Yazar "Yazici, Mehmet" seçeneğine göre listele
Listeleniyor 1 - 18 / 18
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Assessment of cardiac functions in patients with adenotonsillar hypertrophy(Duzce University Medical School, 2011) Ordu, Serkan; Ozhan, Hakan; Uzun, Hakan; Alemdar, Recai; Erden, Ismail; Yazici, Mehmet; Gultekin, ErolBackground: The aim of this study is to compare cardiac function in children with and without adenotonsillar hypertrophy (ATH). Materials and methods: Ninety-one children (26 female 65 male) who were diagnosed as ATH in the pediatric outpatient clinic and twenty-three completely healthy, age-sex matched children (10 female 13 male) were included in the study. All patients underwent a complete twodimensional transthoracic echocardiographic and Doppler study. Results: Mean mitral E, A and deceleration time were significantly longer in ATH group. Also chamber areas and volumes were bigger. Pulmonary and mitral regurgitation were statistically more frequent in ATH group. Adenotonsillar grade was positively related with mean pulmonary arterial pressure (r: 0.44 p: <0.001). Mitral valve thickness was strongly correlated with tonsillar hypertrophy grade (r: 0.73; p.<0.001). Conclusions: ATH may lead to mild diastolic dysfunction and chamber dilatation. Mitral valve thickness was strongly correlated with adenotonsillar grade. © 2011 Düzce Medical Journal.Öğe Assessment of quality of life and anxiety levels in patients who underwent electrophysiologic study due to unexplained palpitations(Turkish Soc Cardiology, 2013) Ozlu, Mehmet Fatih; Yildirim, Osman; Erdem, Alim; Ozturk, Serkan; Ayhan, Suzi Selim; Canan, Fatih; Yazici, MehmetObjectives: To compare the quality of life and anxiety levels of the patients with normal and abnormal results detected during an electrophysiologic study (EPS) that was performed due to undocumented episodes of palpitations. Study design: The patients (n=128) with complaints of palpitations who underwent EPS because their arrhythmias could not be documented were included in the study. The quality of life and anxiety levels of patients with abnormal EPS results were compared to those with normal results using the 26-item short form of the World Health Organization quality of life scale and state-trait anxiety inventory. Results: SVT was found in 72 patients by diagnostic EPS. Quality of life scores were significantly poorer in the SVT group than those of the normal EPS group (p=0.0000.001). Likewise, the anxiety scores of the patients in the SVT group were higher than those of the group with normal EPS findings (p=0.000). Age, physical quality of life, psychological quality of life, state-and trait anxiety were found to be independent predictors of SVT in multivariate regression analysis. Conclusion: The level of anxiety was found to be higher and quality of life relatively lower in patients with palpitations due to SVT. In clinical practice during evaluation process of the patients with palpitations, it should be kept in mind that recognized psychiatric symptoms may be secondary to an underlying arrhythmia.Öğe Color M-mode regurgitant flow propagation velocity: A new echocardiographic method for grading of mitral regurgitation(2004) Akdemir, Ramazan; Özhan, Hakan; Gündüz, Hüseyin; Yazici, Mehmet; Erbilen, Enver; Albayrak, Sinan; Ünlü, HakanThe aim of this study was to evaluate the reliability of mitral regurgitation color M-mode regurgitant flow propagation velocity (RFPV) in grading mitral regurgitation (MR). This new transthoracic Doppler echocardiographic technique is easier and equally or more practical than qualitative and quantitative methods used to grade MR in patients both with normal and low left ventricular ejection fraction (LVEF). Color M-mode echocardiography allows resolution of regurgitant flow propagation along the echocardiography beam inside the left atrium. The characteristics of the velocity of this jet have not been studied in detail before. The present study compares the different qualitative and quantitative methods of MR grading with the RFPV. We prospectively examined 52 consecutive patients with grades of MR mild in 10 patients, moderate in 19 patients and severe in 23 patients with quantitative pulse Doppler echocardiography. MR was evaluated by vena contracta diameter (VCD), regurgitant jet area (RJA) and RFPV. These qualitative and quantitative methods were compared with the pulsed Doppler quantitative flow measurements and concordance of these 3 methods was determined. The mean RFPV for mild, moderate and severe MR were 26.4±7 cm/s, 43.3±7 cm/s and 60.3±7.3, respectively (p<0.001). RFPV is highly sensitive and moderately specific in differentiating mild and severe MR from other subgroups. Sensitivity and specificity were 92.1-64.3% for mild and 100-68.5% for severe MR, respectively. Significant correlation was observed between pulse Doppler quantitative grades, RFPV, VC and RJA (p<0.0001, r=.87; p<0.0001, r=-.84; p<0.0001, r=.76, respectively). This results show that RFPV is a reliable and simple semi-quantitative new method that can be used for determining severity of MR.Öğe Dev arteriyosklerotik aksiller anevrizması: Olgu sunumu(2005) Tetik, Ömer; Yazici, Mehmet; Bayatli, Kıvanç; Gürbüz, AliArteriyosklerotik aksiller arter anevrizmaları çok nadirdir. Altmış dokuz yaşında erkek hasta, sağ kol ve önkolda uyuşma ve koltuk altında şişlik yakınmasıyla başvurdu. Hastaya, dokuz yıl önce sol aksiller arter anevrizması nedeniyle anevrizmektomi ve greft interpozisyonu yapılmıştı. Dubleks ultrasonografide 40x50 mm, dinamik toraks bilgisayarlı tomografide 44 mm boyutlarında aksiller arter anevrizması saptandı. Genel anestezi altında, aksiller arter anevrizması rezeke edildi. Histopatolojik incelemede arteriyosklerotik dejeneratif değişiklikler görüldü. Ameliyat sonrası dönemi sorunsuz geçiren hasta yedinci günde taburcu edildi.Öğe Diyabetik hastalarda egzersiz stres testinde hesaplanan Qt parametrelerine trimetazidinin etkisi(2005) Özhan, Hakan; Yazici, Mehmet; Albayrak, Sinan; Erbilen, Enver; Gülcan, Erim; Bulur, SerkanAmaç: Çalışmamızda normal epikardiyal koroner arterlere sahip tip II diyabetik hastalarda, egzersizle QT parametrelerindeki değişim ve buna trimetazidin tedavisinin etkisi araştırıldı.Gereç ve Yöntem: Çalışmaya koroner anjiografisi normal olan tip II diabetes mellitus (DM) tanısı almış 19 hasta (ortalama yaş; 52±15, erkek/kadın; 9/10) ve 20 sağlıklı birey (ortalama yaş; 51±11, erkek/kadın; 10/10) alındı. Tüm bireylere trimetazidinle 3 aylık tedavi öncesi ve sonrası Bruce protokolü ile semptom-sınırlı treadmill egzersiz testi (EST) uygulandı. Çalışmaya alınan bireylerin klinik, biyokimyasal, ekokardiyografik ve elektrokardiyografik değerleri kaydedildi. EST sırasında belli aralıklarla QT intervalleri, Bazzet formülüyle hıza göre düzeltililen QT dispersiyonu (QTcD) kaydedildi.Bulgular: EST öncesinde, hastaların QTcD değerleri kontrollerden yüksekti. Pik egzersizde ölçülen QTcD'de (pik QTcD) kontrol grubunda anlamlı değişiklik olmazken hasta grubunda belirgin bir artış (sırasıyla; 31.7±6.9 ms; p>0.05, 53.7±9.6 ms; p<0.001) saptandı. EST sonrası QTcD değerleri de azalmasına rağmen kontrollere göre yüksekti (43.4±8.1 ms; p<0.01) . Tedavi sonrasında yapılan EST öncesi, sonrası ve pik egzersizde hesaplanan QTcD değerleri azalmış ve kontrollerinkine benzer bulundu (sırasıyla; 34.7±6.9 ms, 35.9±8.9 ms, 33.9±7.3 ms, p>0.05). Bunlardan pik QTcD değerleri tedavi öncesine göre belirgin olarak azaldı (35.9±8.9 ms; p<0.005).Sonuç: Bu bulgular, tip II DM'li hastalarda QTcD'de özellikle egzersizle belirginleşen artışın ventriküler aritmiyi tetikleyebileceği ve dolayısıyla ani ölüm sıklığındaki artışla ilişkili olabileceğini düşündürmektedir. Trimetazidinle tedavi sonrası pik QTcD'deki belirgin azalma ilacın hücresel düzeydeki anti-iskemik etkisinden kaynaklanan dolaylı bir elektrofizyolojik sonuç olarak görülebilir.Öğe Effect of reperfusion on P-wave duration and P-wave dispersion in acute myocardial infarction: Primary angioplasty versus thrombolytic therapy(2004) Akdemir, Ramazan; Özhan, Hakan; Gündüz, Hüseyin; Tamer, Ali; Yazici, Mehmet; Erbilen, Enver; Albayrak, SinanAtrial fibrillation is a common arrhythmia occurring in about 10-20% of patients with acute myocardial infarction. P-wave dispersion and P-wave duration have been used to evaluate the discontinuous propagation of sinus impulse and the prolongation of atrial conduction time respectively. This study was conducted to compare the effects of reperfusion either by thrombolytic therapy or primary angioplasty on P wave duration and dispersion in patients with acute anterior wall myocardial infarction. We have retrospectively evaluated 72 consecutive patients (24 women, 48 men; aged 58 ±12 years) experiencing a first acute anterior wall myocardial infarction (AMI). Patients were grouped according to the reperfusion therapy received (primary angioplasty (PTCA) versus thrombolytic therapy). Left atrial diameter and left ventricular ejection fraction (LVEF) were determined by echocardiography in all patients. Electrocardiography was recorded from all patients on admission and on pach day of hospitalization. Maximum (P max) and minimum (P min) P wave durations and P wave dispersions (PWd) were calculated before and after treatment. There were no significant differences between the groups regarding age, gender, left ventricular ejection fraction (LVEF), left atrial diameter and volume, cardiovascular risk factors and duration from symptom onset to treatment. PWd and P wave durations were significantly reduced after PTCA (mean P max was 113±11 ms before and 95±17ms after the treatment [p=0.007]. Mean PWd was 46±12 ms before and 29±10 ms after the treatment (p=0.001). Also, P max and PWd were significantly lower in PTCA group (for P max 97±22 ms versus 114±16 ms and for PWd 31±13 ms versus 55±5 ms, respectively). Primary angioplasty reduces P max and P wave dispersion.Öğe Efficacy of nebivolol on flow-mediated dilation in patients with slow coronary flow(2009) Albayrak, Sinan; Ordu, Serkan; Yuksel, Hatice; Ozhan, Hakan; Yazgan, Ömer; Yazici, MehmetSlow coronary flow (SCF) is the phenomenon of slow progression of angiographic contrast in the coronary arteries in the absence of stenosis in the epicardial vessels in some patients presenting with chest pain. There are no definite treatment modalities for patients with SCF. Our aim was to investigate the efficacy of nebivolol in patients with slow coronary flow by monitoring its effects on endothelial function and different markers of inflammation. Forty-two patients (16 females, 26 males; mean age, 55±10) with slow coronary flow (SCF) were included in the study. After baseline assessment, the patients were administered nebivolol 5 mg once daily. After 12 weeks of nebivolol therapy, the biochemical and ultrasonographic examinations were repeated. Chest pain relief was detected in 38 patients after treatment (90%). Systolic and diastolic blood pressure and high sensitive CRP were significantly decreased after nebivolol therapy. Among brachial artery dilation variables that reflect endothelial function, basal resistive index (RI), post-flow mediated dilation RI, and post-nitrate mediated dilation RI were significantly decreased after therapy. Nebivolol is effective at improving endothelial function in patients with SCF. It controls chest pain, decreases CRP, and has favorable effects on brachial artery dilation variables in patients with coronary slow flow.Öğe Fibromiyalji sendromunda kardiyovasküler sistemin değerlendirilmesi: doku Doppler ekokardiyografik inceleme(2010) Yazici, Selma; Yazici, Mehmet; Albayrak, Sinan; Makarç, Sevim; Kolbas, Melek; Erbilen, Enver; Akdemir, RamazanAmaç: Biz Fibromiyalji (FM) hastalarında kardiyak yapı ve fonksiyonların hem geleneksel hem de yeni ve faydalı bir metot olan doku Doppler ekokardiyografik (DDE) yöntemle incelemeyi amaçladık. Ayrıca, hastalığın patogenezinde olası mekanizmalardan biri olarak gösterilen otonom fonksiyon bozukluğunu elektrokardiyografik olarak QT parametrelerini (QT maksimum, QT minimum ve QT dispersiyonu) ölçerek değerlendirdik. Yöntem: Çalışma aynı kliniğe başvuran 42 hasta (ortalama yaş 41, 38 kadın ) ve kontrol grubu olarak alınan tamamen sağlıklı 38 kişi üzerinde yapıldı. Bireylerin her birine tam bir fizik muayene, elektrokardiyografik (50 mm/s hızla kaydedilen) ve ekokardiyografik (hem geleneksel, hem de DDE) ile değerlendirme yapıldı. Bulgular: Elektrokardiografik kayıtların analizinde QT dispersiyonunda hafif fakat istatistiksel olarak anlamlı olmayan bir artış saptandı. Geleneksel ekokardiyografik parametreler açısından hasta grubu ile kontrol grubu benzerdi. Bununla birlikte bu çalışmanın önemli bir bulgusu hasta grubunda DDE yöntemi ile saptanan gevşeme bozukluğu idi. Em dalga hızı ve Em/Am oranları FM hastalarında kontrollere kıyasla anlamlı düzeyde düşüktü (sırasıyla, p < 0.005, p < 0.01). Sm ve Am dalga hızları ise her iki grupta da benzerdi. Sonuç: Bu çalışmada hasta grubunda DDE yöntemi ile saptanan sol ventrikülün gevşeme bozukluğu FM’de görülen yorgunluk ve nefes darlığı gibi bazı semptomları kısmen açıklayabilir. Ayrıca tam bir kardiyak değerlendirme yapılması ile fibromiyaljinin patogenezindeki otonomik disfonksiyon teorisini destekleyecek bulgular elde edilebilir.Öğe Mean platelet volume in patients with non-alcoholic fatty liver disease(2010) Ozhan, Hakan; Aydin, Mesut; Yazici, Mehmet; Yazgan, Omer; Basar, Cengiz; Gungor, Adem; Onder, ElifMean platelet volume (MPV) is an indictor of platelet activation. Platelet activation and aggregation are central processes in the pathophysiology of coronary heart disease. Non-alcoholic fatty liver disease (NAFLD) is present up to onethird of the general population and the majority of patients with cardio-metabolic risk factors such as abdominal obesity, type 2 diabetes and other components of the metabolic syndrome (MS). The aim of the current study was to investigate the MPV in patients who had NAFLD. MPV values of the patients with NAFLD and of the patients without fatty liver disease were compared. NAFLD patients had significantly higher body mass index compared to the control cases. Among biochemical variables, fasting plasma glucose and triglyceride were significantly higher in the NAFLD group. NAFLD cases also had lower platelet count and higher MPV (10.43 ± 1.14 vs. 9.09 ± 1.25; p < 0.001, respectively). MPV was positively correlated with AST (r: 0.186, p < 0.042), ALT level (r: 0.279; p 0.002) and the presence of NAFLD (0.492; p < 0.001) but negatively correlated with platelet number (r: -0.26; p 0.004) and creatinine (r: -0.255; p 0.005). In logistic regression analysis (age, gender, NAFLD, body mass index, high-density lipid (HDL) cholesterol, systolic and diastolic blood pressure, triglyceride and fasting plasma glucose were used as covariates) only NAFLD was found to be the independent predictor of MPV (Odds Ratio (OR) 21.98) [95% confidence interval (CI): 2.404-201.048; p: 0.006]. We have shown for the first time in the literature that, patients with NAFLD have higher MPV. It may have prognostic value in NAFLD patients indicating a possible cardiovascular disease (CVD) risk increase. © 2010 Informa UK Ltd.Öğe Mild Renal Dysfunction Among Turkish Adults: Prevalence and Its Association With Insulin Resistance(Turk Nefroloji Diyaliz Transplantasyon Dergisi, 2006) Onat, Altan; Yazici, Mehmet; Hergenc, Gulay; Uyarel, Huseyin; Esen, A. Metin; Karabulut, Ahmet; Can, GunayObjectives: To investigate the prevalence of mild renal dysfunction and its association with insulin resistance (IR), metabolic syndrome (MS) or its components among Turkish adults. Methods: Serum creatinine concentrations were measured in 1048 male and female subjects. After excluding cases with diabetes mellitus, 933 participants of a representative cohort were studied cross-sectionally. Glomerular filtration rate (GFR) was estimated based on serum creatinine concentrations using the Modification of Diet in Renal Disease formula. GFR was divided into 3 categories constituting chronic kidney disease stages 2 and 3 3. MS was identified by modified criteria of the Adult Treatment Panel-III. Results: MS existed in 38.7% of the cohort. Mild renal dysfunction (estimated GFR 60 to 89.9 mL/min/1.73 m(2)) existed in 50% of the study sample in both genders. Compared to the group with normal GFR, in category II, age-adjusted estimates of body mass index, homeostatic model assessment (HOMA) index, blood pressures, total, HDL-, LDL-cholesterol and serum proteins were all significantly elevated in both genders, as were apo B and log TSH in women alone. Stated variables were also significantly and inversely correlated with GFR. Whereas MS was not significantly associated with GFR categories, nor with reduced GFR when controlled for HOMA, HOMA D adjusted for MS as well as for sex, age and systolic BP-was significantly associated with likelihood for reduced GFR. Conclusions: Mild impairment of kidney function is very common in nondiabetic middle-aged and elderly adults, is associated mainly with IR and related cardiovascular risk factors, in the absence of MS-related atherogenic dyslipidemia. IR is important even in mild reduction in GFR, an action independent of central obesity-related components of MS.Öğe OUTCOME OF PRIMARY PERCUTANEOUS INTERVENTION IN PATIENTS WITH INFARCT RELATED CORONARY ARTERY ECTASIA(Elsevier Ireland Ltd, 2010) Erden, Ismail; Ordu, Serkan; Alemdar, Recai; Aydin, Mesut; Ozhan, Hakan; Yazici, Mehmet; Basar, CengizÖğe Pioglitazone improves ventricular diastolic function in patients with diabetes mellitus: A tissue Doppler study(Acta Cardiologica, 2010) Ordu, Serkan; Ozhan, Hakan; Alemdar, Recai; Aydin, Mesut; Basar, Cengiz; Caglar, Onur; Yazici, MehmetObjective - Pioglitazone treatment in type 2 diabetes mellitus produced significant improvements in glycaemic control, plasma lipids, blood pressure and inflammation. The aim of this study was to investigate the effect of pioglitazone on systolic and diastolic function in diabetic patients. Methods and results - Forty-nine diabetic patients were included in the study.The patients had never received thiazolidinedione therapy before. Clinical and echocardiographic variables were measured. 30 mg pioglitazone were administered. The patients were followed up for six months and all the measurements were re-evaluated for comparison. Body mass index (BMI) significantly increased after treatment. Fasting glucose, HbA1c and systolic blood pressure decreased. Insulin resistance improved and the HOMA-IR index decreased after pioglitazone treatment. Mean aortic diameter, left atrial systolic and diastolic volumes significantly decreased after therapy. Among diastolic function variables mitral E wave, E/A, ejection time and pulmonary vein peak reverse flow velocity (PVA) significantly increased whereas isovolumetric relaxation time (IVRT), isovolumetric contraction time (IVCT), deceleration time, E/E' and pulmonary vein late systolic flow (PVS2) decreased after pioglitazone therapy. Among tissue Doppler variables early (E) ventricular inflow velocities measured from the tricuspid lateral annulus, the mitral septal and lateral annulus, the anterior, inferior and posterior free wall significantly increased. Late (A) ventricular inflow velocities measured from the anterior, inferior free wall and the mitral septal annulus also increased. Conclusion - Pioglitazone treatment in type 2 diabetes mellitus produced significant improvements in measures of glycaemic control and diastolic ventricular function.Öğe Predictive value of mean platelet volume in young patients with non- ST-segment elevation acute coronary syndromes: A retrospective observational study(2013) Özlü, Mehmet Fatih; Öztürk, Serkan; Ayhan, Suzi Selim; Tosun, Mehmet; Alçelik, Aytekin; Erdem, Alim; Yazici, MehmetAmaç: Trombositler akut koroner sendromların oluşumu ve ilerlemesinde önemli bir rol oynamaktadır. Bu çalışmada ST yükselmesi olmayan akut koroner sendromlu (NSTE-AKS) genç hastalarda ortalama trombosit hacminin öngördürücü değerini araştırmayı amaçladık. Yöntemler: Bu, 45 yaş altındaki 79 NSTE-AKS hastasının ve normal koroner anatomiye sahip 45 kontrol bireyinin MPV değerlerini karşılaştıran geriye dönük gözlemsel bir çalışmadır. NSTE-AKS grubunu 41 ST yükselmesi olmayan miyokart enfarktüsü (NSTEMI) ve 38 kararsız angina pektoris (USAP) hastası oluşturmuştur. MPV, Coulter Sayaç adı verilen otomatik bir hematolojik tahlil cihazı kullanılarak ölçülmüştür. MPV’nin prediktif değeri lojistik regresyon analizi kullanılarak ve NSTE-AKS ve kontrol grupları arasında MPV karşılaştırılması Mann-Whitney U testi ile değerlendirilmiştir. Bulgular: NSTE-AKS grubundaki MPV değerleri kontrol grubuna göre anlamlı olarak yüksek bulundu (8.49±1.22’a karşılık 7.78±0.65 fL, p=0.001). Lojistik regresyon analizinde, MPV’nin NSTE-AKS’nin bağımsız bir belirleyicisi olduğu bulunmuştur (OR=3.1, %95 CI 1.2-8.2, p=0.022). NSTEMI grubunda MPV değerleri USAP grubundan anlamlı olarak farklı değildi (8.78±1.38 versus 8.17±0.95 fL, p=0.66). Benzer şekilde, 3 grubun (Kontrol, USAP ve NSTEMI) MPV değerleri arasında anlamlı derecede farklılık olduğu tespit edilmiştir (7.78±0.65, 8.18±0.95, 8.78±1.38 fL respectively, p=0.001). Sonuç: Sonuç olarak, kontrol grubu ile karşılaştırıldığında genç NSTE-AKS hastalarında MPV değerleri daha yüksek bulunmuştur. Aynı zamanda artmış MPV, NSTE-AKS’ın bağımsız bir belirleyicisi olarak bulunmuştur.Öğe Relation of neutrophil/lymphocyte ratio with the presence and extent of coronary artery ectasia(Turkish Soc Cardiology, 2013) Ayhan, Selim; Ozturk, Serkan; Erdem, Alim; Ozlu, Mehmet Fatih; Ozyasar, Mehmet; Erdem, Kemalettin; Yazici, MehmetObjectives: It has been shown that the neutrophil to lymphocyte ratio (N/L ratio) is associated with cardiovascular events and mortality. In this study, we investigated the N/L ratio in patients with coronary artery ectasia (CAE). Study design: Fifty patients (29 men, 21 women; mean age, 51.1+/-7.1 years) diagnosed as CAE using coronary angiography were included in the study. The control group consisted of 28 patients (16 men, 12 women; mean age, 49.5+/-9.4 years) who had normal coronary arteries as determined by coronary angiography. Baseline characteristics were recorded. The number of ectatic segments was noted. Hematologic parameters were measured and the N/L ratio was calculated. Results: The N/L ratio was significantly higher in the CAE group compared with the control group (median [25-75% percentile] 2.2 [1.6-3.0] vs. 1.8 [1.4-2.0], p=0.014, respectively). The Spearman correlation analysis demonstrated that the N/L ratio positivelyÖğe The Risk Factor Survey of 2003 in Western Turkey Indicates Trend to Declining Coronary Mortality and Urban Overall Mortality(2003) Onat, Altan; Yazici, Mehmet; Sari, Ibrahim; Türkmen, Serdar; Uzunlar, Bülent; Uyarel, Hüseyin; Özmay, MehmetWith the aim of assessing, among others, the coronary morbidity and mortality in the past 27-month period, the last survey of the Turkish Adult Risk Factor Study was conducted in August, 2003 in the Marmara and Central Anatolian regions. Epidemiological methods applied were as previously described. In a total of 1560 individuals of the cohort, 1028 men and women were examined. Furthermore, information was obtained in 422 persons, and death was ascertained in 18 men and 13 women. Eleven new deaths of coronary origin were diagnosed at a follow-up over 2965 person-years. Estimated annual all-cause mortality amounted to 10.5 per mille, coronary mortality to 3.7 per mille. In the age-bracket 45-74 years, total mortality was 13.4 and coronary mortality 4. 2 per mille. A total of 28 cases of new fatal and nonfatal coronary heart disease (CHD) corresponded to an annual rate of 10.6 per mille. Furthermore, randomly selected 200 men and women aged 38 to 69 years from 11 communities were newly recruited in the survey's cohort for future follow-up. Though no evidence for a reduction existed in overall new CHD events, coronary and overall mortality tended to decline (to 5 and 12 per 1000 person-years, respectively) since year 2000; the decline in overall mortality appeared to take place in urban areas.Öğe Serum total and high-density lipoprotein phospholipid levels in a population-based study and relationship to risk of metabolic syndrome and coronary disease(Sage Publications Inc, 2008) Hergenc, Gulay; Onat, Altan; Sari, Ibrahim; Yazici, Mehmet; Eryonucu, Beyhan; Can, GunayThe aim of study was to investigate the role of serum total (TPL) and high-density lipoprotein phospholipids (HDL-pl) as a risk factor in coronary heart disease (CHD) and metabolic syndrome (MS). In a random sample, total and HDL-pI were measured in 1088 and 642 adults from Turkey, respectively, who have a high prevalence of MS; this was done with an enzymatic method that measures total phosphatidylcholine, sphingomyelin, and lysophosphatidylcholine. Serum TPL and HDL-pl levels were significantly higher in women (TPL, 2.8 mmol/L; HDL-pl, 1.21 mmol/L) than in men. Strong correlations existed between serum TPL levels and non-HDL cholesterol (HDL-C), triglycerides, apolipoprotein (apo) B, complement C3, and gamma-glutamyltransferase. Non-HDL-C, HDL triglyceride, and apo A-I were strongly correlated with HDL-pl. Linear regression analyses revealed HDL-C, apo B, triglycerides, diabetes, and female gender as independent significant determinants of TPL levels in adults. HDL-C and impaired glucose regulation were sole significant variables, together contributing one-quarter of serum HDL-pl. Individuals with MS or diabetes had significantly higher TPL concentrations. The gender- and age-adjusted odds ratio (OR) of TPL for MS was 1.73 (95% confidence interval, 1.35-2.21), whereas the multiadjusted OR of HDL-pl per 1 SD increment corresponded to a significantly reduced independent MS likelihood by 26% in women (and 18% in the entire group). The multiadjusted OR of HDL-pl for CHD in men and women combined was 0.32 (P =.057) corresponding to a reduced CHD likelihood by 32% per I SD increment of HDL-pl. Plasma TPL levels point to an adverse relationship to MS, whereas their role in CHD risk needs further investigation. HDL-pls, in contrast, mark substantial protection from MS as well as from CHD.Öğe Simultaneous anterior and inferior myocardial infarction due to occlusion of the left anterior descending coronary artery(2004) Akdemir, Ramazan; Gündüz, Hüseyin; Özhan, Hakan; Yazici, Mehmet; Erbilen, Enver; Uyan, Cihangir-Öğe Türk yetişkinlerinde serum albümin düzeylerinin geleneksel risk faktörleri ve insülin direnci ile ilişkisi(2007) Yazici, Mehmet; Onat, Altan; Hergenç, Gülay; Esen, Ali Metin; Can, Günay; Uyarel, HüseyinAmaç: Türk yetişkinlerinde serum albümin düzeyleri ile insülin direnci, metabolik sendrom (MS), geleneksel koroner kalp hastalığı (KKH) ve risk faktörleri arasındaki ilişki araştırıldı. Çalışma planı: Serum albumin konsantrasyonları, Marmara ve İç Anadolu bölgeleri nüfusunu temsil eden 1052 kişide kolorimetrik yöntemle ölçüldü ve kesitsel olarak değerlendirildi. Metabolik sendrom tanımı modifiye ATP III (Adult Treatment Panel III) ölçütlerine göre yapıldı.Bulgular: Ortanca yaşı 53 olan örneklemde, MS tanısı erkeklerin %44.7'sinde, kadınların %49.4'ünde kondu. Serum albümin konsantrasyonu erkeklerde ortalama 4.39±0.38 mg/dl, kadınlarda 4.34±0.33 mg/dl bulundu (p=0.01). İkili korelasyonlarda serum albümin, her iki cinsiyette apolipoprotein B, HDL-kolesterol ve toplam bilirübin ile doğrusal; kadınlarda sistolik kan basıncı ile doğrusal; erkeklerde log CRP ile ters yönde anlamlı ilişki sergiledi. On bir değişkeni içeren bir lineer regresyon modelinde, albümin düzeyi için her iki cinsiyette yaş ters yönde, toplam kolesterol pozitif yönde bağımsız belirteç olarak saptandı. Kadınlarda albümin düzeyini bağımsız ve ters yönde etkiler görünen sigara içimi, erkeklerde anlamlılık sınırına yakın bir ilişki gösterdi. Kadınlarda kreatinin pozitif, erkeklerde diyastolik kan basıncı pozitif, log HOMA ters yönde bağımsız belirteç idi. Yaş ve cinsiyet ayarlı analizinde serum albümi ile MS ve KKH arasında anlamlı bağıntı saptanmadı. Sonuç: Türk erkeklerinde serum albümin düzeyinde görülen azalmaya, böbrek disfonksiyonundan bağımsız olarak insülin direnci katkıda bulunuyor olabilir. İnsülin direnci bu bağlamda, oksidatif stres ve subklinik kronik inflamasyona aracılık ediyor olabilir
