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Öğe Akut miyokard infarktüs geçiren hastalarda travma sonrası stres bozukluğu belirtileri(2015) Semiz, Murat; Erdem, Fatma; Erdem, Alim; Tuman, Taha Can; Oran, Meral Demir; Kayka, Nefise; Yıldırım, OsmanAmaç: Bu çalışmanın amacı akut miyokard infarktüs (AMİ) geçiren hastalarda depresyon, anksiyete ve travma sonrası stres bozukluğu (TSSB) belirtilerini araştırmaktır. Çalışmamızda ruhsal belirtilerin klinik bulgular ile ilişkisi de incelenmiştir. Yöntem : Bu çalışmaya AMİ geçirdikten bir ay sonra kardiyoloji polikliniğine kontrol amaçlı gelen 50 hasta alınmıştı r. Hastalara sosyodemografik form, Hastane Ankiyete -Depresyon (HAD) ve Travma Sonrası Stres Bozukluğu Kontrol Listesi (Sivil Sürümü) (PTSB -CL) ölçekleri doldurtulmuştur. AMİ sonrası TSSB belirtilerine yol açabilecek bedensel, fiziksel veya ruhsal olay yaşa yan hastalar çalışmaya alınmamıştır. Bulgular: Hastaların anksiyete ölçeğinin ortalama puanı 8.7±4.3 olarak bulundu. Anksiyete ölçeğinin kesme puanına göre değerlendirme yapıldığında; hastaların % 26’sının anksiyete bozukluğu olabileceği gösterildi. Depres yon ölçeğinin ortalama puanı 7.2±3.6 idi ve ölçeğin kesme puanına göre hastaların % 36’sında (n=18) depresif bozukluk olabileceği saptandı. PCL -C ölçeğinin ortalama puanı 22.1±5.1 idi. Hastaların % 24’ü PCL -C ölçeğine göre kesme puanının üzerinde bir değerdeydi ve bu hastalarda TSSB olasılığı düşünüldü. Sonuç : Bu çalışmada AMİ geçiren hastalarda yüksek oranda TSSB belirtileri saptanmıştır. Hastanede yatış süresi ve taburculuk sonrası anjina şikayetleri TSSB belirtileri ile ilişkili bulunmuştur. AMİ geçiren hastalarda depresif bulguların yanı sıra TSSB belirtilerine de dikkat edilmesi gerektiğini düşünmekteyiz.Öğe Angioedema probably related to fluoxetine in a preadolescent being followed up for major depressive disorder(Mary Ann Liebert, Inc, 2013) Tuman, Taha Can; Demir, Nuran; Topal, Zehra; Tuman, Bengü Altunay; Tufan, Evren AliÖğe Bir ergende esrarın tetiklediği mani(Cannabis-induced mania in an adolescent)(2014) Tuman, Taha Can; Asdemir, Akif; Baştürk, Mustafa-Öğe Body-focused repetitive behaviors in children and adolescents, clinical characteristics, and the effects of treatment choices on symptoms: A single-center retrospective cohort study(Dermatovenerological Soc Slovenia, 2022) Hangül, Zehra Topal; Tuman, Taha Can; Tuman, Bengü Altunay; Saygılı, Gizem Yılmaz; Tufan, Ali EvrenIntroduction: This study determines clinical features of body-focused repetitive behaviors (BFRBs) among a sample of Turkish children and adolescents, evaluates the naturalistic treatments selected in this sample, and determines the effects of those treatments during a 3-month follow-up. Methods: The study included a cohort of 67 patients 9 to 17 years old attending a tertiary center between March and June 2013 with complaints of nail biting, skin picking, and/or hair pulling. The patients completed psychometric scales and were evaluated for symptom severity, improvement, and adverse effects after an initial interview and at control visits during the 4th and 8th weeks. Results: The most common BFRB was nail biting. In nail-biting behavior, subjective awareness was higher, and urges prior to the behavior and release after the behavior were found to be higher. Although there was no significant difference between the choice of treatment and the course of psychiatric measures, significant improvement was found in functionality after treatment. Conclusions: Despite its limitations, the small number of studies on BFRBs increases the importance of studies in this area.Öğe Cannabis-induced mania in an adolescent(Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2014) Tuman, Taha Can; Asdemir, Akif; Baştürk, MustafaÖğe Deep vein thrombosis associated with low dose clozapine(2016) Tuman, Taha Can; Çakır, Uğur; Güçlü, Gülşah; Yıldırım, Osman[No Abstract Available]Öğe Depression in pregnancy is associated with decreased glutathione peroxidase activity in fetal cord blood(Pergamon-Elsevier Science Ltd, 2016) Camkurt, Mehmet Akif; Findikli, Ebru; Bakacak, Murat; Karaaslan, Mehmet Fatih; Tolun, Fatma Inanc; Tuman, Taha CanThe investigation of fetal cord blood (FCB) during child delivery has created a novel topic in the field of psychiatric research. The umbilical vein receives nutrients and oxygen from the mother's circulation and transports them to the fetal circulation. Investigating fetal cord blood during delivery is beneficial for understanding the fetal environment. Depression in pregnancy is associated with medical and emotional burdens. In this study, we aimed to investigate glutathione peroxidase (Gpx) and myeloperoxidase (MPO) activity in the FCB of depressed mothers and healthy controls. Our study included 45 depressed mothers and 59 healthy controls. The FCB samples were collected from the umbilical vein during delivery. We found that Gpx levels were significantly decreased in the FCB of depressed mothers than healthy controls, medians were 0.14 U/ml and 0.16 respectively, Z: -3.567 and p < 0.001. MPO levels were similar in both groups, medians were 1.0 U/L and 1.2 U/L respectively, Z: -1.837 and p:0.066. Depression in pregnancy may be associated with decreased antioxidant levels, and this condition may cause an oxidative load, which may lead to improper brain development. Future studies should be performed in larger samples to clarify our preliminary results. (C) 2016 Elsevier Ltd. All rights reserved.Öğe Depression, posttraumatic stress and correlates among the relatives of the patients in the intensive care unit(2016) Yılmaz, Mehmet; Çakır, Uğur; Tuman, Taha Can; Öncül, Sema; Gaygusuz, Elif AtarObjective: In this study, it was aimed to determine depression, anxiety, posttraumatic stress, and related factors among relatives of patients admitted to the intensive care unit. Methods: A total of 67 patient relatives, 31 (46.3%) male and 36 (53.7%) female were included in the study. Acute Physiologic and Chronic Health Evaluation II (APACHE II) scores were calculated in order to determine patients' disease severity. Impact of Event Scale Revised (IES-R) was used to assess the severity of posttraumatic stress and Hospital Anxiety and Depression Scale (HADS) was used to determine the level of anxiety and depression. Results: The mean age of the patients was 65.7±16.1 years ranging from 18 to 90. The number of males among these were 31 (46.3%) and females were 36 (57.3%). The mean IES-R score for all of the patients' relatives was 36.6±17. The mean score for females was 46±15.7 and the mean score for males was 36.3± 6.8. The difference between the genders was found statistically significant (p<0.05). The ratio of individuals with high risk was 64.2% (n=43) with 59.1% (n=26) for males and 73.9% (n=17). The difference between the genders was not statistically significant (p>0.05). The mean HADS depression score for all the patients' relatives was 10.4±4.7; the mean score for females was 12.6±4.1 and the mean score for males was 9.2±4.7 (p<0.05). The rate of individuals with a high risk for depression was calculated as 50.7% (n=34) among all, 40.9% (n=18) for males and 69.6% (n=16) for females (p<0.05). The average HADS anxiety score was 10.5±4.7; 13±4.5 for females and 9.2±4.3 (p<0.05). The rate of individuals with a high risk for anxiety was calculated as 41.8% (n=28) among all, 29.3% (n=13) for males and 65.2% (n=15) for females (p<0.05). Conclusion: High severity of posttraumatic stress, depression, and anxiety levels was observed in individuals included in this study. It seems that evaluation of relatives of patients admitted to intensive care unit in terms of depression, anxiety, and posttraumatic stress is an important issue.Öğe Depression, Posttraumatic Stress and Correlates Among the Relatives of the Patients in the Intensive Care Unit(2016) Yilmaz, Mehmet; Çakir, Uğur; Tuman, Taha Can; Öncül, Sema; Gaygusuz, Elif Atar; Esen, Osman; Taş, Halil IbrahimObjective: In this study, it was aimed to determine depression, anxiety, posttraumatic stress, and related factors among relatives of patients admitted to the intensive care unit. Methods: A total of 67 patient relatives, 31 (46.3%) male and 36 (53.7%) female were included in the study. Acute Physiologic and Chronic Health Evaluation II (APACHE II) scores were calculated in order to determine patients' disease severity. Impact of Event Scale Revised (IES-R) was used to assess the severity of posttraumatic stress and Hospital Anxiety and Depression Scale (HADS) was used to determine the level of anxiety and depression. Results: The mean age of the patients was 65.7±16.1 years ranging from 18 to 90. The number of males among these were 31 (46.3%) and females were 36 (57.3%). The mean IES-R score for all of the patients' relatives was 36.6±17. The mean score for females was 46±15.7 and the mean score for males was 36.3± 6.8. The difference between the genders was found statistically significant (p<0.05). The ratio of individuals with high risk was 64.2% (n=43) with 59.1% (n=26) for males and 73.9% (n=17). The difference between the genders was not statistically significant (p>0.05). The mean HADS depression score for all the patients' relatives was 10.4±4.7; the mean score for females was 12.6±4.1 and the mean score for males was 9.2±4.7 (p<0.05). The rate of individuals with a high risk for depression was calculated as 50.7% (n=34) among all, 40.9% (n=18) for males and 69.6% (n=16) for females (p<0.05). The average HADS anxiety score was 10.5±4.7; 13±4.5 for females and 9.2±4.3 (p<0.05). The rate of individuals with a high risk for anxiety was calculated as 41.8% (n=28) among all, 29.3% (n=13) for males and 65.2% (n=15) for females (p<0.05). Conclusion: High severity of posttraumatic stress, depression, and anxiety levels was observed in individuals included in this study. It seems that evaluation of relatives of patients admitted to intensive care unit in terms of depression, anxiety, and posttraumatic stress is an important issue.Öğe DSM-5 kriterlerine göre tanı konan depresyon, yaygın anksiyete bozukluğu, panik bozukluk ve sosyal anksiyete bozukluğu hastalarında serum oksitosin düzeylerinin sağlıklı kontrollerle karşılaştırılması(Bolu Abant İzzet Baysal Üniversitesi, 2015) Tuman, Taha Can; Yıldırım, OsmanGiriş ve Amaç: Oksitosin, doğum, emzirme, anne-çocuk ve çiftler arasında bağlanma üzerindeki etkileri iyi bilinen bir hormondur. Ayrıca, oksitosin endojen antistres, antidepresan ve anksiyolitik hormon olarak adlandırılmakta ve stresli durumlarda artan HPA eksen ve amigdala hiperaktivitesini azalttığı, stresle başa çıkmayı kolaylaştırdığı, sosyal işlevselliği arttırdığı bildirilmektedir. Bu çalışmada depresyon, YAB, SAB, PB ve PB+Agorafobi hastalarında serum oksitosin seviyelerinin kontrol grubu ile karşılaştırılması amaçlanmıştır. Gereç ve Yöntem: Bu çalışmaya Ekim 2013 ile Ocak 2015 tarihleri arasında AİBÜ Üniversitesi Tıp Fakültesi Psikiyatri polikliniğine başvuran, ayaktan takip edilen, psikotrop kullanmayan, 18-65 yaşları arasında Major Depresyon tanısı konan 50 (25 erkek, 25 kadın), YAB tanısı konan 25 (9 erkek, 16 kadın), SAB tanısı konan 31 (14 erkek, 17 kadın) ve PB tanısı konan 40 (17 erkek, 23 kadın) ve 30 (13 erkek, 17 kadın) sağlıklı kontrol olmak üzere toplam 176 katılımcı alınmıştır. Çalışmaya alınan tüm gruplara Hamilton Depresyon Derecelendirme Ölçeği (HAM-D) ve Hamilton Anksiyete Değerlendirme Ölçeği (HAM-A), Algılanan Stres Ölçeği (ASÖ), Anksiyete Duyarlılığı İndeksi (ADİ-3) uygulanmıştır. Ayrıca YAB grubuna Yaygın Anksiyete Bozukluğu 7 Maddeli (YAB-7) testi ve PB grubuna Panik Bozukluğu Şiddeti Ölçeği (PBŞÖ), SAB grubuna Liebowitz Sosyal Fobi Ölçeği (LSFÖ) uygulanmıştır. Çalışmaya dahil edilen tüm grupların serum oksitosin seviyeleri ELISA yöntemiyle ölçülmüştür. Bulgular: Depresyon grubunda serun oksitosin düzeyi kontrol grubuna göre anlamlı olarak düşük, YAB, SAB ve PB+Agorafobi grubunda serum oksitosin seviyeleri kontrol grubuna göre anlamlı olarak yüksek, PB grubunda ise kontrol grubuna göre istatistiksel olarak anlamlı fark olmasa da yüksek olma eğilimindeydi. Depresyonun anksiyeteli alt tipinde melankolik ve atipik alt tipe ve kontrol grubuna göre oksitosin düzeyi anlamlı olarak yüksekti. PB+Agorafobi grubunda PB grubuna göre oksitosin düzeyi anlamlı olarak yüksekti. SAB grubunda genelleşmiş ve performans alt tiplerinde oksitosin düzeyleri arasında fark saptanmadı.Sonuç: Bu çalışmada depresyon hastalarında saptanan oksitosin düşüklüğü, oksitosinin, serotonin, dopamin ve norepinefrin üretimini arttırdığı, BDNF üretimini ve MAP kinaz yolağını aktive ettiği, CREB fosforilasyonunu arttırdığı düşünüldüğünde depresyon gelişimine katkıda bulunan bir faktör olabilir. Depresyon grubunda anksiyeteli alt tipte, YAB, SAB ve PB+Agorafobi grubunda görülen oksitosin yüksekliği ise artmış anksiyeteyi ve stresi azaltmaya yönelik ya da oksitosin reseptöründeki muhtemel işlev bozukluğu nedeniyle kompansatuar bir mekanizma olabilir. Anahtar Kelimeler: Depresyon, YAB, SAB, PB, Agorafobi, OksitosinÖğe Effect of olanzapine treatment on INR of a patient receiving warfarin therapy(Cukurova Univ, Fac Medicine, 2016) Arslan, Derya; Tuman, Taha Can; Çakır, UğurOlanzapine is an atypical antipsychotic drug, commonly used in the management of psychotic symptoms in patients with schizoprenia and bipolar affective disorder. Deep venous thrombosis is a manifestation of venous thromboembolism. It is very well known that use of antipsychotic drugs increase the risk of thrombosis in a patient with schizophrenia. It has been reported in many studies the effects of olanzapine on thrombosis but there isn't any report about the effect of olanzapine on international normalized ratio (INR). in the medical literature. In this paper, a patient with schizophrenia and also family history of deep venous thrombosis who emerged deep venous thrombosis after being started on olanzapine treatment and effect of olanzapine treatment on INR has been reported.Öğe Elevated neutrophil/lymphocyte ratio in patients with schizophrenia(Medicinska Naklada, 2014) Semiz, Murat; Yıldırım, Osman; Canan, Fatih; Demir, Süleyman; Hasbek, Ekrem; Tuman, Taha Can; Kayka, NefiseBackground: Inflammatory mechanisms are reported to play important roles in the pathophysiology of schizophrenia. The neutrophil-lymphocyte ratio (NLR) is a simple and easily accessible indicator of the systemic inflammatory response. Our goal was to investigate whether NLR was higher in patients with schizophrenia than in healthy comparison subjects similar in age, sex, and body mass index. Subjects and methods: In this multicenter cross-sectional study, we analyzed 156 non-obese patients with schizophrenia and 89 healthy control subjects for complete blood count. The Brief Psychiatric Rating Scale was used to determine the severity of clinical pathology. Results: The mean +/- SD NLR of patients with schizophrenia was significantly higher than that of healthy controls (2.6 +/- 1.1 vs. 1.9 +/- 0.6, respectively, p<0.001). NLR did not significantly correlate with severity and duration of schizophrenia (r=0.065. p>0.05). Conclusions: Our findings suggest that NLR levels are increased in physically healthy, non-obese, patients with schizophrenia when compared with physically and mentally healthy individuals. To our knowledge, this is the first study that demonstrated the association between NLR and schizophrenia.Öğe Emotional and cognitive conflict resolution and disruptive mood dysregulation disorder in adolescent offspring of parents diagnosed with major depressive disorder, bipolar disorder, and matched healthy controls(Taylor and Francis Ltd., 2021) Topal, Zehra; Demir, Nuran; Tufan, Evren; Tuman, Taha Can; Semerci, BengiAims: Children of parents with mood disorders have an elevated risk for various psychopathologies. In this study rate of psychopathologies among adolescent offspring of parents with major depressive (MDDoff) and bipolar disorder (BDoff), including disruptive mood dysregulation disorder (DMDD) along with the offspring ability to resolve cognitive and emotional conflicts were evaluated. Method: 12–16 years old children of parents with MDD (n = 31, children= 36), BP (n = 20, children = 26) and controls (n = 25, children = 28) were enrolled. Children and parents were evaluated by using the Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS) and the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID); respectively. The parents completed the Child Behavior Checklist (CBCL)-dysregulation profile. The Stroop test-TBAG form and emotional Stroop test were given out to evaluate conflict resolution ability. Results: The most common diagnoses among the whole sample were attention deficit and hyperactivity, separation anxiety and oppositional defiant disorders. Five cases (5.5%) of lifetime DMDD were found (three from MDDoff, the rest from BDoff). Completion times for the Stroop test-TBAG form were ranked as: BDoff > MDDoff > Hoff. In the emotional Stroop test, the BDoff responded significantly later and had significantly reduced correct responses. Conclusion: Rates of lifetime DMDD were similar in the MDDoff and BDoff groups. BDoff may experience greater difficulties in resolving cognitive and emotional conflicts.Öğe Evaluation of malondialdehyde, superoxide dismutase and catalase activity and their diagnostic value in drug naive, first episode, non-smoker major depression patients and healthy controls(Elsevier Ireland Ltd, 2016) Camkurt, Mehmet Akif; Findikli, Ebru; Izci, Filiz; Kurutas, Ergul Belge; Tuman, Taha CanMajor depression is a most frequent disorder, its diagnosis depends on pkient interview, and yet we do not have a reliable biomarker for depression. Oxidative stress is defined as increase in oxidation or decrease is antioxidant defense mechanisms. Here, we aimed to investigate malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) activity and their diagnostic performance in depressed patients and healthy controls. We collected blood samples from 50 patients and 50 controls. We found MDA levels were significantly higher in the patients than controls, with medians at 4.04nmol/mg and 1.64nmol/mg, respectively, p < 0.001. SOD activity was significantly decreased in depressed patients than healthy controls, with means at 143.50U/mg and 298.12U/mg, respectively, p < 0.001. CAT activity was similar in both groups, p=0.517. ROC analysis showed good diagnostic value for MDA and SOD, with the area under the curve at 1.0 for both. We found high correlation between SOD and Ham-D scores (r=0.747, p < 0.0001) and between MDA and Ham-D scores (r=0.785, p < 0.0001). Overall, these results demonstrate that oxidative stress is increased in depressed patients. MDA increase seem to be a common finding for major depression. We believe MDA could be a good biomarker candidate for major depression, but not SOD. Future studies should focus on the diagnostic value of MDA in larger samples. (C) 2016 Elsevier Ireland Ltd. All rights reserved.Öğe Increased neutrophil/lymphoctye ratio in patients with bipolar disorder: A preliminary study(Medicinska Naklada, 2015) Çakır, Uğur; Tuman, Taha Can; Yıldırım, OsmanBackground: In this study, it has been aimed to investigate whether neutrophil-lymphocyte ratio (NLR) was higher in non-obese patients with bipolar disorder (BD) than in a healthy control group matched for age, sex, and body mass index, and also to determine if there was an interaction between NLR and severity of the bipolar disorder. Subjects and methods: In this retrospective study, 103 non-obese patients with BD and 126 healthy control subjects were analyzed for complete blood count. The Young Mania Rating Scale (YMRS) was used to determine the severity of the disorder. Results: The NLR was higher in female patients than in female comparison subjects (3.2 +/- 2.2; versus 1.7 +/- 0.4) (p<0.001). Also, compared with the healthy male subjects, the male patients had significantly higher neutrophil/lymphocyte ratio (3.3 +/- 2.4; versus 2.0 +/- 0.7) (p<0.001). In the patients with bipolar disorder, NLR did not significantly correlate with severity (as measured with the YMRS) (r=0.052; p=0.204) and duration of the disorder (r=0.045; p=0.301). Conclusions: Results of this study revealed that patients with bipolar disorder have statistically significant elevated NRL than healthy compares. According to this finding, elevated levels of NLR may be involved in inflammatory pathophysiology of bipolar disorder. Further studies are needed for a better understanding of the mechanism between elevation of NRL in patients with bipolar disorder.Öğe The Myocardial Perfusion Scintigraphy in Predicting Risk for Coronary Artery Disease in Patients with Anxiety and Depression Symptoms(2016) Çalışkan, Billur; Korkmaz, Ayşe Nurdan; Yıldırım, Osman; Tuman, Taha Can; Kayka, Nefise; Erdem, AlimIntroduction: An association between psychological factors and cardiovascular disease, has long been suspected. However, it is not clear whether chest pain is caused by emotional distress or whether coronary spasms are caused by the onset of coronary artery disease (CAD). We aimed to predict the risk for CAD in patients referred to myocardial perfusion imaging (MPI) with chest pain using depression, stress, and anxiety symptoms.Methods: The emotional status of all patients was evaluated using the Hospital Anxiety and Depression Scale (HADS-A and HADS-D), the State and Trait Anxiety Inventory (STAI-1 and STAI-2), the Perceived Stress Scale (PSS), and the Anxiety Sensitivity Index-3 (ASI). Myocardial perfusion was measured using a 17-segment model and 5-point scoring system (0: normal perfusion; 4: no perfusion). Results: MPI revealed reversible perfusion defects in 24 of 141 patients and no perfusion defects in 117 patients. The STAI-2 and HADS-A and HADS-D scores were significantly higher in patients with myocardial ischemia than in those without (STAI-2: 50.8 ± 7.5 vs. 46.3 ± 7.1, respectively; p = 0.008; HADS-A: 9.5 ± 3.9 vs. 7.8 ± 3.4, respectively; p = 0.033; HADS-D: 8.7 ± 3.0 vs. 7.3 ± 3.0, respectively; p = 0.05). Unadjusted correlation analysis showed that there was statistically significant correlation between reversible perfusion defects and anxiety scores (r=0.186, p= 0.029).Conclusion: The patients with symptoms of depression and high-trait anxiety may be at higher risk of myocardial ischemia than patients without such symptoms. Thus, the emotional status of patients should be taken into consideration during clinical evaluation for CAD.Öğe A new diagnostic tool for masked hypertension: impaired sleep quality(Termedia Publishing House Ltd, 2016) Erdem, Fatma Hızal; Çakır, Uğur; Yıldırım, Osman; Alçelik, Aytekin; Dönmez, İbrahim; Tuman, Taha Can; Çağlar, Sabri OnurIntroduction: The aim of this study was to evaluate the relationship between masked hypertension and impaired sleep quality. Additionally, we evaluated the diagnostic role and prevalence of poor sleep quality among patients with newly diagnosed masked hypertension. Material and methods: A total of 112 individuals, 72 patients with newly diagnosed masked hypertension and 40 normotensive healthy volunteers, were included in this study. All patients underwent evaluation comprising 12-lead electrocardiography, transthoracic echocardiography, 24-hour Hotter ECG, and basic laboratory tests. Additionally, all participants completed questionnaires, including the Pittsburgh Sleep Quality Index (PSQI). Results: The total PSQI score was significantly higher in the masked hypertension group than in the normotensive healthy volunteers (4.13 +/-2.43 vs. 2.33 +/-1.67, p < 0.001). A PSQI score > 5 was found in 45.8% (n = 33) of patients in the masked hypertension group and 15% (n = 6) of patients in the normotensive group (p < 0.001). The non-dipper pattern was found in 17.5% of the healthy volunteer group and 59.94% (n = 41) of the masked hypertension group (p < 0.001). When we compared the dipping pattern of the masked hypertension groups, there was a significant difference in PSQI score between the dipper and non-dipper groups (4.87 +/-3.21 vs. 3.58 +/-2.33, p < 0.001). Multiple logistic regression analyses showed that masked hypertension, LV mass, and LV mass index score were independent predictors of poor PSQI. Conclusions: This study demonstrates impaired sleep quality in subjects with masked hypertension, particularly those with a non-dipper pattern. Additionally, this study indicates that impaired sleep quality may help diagnose masked hypertension, particularly in the non-dipper group.Öğe New diagnostic tool for masked hypertension; impaired sleep quality(2015) Erdem, Fatma Hızal; Çakır, Uğur; Yıldırım, Osman; Alçelik, Aytekin; Dönmez, İbrahim; Tuman, Taha Can; Çağlar, Sabri Onur; Erdem, Alim; Yazıcı, MehmetBackground: The aim of this study was to evaluate a relationship between MHTand impaired sleep quality. Additionally, we evaluated the diagnostic role and prevalence of poor sleep quality among patients with newly diagnosed masked hypertension (MHT). Methods: A total of 112 individuals, 72 patients with new diagnosed MHT and 40 normotensive healthy volunteers were included in this study. All patients underwent evaluation comprising 12-lead electrocardiography (ECG), transthoracic echocardiography, 24-hour Holter ECG, and basic laboratory tests.Additionally,all participants completed questionnaires, including the Pittsburgh Sleep Quality Index (PSQI). Results: The total PSQI score was significantly higher in the MHT group than in the normotensive healthy volunteers (4.13±2.43 vs. 2.33±1.67, p<0.001). A PSQI score >5 was found in 45.8% (n=33) of patients in the MHT group and 15% (n=6) of patients in the normotensive group (p<0.001). Non-dipper pattern was found %17.5 in healthy volunteer group, however %59.94 (n=41) in MHT group (p<0.001). When we compared the dipping pattern of the MHT groups, there was a significant difference in PSQI score between the dipper and non-dipper groups (4.87±3.21 vs. 3.58±2.33, p<0.001). Conclusions: This study demonstrates impaired sleep quality in subjects with MHT, particularly those with a non-dipper pattern. Additionally, this study indicates impaired sleep quality maybe helped diagnose of MHT, particularly in the nondipper group.Öğe Olanzapine induced urinary incontinence(2016) Tuman, Taha Can; Çakır, Uğur; Yıldırım, Osman[No Abstract Available]Öğe Paroxetine as an option for persistent genital arousal disorder(Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2016) Camkurt, Mehmet Akif; Fındıklı, Ebru; Tuman, Taha CanTo the Editors, Persistent genital arousal disorder (PGAD) is a relatively new diagnosis in psychiatry. This disorder is frequently reported in females. Goldmeier et al. defined six criteria for PGAD: 1. Sexual arousal persists for an extended period, 2. Physiological arousals don’t resolve with ordinary orgasm, 3. Arousals are unrelated to sexual desire, 4. Arousals are triggered by nonsexual stimuli, 5. Unwanted experience of symptoms, and 6. Symptoms cause distress.1 According to previous literature, anxiety and sexual stimuli could be related to each other, so PGAD could be comorbid with anxiety disorders like obsessive compulsive disorder (OCD).2 Here we demonstrate a case of PGAD comorbid with OCD, where the patient benefited from paroxetine in terms of both disorders.
