Effect of serum parathormone level on retinal thickness and choroidal thickness in chronic renal disease

Purpose: To evaluate effects of serum parathormone level on retinal thickness and choroidal thickness in non-diabetic predialysis chronic renal disease (CRD) patients. Materials and Methods: Sixty-five eyes of 45 non-diabetic predialysis CHD patients and 20 healthy subjects were included in this cross-sectional study. Twenty-five CHD patients had high serum PTH levels and 20 CHD patients had PTH levels within normal limits. Spherical equivalent, central corneal thickness (CCT), intraocular pressure (IOP), retinal and choroidal thicknesses of CHD patients and healthy control subjects were measured. Serum creatinine, calcium, phosphor, C-reactive protein (CRP), vitamin D3 and PTH levels were recorded. Statistical analysis of data was carried out using independent samples t test, one-way analysis of variance and Pearson correlation analysis. Results: There was no statistically significant difference in serum calcium, phosphor, vitamin D3 and CRP levels (range of p values: 0.117-0.412) except for serum PTH levels (p<0.001). There was no statistically significant difference in age, spherical equivalent, CCT, and IOP measurements of groups (p values were ranging between 0.067-0.792). There was statistically significant difference in nasal and temporal retinal segment thicknesses between CHD patients and healthy control subjects (p values were 0.044 and 0.024, respectively). Patients with high serum PTH levels had thicker choroid than other 2 groups for all the measured segments, however this difference was not statistically significant (range of p values: 0.438-0.794). Conclusions: Retinal thickness decreased in non-diabetic predialysis CHD patients and high serum PTH levels might affect choroidal thickness in this group of CHD patients.