker, Arzu
dc.date.accessioned2024-09-25T19:56:21Z
dc.date.available2024-09-25T19:56:21Z
dc.date.issued2024
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractEpilepsy is a chronic clinical disorder and does not have a rational treatment, which basically aims to prevent seizure activity. Therefore, developing new treatment strategies that can intervene in epileptogenesis will make important contribution to epilepsy treatment. In order to find new compounds and develop new treatment strategies, here, we explored the potential antiepileptic effects of Allium schoenoprasum L. commonly known as chives. Two different epilepsy models were used to study the potential antiepileptic effects of A. schoenoprasum L. The first epilepsy model was induced by intracortical injection of 500 IU penicillin. The second epilepsy model was induced by injecting pentylenetetrazol (PTZ) at the dose of 60 mg intraperitoneally (i.p.). In the penicillin model, the animals were given A. schoenoprasum L. extract (200 or 400 mg/kg i.p.) after penicillin was applied and electrocortical activity was recorded for 120 min. In the PTZ model, the animals were given A. schoenoprasum L. extract at doses of 200 or 400 mg/kg orally for 7 days, after which the PTZ was applied, and tonic-clonic seizures were video recorded. A. schoenoprasum L. did not significantly change either the spike frequency or amplitude in the penicillin epilepsy model. Although it did not change the seizure score in the PTZ epilepsy model it reduced the death rate and significantly decreased the tonic-clonic seizure duration. The result suggests that A. schoenoprasum L. may have antiepileptic effects when applied chronically.en_US
dc.description.sponsorshipBolu Abant Izzet Baysal University Scientific Research Projects Unit [2021.08.02.1501]en_US
dc.description.sponsorshipThis study was supported by the Bolu Abant Izzet Baysal University Scientific Research Projects Unit, Grant No: 2021.08.02.1501.en_US
dc.identifier.doi10.56042/ijeb.v62i05.2825
dc.identifier.endpage365en_US
dc.identifier.issn0019-5189
dc.identifier.issn0975-1009
dc.identifier.issue5en_US
dc.identifier.startpage359en_US
dc.identifier.urihttps://doi.org/10.56042/ijeb.v62i05.2825
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13244
dc.identifier.volume62en_US
dc.identifier.wosWOS:001222087800002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherNatl Inst Science Communication-Niscairen_US
dc.relation.ispartofIndian Journal of Experimental Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.subjectAntiepileptic drugsen_US
dc.subjectChivesen_US
dc.subjectHerbalen_US
dc.subjectSeizureen_US
dc.subjectTraditional medicineen_US
dc.titleAntiepileptic effects of Allium schoenoprasum L. in the acute epilepsy model in ratsen_US
dc.typeArticleen_US

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