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Öğe Adjustment disorder after botulinum toxin injection in an adolescent palatal myoclonus case: the importance of informed consent in the treatment of neuropsychiatric disorders in children and adolescents(Elsevier Sci Ltd, 2018) Öztürk, Yusuf; Topal, Zehra; Demir, Nuran; Tufan, Ali EvrenInformed consent in clinical practice is a process in which a patient consents to participate or undergo the proposed procedures after being informed of its procedures, risks, and benefits. Ideally, the patient is expected to give his/her consent solely after fully understanding the information about the procedures, benefits, and risks involved in the practice. According to the doctrine, the necessary information should be given by the physician and he/she should also respect the decision of the patient which is based on this information.1 Although the importance of providinginformation about the proposed treatment’s effects and side effects to children and adolescents before treatment is accepted by physicians, this issue is given little importance in research and case presentations.2 In this case, it was aimed to discuss the importance of informed consent and multi-disciplinary approach in treatment by presenting an adolescent patient who was diagnosed with palatal myoclonus and treated with botulinum toxin. Although the neurological treatment was effective, the patient developed adjustment disorder (with depressive mood) due to dysphonia after the procedure.Öğe Angioedema probably related to fluoxetine in a preadolescent being followed up for major depressive disorder(Mary Ann Liebert, Inc, 2013) Tuman, Taha Can; Demir, Nuran; Topal, Zehra; Tuman, Bengü Altunay; Tufan, Evren AliÖğe CYP450 2D6 and 2C19 genotypes in ADHD: not related with treatment resistance but with over-representation of 2C19 ultra-metabolizers(De Gruyter Open Ltd, 2022) Kutuk, Meryem Ozlem; Tufan, Ali Evren; Topal, Zehra; Acikbas, Ufuk; Guler, Gulen; Karakas, Bahriye; Basaga, HuveydaObjectives: Cytochrome P450 (CYP450) is a major enzyme system involved in drug metabolism as well as regulation of brain function. Although individual variability in CYP enzymes have been studied in terms of personality traits and treatment effects, no study up to now evaluated CYP polymorphisms in children with attention deficit/hyperactivity disorder (ADHD). We aimed to define the genetic profiles of CYP2D6 and CYP2C19 relevant alleles in children with ADHD according to treatment status and compare the frequencies according to past results. Methods: Three hundred and seventeen patients with ADHD-Combined Presentation were enrolled; symptom severity was evaluated by parents and clinicians while adverse effects of previous treatments were evaluated with parent and child reports. Reverse blotting on strip assays was used for genotyping and descriptive and bivariate analyses were conducted. A p-value was set at 0.05 (two-tailed). Results: Children were divided into treatment-naïve (n=194, 61.2%) and treatment-resistant (n=123, 38.8%) groups. Within the whole sample PM, EM and UM status according to 2D6 were 3.8% (n=12), 94.3% (n=299) and 21.9% (n=6); respectively. PM, IM, EM and UM status according to 2C19 were 2.5% (n=8), 19.8% (n=63), 48.6% (n=154) and 29.0% (n=92), respectively. No relationship with treatment resistance, comorbidity or gender could be found. Importantly, CYP2C19 UMs were significantly more frequent in ADHD patients compared to previous studies in the general population. Conclusions: CYPs may be a rewarding avenue of research to elucidate the etiology and treatment of patients with ADHD. © 2022 Walter de Gruyter GmbH, Berlin/Boston.Öğe Emotional and cognitive conflict resolution and disruptive mood dysregulation disorder in adolescent offspring of parents diagnosed with major depressive disorder, bipolar disorder, and matched healthy controls(Taylor and Francis Ltd., 2021) Topal, Zehra; Demir, Nuran; Tufan, Evren; Tuman, Taha Can; Semerci, BengiAims: Children of parents with mood disorders have an elevated risk for various psychopathologies. In this study rate of psychopathologies among adolescent offspring of parents with major depressive (MDDoff) and bipolar disorder (BDoff), including disruptive mood dysregulation disorder (DMDD) along with the offspring ability to resolve cognitive and emotional conflicts were evaluated. Method: 12–16 years old children of parents with MDD (n = 31, children= 36), BP (n = 20, children = 26) and controls (n = 25, children = 28) were enrolled. Children and parents were evaluated by using the Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS) and the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID); respectively. The parents completed the Child Behavior Checklist (CBCL)-dysregulation profile. The Stroop test-TBAG form and emotional Stroop test were given out to evaluate conflict resolution ability. Results: The most common diagnoses among the whole sample were attention deficit and hyperactivity, separation anxiety and oppositional defiant disorders. Five cases (5.5%) of lifetime DMDD were found (three from MDDoff, the rest from BDoff). Completion times for the Stroop test-TBAG form were ranked as: BDoff > MDDoff > Hoff. In the emotional Stroop test, the BDoff responded significantly later and had significantly reduced correct responses. Conclusion: Rates of lifetime DMDD were similar in the MDDoff and BDoff groups. BDoff may experience greater difficulties in resolving cognitive and emotional conflicts.Öğe Evaluating clonidine response in children and adolescents with attention-deficit/hyperactivity disorder(Amer Inst Mathematical Sciences-Aims, 2018) Kütük, Meryem Özlem; Güler, Gülen; Tufan, Ali Evren; Sungur, Mehmet Ali; Topal, Zehra; Kütük, ÖzgürAttention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in childhood, which is generally treated with stimulant and non-stimulant medications. However, 10-30% of patients in clinical setting do not present with adequate response to initial stimulant treatment. Thereby, clonidine may be considered for those patients who have failed to respond to psychostimulant/atomoxetine monotherapy or as an augmentation for inadequate response/comorbidity. This observational study evaluated its effectiveness as a single drug in ADHD cases unresponsive to previous treatment trials. Seventeen ADHD cases that were non-responders to stimulant, non-stimulant and combination therapy for the primary symptoms of ADHD were included in the study. Four cases dropped out before follow up, leaving thirteen cases who were administered immediate release clonidine treatment alone with a mean dose of 0.2 +/- 0.05 mg/day at baseline. The trial lasted for 12 weeks, and treatment outcomes were evaluated by the Turgay DSM-IV Based Child and Adolescent Behavior Disorders Screening and Rating Scale (T-DSM-IV-S) and the Clinical Global Impressions-Severity (CGI-S) and Improvement (CGI-I) scales. Mean age of the sample was 12.5 years (SD = 3.0) and eleven of the subjects had another comorbid psychopathology. Only two cases were evaluated as "very much improved", while another patient was judged to be "minimally improved" after 12 weeks of clonidine treatment. Attrition during follow-up was associated with higher median scores on the hyperactivity and impulsivity subscales (Mann-Whitney U test, p = 0.02). According to the T-DSM-IV-S, CGI-S, and CGI-I scales, clonidine treatment by itself had minimal benefits in this sample of treatment of refractory cases with ADHD evaluated at the study center. Clonidine is not available in Turkey pharmaceutical marketing system and patients' access to drug is limited. Our results provide first data regarding the use of clonidine in Turkish ADHD patients.Öğe Evaluation of peripheral inflammatory markers, serum B12, folate, ferritin levels and clinical correlations in children with autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD)(TAYLOR & FRANCIS LTD, 2021) Topal, Zehra; Tufan, Ali Evren; Karadağ, Mehmet; Gökçen, Cem; Akkaya, Canan; Sarp, Ayşe Sevde; Bahsi, İlhan; Kılınç, MetinAim The aim of the current study is to compare serum B12, folate, and ferritin levels and peripheral inflammatory indicators between children with Autism Spectrum Disorders (ASD), Attention Deficit Hyperactivity Disorder (ADHD), and healthy controls (HC) and to evaluate the correlation of those with symptoms. Materials and Methods A total of 203 children were evaluated (ASD = 72; ADHD = 61; HC = 70). Diagnoses of ASD and ADHD were ascertained according to Schedule for Affective Disorders and Schizophrenia for School-Age Children - Present and Lifetime Version (K-SADS-PL). Control group was chosen among the healthy children who applied to general pediatrics outpatient clinic. Gilliam Autism Rating Scale-2 is used to assess autistic symptoms and Atilla Turgay DSM-IV Based Child and Adolescent Behavior Disorders Screening and Rating Scale is used for ADHD symptoms. Results Neutrophil levels (p = 0.014) and neutrophil/lymphocyte ratio (NLR) (p = 0.016) were higher in the ADHD and ASD groups compared to HC. Neutrophil values explained 70.1% of the variance across groups while NLR explained a further 29.9% of the variance. NLR significantly correlated with social interaction problems in ASD (r = 0.26, p = 0.04). There were no significant differences between groups in terms of vitamin B12, folate and ferritin levels. Conclusion Our results may support involvement of inflammation in the underlying pathophysiology of neurodevelopmental disorders. However, these parameters should be analyzed in a wider population to clarify the effect on the etiology and symptomatology of neurodevelopmental disorders.Öğe Evaluation of the psychiatric research output from Turkey via web of science database: A bibliometric analysis(Turkish Assoc Psychopharmacology, 2020) Topal, Zehra; Bahşi, İlhan; Tufan, Ali EvrenBackground: Global scientific research output is continuously accelerating. Although psychiatric scientific output is increasing, factors such as health systems, scientific programs and financial supports that vary between countries lead to varied levels of contribution. This cross sectional bibliometric study aims to analysis the articles bibliometrically which conducted by researchers from Turkey and indexed in SCI-E index of the Web of Science (WoS)database in the category of Psychiatry. Methods: According to 2019 data, in the WoS database, journals in the Psychiatry category and indexed in the SCI-E were determined. Publications from Turkey that were published in these journals was determined. For each publication, all information relevant to the analysis was exported to Microsoft Excel and EndNote Desktop. Also, VOSviewer software was used to create a collaboration and word co-occurrence network. Results: There were 5293 publications which have at least one author from Turkey. Only 774 articles (14.62%) were written as international collaborations. The authors from Turkey were collaborating with the researchers from 66 diffrent countries and USA was leading these countries with 420 publications (%7.93), followed by England (3.3%) and Germany (2.4), respectively. The total number of citations was 53931 for these publications (mean: 10.19 +/- 22.51). The most prolific institution is Istanbul University while the most frequently selected journal by Turkish authors is Psychiatry and Clinical Psychopharmacology. Conclusions: Bibliometric studies are crucial in evaluating domain specific research and in planning for efficient use of limited resources. Psychiatric literature from Turkey greatly increased within the last two decades. However, international collaborations are still limited and most of the publications are in journals published in Turkey.Öğe Huntington chorea-related dementia and bereavement in a child proband of a family having three generations with Huntington's chorea(2018) Öztürk, Yusuf; Topal, Zehra; Demir, Nuran Samurcu; Tufan, Ali Evren[No Abstract Available]Öğe Huntington chorea-related dementia and bereavement in a child proband of a family having three generations with huntington’s chorea(Cukurova University, Faculty of Medicine, 2018) Öztürk, Yusuf; Topal, Zehra; Demir Samurcu, Nuran; Tufan, Ali EvrenHuntington's chorea (HC) is a dominantly inherited, fatal neurodegenerative disease characterized by movement disorders, cognitive decline and psychiatric manifestations.1 In the childhood-onset Huntington's disease, the most frequent symptoms at disease onset involve cognitive dysfunction and behavioral disorders. Parents usually seek medical attention for their children for delay in achieving developmental milestones, poor academic functioning, or evident regression in cognitive and language skills.2 In this study, the evaluation and treatment of a child with early-onset HC and bereavement from a family with three-generations affected with HC is presented.Öğe İlkokul ve ortaokul öğrencilerinde mizah tutumunun gelişimi: 4-8. sınıf öğrencileri özelinde(Bolu Abant İzzet Baysal Üniversitesi, 2013) Topal, Zehra; Kıbrıs, İbrahimBu çalışmanın temel amacı ilkokul ve ortaokul düzeyindeki öğrencilerin mizaha karşı tutumlarını belirleyerek kültür ve çevre etkisiyle birlikte öğrencilerin bilişsel düzeylerinin mizah ilgisine ve tercihlerine olan etkisini ortaya koymaktır. Bu araştırmada İlkokul ve ortaokul öğrencilerinin mizaha karşı tutumlarının gelişimi nasıl oluşmaktadır Öğrencilerin mizaha karşı tutumları ve ilgileri neye göre şekillenmekte ve değişiklik göstermektedir? Sorularına cevap arandı. Bu bağlamda araştırmanın amaç, problem ve hedeflerine uygun olarak belirlenen çalışma grubuna on beş maddelik Kişisel Bilgi Formu, otuz iki maddelik Mizah Tutum Ölçeği, her sınıf düzeyi için ayrı ayrı belirlenen altı farklı fıkra ve bu fıkralara ait dört soruluk Akademik Başarı Testi ve dört soruluk Mizah İlgi Formu uyguladı. Çalışmanın başka bir amacı da ilk defa bu araştırma için hazırlanıp uygulanan Mizah Tutum Ölçeği?nin geçerlik ve güvenirliğinin ilkokul ve ortaokul öğrencileri üzerinde sınanmasıdır. Bu amaçla geliştirilen Mizah Tutum Ölçeği, çalışma öncesinde yaşları 9 ila 15 arasında değişen, ( X = 11,67) 56?sı kız, 44?ü erkek (4., 5., 6., 7. ve 8. sınıf) toplam 100 ilkokul ve ortaokul öğrencisine uygulanmıştır. Araştırma verileri SPSS (Statistic Package For Social Science) programı ile çözümlenmiştir. Yapılan ivuygulama sonucunda elde edilen güvenirlik kat sayısı olan Cronbach alfa (?) değeri .84 çıkmıştır. Otuz iki (32) maddeden oluşan Mizah Tutum Ölçeği beşli likert tipi bir ölçek olup bu ölçek ile elde edilen veriler öğrencilerin mizaha karşı olan tutumlarını ölçmek amacıyla kullanılmıştır. Anket sonuçlarından toplanan veriler bilgisayar ortamında SPSS paket programı ile çözümlenmiş, verilerin frekans, yüzdelik dağılım vb. hesaplamaları yapılmıştır. Sonuçlar Mizah Tutum Ölçeği?nin ilkokul ve ortaokul öğrencileri ile yürütülen çalışmalarda kullanılmaya uygun geçerli ve güvenilir bir ölçme aracı olduğunu ortaya koymuştur. Çalışma grubunun mizah ilgisini ve yaşa göre mizah tercihlerini belirlemek için Mizah İlgi Formundan faydalanılmıştır. Bunun yanında, öğrencilerin okudukları fıkralara ait karikatür çizmeleri de istenmiş ve elde edilen karikatürler Karikatür Çizimi İnceleme Kriter Formuyla değerlendirilmiş ve yorumlanmıştır. Araştırmada örneklem olarak seçilen İstanbul ili, Beyoğlu ilçesi İhsan Şerif İlkokulu (4. sınıf), İhsan Şerif Ortaokulu (5., 6., 7. ve 8. sınıf), Hasköy İlkokulu (4. sınıf), Hasköy Ortaokulu (5., 6., 7. ve 8. sınıf), Cemal Artüz İlkokulu (4. sınıf) ve Cemal Artüz Ortaokulu (5., 6., 7. ve 8. sınıf) öğrencileri, aynı zamanda deney grubu olarak belirlenmiştir. Araştırma sonucunda, öğrencilerin mizah gelişim sürecinde; annenin eğitim düzeyi, yaşanılan çevre, sahip olunan kültür, öğrencilerin yaşı ve hazır bulunuşluk düzeyinin etkili olduğu anlaşılmıştır. Erkek öğrencilerin kız öğrencilere göre mizaha karşı tutumlarının daha olumlu olduğu, bununla beraber günlük yaşamda erkek öğrenciler kız öğrencilere göre mizah unsurlarını daha fazla kullandıkları tespit edilmiştir. Sınıf düzeyi yükseldikçe mizah puanlarının düzeyinde de fark edilir bir artışolduğu belirlenmiştir. Ayrıca cinsiyete göre de mizah puanlarında anlamlı bir farklılık bulunmuş olup bu fark erkek öğrencilerin lehinedir. Öğrencilerin mizah ilgisinin ve mizah tercihlerinin oluşmasında kültürün etkili volduğu sonucuna ulaşılmıştır. Öğrencilerin mizah tercihlerinin Karadeniz, fabl, hastadoktor (deli) fıkra türlerinden yana olduğu belirlenmiştir. Bunun yanında Karadeniz fıkralarının Nasreddin Hoca fıkralarına göre daha çok beğenildiği saptanmıştır. Genel anlamda Karadeniz fıkraları en çok beğenilen fıkra türü olduğu, ikinci sırada fabl türü fıkrsların, üçüncü sırada da Bektaşî fıkralarının yer aldığı anlaşılmıştır. Karikatür çizimlerinde de yine aynı fıkralara yönelik daha fazla çizimlerin yapıldığı tespit edilmiştir. Ayrıca somut işlemler döneminde buluan öğrenciler ile soyut işlemler döneminde bulunan öğrencilerin karikatür çizimlerinde farklılıklar gösterdiği saptanmış olup bu farklılıklar Fıkra İnceleme Kriter Formundaki maddelere göre incelenerek sonuçları yorumlanmıştır. Farklı disiplinlerle de bağlantılı olan bu araştırma alana özgün bir çalışma kazandırılması bakımından önemlidir. Anahtar Kelimeler: Mizah, Mizah Tutum Ölçeği, Çocuk ve Dil Gelişimi, Karikatür, FıkraÖğe Iron and ferritin levels of children and adolescents with attention deficit hyperactivity disorder and attention deficit hyperactivity disorder-not otherwise specified(Galenos Yayincilik, 2020) Öztürk, Yusuf; Topal, Zehra; Demir, Nuran; Tufan, Ali EvrenAim: The study aimed to compare the levels of iron and ferritin in children with Attention Deficit Hyperactivity Disorder (ADHD) and Attention-Deficit Hyperactivity Disorder-Not Otherwise Specified (ADHD-NOS) and to assess the relationship between ADHD symptom severity and anxiety symptom severity with iron and ferritin levels. Materials and Methods: This study was planned as a cross-sectional, retrospective study. The study was performed by scanning the records of patients who applied to our clinic between January 2012 and January 2013. Accordingly, 205 ADHD and ADHD-NOS case records were evaluated. Patients were diagnosed clinically according to Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV-TR) criteria. ADHD symptom severity was assessed by the Turgay DSM-IV-TR-Based Child and Adolescent Behavior Disorders Screening and Rating scale. Anxiety symptom severity was assessed by The Screen for Anxiety Related Emotional Disorders. Results: Among the whole sample, 99 (48.3%) patients had ADHD and 106 (51.7%) had ADHD-NOS. In the ADHD group, the average age of the children was 10.88 +/- 3.02 years, while that of the children in the ADHD-NOS group was 9.93 +/- 2.49 years. Iron and ferritin were measured in 81 of the 205 patients participating in the study. There was no statistically significant difference between the two groups in terms of iron or ferritin levels (p>0.05). Statistically significant negative correlations between ADHD hyperactivity symptom severity and iron levels, and ADHD attention deficit symptom severity and ferritin levels were found. Ferritin levels correlated statistically with the total number of psychiatric diagnoses in the children. Conclusion: Iron and ferritin levels may be differentially affected in children with ADHD. The results we obtained from our study should be supported by studies with larger samples.Öğe A manic episode due to interaction of antibiotic and steroid treatment in an adolescent with asthma diagnosis: a case report(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2016) Tufan, Ali Evren; Karadayı, Hüsna; Boztaş, M. Hamid; Nasıroğlu, Serhat; Topal, Zehra; Çakır, Emine DemirbaşMood disorders are included among commonly encountered psychiatric disorders. In addition to genetic factors, it is believed that steroids and some antibiotics can also lead to mood disorders via as yet unknown mechanisms. In light of the prevalent use of antibiotics and steroids, elucidating the past treatment history in some cases of mood disorders with acute presentations may be important in appropriate treatment recommendations. In this case report, a manic episode developing in an adolescent with asthma who used inhaled steroid and clarithromycin has been presented and methods of treatment that should be used has been discussed.Öğe Otizm Spektrum Bozukluğunda Tamamlayıcı ve Alternatif Tedavilerin Kullanımı(2022) Topal, Zehra; Tufan, Ali EvrenOtizm Spektrum Bozukluğu (OSB) etyolojisinde birden fazla faktörün rol aldığı nörogelişimsel bir bozukluktur. OSB tanılı çocukların ebeveynleri geleneksel tıbbi tedavilerden yeterince fayda sağlayamadıkları gerekçesiyle sıklıkla tamamlayıcı ve alternatif tedavilere (TAT) yönelebilmektedir. Bu gözden geçirme yazısında TAT kavramının tanımı, kullanım yaygınlığı, OSB’de kullanılan TAT yöntemleri ve etkinliklerinin incelenmesi ve ülkemizdeOSB’li çocuklarda TAT kullanımı ile ilgili çalışmaların gözden geçirilmesi amaçlanmıştır. TAT uygulamalarının OSB’de etkinliklerine dair güncel veriler sınırlı olmakla birlikte kullanım oranları göz önüne alındığında hekimlerin TAT yöntemleri hakkında bilgi sahibi olmaları, ailelerle TAT kullanımını açık bir şekilde sormaları ve bilgi paylaşımında bulunmaları gerekmektedir.Öğe Possible exogenous growth hormone induced mood disorder with mixed features in a child(Mary Ann Liebert, Inc, 2015) Tuman, Taha Can; Topal, Zehra; Demir, Nuran; Arısoy, Özden; Taşkıran, Sarper; Tufan, Ali EvrenÖğe The prevalence of childhood psychopathology in Turkey: a cross-sectional multicenter nationwide study (EPICPAT-T)(Taylor & Francis Ltd, 2019) Ercan, Eyüp Sabri; Demirbaş Çakır, Emine; Cansız, Mehmet Akif; Topal, Zehra; Demir, NuranAim: The aim of this study was to determine the prevalence of childhood psychopathologies in Turkey. Method: A nation-wide, randomly selected, representative population of 5830 children (6-13 years-old) enrolled as a 2nd,3rd or 4th grade student in 30 cities were evaluated for presence of a psychiatric or mental disorder by a Sociodemographic Form, Kiddie Schedule for Affective Disorders and Schizophrenia for School Age Children-Present and Lifetime Version (K-SADS-PL), and DSM-IV-Based Screening Scale for Disruptive Behavior Disorders in Children and Adolescents scales. Impairment criterion was assessed via a 3 point-Likert scale by the parent and the teacher independently. Results: Overall prevalence of any psychopathology was 37.6% without impairment criterion, and 17.1% with impairment criterion. Attention-deficit hyperactivity disorder was the most frequent diagnosis, followed by anxiety (19.5% and 16.7% without impairment, 12.4% and 5.3% with impairment, respectively). Lower education level and presence of a physical or psychiatric problem of the parents were independent predictors of any psychopathology of the offspring. Conclusion: This is the largest and most comprehensive epidemiological study to determine the prevalence of psychopathologies in children and adolescents in Turkey. Our results partly higher than, and partly comparable to previous national and international studies. It also contributes to the literature by determining the independent predictors of psychopathologies in this age group.Öğe Rates of disruptive mood dysregulation disorder among adolecent offspring of parens with recurrent major depressive disorder versus those with bipolar disorder and matched healthy controls(Elsevier Science Inc, 2016) Topal, Zehra; Demir, Nuran; Tuman, Taha Can; Yıldırım, Osman; Tufan, EvrenObjectives: Offspring of parents with mood disorders have increased risk for irritability as well as psychopathologies. Disruptive Mood Dysregulation Disorder (DMDD) is characterized by severe, mpairing, temper outbursts along with irritability. Recent data suggest that episodic and chronic irritability in childhood may have different developmental trajectories. Here we aimed to determine the rates of DMDD, via DSM-5 criteria, in adolescent offspring of parents with recurrent depression and bipolar disorders (BP-I) and to compare those rates with matched healthy controls. A priori study hypothesis was: DMDD diagnosis would be significantly more common among mood disorder offspring.Öğe Relationships between vitamin b12, folate levels and clinical features in attention deficit hyperactivity disorder and attention deficit hyperactivity disorder-not otherwise specified(Galenos Yayincilik, 2020) Öztürk, Yusuf; Topal, Zehra; Demir, Nuran; Tufan, Ali EvrenAim: In this study, we aimed to compare the levels of vitamin 812 and folate in children with Attention Deficit and Hyperactivity Disorder (ADHD) and Attention Deficit and Hyperactivity Disorder-Not Otherwise Specified (ADHD-NOS). Materials and Methods: This study was planned as a cross-sectional, retrospective study. Patients were recruited between January 2012 and January 2013 and 205 case records were evaluated. The ADHD and ADHA-NOS groups were compared according to vitamin B12 and folate levels. Symptom severity was evaluated by the Turgay DSM-IV-Based Child and Adolescent Behavior Disorders Screening and Rating scale. Anxiety symptom severity was assessed by The Screen for Anxiety Related Emotional Disorders. Results: The average age of the children in the ADHD group was 10.88 +/- 3.02 (n=99) years, and the average age of the children in the ADHD-NOS group was 9.93 +/- 2.49 (n=106) years. There was no statistically significant difference between two groups in terms of Vitamin B12 level and folate level (p>0.05). A statistically significant negative correlation between the total number of diagnoses of a child and vitamin 812 levels was found. Folate levels correlated significantly with anxiety total scores generalized anxiety subscale. Conclusion: Vitamin B12 levels may be affected in children with impairing ADHD symptoms and increased comorbidities. The results of the study should be supported by future studies.Öğe Remission rates, time to remission, and related factors in adolescents with major depressive disorder(Aves, 2021) Topal, Zehra; Öztürk, Yusuf; Demir, Nuran; Adıgüzel, Öznur; Karadağ, Mehmet; Tufan, Ali EvrenObjective: Major depressive disorder (MDD) is a common disorder in children and adolescents that can cause serious morbidity and mortality. Although response rates to treatment are high, less than half of the adolescents with MDD achieve remission. The present study aims to evaluate remission rates, time to remission, and the predictors of remission in adolescents with MDD. Methods: This study included 34 adolescents with MDD who were followed-up for a minimum period of 120days. The adolescents were assessed with the Clinic Global Impression Scale, Beck Depression Inventory, Young Mania Rating Scale, Child Mania Rating Scale, and Screen for Child Anxiety-Related Emotional Disorders at the baseline and at weeks 4, 8, and 12. Results: 67.6% of the adolescents had at least one comorbid diagnosis. The remission rate at week 12 was 735%. The mean time to remission was 72.0days. The female adolescents achieved a significantly higher remission rate than the males. Conclusion: The majority of adolescents achieved remission following acute treatment, and that the time to remission for the female adolescents was shorter compared with the males. Remission time does seem neither to be related to the number of medications prescribed nor to the number of comorbid diagnoses.Öğe Response of catatonia to amisulpride and lorazepam in an adolescent with schizophenia(Mary Ann Liebert, Inc, 2018) Binici, Nagihan Cevher; Topal, Zehra; Samurcu, Nuran Demir; Cansız, Mehmet Akif; Savcı, Ugur; Öztürk, Yusuf; Özyurt, GoncaLetters to the editorÖğe Retrospective analysis of patients with disruptive mood dysregulation disorder and psychopharmacologic treatment preferences(YERKURE TANITIM & YAYINCILIK HIZMETLERI A S, 2021) Topal, Zehra; Öztürk, Yusuf; Tufan, Ali Evren; Demir, Nuran; Semerci, BengiObjective: DMDD is a new diagnosis listed in the DSM-5. Here, we aimed to present a retrospective analysis of cases with probable DMDD and their psychopharmacological treatment characteristics. Methods: 200 patients complaining of irritability and temper tantrums were evaluated retrospectively. To differentiate those with probable DMDD; Young Mania Rating Scale, Children's Depression Inventory, Screen for Anxiety and Related Disorders, Atilla Turgay Scale for DSM-IV-TR Disruptive Behavior Disorders scores were used. Results: 99 patients were found to fulfill criteria for DMDD. 85 patients (88 %) were prescribed drugs. Most common drugs were risperidone, methylphenidate, atomoxetine, OROS methylphenidate, sertraline and fluoxetine in descending order. Females are more frequently prescribed SSRIs while males are prescribed other drugs. Conclusion: As a new diagnosis, the treatment guidelines for DMDD are still unclear. The preliminary results of this study suggest that clinicians tend to prescribe stimulants/atomoxetine, atypical antipsychotics, and SSRIs for this group of patients.
