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Öğe Effect of Inhaler Budesonide on Nasal and Oropharyngeal Carriage of Staphylococcus aureus in Asthma Patients(Bilimsel Tip Publishing House, 2007) Talay, Fahrettin; Karabay, Oguz; Yilmaz, Fahrettin; Kocoglu, EsraWe aimed to investigate the effect of inhaler budesonide spray that was used for one month to treat asthma on nasal and oropharyngeal carriage of Staphylococcus aureus. Fourty two asthma patients (32 female, 10 male) and 42 healthy control groups (33 female, 9 male) were accepted for this study. Oropharyngeal cultures were obtained from asthmatics admitted to the outpatient clinic of chest disease, before and after one- month 800 g/day inhaler budesonide therapy, evaluated for nasal and oropharyngeal carriage for S. aureus and compared with one single culture that was obtained from healthy controls. Three nasal and four oropharyngeal cultures were found to be positive for S. aureus in pretreatment cultures, and 4 nasal and 4 oropharyngeal cultures were positive after treatment. Five nasal and two oropharyngeal cultures were positive for S. aureus in control group. There was no difference in nasal and oropharyngeal S. aureus colonization in asthmatics before treatment compared to controls, and after treatment compared to pretreatment values (p > 0.05). There was no relationship between nasal and oropharyngeal colonization of S. aureus and gender, age, smoking, presence of atopy, and the degree of the illness in three groups (p > 0.05). We thought that the orally used inhaler steroid, budesonide which was administered to treat asthmatic do not affect the colonization of S. aureus in the nose and oropharynx.Öğe The effect of topical etofenamate with nicotinate on the success of peripheric venous cannulation(2008) Gülcü, Nebahat; Karaaslan, Kazim; Yilmaz, Fahrettin; Koço?lu, HasanObjective: Venipuncture is a commonly performed procedure in hospitalized patients. In this study we aimed to investigate the effects of etofenamate with nicotinate (Thermo-Rheumon® Cream) on the effectiveness on venous cannulation success and procedural pain in pediatric patients. Patients and Methods: Sixty children, aged 7-12 yr, ASA physical status I-II, undergoing elective adenoidectomy and/or tonsillectomy surgery were allocated into two groups. In group etofenamate (n=30), topical agent was applicated on dorsum of the non dominant hand before venipuneture then covered with a transparent dressing for 10 min. In EMLA (cutectic mixture of local anesthetics) group (n=30), cream was applicated 1 hour before the procedure then covered with a transparent dressing. In both groups, venous cannulation was performed with 22 G cannula. Difficulty in cannulation was evaluated by a 4 point scale and procedural pain by facial pain scale (range 0-10) and behavioral response scale (range 0-3) were scored. Results: Significant venipuncture success at the first attempt was observed in group etofenamate compared with EMLA group (p<0.05). The incidences of pruritus, erythema and discomfort were higher in etofenamate group (p<0.05). Both facial and behavioral pain scores were found lower in EMLA group (p<0.05). Conclusion: We concluded that etofenamate with nicotinate may provide significant benefit in augmenting the venipuneture success during intravenous cannula insertion in pediatric population but the effect on procedural pain is limited.Öğe Effectiveness of rapid antigen test with throat gargle in detecting group A beta-hemolytic streptococci(2008) Yilmaz, Fahrettin; Karabay, O?uz; Ince, Nevin Koç; Ekerbiçer, Hasan; Koço?lu, EsraOBJECTIVES: The most important disadvantage of rapid antigen tests (RAT) is low sensitivity for the diagnosis of group A beta-hemolytic streptococci (BHS). We determined the sensitivity, specificity, positive and negative predictive values of RAT in gargling samples. PATIENTS AND METHODS: The study included 106 patients (53 females, 53 males, mean age 22+/-12 years; range 16-65 years) with an initial diagnosis of tonsillopharyngitis. Swab samples were taken from the posterior pharyngeal wall and tonsil surface with a sterile cotton swab. Then, gargle samples were obtained by gargling for 10 seconds with sterile 0.9% NaCl to be examined by the RAT for group A BHS. Throat cultures were processed using standard microbiologic techniques. RESULTS: Throat cultures were positive in 12 patients (11.3%) and negative in 94 patients (88.6%). Rapid antigen test yielded five positive (4.7%) and 101 negative (95.2%) results. The sensitivity and specificity rates of RAT with throat gargling were 41.7% and 100%, with positive and negative predictive values of 100% and 93.1%, respectively. CONCLUSION: Despite satisfactory specificity, positive and negative predictive rates of RAT with throat gargling, its low sensitivity limits its use for the diagnosis of group A BHS.Öğe The efficacy of N-2-butyl cyanoacrylate in the fixation of nasal septum to the anterior nasal spine in rabbits(Springer, 2007) Alkan, Seyhan; Dadas, Burhan; Celik, Deniz; Coskun, Berna Uslu; Yilmaz, Fahrettin; Basak, TuelayIn nasal septal surgery, fixing the caudal portion of the nasal septum to the anterior nasal spine is difficult with the present techniques. N-2-butyl cyanoacrylate is a form of cyanoacrylate which is bioabsorbable and biocompatible. The feasibility and efficacy of the compound, which is easy to apply to the tissues, for the above purpose is investigated in this experimental study. Fourteen New Zealand rabbits were included in the study. The nasal septum was exposed with the open approach (transcolumellar). In the study group (n = 10), the septum was detached from the nasal floor and attached to a point 3 mm lateral to the nasal spine on the right side, using 2-butyl cyanoacrylate. In control group (n = 4) it was deviated 3 mm to the right side and left for spontaneous healing without using any fixation method. Beginning on the third postoperative week, one animal was sacrificed under general anesthesia, every week in the study group and every third week in the control group, and the septum was analysed. Foreign body reaction, histotoxicity, and the structure of the regenerative tissue in the junction of bone and cartilage were analysed with histopathology. The success of stabilization in the study group, where the septum was attached with N-2-butyl cyanoacrylate, was significantly superior to the control group where no fixation method was used (P < 0.05). Histopathologically, there were no differences between the two groups with respect to foreign body reaction, histotoxicity, and the tissue that formed between the bone and cartilage (P > 0.05). This study demonstrated that N-2-Butyl cyanoacrylate was successful in the fixation of the caudal edge of the nasal septum to the anterior nasal spine. No serious infections, foreign body reaction, necrosis or histotoxicity were observed.Öğe Extensive oral ulcerations(New Zealand Medical Assoc, 2006) Goksugur, Nadir; Yilmaz, FahrettinÖğe The impact of dexmedetomidine vs midazolam on coagulation factors during nasal surgery(2008) Karaaslan, Kazim; Gülcü, Nebahat; Yilmaz, Fahrettin; Serin, Erdinç; Çolak, Cemil; Koço?lu, HasanObjective: Dexmedetomidine is an ?2 adrenergic receptor agonist and has sedative analgesic properties. We aimed to investigate the effects of dexmedetomidine coagulation system in monitored anesthesia care (MAC) patients, and to compare it with that of midazolam. Material and Methods: Sixty patients undergoing nasal surgery with local anesthesia were recruited. In Group D, dexmedetomidine was infused iv 1 ?g kg-1 over 10 min followed by 0.5 ?g kg-1 h-1. In Group M, midazolam was given iv 40 ?g kg-1 followed by 50 ?g kg-1 h-1. The effects of both drugs on coagulation system were evaluated by means of hemoglobin (Hb), hematocrit (Hte), platelet count, fibrinogen, protrombin time, active partial tromboplastine time (aPTT), INR, protein C, protein S and antitromhin III (ATIII) parameters with preoperatively (t0), early (t1) and 6 hours after postoperatively (t2). Results: Postoperative early (t1) and late (t2) Hb, Hte, aPTT and ATIII were decreased in both groups, and fibrinogen were decreased on these times in group M compared with preoperative values (p<0.05). Fibrinogen values were lower in t1 and t2 measurement in group M compared with group D (p<0.05). Conclusion: We conclude that the uses of dexmedetomidine or midazolam in MAC for nasal surgery do not have any effect on coagulation parameters.Öğe Tularaemic cervical lymphadenopathy(New Zealand Medical Assoc, 2007) Karabay, Oguz; Yilmaz, Fahrettin; Gurcan, Saban; Goksugur, Nadir
