Akut hepatitli 596 erişkin olgunun retrospektif değerlendirilmesi
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Dosyalar
Tarih
2012
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Cilt Başlığı
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışmanın amacı retrospektif olarak, kliniğimizde yatan akut hepatitli erişkin hastaların etiyolojik, epidemiyolojik, klinik ve laboratuvar bulgularının değerlendirilmesidir. Gereç ve Yöntemler: Bu çalışma, 2001-2005 yılları arasında akut hepatit ön tanısı ile yatırılan 596 erişkin hastayı kapsamaktadır. Yaş, cinsiyet, etiyoloji, bulaş yolları, prodrom süresi, fizik muayene, laboratuvar bulguları ve prognoz değerlendirilmiştir. Viral hepatit belirleyicilerinin saptanmasında ELISA ve PCR yöntemleri kullanılmıştır. Bulgular: Yaşları 16-85 arasında değişen olgularda en sık akut hepatit B (%53,5) ve hepatit A (%35,9) saptandı. Diş tedavisi (%5,7), bulaş açısından en sık saptanan risk faktörü olarak belirlendi. Ancak, bulaş yolu olguların çoğunda (%83) saptanmadı. En sık yakınmaları sarılık, halsizlik, bulantı- kusma, idrarda koyulaşma, bulguları ise ikter, hepatomegali ve ateşti. B tipi akut hepatit olgularının sekizinde karaciğer yetmezliği gelişti ve mortalite oranı %0,3 olarak belirlendi. Sonuç: Akut hepatitte viral etkenler, özellikle HBV ilk sıralarda yer almaktadır. Diş tedavisi bulaş açısından önemli görülmesine rağmen olguların çoğunda maruziyet kaynağı bilinmemektedir. Akut hepatit B’de karaciğer yetmezliği ve mortalite, diğer hepatit virüslerine göre daha sık görülmektedir.
Objective: The purpose of this study is to retrospectively analyze etiological, epidemiological, clinical and laboratory findings of adult patients with acute hepatitis hospitalized in our clinic. Materials and Methods: This study included 596 adult patients who were hospitalized with a preliminary diagnosis of acute hepatitis between 2001-2005. The age, gender, etiology, transmission routes, prodromal period, physical examination and laboratory findings were evaluated. ELISA and PCR methods have been used in detection of viral hepatitis markers. Results: Acute hepatitis B (53.5%) and hepatitis A (35.9%) were the most common types in our patients aged between 16-85. Dental treatment (5.7%) was found as the most common risk factor in view of transmission. However, transmission route could not been determined in the majority of cases (83.3%). The most common complaints were jaundice, fatigue, nausea and vomiting, darkening of urine, respectively. The most common findings were jaundice, hepatomegaly and fever, respectively. Acute liver failure developed in eight patients with cases of acute hepatitis B and mortality rate was determined as 0.3%. Conclusion: Viral pathogens especially HBV is in the first place in acute hepatitis,. Although dental treatment is considered as important for the transmission, the source of exposure is not known in most of the cases. Hepatic failure and mortality is more frequently seen in acute hepatitis B compared with other hepatitis viruses.
Objective: The purpose of this study is to retrospectively analyze etiological, epidemiological, clinical and laboratory findings of adult patients with acute hepatitis hospitalized in our clinic. Materials and Methods: This study included 596 adult patients who were hospitalized with a preliminary diagnosis of acute hepatitis between 2001-2005. The age, gender, etiology, transmission routes, prodromal period, physical examination and laboratory findings were evaluated. ELISA and PCR methods have been used in detection of viral hepatitis markers. Results: Acute hepatitis B (53.5%) and hepatitis A (35.9%) were the most common types in our patients aged between 16-85. Dental treatment (5.7%) was found as the most common risk factor in view of transmission. However, transmission route could not been determined in the majority of cases (83.3%). The most common complaints were jaundice, fatigue, nausea and vomiting, darkening of urine, respectively. The most common findings were jaundice, hepatomegaly and fever, respectively. Acute liver failure developed in eight patients with cases of acute hepatitis B and mortality rate was determined as 0.3%. Conclusion: Viral pathogens especially HBV is in the first place in acute hepatitis,. Although dental treatment is considered as important for the transmission, the source of exposure is not known in most of the cases. Hepatic failure and mortality is more frequently seen in acute hepatitis B compared with other hepatitis viruses.
Açıklama
Anahtar Kelimeler
Akut Hepatit, Epidemiyoloji, Klinik, Laboratuvar, Acute Hepatitis, Epidemiology, Clinical Presentation, Laboratory
Kaynak
Viral Hepatitis Journal
WoS Q Değeri
Scopus Q Değeri
Cilt
18
Sayı
3
