Depresyonlu postmenopozal osteoporozlu olgularda kalsitriolün, kemik mineral yoğunluğu, ağrı ve yaşam kalitesi üzerine etkisinin değerlendirilmesi
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Tarih
2003
Dergi Başlığı
Dergi ISSN
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Bu çalışmanın amacı, postmenopozal osteoporotik kadınlarda depresyonun kemik kaybına olan etkisini ve bu hastalarda kalsitriol tedavisine verilen cevabı araştırmaktır. Bu çalışmaya 72 kadın hasta alınmıştır ( ortalama yaş 65 ± 6.9). Bu hastaların 27'sinde depresyon tespit edildi (37.5%) ve 45'inin depresyonu yoktu (62.5 %). Bütün hastalar, DEXA, Hamilton depresyon skalası, Short Form-36 ve Vizüel Analog Skalası ile değerlendirildiler. Depresyonlu hastalarda, L1-L4 T skor (-3.29 ± 1.07), Femur total T skor (-2.60 ±1.00) ve Z skor (-0.97 ±0.82) değerleri, depresyonu olmayan hastalardaki değerlere göre (sırasıyla, -2.71±0.83, -1.86±1.16 ve -0.50 ±0.91) anlamlı olarak düşük idi. Kalsitriol tedavisinden sonra her iki grubun T ve Z skorlarında anlamlı artış oldu. Depresyonlu hastalardaki L1-L4 T skoru ve Z skoru ve Femur total T skor değerleri daha fazla arttı. SF-36 skorları depresyonlu hastalarda (75.9±19.8) depresyonsuz hastalara göre (86.5±14.4) daha düşük saptandı (p= 0.041). Tedaviden önce Hamilton skoru ile L1-4 Z skoru (R= -0.432, p=0.024), Femur total T skoru (R=-0.528, p= 0.005) arasında negatif korelasyon bulundu. Ağrının düzelme derecesi her iki grupta da eşitti. Sonuç olarak, depresyonlu hastalarda postmenopozal kemik kaybının daha fazla olduğu ve bu hastaların kalsitriol tedavisine cevabının daha fazla olduğu sonucuna varıldı.
The aim of this study was to determine whether depression was affect on bone loss in postmenopausal osteoporotic (PMO) women and response to calcitriol treatment in this patients. Seventy two females (mean age 65 ± 6.9) were included in this study. Out of these patients, 27 (37.5%) had depression, 45 (62.5%) were normal. All cases were evaluated by DXA, Hamilton depression scale, Short Form-36 (SF-36) scale and visual analog scale. In the patients with depression, L1-L4 t-score (-3.29 ± 1.07), femur total t-score (-2.60 ± 1.00) and z-score (-0.97 ± 0.82) were significantly lower than PMO patients without depression (respectively; -2.71 ± 0.83, - 1.86 ± 1.16 and –0.50 ± 0.91). Improvement of t- and z- scores in both groups were statistically significant after calcitriol treatment. Improvement of L1-L4 t- and z-scores and femur neck t-score were higher in patients with depression. SF-36 scores (75.9 ± 19.8) were lower in patients with depression than patients without depression (86.5 ± 14.4) (p=0.041). Negative correlations between Hamilton score and L1-L4 z-score (R=-0.432, p=0.024), femur neck t-score (R=-0.528, p=0.005) were found before treatment. Improvement of pain in both groups were similar. In conclusion, postmenopausal bone loss was higher and the response to calcitriol treatment was better in patients with depression.
The aim of this study was to determine whether depression was affect on bone loss in postmenopausal osteoporotic (PMO) women and response to calcitriol treatment in this patients. Seventy two females (mean age 65 ± 6.9) were included in this study. Out of these patients, 27 (37.5%) had depression, 45 (62.5%) were normal. All cases were evaluated by DXA, Hamilton depression scale, Short Form-36 (SF-36) scale and visual analog scale. In the patients with depression, L1-L4 t-score (-3.29 ± 1.07), femur total t-score (-2.60 ± 1.00) and z-score (-0.97 ± 0.82) were significantly lower than PMO patients without depression (respectively; -2.71 ± 0.83, - 1.86 ± 1.16 and –0.50 ± 0.91). Improvement of t- and z- scores in both groups were statistically significant after calcitriol treatment. Improvement of L1-L4 t- and z-scores and femur neck t-score were higher in patients with depression. SF-36 scores (75.9 ± 19.8) were lower in patients with depression than patients without depression (86.5 ± 14.4) (p=0.041). Negative correlations between Hamilton score and L1-L4 z-score (R=-0.432, p=0.024), femur neck t-score (R=-0.528, p=0.005) were found before treatment. Improvement of pain in both groups were similar. In conclusion, postmenopausal bone loss was higher and the response to calcitriol treatment was better in patients with depression.
Açıklama
Anahtar Kelimeler
Kalsitriol, Depresyon, Postmenopozal Osteoporoz, Calcitriol, Depression, Postmenopausal, Osteoporosis
Kaynak
Osteoporoz Dünyasından
WoS Q Değeri
Scopus Q Değeri
Cilt
9
Sayı
4
