Small bowel perforation due to bevacizumab therapy in metastatic colon carcinoma: a case report and review of the literature

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dc.authoridoksuzoglu, berna/0000-0002-2756-8646
dc.contributor.authorUyeturk, Ummugul
dc.contributor.authorOksuzoglu, Berna
dc.contributor.authorArslan, Ulku Yalcintas
dc.contributor.authorAlkis, Necati
dc.date.accessioned2024-09-25T19:56:27Z
dc.date.available2024-09-25T19:56:27Z
dc.date.issued2011
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractBevacizumab is a monoclonal antibody which targets the vascular endothelial growth factor molecule. It is indicated for the treatment of recurrent and metastatic colorectal cancer. A 66-year-old woman was operated with left hemicolectomy who had a tumor in the left colon causing a total obstruction. Her tumor stage was IV (T3N1M1). 5-Fluorouracil, folinic acid,irinotccan and bevacizumab chemotherapy was started to the patient at the forty day of the colon operation. The patient was hospitalized after first administration of the 5th chemotherapy cycle because of febrile neutropenia. Abdominal pain began although the neutrophil count was within the normal ranges. The patient was operated with the diagnosis of acute abdomen. A one centimeter sized perforation was seen at the ilial loop which was 80 cm proximal to the ileocaecal valve. The patient died 8 days after the operation. Although bevacizumab is generally a well-tolerated agent, one must pay attention.en_US
dc.identifier.doi10.5505/tjoncol.2011.460
dc.identifier.endpage181en_US
dc.identifier.issn1300-7467
dc.identifier.issue4en_US
dc.identifier.startpage178en_US
dc.identifier.urihttps://doi.org/10.5505/tjoncol.2011.460
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13311
dc.identifier.volume26en_US
dc.identifier.wosWOS:000439265500006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherKare Publen_US
dc.relation.ispartofTurk Onkoloji Dergisi-Turkish Journal of Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectBevacizumaben_US
dc.subjectsmall intestine perforationen_US
dc.subjectmetastatic colon carcinomaen_US
dc.titleSmall bowel perforation due to bevacizumab therapy in metastatic colon carcinoma: a case report and review of the literatureen_US
dc.typeArticleen_US

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