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Öğe 112 Komuta Kontrol Merkezi aracılığıyla 3. basamak yoğun bakım ünitesine sevki danışılan hastaların retrospektif İncelenmesi(2020) Yoldaş, HamitAmaç: Bu çalışmada dış merkezden 112 Komuta Kontrol Merkezi (112 KKM) aracılığı ile sevk edilmesi düşünülerek danışılan hastaların retrospektif olarak değerlendirilmesini amaçladık. Gereç ve Yöntem: Yoğun bakım ünitemize Mayıs 2014-Nisan 2015 tarihleri arasında sevk edilmek üzere 112 KKM aracılığıyla danışılan 157 olgu retrospektif olarak incelendi. Dış merkezden hasta kabülümüzde doldurduğumuz konsültasyon kağıtları taranarak yaş, cinsiyet, tanısı, sevk mesafesi, mevcut Glaskow Koma Skoru (GKS) ve sevk nedenleri kaydedildi. Bulgular: Hastaların 64’ü kadın (%40.8), 93’ü erkek (%59.2). Yaş ortalaması 62.4 olarak tespit edildi. Bunların 65 yaş altı olan hastalar %45.2’sini, 65 yaş üstü ise %54.8’sini oluşturuyordu. Hastaların 12 tanesi il içinden (%7.6), 145’i (% 92.4) ise il dışından danışıldı. En sık sevk nedeni olarak sevk edilen merkezin yoğun bakımında yer yokluğu olarak tespit edildi. Hastaların 49’u (%41.8) yoğun bakımımızda yer olmadığı için, 5 tanesi (%4.2) yetersiz bilgi verildiği için, 21’i ise (%17.9) tarafımızdan yoğun bakım endikasyonu olmadığı için reddedildi. Sonuç: Sonuç olarak sevk edilmek istenen hastaların çoğunluğunu geriyatrik hasta grubu oluşturmaktadır. Hastaların yer yokluğu nedeniyle sevk edilmeye çalışılıyor olması yoğun bakım ihtiyacını ortaya çıkarmaktadır.Öğe Abant İzzet Baysal Üniversitesi Sağlık Araştırma ve Uygulama Merkezi'nde çalışan hekimlerin kardiyopulmoner resusitasyon konusundaki yaklaşımları(Aves, 2016) Yoldaş, Hamit; Koçoğlu, Hasan; Bayır, Hakan; Yıldız, İsa; Akkaya, Akçan; Demirhan, AbdullahObjective: We aimed to evaluate the attitudes of doctors about cardiopulmonary resuscitation (CPR) in this research. Methods: Overall, 234 doctors who were working in Abant Izzet Baysal University Health Research and Application Center and who accepted to participate in this research were included. Research data were obtained by a questionnaire containing questions about demographic characteristics of doctors and their knowledge about CPR. Questionnaires were applied between 27.02.2012 and 04.06.2012. The chi-square test was used for categorical variables. A value of p< 0.05 was considered statistically significant. Results: It was determined that 90% of the participants included in the study applied and/or observed CPR, and 62% of participants did not attend any CPR course. In addition, 64.1% of the doctors were found to be aware of guidelines prepared every 5 years. Although 65.2% of the doctors who attended a course previously gave a correct answer for the question about the number of cardiac compressions during adult CPR, 47.6% of the doctors who did not attend a course gave the correct answer (p= 0.014). Additionally, 71.9% of participants who attended a course previously and 51.7% of participants who did not replied correctly to the question 'What should be done immediately after defibrillation during CPR?' And also the results for the question about how many joules is necessary to begin defibrillation with a monophasic defibrillator were statistically significant according to the attendance for a CPR course (p< 0.005). Conclusion: In this study, we have identified the lack of knowledge of the doctors about resuscitation.Öğe Abant İzzet Baysal Üniversitesi Sağlık Araştırma ve Uygulama Merkezinde çalışan hekimlerin kardiyopulmoner resusitasyon konusundaki yaklaşımları(Bolu Abant İzzet Baysal Üniversitesi, 2012) Yoldaş, Hamit; Koçoğlu, HasanAraştırma, doktorların kardiyopulmoner resüsitasyon konusundaki yaklaşımlarını değerlendirmek amacıyla tanımlayıcı olarak planlandı.Araştırmanın evrenini; Abant İzzet Baysal Üniversitesi Sağlık Araştırma ve Uygulama Merkezi'nde görev yapan 246 doktor oluşturmaktadır. Örneklemi ise; bu hastanede çalışan ve araştırmaya katılmayı kabul eden 234 doktor oluşturdu.Araştırma verileri anket formu ile toplandı. Anket formu; doktorların demografik özellikleri ve KPR konusundaki bilgilerine yönelik 30 sorudan meydana geldi (Ek 1). Anket sorularının hazırlanmasında konu ile ilgili literatürlerden yararlanıldı. Soru formları 27.02.2012--04.06.2012 tarihleri arasında uygulandı.Çalışma verileri değerlendirilmesinde tanımlayıcı istatistiksel metodlar, Mann Whitney U ve Independest Samples "t" testleri kullanıldı.Araştırmaya katılan doktorların %90'ının KPR uyguladıkları ve/veya izledikleri tespit edildi.Araştırmaya katılan doktorların büyük çoğunluğunun, %62'sinin (n:145), KPR kursuna katılmadığı saptandı.Çalışmada, doktorların büyük çoğunluğunun, %64.1 (n:150) beş yılda bir hazırlanan kılavuzdan haberdar olmadıkları anlaşıldı.Çalışmaya katılan doktorların tamamına yakınının, %92.7'sinin (n:217), bilinci kapalı bir hastanın solunumunu kontrol etme yöntemi olan `bak-dinle-hisset'i bildiği tespit edildi.Sonuç olarak doktorların çoğunun KPR konusunda yeterli bilgiye sahip olmadıkları anlaşıldıAnahtar sözcükler: Doktor, Kardiak arrest, Kardiyopulmoner ResüsitasyonÖğe Acinetobacter Infection and Resistance Profile of Intensive Care Units in a City of Northwestern Anatolia(2016) Yıldız, İsa; Bayır, Hakan; Küçükbayrak, Abdülkadir; Yoldaş, Hamit; Balcı, Mehmet; Erkuran, Mansur Kürşat; Akkaya, Kadir KorkmazIntroduction: Determination of suitable antibiotics in treatment of Acinetobacter infections is through the hospital ascertaining the resistance state to bacteria causing the problem. In this study, the evaluation of antibiotics sensitivity of Acinetobacter strains isolated as infection factor in patients hospitalized in intensive care units is aimed.Methods: Acinetobacter strains isolated from the samples of patients hospitalized in the 2nd and 3rd Stage adult intensive care units of a province in in northwestern Anatolia have been studied.Results: A total of 165 patients were included in the study. The most isolated samples were respiratory tract samples, blood and urine. The antibiotics which the factors were most sensitive were cholistin (66,1%) gentamicin (22,4%) and trimethoprim sulfamethoxazole (18,2%).Conclusion: We face increasing resistance ratios in Acinetobacter strains. Necessary precautions should be taken for this.Öğe Association between hemogram parameters and survival of critically Ill patients(Sage Publications Inc, 2019) Karagöz, İbrahim; Aktaş, Gülali; Yoldaş, Hamit; Yıldız, İsa; Ögün, Muhammed Nur; Bilgi, Murat; Demirhan, AbdullahAim: Recently, hemogram parameters, such as mean platelet volume (MPV), had been proposed as novel inflammatory and prognostic factors. In present retrospective analysis, we aimed to determine and compare MPV of survived and dead patients whom admitted to intensive care unit (ICU) of our institution. Methods: We recorded hemogram parameters and other laboratory data and demographic characteristics of patients treated in ICU. Patients are divided into 2 groups-dead patients and survived patients. Laboratory data of survived patients compared to those of dead patients. Results: Age, gender, and other laboratory variables were not significantly different between dead and survived patients. On the other hand, MPV of survived patients was significantly higher than that of the dead patients (P = .001). Conclusion: We think that elevated MPV levels in an ICU patient should alert clinicians for worse outcome. Physicians should be more careful in the management of these patients.Öğe Association between hemogram-derived indices and culture-positive infections in intensive care population(Comenius Univ, 2019) Yoldaş, Hamit; Karagöz, İbrahimAIM: To investigate the relationship between hemogram parameters and bacterial growth in cultures of blood, urine or sputum in intensive care unit patients. METHODS: This retrospective, observational, cross-sectional study was conducted in a tertiary referral hospital between March 2015 and December 2017. Baseline demographic and clinical characteristics, hemogram parameters and other laboratory test results of patients admitted to intensive care unit were recorded. Patients were divided into two groups as patients who were infected, and those who did not have any infectious agents grown in the culture dish, and then the groups were compared with each other. RESULTS: There were no significant differences between the groups in terms of baseline demographic and clinical characteristics. When the groups were compared in terms of hemogram parameters, the neutrophil-to-lymphocyte ratio (p < 0.001), platelet-to-lymphocyte ratio (p = 0.013), plateletcrit (p = 0.028) and mean platelet volume (p < 0.001) were significantly higher in infected patients than in non-infected patients. CONCLUSION: We suggest that neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, plateletcrit, and mean platelet volume could be used as infection markers in the intensive care unit population (Tab. 1, Ref. 25).Öğe Comparison of analgesic effects of pure bupivacaine and morphine added as bupivacaine adjuvant in USG guided adductor canal block following total knee arthroplasty(2020) Türkoğlu, Kübra; Yıldız, İsa; Özturan, Kutay Engin; Işık, Cengiz; Karagoz, İbrahim; Yoldaş, Hamit; Bilgi, MuratObjectives: Total knee arthroplasty (TKA) is an operation that causes severe postoperative pain. Adductor canal block (ACB) is separated from the other peripheral blocks as a method that can provide analgesia by sensory blockade only. The aim of this study was to compare the analgesic effect of morphine-bupivacaine with pure bupivacaine in USGguided ACB after TKA. Methods: Sixty patients aged between 40-80 years with ASA I-III physical status who were scheduled for TKA surgery in our hospital were included in this prospective randomized study. Patients were randomly divided into two groups as Group BM (bupivacaine+morphine) and Group B (bupivacaine) by closed envelope method, and then the groups were compared with each other. Results: In Group BM, compared to Group B, there was a significant decrease in visual analogue scale (VAS) values during rest and movement at 8th hour, 12-24 hours time zone analgesic consumption and additional analgesia usage. Conclusion: We conclude that the morphine added to bupivacaine in the adductor canal block reduces the VAS value at 8th hour and analgesic consumption.Öğe Comparison of cerebral effects of thiopental and propofol infusion in traumatic brain injured rats(2022) Kiliccioğlu, Yıldıray; Yildiz, Isa; Yoldaş, Hamit; Karagoz, Ibrahim; Tekçe, Buket Kin; Çetinkaya, Ayhan; Bilgi, MuratObjective: Head trauma is a lethal, disabling, and pathological condition requiring long-term treatment and care. Thiopental and propofol infusions are frequently used for sedation in the intensive care unit (ICU). However, we do not have clear data on whether they are neuroprotective or neurotoxic. We aimed to compare the early cerebral effects of propofol and thiopental, which are used for sedation in acute head trauma. Methods: A total of 30 rats were included in this experimental study, and the animals were randomly divided into three groups; 5 ml/kg/h 0.9% dose NaCl infusion was given in the control group, 30 mg/kg/h dose propofol infusion was given in the propofol group, and 140 mcg/kg/h dose of thiopental infusion was given in the thiopental group. Blood samples were taken 4 hours after infusion. A craniotomy was performed, the brain was removed, and it was placed in 10% neutral formalin for histological examination. The materials were examined biochemically and histologically and then compared between the groups. Results: The S100B value between the groups was significantly lower in the thiopental group than in the control group (p=0.018). Tau protein levels were significantly lower in the propofol group than in the control group (p=0.07). In histological examinations, the number of apoptotic cells in the propofol and thiopental groups were significantly lower than in the control group (p=0.02). There was no significant difference between the propofol and thiopental groups in apoptotic cell numbers (p=0.3). Conclusion: Our study demonstrated that thiopental and propofol infusions following a head trauma reduced apoptotic cell death and caused a decrease in trauma markers.Öğe Comparison of effects of low and high flow desflurane anaesthesia on hemogram parameters(2019) Yoldaş, Hamit; Karagoz, İbrahim; Ekici, Mustafa Ayhan; Eş, Abdulhamit; Yıldız, İsa; Demirhan, Abdullah; Bilgi, MuratObjectives: To compare the effects of low and high flow desflurane anaesthesia on hemogram parameters in lower abdominal surgeries. Methods: Sixty female patients who underwent lower abdominal surgery under general anaesthetic were included in this prospective study. Patients were randomly divided into two groups, as Group I (low flow) and Group II (high flow), and then compared with each other according to their demographic features and hemogram parameters. Results: Groups were statistically similar, and there were no significant differences in terms of demographic data between the groups (p>0.05). The comparisons of hemogram parameters within the groups showed that there were significant differences in plateletcrit, platelet-lymphocyte ratio and neutrophil-lymphocyte ratio values in Group I (p<0.05). The comparisons of hemogram parameters within Group II showed a statistically significance in plateletcrit and platelet-lymphocyte ratio values. A statistically significant difference was found for red cell distribution width, neutrophil- lymphocyte ratio, platelet-lymphocyte ratio and plateletcrit values between groups for the pre-operative and post-operative values of hemogram parameters (p<0.05). Conclusion: Our study showed that the administration of low flow anaesthesia led to a positive effect on the inflammatory response by lowering neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and red cell distribution width values, in comparison to high flow anaesthesia.Öğe A difficult intensive care unit monitorization case: a suicidal attempt at 13 years of age by hanging(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2016) Yıldız, İsa; Söylemez, Esma; Karadayı, Hüsna; Erkuran, Mansur Kürşad; Bayır, Hakan; Yoldaş, HamitSuicide among young population is a global challenge increasing over time. Family problems, drug addiction, increased risk of childhood depression may lead to suicidal attempts by hanging with a rope, which is a rarely selected method at younger ages. Increased suicidal attempt rates cause increased rates of intensive care unit monitorization. Psychosocial support is quite important at this age group. In this report, a 13 years old girl, who was monitorized at the intensive care unit after she attempted suicide by hanging, would be discussed.Öğe A Difficult Intensive Care Unit Monitorization Case: a Suicidal Attempt at 13 Years of Age by Hanging(2016) Yoldaş, Hamit; Soylemez, Esma; Karadayi, Husna; Erkuran, Mansur Kürşad; Bayir, Hakan; Yildiz, IsaZor bir yoğun bakım takibi: 13 yaşında ası ile özkıyım Özkıyım gün geçtikçe genç nüfus arasında artış gösteren global bir sorundur. Aile içi sorunlar, madde bağımlılığı, çocukluk depresyonlarındaki artış küçük yaşlarda ası gibi nadir yöntemlerin seçilmesine yol açabilmektedir. Küçük yaşlarda intihar oranının artması yoğun bakım takiplerine neden olabilmektedir. Psikososyal destek bu yaş gruplarında oldukça önemlidir. Bu sunumda onüç yaşında ası ile özkıyım girişimi sonrası yoğun bakımda takip edilen bir kız çocuğu tartışılacaktırÖğe An easy and reliable way to prevent electrocardiographic deteriorations of patients undergoing off-pump coronary artery bypass surgery: Preoperative anxiolytic treatment(Soc Brasil Cirurgia Cardiovasc, 2019) Demirhan, Abdullah; Velioğlu, Yusuf; Yoldaş, Hamit; Karagöz, İbrahim; Coşgun, Mehmet; Çalışkan, Duygu; Yıldız, İsa; Erdem, Kemalettin; Bilgi, MuratObjective: To investigate the effects of preoperative anxiety relieving on electrophysiological changes in patients undergoing off-pump coronary artery bypass surgery. Methods: A total of 61 patients at ASA III risk group in the age range of 18-65 years were enrolled in the present study. Patients were randomly divided into two groups. Group S (Sedation group) was administered 0.04 mg/kg lorazepam per os (PO) twice before the operation. Group C (control group) was not administered with any anxiolytic premedication. State Trait Anxiety Inventory (STAI-I) and Beck Anxiety Inventory (BAI) were used to evaluate the level of anxiety. Electrocardiography (ECG), pulse oximeter and standard monitoring were performed for each patient. QT and P dispersions in each derivation of all ECGs were calculated. Results: Preoperative STAI-I scores were significantly lower in sedation group compared to the controls. Mean values of QT dispersion measured before induction, at the 1st minute of induction, 30th second of intubation and 4th minute of intubation in sedation group were significantly reduced compared to controls (P=0.024; P=0.027; P=0.001; P=0.033, respectively). The mean values of P dispersion measured before induction, at the 3rd minute of induction, 30th second of intubation and 4th minute of intubation in sedation group were significantly reduced compared to controls (P=0.001; P=0.020; P=0.023; P=0.005, respectively). Conclusion: Elevated anxiety levels in patients undergoing coronary bypass surgery have a negative effect through prolonged QT and P-wave dispersion times. Anxiolytic treatment before surgery may be useful to prevent ventricular and atrial arrhythmias and associated complications through decreasing the QT and P-wave dispersion duration.Öğe Effects of bispectral index-controlled use of magnesium on propofol consumption and sedation level in patients undergoing colonoscopy(2019) Yoldaş, Hamit; Yıldız, İsa; Karagöz, İbrahim; Demirhan, Abdullah; Bilgi, Murat; Şit, Mustafa; Ogün, Muhammed NurObjective: The aim of this study is to investigate the effects of bispectral index-controlled use of magnesium on propofol consumption, periprocedural hemodynamic response and patient comfort.Material: A total of 60 patients were enrolled in the study. In Group 1 (magnesium), a single dose 50 mg/kg magnesium sulfate diluted with 100 mL 0.9% NaCl was administered 10 min-utes before the beginning of the procedure. Initially bolus dose of 0.5 mg/kg propofol was ap-plied. The maintenance dose of propofol was 60 mcg/kg/min. During the procedure, the propo-fol infusion was increased by titration until the bispectral index (BIS) value of 70 was achieved. In Group 2 (saline), 100 ml 0.9% NaCl was administered 10 minutes before the beginning of the procedure. The bolus and maintenance doses of propofol, and target BIS values were the same as those in Group 1.Results: When BIS values were compared between the groups, the initial BIS values in the magnesium group (Group 1) were significantly higher than those of the saline group (Group 2) (p<0.05). The time to reach BIS 70 was significantly shorter in the magnesium group (p<0.05). Propofol consumption was greater in Group 2 than in Group 1 (p<0.05). The time to reach BIS 70 was significantly shorter in Group 1 (p<0.05). No significant difference was found between the groups in terms of patient- and endoscopist-satisfaction (p<0.05).Conclusion: The use of magnesium in addition to propofol may be an efficient and reliable op-tion to reduce the drug consumption during colonoscopic interventions.Öğe The effects of certain TRP channels and voltage-gated KCNQ/Kv7 channel opener retigabine on calcitonin gene-related peptide release in the trigeminovascular system(Sage Publications Ltd, 2022) Çıtak, Arzu; Kılınç, Erkan; Torun, İbrahim Ethem; Ankaralı, Seyit; Dağıstan, Yaşar; Yoldaş, HamitBackground Calcitonin gene-related peptide release in trigeminovascular system is a pivotal component of neurogenic inflammation underlying migraine pathophysiology. Transient receptor potential channels and voltage-gated KCNQ/Kv7 potassium channels expressed throughout trigeminovascular system are important targets for modulation of calcitonin gene-related peptide release. We investigated the effects of certain transient receptor potential (TRP) channels the vanilloid 1 and 4 (TRPV1 and TRPV4), the ankyrin 1 (TRPA1), and metastatin type 8 (TRPM8), and voltage-gated potassium channel (Kv7) opener retigabine on calcitonin gene-related peptide release from peripheral (dura mater and trigeminal ganglion) and central (trigeminal nucleus caudalis) trigeminal components of rats. Methods The experiments were carried out using well-established in-vitro preparations (hemiskull, trigeminal ganglion and trigeminal nucleus caudalis) from male Wistar rats. Agonists and antagonists of TRPV1, TRPV4, TRPA1 and TRPM8 channels, and also retigabine were tested on the in-vitro release of calcitonin gene-related peptide. Calcitonin gene-related peptide concentrations were measured using enzyme-linked immunosorbent assay. Results Agonists of these transient receptor potential channels induced calcitonin gene-related peptide release from hemiskull, trigeminal ganglion and trigeminal nucleus caudalis, respectively. The transient receptor potential channels-induced calcitonin gene-related peptide releases were blocked by their specific antagonists and reduced by retigabine. Retigabine also decreased basal calcitonin gene-related peptide releases in all preparations. Conclusion Our findings suggest that favorable antagonists of these transient receptor potential channels, or Kv7 channel opener retigabine may be effective in migraine therapy by inhibiting neurogenic inflammation that requires calcitonin gene-related peptide release.Öğe Effects of lidocaine oropharyngeal spray applied before endotracheal intubation on qt dispersion in patients undergoing coronary artery bypass grafting: A prospective randomized controlled study(Soc Brasil Cirurgia Cardiovasc, 2020) Bilgi, Murat; Velioğlu, Yusuf; Yoldaş, Hamit; Coşgun, Mehmet; Yüksel, Ahmet; Karagöz, İbrahim; Yıldız, İsa; Eş, Abdülhamit; Erdem, Kemalettin; Demirhan, AbdullahObjective: To investigate the effects of lidocaine oropharyngeal spray applied before endotracheal intubation on hemodynamic responses and electrocardiographic parameters in patients undergoing coronary artery bypass grafting. Methods: A total of 60 patients who underwent coronary artery bypass grafting surgery were included in this prospective randomized controlled study. Patients were randomly divided into two groups, the topical lidocaine group (administration of 10% lidocaine oropharyngeal spray, five minutes before laryngoscopy and endotracheal intubation) and the control group. Both groups were compared with each other in terms of main hemodynamic parameters including mean arterial pressure and heart rate, as well as P and QT wave dispersion durations, before and after endotracheal intubation. Results: The groups were similar in terms of age, gender, and other demographics and basic clinical characteristics. There was a statistically significant difference between the groups in terms of QT dispersion durations after laryngoscopy and endotracheal intubation. The increase in QT dispersion duration was not statistically significant in the topical lidocaine group, whereas the increase in QT dispersion duration was statistically significant in the control group. When the groups were compared in terms of P wave dispersion durations, there were significant decreases in both groups, but there was no significant difference between the groups. Conclusion: Our study revealed that the topical lidocaine administration before endotracheal intubation prevented increase of QT dispersion duration in patients undergoing coronary artery bypass grafting.Öğe Effects of magnesium sulphate on liver ischemia/reperfusion injury in a rat model(2019) Akkoca, Kerem; Yoldaş, Hamit; Şit, Mustafa; Karagöz, İbrahim; Yıldız, İsa; Demirhan, Abdullah; Bilgi, MuratAim: To investigate the protective efficacy of magnesium sulphate in a model of rat liver ischemiareperfusion (I/R) injury. Method: 32 adult female Wistar-Albino rats (250 to 350 g) were used in this experimental study. Rats were divided into 4 groups according to liver ischemia and magnesium sulfate application methods. Group 1 (C); control, group 2 (M); magnesium sulphate, group 3 (I/R); liver I/R, group 4 (I/R+M); I/R + magnesium sulphate treated. The blood samples were centrifuged for the study of aspartate aminotransferase (AST), alanine aminotransferase, prothrombin time (PT), international normalized ratio (INR) troponin I, total antioxidant status (TAS), total oxidant status (TOS) assays. The livers of the animals were removed at the end of the study and samples were taken for histopathological examination. Results: AST and INR values were significantly decreased in I/R+M group compared to I/R group. There was no significant difference in ALT values of the groups. Although not statistically significant, the TAS values were increased in I/R + M group compared to I/R group rats. In addition, the value of TOS was found to be lower in I/R + M group rats. In the histopathological examination, the mean values of apoptosis and necrosis were lower in the IR+M group compared to the I/R group. Conclusion: The main finding of the present study suggested that magnesium sulphate pretreatment moderately decreased the liver damage through its anti-inflammatory and anti-oxidant effects in a rat model of liver I/R.Öğe Evaluating the efficiency of different propofol doses associated with age and gender in rats(2022) Yildiz, Isa; Yoldaş, Hamit; Çetinkaya, Ayhan; Çakmak, Mücahit; Çamsari, Çağrı; Ayaz, ErolAim: To investigate the effect of different intraperitoneal (IP) doses of propofol on the duration and depth of anesthesia according to age and gender. Method: The rats were divided into three main groups according to propofol dose (GI: 5 mg/kg, GII: 10 mg/kg and GIII: 15 mg/kg). These three groups were divided into two subgroups as male and female. (M: Male, F: Female). Male and female groups in each dose group were divided into five different sub-age groups: 1: 2-6 months (0-12 years = Childhood), 2: 7-12 months (12-18 years = Adolescent), 3: 13-18 months (30-45 years = Young adult), 4: 19-24 months (45-60 years = Adult) and 5: older than 25 months (65 years old = Elderly). The duration and depth of anesthesia in different ages and genders were compared statistically. Results: There were differences with regard to the palpebral, pinch, corneal and muscle tone reflexes at propofol administration doses of 5 mg/kg (GI), 10 mg/kg (GII) and 15 mg/kg (GIII) in different ages and genders (Table 1). We detected that 50 minutes of deep anesthesia was achieved with a dose of 10 mg/kg up to 18 months and older than 24 months male rats. A dose of 10 mg/kg was sufficient for short-term (20-minute deep anesthesia) procedures in male rats aged 19-24 months. We detected that 50 minutes of deep anesthesia was achieved with a dose of 15 mg/kg in 7-12 and 13-18 month old female rats. A dose of 10 mg/kg dose was sufficient for short-term procedures in 0-6 month old female rats. However, only superficial anesthesia was detected at the dose of 15 mg/kg in female rats older than 18 months. Conclusion: The present study demonstrated that 10 or 15 mg/kg low doses of intraperitoneal propofol administration affected the duration and depth of anesthesia in different ages and genders in rats.Öğe Evaluation of olfactory memory after sevoflurane anesthesia: is really short-term memory influenced?(Scientific Publishers India, 2016) Bayır, Hakan; Yıldız, İsa; Yoldaş, Hamit; Karagöz, İbrahim; Kurt, Adem Deniz; Şereflican, MuratObjective: Olfactory disorders can negatively effect the quality of life. Few clinical studies and case reports have investigated the relationship between anesthesia and olfactory dysfunction. The aim of this study was to investigate the effect of sevoflurane on olfactory memory with Brief-Smell Identification Test (TM) in patients used sevoflurane. Patients and Methods: This, prospective, clinical study was performed on 60 ASA physical status I-II patients, between 18-65 years of age who were scheduled for expected surgery duration of 40-120 minutes. All patients were preoperatively informed about Brief-Smell Identification Test. For induction 2 mg.kg(-1)propofol, 0.5 mg.kg(-1) rocuronium and 1 mu g.kg(-1) iv fentanyl were administered. Anesthesia was maintained with the inhalational of anesthetic sevoflurane (2%). Brief-Smell Identification Test scores are recorded 30 minutes before the surgery and when the Aldrate Recovery Score reached 10 in the postoperative period. Preoperative and postoperative results were compared and p-values<0.05 were considered statistically significant. Results: The patients mean age were 47.1 +/- 13.8. There was no statistically significant difference between the mean preoperative and intraoperative HR and MAP values. Preoperative total correct answer rate to odorous substances was 85.4%, and postoperative rate was 84.5%. Percentage of the odor identification by the patients revealed no statistically significant difference when pre and post-operative rates were compared (P>0.05).Öğe Novel mortality markers for critically Ill patients(Sage Publications Inc, 2020) Yoldaş, Hamit; Karagöz, İbrahim; Ögün, Muhammed Nur; Velioğlu, Yusuf; Yıldız, İsa; Bilgi, Murat; Demirhan, AbdullahAim: Inflammatory markers, such as the neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), derived from a complete blood count have recently attracted attention as potential markers of morbidity and mortality in various diseases. The aim of the present study was to assess the usefulness of the NLR and PLR as markers of hospital stay and mortality of patients in intensive care units (ICUs). Methods: Patients treated in the ICU of our institution between October 2016 and August 2017 were enrolled in the study. After obtaining approval from the institutional committee, patient data were sourced from the institution's computerized database and retrospectively analyzed. The patients were assigned to 2 groups according to the outcomes: survivors and deceased. Results: The NLR of survivors and deceased patients was 2.06 (1.18-21.68) and 10.42 (2.85-48.2), respectively. The NLR was significantly elevated in deceased patients as compared with that of survivors (P < .001). Similarly, the median PLR of patients in the deceased group (268.9 [150-3000]) was significantly higher than that of patients in the survivor group (55.7 [11.8-152.5]). The difference in the PLR between groups was significant (P < .001). Conclusion: Both the NLR and PLR, as well as C-reactive protein, predicted mortality in this critically ill population. The PLR and NLR are easy-to-measure, inexpensive markers. Physicians should be aware of elevations in PLR and NLR in patient care in ICUs.Öğe A pediatric case of anesthesia mumps after general anesthesia(Medknow Publications & Media Pvt Ltd, 2015) Bayır, Hakan; Yıldız, İsa; Şereflican, Murat; Yoldaş, Hamit; Demirhan, Abdullah; Kurt, Adem D.
