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Öğe The association between serum uric acid to high density lipoprotein-cholesterol ratio and non-alcoholic fatty liver disease: The abund study(Associação Médica Brasileira, 2021) Kösekli, Mehmet Ali; Kurtkulağı, Özge; Kahveci, Gizem; Duman, Tuba Taslamacıoğlu; Tel, Burçin Meryem Atak; Bilgin, Satılmış; Demirkol, Muhammed Emin; Aktaş, GülaliOBJECTIVE: Non- alcoholic fatty liver disease, which is characterized by lipid being deposited into hepatocytes, affects nearly one in three adults globally. Inflammatory markers were suggested to be related with hepatic steatosis. Uric acid to HDL cholesterol ratio is proposed as a novel inflammatory and metabolic marker. We aimed to compare Uric acid to HDL cholesterol ratio levels of patients with Non-alcoholic fatty liver disease to those of healthy controls and find out potential correlations between Uric acid to HDL cholesterol ratio and other inflammatory and metabolic markers of Non-alcoholic fatty liver disease. METHODS: Patients with a diagnosis of Non-alcoholic fatty liver disease who were on clinical follow-up in our institution were enrolled in the study as the Non- alcoholic fatty liver disease group, while healthy volunteers were enrolled as the control group. The Uric acid to HDL cholesterol ratio of the groups was compared and potential correlations were studied between Uric acid to HDL cholesterol ratio and fasting blood glucose, transaminases, serum lipids (triglyceride, LDL- cholesterol), weight, and body mass index. RESULTS: The Uric acid to HDL cholesterol ratio of the Non-alcoholic fatty liver disease (13 +/- 5%) group was significantly higher compared to the Uric acid to HDL cholesterol ratio of the control (10 +/- 4%) group (p<0.001). Uric acid to HDL cholesterol ratio was significantly and positively correlated with fasting blood glucose, transaminases, triglyceride, body weight, waist circumference, hip circumference, and body mass index. A ROC analysis revealed that a Uric acid to HDL cholesterol ratio level greater than 9.6% has 73% sensitivity and 51% specificity in determining Non-alcoholic fatty liver disease. CONCLUSION: Due to the inexpensive and easy-to-assess nature of Uric acid to HDL cholesterol ratio, we suggest that elevated Uric acid to HDL cholesterol ratio levels be considered a useful tool in diagnosing hepatic steatosis.Öğe C-reactive protein-to-lymphocyte ratio is a reliable marker in patients with COVID-19 infection: the CLEAR COVID study(Mexican Acad Surgery, 2022) Demirkol, Muhammed Emin; Bilgin, Satılmış; Kahveci, Gizem; Kurtkulağı, Özge; Tel, Burçin Meryem Atak; Duman, Tuba Taslamacıoğlu; Aktaş, GülaliObjective: COVID-19 infection is characterized with elevation of inflammatory markers in bloodstream. A novel inflammatory marker, C-reactive protein (CRP)-to-lymphocyte ratio (CLR), is suggested to be associated with inflammation. We aimed to compare the CLR values of the deceased COVID-19 patients to the CLR of survived subjects. Materials and Methods: The patients with COVID-19 whom presented to outpatient or inpatient clinics of AbantIzzet Baysal University Hospital were enrolled to the present retrospective study. Subjects were grouped as either deceased or survived. CLR values of the groups were compared. Results: Study cohort was consisted of 568 subjects in deceased and 4753 patients in survived group. Median CLR of the deceased and survived groups were 90 (0.2-1679)% and 11 (0.2-1062)%, respectively (p < 0.001). The sensitivity (75%) and specificity (70%) of CLR (> 23.4% level) in detecting mortality were higher than those of CRP and ferritin (AUC: 0.80, p < 0.001, 95% CI: 0.78-0.82). Conclusion: We suggest that elevated CLR levels in COVID-19 patients on admission should alert physicians for poor outcome.Öğe Control level of type 2 diabetes mellitus in the elderly is associated with polypharmacy, accompanied comorbidities, and various increased risks according to the beers criteria(MDPI, 2023) Tel, Burçin Meryem Atak; Aktaş, Gülali; Bilgin, Satılmış; Baltacı, Sümeyye Buse; Duman, Tuba TaslamacıoğluComorbidity rates in the geriatric population have increased because of rising life expectancy; thus, patients have had to use more medications. Type 2 diabetes mellitus, one of the most common diseases, may influence the number of drugs used in geriatric patients. The present study was designed to investigate the association between the level of type 2 DM and polypharmacy. Fifty patients with type 2 diabetes over the age of 65 were included according to the inclusion criteria; 23 were well-controlled and 27 had poorly controlled diabetes. The groups were similar in terms of age, sex, WBC, Hb, Plt, AST, ALT, serum creatinine, fasting glucose, and eGFR levels. Patients with HbA1c values above 7.5 were classified as poorly controlled diabetes patients, and those below were considered well-controlled diabetes patients and were evaluated for inappropriate medication use. The number of medications used daily by the cases (p < 0.001), the number of concomitant diseases (p = 0.001), and the number of increased risks according to the Beers Criteria (p = 0.02) were observed to be high in poorly controlled type 2 diabetes mellitus subjects. HbA1c levels were related to the number of medications (r = 0.4, p = 0.004), comorbidities (r = 0.28, p = 0.04), and the number of increased risks according to the Beers Criteria (r = 0.31, p = 0.014). In conclusion, the number of medications used in patients with poorly controlled type 2 diabetes mellitus was found to be more elevated than in individuals with well-controlled type 2 diabetes mellitus. The HbA1c values varied among patients regarding polypharmacy, comorbidities, and increased risks according to the Beers Criteria.Öğe Correlation between serum triglyceride to hdl cholesterol ratio and blood pressure in patients with primary hypertension(Wiley, 2022) Kurtkulağı, Özge; Aktaş, Gülali; Duman, Tuba Taşlamacıoğlu; Bilgin, Satılmış; Tel, Burçin Meryem Atak; Kahveci, GizemHypertension (HT) is associated with significant morbidity and mortality. The efficacy of the treatment in HT patients is mostly depending on the office or home blood pressure monitoring. Triglyceride to high density lipoprotein (HDL) cholesterol ratio (THR) is an inflammatory and metabolic predictor. We aimed to compare THR levels of the HT patients with poorly controlled blood pressure levels to those with well-controlled hypertensive subjects. In present cross sectional study, we grouped patients with HT either as well or poorly controlled hypertensive subjects according to the blood pressure measurement. THR of the groups compared. The THR of the poorly controlled HT group (3.9 [1.91-88.7]%) was significantly higher than the THR of the well-controlled HT group (3.07 [0.71-35.8]%), (p < .001). The sensitivity and specificity of THR higher than 3.26% in predicting poor blood pressure control were 72% and 52%, respectively (AUC: 0.64, p <.01, %95 CI: %59-70). High THR levels in HT patients may warrant closer monitorization of blood pressure since it may predict poor blood pressure control in this population.Öğe Could triglyceride to high density lipoprotein-cholesterol ratio predict hepatosteatosis?(2021) Kurtkulaği, Özge; Bilgin, Satilmis; Kahveci, Gizem; Tel, Burçin Meryem Atak; Kösekli, Mehmet AliAim: The triglyceride / HDL cholesterol (TG/HDL-c) ratio is increased in a variety of diseases including, coronary heart disease and type 2 diabetes mellitus. However, its role in non-alcoholic hepatosteatosis is not well understood. In present study, we aimed to compare the TG/HDL-c levels of the patients with non-alcoholic hepatosteatosis to those of the healthy subjects. Methods: Medical data of the patients with non-alcoholic hepatosteatosis whom presented to the outpatient internal medicine clinics of our institution were retrospectively analyzed. Healthy subjects whom admissions to our clinics were due to check up were enrolled to the study as control group. TG/HDL-c of the groups compared. Results: TG/HDL-c level of the liver steatosis group (5 (2-22) %) was higher than the control group (2.7 (1-8) %), (p<0.001). TG/HDL-c was significantly and positively correlated with fasting blood glucose (r=0.31, p<0.001), C - reactive protein (r=0.25, p<0.001) and LDL-cholesterol (r=0.3, p<0.001) levels. A TG/HDL-c value greater than 3.1% has 91% sensitivity and 77% specificity in detecting hepatosteatosis. Conclusions: We suggest that TG/HDL-c ratio could be a useful marker of non-alcoholic hepatosteatosis due to its inexpensive and easy to assess nature.Öğe Does Mean Platelet Volume to Lymphocyte Ratio Associates with Irritable Bowel Syndrome and Its Subtypes?(2019) Duman, Tuba Taslamacioğlu; Tel, Burçin Meryem AtakINTRODUCTION: Hemogram parameters are considered as inflammatory markers in various diseases. The objective of this study was to assess mean platelet volume to lymphocyte ratio (MPVLR) of subjects with IBS and to compare to those in healthy population.METHODS: Patients with IBS whose admissions to our outpatient internal medicine clinic were enrolled to the study. Patients with IBS were divided into two groups according to the predominant symptom, either IBS diarrhea predominant (IBS-D) or IBS constipation predominant (IBS-C). Healthy volunteers were enrolled as control group. General characteristics and MPVLR levels of the groups compared.RESULTS: The MPVLR of IBS-C, IBS-D and control groups were 0.005 (0.001), 0.004 (0.001) and 0.003 (0.001), respectively (p<0.001). Post Hoc test revealed that MPVLR of IBS-C and IBS-D groups were similar (p=0.44) and MPVLR of control groups was significantly lower than that of the IBS-C (p<0.001) and IBS-D (p<0.001) groups.DISCUSSION and CONCLUSION: The main outcome of present study was that MPVLR could be used as a marker of IBS. However, it is not useful in differentiating IBS constipation predominance from IBS diarrhea predominance. In conclusion, despite increased MPVLR could not differentiate IBS constipation predominance from the IBS diarrheapredominance, it could be useful in establishing the diagnosis of IBS.Öğe Does mean platelet volume to lymphocyte ratio associates with irritable bowel syndrome and its subtypes?(2019) Duman, Tuba Taslamacıoğlu; Tel, Burçin Meryem AtakINTRODUCTION: Hemogram parameters are considered as inflammatory markers in various diseases. The objective of this study was to assess mean platelet volume to lymphocyte ratio (MPVLR) of subjects with IBS and to compare to those in healthy population. METHODS: Patients with IBS whose admissions to our outpatient internal medicine clinic were enrolled to the study. Patients with IBS were divided into two groups according to the predominant symptom, either IBS diarrhea predominant (IBS-D) or IBS constipation predominant (IBS-C). Healthy volunteers were enrolled as control group. General characteristics and MPVLR levels of the groups compared. RESULTS: The MPVLR of IBS-C, IBS-D and control groups were 0.005 (0.001), 0.004 (0.001) and 0.003 (0.001), respectively (p<0.001). Post Hoc test revealed that MPVLR of IBS-C and IBS-D groups were similar (p=0.44) and MPVLR of control groups was significantly lower than that of the IBS-C (p<0.001) and IBS-D (p<0.001) groups. DISCUSSION and CONCLUSION: The main outcome of present study was that MPVLR could be used as a marker of IBS. However, it is not useful in differentiating IBS constipation predominance from IBS diarrhea predominance. In conclusion, despite increased MPVLR could not differentiate IBS constipation predominance from the IBS diarrhea predominance, it could be useful in establishing the diagnosis of IBS.Öğe Evaluation of the effectiveness of long-acting insulin analogs in patients with type 2 diabetes mellitus(Springer Heidelberg, 2023) Duman, Tuba Taslamacıoğlu; Aktaş, Gülali; Tel, Burçin Meryem Atak; Bilgin, Satılmış; Kahveci, Gizem; Kurtkulağı, ÖzgeAim In this study, we aimed to evaluate the effectiveness of long-acting insulin analogs in the treatment of type 2 diabetes mellitus (T2DM) in our clinic. Methods Patients with T2DM who were prescribed long-acting insulin analog therapy in our internal medicine outpatient clinic between November 2017 and December 2019 were included in the study. Patients' age, gender, duration of diabetes, HbA1c values, insulin doses and injections in previous treatment, and fasting blood glucose levels before the initiation of long-acting insulin analog were recorded. Fasting blood glucose levels after the initiation of long-acting insulin analog therapy, HbA1c values, total insulin doses in the new treatment and the number of injections, and follow-up times were also recorded from the institutional database. Data of the patients during previous treatment and novel treatment were compared. Results Forty patients were included in our study. Six patients who did not attend their controls and two patients who were observed to be non-compliant even though they presented to control visit were excluded from the study. The remaining 32 patients were enrolled in the study. The average treatment follow-up period of the patients was 6 (3-8) months. Fasting blood glucose (p = 0.014) and HbA1c (p = 0.004) values were significantly reduced after long-acting insulin analog therapy compared to the values during previous treatment. Similarly, total daily insulin dose was decreased after long-acting insulin analog treatment compared to the insulin dose before long-acting insulin analog treatment (p < 0.001). The decrease in the number of daily insulin injections after long-acting insulin analogs treatment compared to the number of injections before long-acting insulin analog treatment was statistically significant (p < 0.001). Conclusion We think that the addition of new long-acting insulin analogs to the treatment in patients with T2DM may be beneficial in achieving the target blood glucose, A1c, and may also be associated with treatment compliance.Öğe Frailty in diabetic subjects during COVID-19 and its association with HbA1c, mean platelet volume and monocyte//lymphocyte ratio(Via Medica, 2022) Tel, Burçin Meryem Atak; Bilgin, Satılmış; Kurtkulağı, Özge; Kahveci, Gizem; Duman, Tuba Taşlamacıoğlu; Sağdıç, Tuğrul; Aktaş, GülaliBackground: Frailty is associated with increased risk of hospitalization in diabetic patients. Both SARS-CoV-2 pandemic and type 2 diabetes mellitus contribute to the frailty. In this study we aimed to observe clinical and laboratory indices of the diabetic subjects during COVID-19 pandemic who were either frail or not according to Edmonton frail score. Material and methods: During the pandemic era, 100 consecutive patients with type 2 diabetes mellitus divided into two groups either as frail or non-frail according to the Edmonton Frail Scale scores. Laboratory and clinical features of the frail and non-frail subjects were compared. Results: Frail patients were older than the non-frail diabetics. Blood urea, serum creatinine, eGFR, plasma albumin, total cholesterol, triglyceride, HbA1c, mean platelet volume (MPV), and monocyte lymphocyte ratio (MLR) levels of the frail and non-frail groups were significantly different. Moreover, Edmonton frail score was significantly and positively correlated with blood urea, serum creatinine, MLR, MPV, HbA1c and inversely correlated with eGFR and plasma albumin levels. Conclusions: We think that HbA1c, MPV and MLR could be surrogate markers of frailty in diabetic elderly during COVID-19 outbreak. Strategies to keep them in normal range do not only improve diabetes control but also reduce the risk of frailty in this population.Öğe Hashimoto's thyroiditis is associated with elevated serum uric acid to high density lipoprotein-cholesterol ratio(Sciendo, 2021) Kurtkulağı, Özge; Tel, Burçin Meryem Atak; Kahveci, Gizem; Bilgin, Satılmış; Duman, Tuba Taslamacıoğlu; Ertürk, Aslı; Balcı, Buse; Aktaş, GülaliBackground. Hashimoto's thyroiditis (HT) is an auto-immune condition characterized with lymphocytic and fibroblastic infiltration of the thyroid gland. The rate of uric acid and HDL cholesterol - so called as uric acid to HDL ratio (UHR) has been shown to be elevated in inflammatory conditions diseases. We aimed to compare UHR and other laboratory parameters of the patients with HT to those values in healthy controls. Methods. The patients diagnosed with HT by medical history, physical examination, elevated thyroid autoantibodies in serum and characteristic sonographic findings in outpatient internal medicine clinics of our institution were enrolled to the present retrospective study. Age and sex matched healthy volunteers were enrolled as controls. UHR of the HT patients and control subjects were compared. Results. The mean UHR of the HT group was 11% +/- 4 %, while UHR of the control group was 8% +/- 2% (p<0.001). UHR was significantly and positively correlated with thyroid stimulating hormone (TSH) (r=0.26, p=0.01) and negatively correlated with free T4 (FT4) (r=-0.22, p=0.04) levels. The sensitivity and specificity of the UHR level were greater than 8.3%: were 74% and 52%, respectively (AUC: 0.74, p<0.001, 95% CI: 0.64-0.84). Conclusion. We suggest that UHR is a reliable and useful marker for HT. Therefore, it may be helpful in establishing the diagnosis of HT in addition to other diagnostic tools.Öğe Inappropriate medication use in older adults according to Beers Criteria in a Tertiary Referral Hospital, in Bolu, Turkey(Science & Innovation, Ltd, 2021) Tel, Burçin Meryem Atak; Aktaş, Gülali; Duman, Tuba Taslamacıoğlu; Kurtkulağı, Özge; Kahveci, Gizem; Demirkol, Muhammed Emin; Bilgin, SatılmışAims - We aimed to study the medications used by older adults for any potentially inappropriate medications. Material and Methods - A hundred and four consecutive subjects over 65 years of age who visited our clinic were enrolled in the study. Possible inappropriate medications were defined according to Beers Criteria. Results - A total of 57 women and 49 men were enrolled in the study. Mean ages of the women and men were 78.6 +/- 6.1 years and 77.4 +/- 5.4 years, respectively (p=0.30). While 18 subjects (17%) had no increased risk due to inappropriate use of medications, 30 were on inappropriate medications that increased renal failure risk, 5 were on inappropriate medication that amplified neurological side effects, 12 were on inappropriate medications that augmented bleeding risk, 20 were on inappropriate medication that lack safety and efficacy data, and 30 were on inappropriate medication that amplified the risk of falls. The number of increased risks according to Beers Criteria was significantly and positively correlated with number of medications used (r=0.366, p<0.001) and the number of comorbidities (r=0.312, p=0.001). Conclusion - The number of increased risks due to inappropriate use of medicines in older adults is positively correlated with the number of medicines used and the number of accompanied diseases. Therefore we suggest that the medicines used by older people should be reviewed in all settings, and unnecessary drugs should be avoided to be prescribed.yÖğe Is serum uric acid-to-HDL cholesterol ratio elevation associated with diabetic kidney injury?(Taylor & Francis Ltd, 2023) Aktaş, Gülali; Yılmaz, Şeyma; Kantarcı, Didar Beyza; Duman, Tuba Taslamacıoğlu; Bilgin, Satılmış; Balcı, Sümeyye Buse; Tel, Burçin Meryem AtakObjectivesDiabetic kidney injury (DKI) is a serious microvascular complicationof type 2 diabetes mellitus (T2DM). Novel markers are being developedto make a timely diagnosis of this complication. Uric Acid to HDLratio (UHR) was reported to be associated with inflammatory andmetabolic diseases such as metabolic syndrome, type 2 diabetesmellitus, thyroiditis, and nonalcoholic hepatosteatosis, recently. Inthe present study, we aimed to show the diagnostic role of UHR indiabetic kidney injury (DKI), a condition characterized with chronicand low-grade inflammation.MethodsWe retrospectively analyzed data of 287 patients who already had T2D Min outpatient clinics of our institution. The study population was divided into two groups according to the presence of DKI. General characteristics and laboratory data, including UHR levels, of the diabetic subjects with DKI were compared to those of patients without DKI.ResultsThe median UHR of the diabetic patients with DKI group (0,13 (0,06-0,33)) was significantly elevated compared to the UHR of diabetic patients without DKI (0,11 (0,04-0,34)) (p < 0.001). Median UHR was significantly and positively correlated with UACR (r=0.14, p=0.02), serum creatinine (r=0.18, p=0.002), and HbA1c (r=0.28, p<0.001) levels. There was also a significant inverse correlation between UHR and GFR (r=-0.19, p=0.001) values. Logistic regression analysis confirmed that a 0.1 point increase in UHR increases DKI odds by 2.3 times. UHR was also correlated with serum creatinine, GFR, and UACR, which are important signs for DKI.ConclusionIn conclusion, we think that UHR could be a diagnostic tool indiabetic kidney injury according to the preliminary results of the present study. UHR has an independent predictive role in DKI, and ithas significant correlation with other markers of kidney functions, therefore, we suggest routine evaluation of UHR in patients with DKIalong with other markers such as serum creatinine, GFR, and UACR.Öğe Is uric acid elevation a random finding or a causative agent of diabetic nephropathy?(Assoc Medica Brasileira, 2019) Koçak, Mehmet Zahid; Aktaş, Gülali; Duman, Tuba Taslamacıoğlu; Tel, Burçin Meryem Atak; Şavlı, HalukOBJECTIVE: In this study, we aimed to analyze the relationship between serum uric acid (UA) and microalbuminuria as a marker of renal injury in type 2 diabetes mellitus. METHODS: A total of 100 patients with type 2 diabetes mellitus were enrolled in the study. Participants were divided into two groups according to the urinary microalbumin/creatinine ratio: diabetic nephropathy and non-nephropathy group. UA and microalbuminuria were compared between the study groups. RESULTS: Serum UA levels of diabetic nephropathy patients were significantly higher than those in the non-nephropathy group (UA in patients with diabetic nephropathy groups: 6.3 (1.82) mg/dl, UA in patients of the non-nephropathic group: 4.85(1.92) mg/dl)(p<0.001). There was a correlation between microalbuminuria and UA (r=0.238). This correlation was statistically significant (p=0.017). CONCLUSION: UA levels may be an important predictor of nephropathy in diabetic patients.Öğe Millennium pandemic: A Review of coronavirus disease (COVID-19)(2020) Bilgin, Satılmış; Kurtkulağı, Özge; Kahveci, Gizem Bakir; Duman, Tuba T.; Tel, Burçin Meryem AtakCoronaviruses, a large family of single-stranded RNA viruses, can infect humans and animals, and can cause neurological, gastrointestinal and hepatic diseases as well as causing various lung diseases, including pneumonia, with shortness of breath, cough and fever. At the end of December 2019, a group of health authorities reported unidentified cases of pneumonia in a seafood market in Wuhan, China. The World Health Organization (WHO) used term 2019 novel coronavirus (COVID-19) to refer to a coronavirus that affected the lower respiratory tract of patients with pneumonia in Wuhan, China on 29 December and the WHO announced that the official name of the 2019 novel coronavirus was coronavirus disease (COVID-19). COVID-19 is seen in many countries around the World and has been accepted as a pandemic by WHO. It is defined as a suspicious case with fever, sore throat, cough, and people with a history of traveling to China or some parts of the country, or someone who contact with a patient who has a history of travel in China or contact with a confirmed COVID-19 infection patient. Currently, there is no proven vaccine or antiviral therapy that can be used against animal or human coronavirus. To control the outbreak, the drugs must be developed as soon as possible. Various drugs have been used in the treatment of COVID-19 and the main ones are chloroquine, remdesivir, lopinavir/ritonavir, oseltamivir, favipiravir. Since the virus affects the whole World, vaccines and/or new curative antiviral drugs are needed to end the pandemic. For this purpose, large-scale observational studies are needed.Öğe A novel inflammatory marker for the diagnosis of Hashimoto's thyroiditis: Platelet-count-to-lymphocyte-count ratio(MDPI, 2023) Erge, Eray; Kızıltunç, Çağrı; Balcı, Sümeyye Buse; Tel, Burçin Meryem Atak; Bilgin, Satılmış; Duman, Tuba Taslamacıoğlu; Aktaş, GülaliBackground: Hashimoto's thyroiditis (HT) is a chronic autoimmune thyroiditis that causes systemic inflammation in the body, leading to hypothyroidism and an enlargement of the thyroid gland. Objectives: This study aims to reveal whether there is a relationship between Hashimoto's thyroiditis and the platelet-count-to-lymphocyte-count ratio (PLR), which is used as a new inflammatory marker. Methods: In this retrospective study, we compared the PLR of the euthyroid HT group and the hypothyroid-thyrotoxic HT group to the controls. We also evaluated the values of thyroid-stimulating hormone (TSH), free T4 (fT4), C-reactive protein (CRP), aspartate transaminase (AST), alanine transaminase (ALT), white blood cell count, lymphocyte count, hemoglobin, hematocrit, and platelet count in each group. Results: The PLR of the subjects with Hashimoto's thyroiditis was found to be significantly different from the control group (p < 0.001), with the rankings as follows: hypothyroid-thyrotoxic HT 177% (72-417) > euthyroid HT 137% (69-272) > control group 103% (44-243). In addition to the increased PLR values, an increase in CRP values was also observed, revealing a strong positive correlation between the PLR and CRP in the HT patients. Conclusion: In this study, we found out that the PLR was higher in the hypothyroid-thyrotoxic HT and euthyroid HT patients than in a healthy control group.Öğe A novel marker for prediabetic conditions: Uric acid-to-HDL cholesterol ratio(Aepress Sro, 2024) Balcı, Sümeyye Buse; Tel, Burçin Meryem Atak; Duman, Tuba; Özkul, Feyza Nihal; Aktaş, GülaliOBJECTIVES: The objective of this study was to identify a parameter that can facilitate the diagnosis of prediabetes and predict the likelihood of its development in individuals at high risk. METHODS: In this retrospective study, the study population was selected from Bolu Abant Izzet Baysal University Hospital's patients. Participants were divided into two groups, prediabetes and healthy group. We excluded individuals with certain conditions or taking certain medications. The study compared the ratios of uric acid to high-density lipoprotein (HDL) between the two groups and identified the optimal point of differentiation. RESULTS: The study analyzed data from 228 individuals, including 125 with prediabetes and 103 healthy controls. Those with prediabetes had a significantly higher median UHR (0.13 (0.07-0.24) %) compared to healthy individuals (0.09 (0.05-0.16) %) (p < 0.001). Higher UHR values were associated with a greater risk of prediabetes. A UHR cut-off points greater than 0.11 % had a sensitivity of 74 % and specificity of 69 % in detecting prediabetes. CONCLUSION: The study provides evidence that UHR can serve as a practical and valuable diagnostic and screening tool for prediabetes (Tab. 2, Fig. 1, Ref. 23). Text in PDF www.elis.skÖğe Platelet to lymphocyte ratio in differentiation of benign and malignant thyroid nodules(2021) Bilgin, Satilmis; Kahveci, Gizem; Tel, Burçin Meryem Atak; Kurtkulaği, Özge; Kösekli, Mehmet AliAim: Differentiation of thyroid nodules, either as benign or malignant, is a real diagnostic challenge.Inflammation has an important role in development of the malignancy. Therefore, inflammatory markers areassociated with malignant thyroid nodules. Platelet /lymphocyte ratio (PLR) is also one of the novelinflammatory indices derived from hemogram tests. We hypothesized whether PLR was associated withmalignant thyroid nodules. For this purpose, we compared PLR levels of the patients with benign thyroidnodules to the PLR of the subjects with malignant nodules.Methods: The subjects who visited outpatient internal medicine clinics of our institution with a diagnosis ofthyroid nodule were enrolled to the present retrospective study. According to the examination of the fine needleaspiration cytology (FNAC) specimen of the nodules, patients grouped into benign or malignant nodule groups.PLR of groups were compared.Results: Median PLR values of the benign and malignant thyroid nodule groups were 106 (48-432) % and 119(48-365) %, respectively (p=0.001). PLR value higher than 106% has 69% sensitivity and 51% specificity indetecting malignant nodules (AUC: 0.59, p=0.001, 95% CI: 0.54-0.65). PLR was positively correlated withTSH level (r=0.10, p=0.34).Conclusion: We suggest that elevated PLR could be an additional tool to differentiate malignant thyroidnodules from benign ones in supportive of sonography, scintigraphy and cytology.Öğe Poorly controlled hypertension is associated with elevated serum uric acid to HDL-cholesterol ratio: A cross-sectional cohort study(Taylor & Francis Ltd, 2022) Aktaş, Gülali; Khalid, Atiqa; Kurtkulağı, Özge; Duman, Tuba Taslamacıoğlu; Bilgin, Satılmış; Kahveci, Gizem; Tel, Burçin Meryem Atak; Sincer, İsa; Güneş, YılmazObjectives The diagnosis and follow-up of hypertension (HT) depend on the blood pressure measurements, which can be affected by several factors. In the present work, we aimed to explore the role of uric acid/HDL-cholesterol ratio (UHR) in HT and whether/or not it was associated with poor blood pressure control. Methods In this retrospective cross-sectional cohort study, all the participants treated for hypertension and then followed up in the internal medicine clinics of our institution were enrolled. Hypertensive patients were grouped as either poorly or well-controlled hypertension groups, according to the suggestions of Joint National Committee VIII criteria and healthy volunteers were enrolled as control group. UHR of the study groups was compared. Results Our study cohort consisted of 535 subjects; 258 in the well-controlled HT group, 186 in the poorly controlled HT group, and 91 in the control group. Median UHR levels of the poorly controlled HT group (13 (4-43) %) were significantly higher than well-controlled HT group 11 (4-22) %) and control group (8 (4-19) %) (p < 0.001). UHR was correlated with systolic (r = 0.33, p < 0.001) and diastolic (r = 0.28, p < 0.001) BP. UHR level greater than 11% has 70% sensitivity and 60% specificity in predicting poor BP control (AUC: 0.73, p < 0.001, 95%CI: 0.68-0.77). UHR was an independent risk factor for poor BP control in HT subjects and a unit elevation in UHR increased the risk of poorer BP control by 7.3 times (p < 0.001, 95%CI: 3.9-13.63). Conclusion Assessment of UHR may be useful in HT patients since elevated UHR levels could be associated with poor blood pressure control in this population.Öğe Red cell distribution width-to-platelet count ratio is a promising predictor of functional bowel disease(Termedia Publishing House Ltd, 2022) Kahveci, Gizem; Aktaş, Gülali; Tel, Burçin Meryem Atak; Bilgin, Satılmış; Kurtkulağı, Özge; Balcı, Buse; Ertürk, Aslı; Duman, Tuba TaslamacıoğluBackground. Hemogram parameters are not only diagnostic tools in haematological diseases, but their role in inflamma-tory conditions is also important. One of these haematological markers is a derived index, the so-called red cell distribution width-to -platelet count ratio (RPR). The role of RPR has been well established in various inflammatory conditions. Objectives. In the present study, we aimed to observe the RPR levels of patients with functional bowel disease (FBD), which is also considered as an inflammatory process, and to compare this to the healthy population. Material and methods. Patients diagnosed with FBD according to Rome IV criteria were included as the study group. Healthy vol-unteers were enrolled as control subjects. Patients with any form of anaemia or haematological disorders or inflammatory diseases were excluded. Age, gender and hemogram parameters were obtained from institutional databases. The data of the study and control groups was compared. Results. 158 subjects were enrolled in the study; 87 in the FBD group and 71 in the control group. The RPR of the FBD and control groups were 7% (2%) and 5% (1%), respectively. The difference in RPR between the FBD and control groups was statistically significant (p = 0.008). A RPR value higher than 6% has a 70% sensitivity and 52% specificity in detecting FBD. There was a significant and positive correlation between RPR levels and the presence of FBD (r = 0.22, p = 0.007). Conclusions. We suggest that elevated RPR levels could yield potential diagnostic benefits in the diagnosis of FBD. However, prospec-tive studies with a larger population are needed to confirm our results.Öğe A relapsing immune thrombocytopenia case in a patient following COVID-19 vaccination(Thieme Medical Publishers Inc, 2022) Tel, Burçin Meryem Atak; Kahveci, Gizem; Duman, Tuba Taslamacıoğlu; Kurtkulağı, Özge; Şentürk, Hilal; Akın, Havva; Aktaş, GülaliThere are several vaccines developed against COVID-19 infection. Inactivated viral vaccines are usually well tolerated. We aimed to present a relapsing immune thrombocytopenia case following inactive COVID-19 vaccine. Here we report a case of relapsing immune thrombocytopenia following inactivated viral vaccine against COVID-19 in a 60-year-old woman with a history of immune thrombocytopenia. The patient responded well to dexamethasone treatment and was discharged from the hospital with full recovery. We suggest that physicians seek the history of a recent inactivate COVID-19 vaccine shot in patients with immune thrombocytopenia.
