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Öğe Bone mineral density: A potential determinant of atherosclerotic plaque morphology in established coronary artery disease?(Elsevier Ireland Ltd, 2011) Sivri, Nasir; Yalta, Tülin; Yalta, Kenan; Yetkin, Ertan; Aksoy, YükselThe potential association between low bone mineral density (BMD) and coronary artery disease (CAD) has drawn particular attention in the recent years, but has yet remained to be thoroughly established. In their recently published article, Beer S. et al. investigated the association between low BMD and angiographically determined CAD in male patients [1]. The authors concluded that neither osteoporosis nor osteopenia is independently associated with the presence of CAD [1]. Likewise, in a previous study comprising postmenopausal women, neither CAD nor cardiovascular risk factors were found to be associated with low BMD [2]. However, as described below, low BMD may be closely associated with ectopic calcification in various tissues including heart valves, coronary arteries and atherosclerotic plaques etc. Extensive calcification of plaques associated with low BMD may particularly elicit propensity to a more stable plaque morphology possibly along with a reduced incidence of acute coronary syndromes (ACSs) in patients with established CAD and osteal pathologies.Öğe Chronotropic incompetence: An obscure cause of heart failure symptoms in survivors of critical diseases?(Elsevier Ireland Ltd, 2011) Yalta, Kenan; Yalta, Tülin; Sivri, Nasir; Aksoy, Yüksel; Yetkin, ErtanIn their recently published article, Ruiz-Bailén M et al. prospectively investigated the course of myocardial dysfunction that had developed in a group of critically ill patients, and comment on different aspects of reversible myocardial dysfunction in a critically ill patient (RMDCIP) [1]. They concluded from their study findings that myocardial segmental contractile dysfunction in response to stress may persist in some patients surviving RMDCIP indicating that myocardial dysfunction may not be totally reversible in these patients [1]. We agree with the authors on the concept of residual myocardial dysfunction in the survivors of RMDCIP. Residual myocardial contractile dysfunction may be totally asymptomatic or may elicit a variety of heart failure symptoms and signs in these patients. However, as described later, chronotropic incompetence associated with a related critical disease may also occur during the disease course, and may indefinitely persist to some degree potentially contributing to heart failure symptoms and signs in a portion of survivors of critical diseases.Öğe Copeptin (C-terminal provasopressin): A promising marker of arrhythmogenesis in arrhythmia prone subjects?(Elsevier Ireland Ltd, 2011) Yalta, Kenan; Sivri, Nasir; Yalta, Tülin; Geyik, Bilal; Aksoy, Yüksel; Yetkin, ErtanNeurohormones have drawn particular attention in the recent years possibly due to their potential diagnostic and prognostic values in a variety of clinical conditions including congestive heart failure (CHF), acute myocardial infarction (AMI), etc. Among neurohormones, arginine vasopressin (AVP) has been known to be secreted by hypothalamus in response to hypovolemia and increased plasma osmolality [1], and was also demonstrated to be a marker of the presence and severity of CHF [2]. However as described below, the potential association between AVP system and arrhythmogenesis may also confer some important therapeutic and prognostic implications in arrhthmia-prone patients. In the recent years, due to the instability and rapid clerance [1], the clinical utility of AVP has been gradually abandoned to some degree, and copeptin (CP), another novel neurohormone of the AVP system, has come into use in the clinical practice.Öğe The effect of smoking on the baroregulatory system: Heart rate turbulence(2012) Erdem, Alim; Yalta, Kenan; Yılmaz, Mehmet Birhan; Turgut, Okan Onur; Yılmaz, Ahmet; Yazıcı, MehmetGiriş: Sigaranın kardiyovasküler sisteme olan zararlı etkileri bilinmektedir. Çalışmamızın amacı sigara içiminin baroregülatuvar mekanizmaya olan etkilerini, kalp hızı türbülansını kullanarak normal kişilerle karşılaştırmaktır. Materyal ve Metod: En az bir yıldır sigara içme öyküsü olan asemptomatik 64 kişi grup 1 olarak kabul edildi. Aynı klinik özelliklere sahip asemptomatik sigara alışkanlığı olmayan 30 kişi grup 2 olarak düzenlendi. Çalışmaya alınan grup 1’deki sigara içicilerinin nikotin bağımlılık indeksi (NBİ) modifiye-Fagerström Nikotin bağımlılık testi (m-FNBT) kullanılarak hesaplandı. Tüm gruplardaki hastalara 24 saatlik elektrokardiyografi Holter takılarak, tamamının HRT (TO, total onset ve TS, total slope) ile bazal ekokardiyografik parametreleri hesaplandı. Bulgular: Gruplar arasında taşıdıkları demografik, klinik ve ekokardiyografik özellikler açısından istatistiksel olarak anlamlı bir fark saptanmadı (p> 0.05). Grup 1’de ortalama TO değeri anlamlı olarak yüksek iken (p< 0.05), ortalama TS değerleri arasında iki grup arasında istatistiksel olarak anlamlı bir fark saptanmadı (p> 0.05). Grup 1’de hesaplanan NBİ değeri ile ortalama TO arasında pozitif korelasyon saptandı (p< 0.05). Sonuç: Kronik sigara içicisi olanlarda, aynı özelliklere sahip içmeyen gruba oranla baroregülatuvar mekanizmada (özellikle TO) bozulma olduğu saptandı.Öğe The effect of smoking on the baroregulatory system; heart rate turbulence(2012) Erdem, Alim; Yalta, Kenan; Yilmaz, Mehmet Birhan; Turgut, Okan Onur; Yilmaz, Ahmet; Özkök, Mesut; Yontar, Osman CanGiriş: Sigaranın kardiyovasküler sisteme olan zararlı etkileri bilinmektedir. Çalışmamızın amacı sigara içiminin baroregülatuvar mekanizmaya olan etkilerini, kalp hızı türbülansını kullanarak normal kişilerle karşılaştırmaktır. Materyal ve Metod: En az bir yıldır sigara içme öyküsü olan asemptomatik 64 kişi grup 1 olarak kabul edildi. Aynı klinik özelliklere sahip asemptomatik sigara alışkanlığı olmayan 30 kişi grup 2 olarak düzenlendi. Çalışmaya alınan grup 1’deki sigara içicilerinin nikotin bağımlılık indeksi (NBİ) modifiye-Fagerström Nikotin bağımlılık testi (m-FNBT) kullanılarak hesaplandı. Tüm gruplardaki hastalara 24 saatlik elektrokardiyografi Holter takılarak, tamamının HRT (TO, total onset ve TS, total slope) ile bazal ekokardiyografik parametreleri hesaplandı. Bulgular: Gruplar arasında taşıdıkları demografik, klinik ve ekokardiyografik özellikler açısından istatistiksel olarak anlamlı bir fark saptanmadı (p> 0.05). Grup 1’de ortalama TO değeri anlamlı olarak yüksek iken (p< 0.05), ortalama TS değerleri arasında iki grup arasında istatistiksel olarak anlamlı bir fark saptanmadı (p> 0.05). Grup 1’de hesaplanan NBİ değeri ile ortalama TO arasında pozitif korelasyon saptandı (p< 0.05). Sonuç: Kronik sigara içicisi olanlarda, aynı özelliklere sahip içmeyen gruba oranla baroregülatuvar mekanizmada (özellikle TO) bozulma olduğu saptandı.Öğe Golden ratio and the heart: a review of divine aesthetics(Elsevier Ireland Ltd, 2016) Yalta, Kenan; Öztürk, Selçuk; Yetkin, ErtanIn human history, certain mathematical figures or concepts had gained a significant reputation largely due to their occult and esoteric meanings. Among these, Golden Ratio and associated concepts, namely golden proportions, had elicited a tremendous breakthrough in our human awareness and perception regarding mundane and spiritual aspects of physical existence. Golden Ratio or Number (with a numerical value of 1.618) that is also referred to as the Greek letter Phi (phi), has been universally expressed on a line partitioned into two unequal lengths (L, the longer and S, the shorter) in such a manner that L / S = (L + S) / L. Besides, appearing in certain number sequences (Fibonacci Series, etc.), golden proportions, to the consternation of observers, appear to be strikingly prevalent across all levels of physical existence from the innermost structures to the colossal galaxies of the universe potentially labeling these concepts as the measures of divine aesthetics. Accordingly, the human body also serves as an epitome of these mysterious concepts as exemplified by its outward appearance including general stature and extremities along with a variety of inner organ systems. Based on preliminary studies, the human cardiovascular system might also be suggested to serve as a major predilection site of divine aesthetics as measured with Golden Ratio and its allies. This appears to be completely in line with the ancient knowledge associating the human heart with the esoteric and spiritual components of human nature including human soul. Within this context, the present paper primarily aims to discuss human manifestations of divine aesthetics as measured with 'Golden Ratio' and associated indices with a particular and detailed emphasis on their potential link with the human cardiovascular system.Öğe Golden ratio: a subtle regulator in our body and cardiovascular system?(Elsevier Ireland Ltd, 2016) Öztürk, Selçuk; Yalta, Kenan; Yetkin, ErtanGolden ratio, which is an irrational number and also named as the Greek letter Phi (phi), is defined as the ratio between two lines of unequal length, where the ratio of the lengths of the shorter to the longer is the same as the ratio between the lengths of the longer and the sum of the lengths. The so-called formula is a mathematical ratio and there exist a variety of examples in natural andman-made structures of great beauty. Moreover, golden ratio is expressed throughout the human body in some ways, including digits, uterus, teeth, and cardiovascular system. Although the association of Fibonacci series or golden ratio with systems and organs of human being has not been assessed in depth yet, the mainstream regulation of cardiovascular system seems to be associated with golden ratio. This raises the idea that there might have been a fine and subtle regulator in our body. In this article, we aimed to elaborate the relationship between the existence of golden ratio and the human body and to discuss the golden ratio and its association with cardiovascular system. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
