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Öğe Assessment of atrial conduction time and P-wave dispersion in patients with gestational diabetes mellitus(Springer India, 2023) Kök, Zafer; Sincer, İsa; Güneş, Yılmaz; UraI, Ülkü MeteObjectives We aimed to assess atrial conduction time and P-wave dispersion (PWD) in gestational diabetes mellitus (GDM) patients. Methods Thirty patients with GDM and 30 healthy pregnant women were included to the study. Atrial conduction times (PA) were calculated by the time interval from the onset of the P wave on the electrocardiography (ECG) to the onset of the late diastolic flow (Am wave) on echocardiography and from the lateral mitral annulus (PA lateral), septal mitral annulus (PA septum), and right ventricular tricuspid annulus (PA tricuspid). The difference between (PA lateral-PA tricuspid) was defined as interatrial electromechanical delay (EMD); the difference between (PA septum-PA tricuspid) as intra-atrial EMD; and the difference between (PA lateral-PA septal) as intraleft atrial EMD. Results Mean PWD was higher in GDM (52.7 +/- 5.1 ms vs. 28.9 +/- 4.2 ms, p < 0.001). PA lateral, PA septal and PA tricuspid were significantly higher in the GDM patients compared to the control group (65.7 +/- 4.2 ms vs. 47.7 +/- 4.7 ms, p < 0.001; 56.1 +/- 3.4 ms vs. 40.8 +/- 3.7 ms, p < 0.001 and 48.4 +/- 3.9 ms vs. 36.0 +/- 3.6 ms, p < 0.001, respectively). Interatrial, intra-atrial, and intraleft atrial EMDs were also significantly higher in the GDM group (median values: 18 ms vs. 12 ms; 10 ms vs 7.5 ms; 8 ms vs. 4 ms, respectively, p < 0.001 for all). There was a positive correlation between intra-atrial delay time and PWD in GDM group (r = 0.39, p = 0.033). Conclusion We suggest that patients with GDM have higher PWD and higher atrial conduction and EMD times compared to otherwise healthy pregnant control group.Öğe Assessment of neutrophil and neutrophil/lymphocyte ratio in coronary collateral developed patients with acute coronary syndrome(Assoc Medica Brasileira, 2020) Mansıroğlu, Aslı Kurtar; Sincer, İsa; Yılmaz, GüneşOBJECTIVE: Inflammation-related markers provide diagnostic and prognostic information for coronary artery disease and acute coronary syndrome. We aimed to compare neutrophil count and neutrophil/lymphocyte ratio (NLR) in acute coronary syndrome patients with coronary collateral development in our study. METHODS: A total of 426 patients (102 unstable angina pectoris (USAP), 223 non-ST-elevation myocardial infarction (non-STEM!), 103 ST-elevation myocardial infarction (STEMI) were compared regarding hemoglobin, platelet, lymphocyte, neutrophil count, and NLR. RESULTS: Neutrophil count and NLR were significantly lower in USAP patients and higher in STEMI patients; 5.14 +/- 1.79 vs. 721 +/- 3.05 vs. 9.93 +/- 4.67 and 2.92 +/- 2.39 vs. 5.19 +/- 4.80 vs. 7.93 +/- 6.38, p <0.001. Other parameters, i.e., hemoglobin, platelet, and lymphocyte count, were not significantly different between the groups. CONCLUSIONS: In our study, it was concluded that there may be a statistically significant difference in the number of neutrophil counts and NLR among the types of acute coronary syndromes with coronary collateral development.Öğe Assessment of the hemogram parameters in patients with paroxysmal supraventricular tachycardia: a retrospective study(Assoc Medica Brasileira, 2020) Coşgun, Mehmet; Güneş, Yılmaz; Sincer, İsa; Mansıroğlu, Aslı KurtarOBJECTIVE: Inflammation has been suggested as a potential mechanism in the pathogenesis of arrhythmia. Hemogram parameters such as monocyte count to high-density lipoprotein cholesterol ratio (MHR), neutrophil/lymphocyte ratio (NLR), and monocyte/lymphocyte ratio (MLR) have been considered to be markers of inflammation and new cardiovascular risk predictors. This retrospective study aimed to investigate the relationship between MHR, NLR, and MLR in patients with paroxysmal supraventricular tachycardia (PSVT). METHODS: A retrospective study conducted at a university hospital in Bolu, Turkey, between 2017 and 2019. Our study included 196 patients who underwent electrophysiological study (EPS) due to palpitation or documented PSVT on electrocardiography (ECG). Patients having documented atrioventricular nodal re-entrant tachycardia (AVNRT) on ECG or inducible AVNRT on EPS were included in the PSVT group (n=130), and patients with palpitation but without inducible arrhythmia on EPS (n=66) were included in the control group. Routine biochemical and hemogram tests were performed before the EPS procedure. RESULTS: When hemogram parameters were compared, there was no statistically significant difference in MHR values [0.010 (0.001-0.030) vs 0.010 (0.001-0.020) p = 0.67]. Additionally, both NLR [2.21(0.74-11.36) vs 1.98(0.72-24.87) p=0.13] and MLR [0.25 (0.03-1.05) vs 0.24(0.07-1.39) p=0.41] were not statistically significant between the two groups. CONCLUSION: There is no significant difference in PSVT patients regarding hemogram parameters including white blood cell subtypes, MLR, NLR, and MHR. Therefore the evaluation of hemogram parameters may not be clinically relevant for PSVT patients.Öğe Association between hemogram parameters and coronary collateral development in subjects with non-ST-elevation myocardial infarction(Assoc Medica Brasileira, 2020) Sincer, İsa; Mansıroğlu, Aslı Kurtar; Aktaş, Gülali; Güneş, Yılmaz; Koçak, Mehmet ZahidOBJECTIVE: Coronary collateral development (CCD) predicts the severity of coronary heart disease. Hemogram parameters, such as mean platelet volume (MPV), eosinophil, red cell distribution width, and platelet distribution width (PDW), are supposed novel inflammatory markers. We aimed to compare hemogram parameter values in patients presenting with non-ST-elevation myocardial infarction (NSTEMI) with adequate or inadequate CCD. METHODS: A total of 177 patients with NSTEMI undergoing coronary arteriography were enrolled and divided into two groups based on the development of CCD: one group with adequate CCD (n=88) and the other with impaired CCD (n=89). RESULTS: Baseline demographics and clinical risk factors were similar between the groups. Hemogram parameters were not significantly different between the two groups. However, compared to the inadequate CCD group, the median PDW was significantly higher in the adequate CCD group, 17.6 (1.4) vs. 17.8 (1.6) p=0.004. In a multivariate analysis, PDW (p=0.001, 95% CI for OR: 0.489(0,319-0,750) was found to be significantly different in the adequate CCD group compared to the inadequate CCD group. Pearson's correlation analysis revealed that PDW was significantly correlated with the Rentrop score (r=0.26, p<0.001). CONCLUSIONS: We suggest that since PDW is an index that is inexpensive and easy to assess, it could serve as a marker of CCD in patients with NSTEMI.Öğe Association of mean platelet volume and red blood cell distribution width with coronary collateral development in stable coronary artery disease(Termedia Publishing House Ltd, 2018) Sincer, İsa; Güneş, Yılmaz; Mansıroğlu, Aslı Kurtar; Coşgun, Mehmet; Aktaş, GülaliIntroduction: The prognostic value of hematological indices in cardiovascular diseases and the association between these parameters and cardiovascular conditions have been established in the literature. Aim: In this study, we aimed to investigate the relation of mean platelet volume (MPV), MPV to platelet ratio (MPR) and red cell distribution width (RDW) with degree of coronary collateral development (CCD) in stable coronary artery disease (CAD) subjects with established critical coronary artery stenosis. Material and methods: A total of 306 patients with stable angina pectoris undergoing coronary arteriography were enrolled and divided on the basis of the development of CCD into two groups: a group with adequate CCD (n = 214) and a group with impaired CCD (n = 92). Routine complete blood count and biochemical parameters were measured before coronary arteriography. Results: The MPV and MPR levels were significantly higher in the inadequate CCD group (10.5 +/- 1.8 fl vs. 8.7 +/- 1.9 fl, p < 0.001 and 0.06 +/- 0.08 vs. 0.05 +/- 0.07, p = 0.036). Patients with inadequate CCD had significantly higher RDW levels compared to patients with adequate CCD (15.5 +/- 1.7% vs. 15.0 +/- 1.9%, p = 0.01). MPV and RDW were significantly associated with Rentrop collateral grading (r = -0.523, p < 0.001 and r = -0.239, p < 0.001, respectively), whereas the association with MPR was not significant. An MPV value greater than 9.95 fl, determined with ROC curve analysis, had 71% sensitivity and 70% specificity in predicting inadequate CCD. An RDW greater than 14.3% has 71% sensitivity and 53% specificity in selecting patients with adequate CCD. Conclusions: The present study suggests that MPV and MPR may be associated with the degree of collateral development in chronic stable CAD. However, the negative association of RDW with inadequate CCD, in combination with previous contradictory reports, raises a doubt about the possible value of RDW in stable CAD. Although these parameters may be affected by various conditions, a high MPV may lead clinicians to suspect possible inadequate collateral development in stable CAD patients.Öğe CARDIOLOGISTS’ AND CARDIOVASCULAR SURGEONS’ AWARENESS, OPINIONS AND PRACTICE BEHAVIORS RELATING TO THE ASSOCIATION BETWEEN PERIODONTAL DISEASE AND CARDIOVASCULAR DISEASE(2020) Ustaoğlu, Gülbahar; Paksoy, Tuğçe; Sincer, İsa; Terzi, MithatAim: There is a growing evidence that periodontal disease is associated with an increased risk of cardiovascular diseases. To assess the awareness levels, views, and clinical practices of cardiologists and cardiovascular surgeons in Turkey on the association of periodontal diseases with the diseases of the cardiovascular system. Material and Methods: A survey that included twenty-three questions was prepared and mailed to 99 cardiologists and cardiovascular surgeons practicing as resident, lecturer or specialist in Turkey. The response rate is 66%. Data was analyzed using SPSS® 18.0 software (SPSS, Chicago, IL, USA). Results: Of the respondents; 80% were males, 98% were at the age of ? 50 years, 59% have been working in a university, and 37% were specialists. Fifty-three percent of lecturer and 38% of specialist received a periodontal treatment more than two years time ago. Fourteen percent of resident, 30% of specialist and 53% of lecturer referred patients to visit the dentist. Eightyeight percent of the residents and lecturers agreed or strongly agreed with the opinion that periodontal disease treatment could lower the risk of an individual to develop a type of cardiovascular disease. Conclusion: Cardiologists and cardiovascular surgeons had a lack of knowledge of the periodontal disease and its impact on systemic health. Programs on oral health in academic curricula of cardiologists and cardiovascular surgeons should be improved to leverage the level of awareness and knowledge on periodontal diseases.Öğe Catheter-directed intra-arterial thrombolysis for lower extremity arterial occlusions(2019) Güneş, Yılmaz; Sincer, İsa; Erdal, EmrahCatheter-directed intra-arterial thrombolysis (CDT) is a rational treatment method in patients with acute/subacute and even some chronic occlusions of lower extremity arteries and bypass grafts having salvageable limb ischemia. Immediate vessel patency can be achieved with an acceptable complication rate in many patients, especially those with fresh thrombus or emboli. It can be also an adjuvant treatment modality for endovascular interventions for chronic occlusions. There is no standard method of CDT including thrombolytic agent dose and technique. Selection of treatment strategy should be based on individual judgment based on viability of limb, lesion characteristics, and risks of hemorrhage.Öğe Comparison of platelet volume indices in acute coronary syndrome(2019) Mansıroğlu, Aslı Kurtar; Sincer, İsa; Güneş, YılmazAim: To compare the parameters showing the platelet volume index in unstable angina pectoris (USAP), non-ST elevation myocardial infarction (non-STEMI) and ST elevation myocardial infarction (STEMI). Methods: The platelet volume indices of 94 USAP, 161 non-STEMI and 86 STEMI cases with a total of 341 patients (245 men, 96 women) were compared. The patients between March 2015 and October 2018 who admitted to Bolu Abant Izzet Baysal University Hospital with the diagnosis of acute coronary syndrome were compared using platelet distribution width (PDW), PDW to platelet ratio (PPR), mean platelet volume (MPV), MPV to platelet ratio (MPR). Results: No significant difference was found between the 3 groups in terms of PDW (p = 0.26), PPR (p = 0.87), MPV (p = 0.41) and MPR (p = 0.78) values. Conclusion: In our study, there was no statistically significant difference between the types of acute coronary syndrome and platelet volume indices.Öğe Could platelet distribution width predict coronary collateral development in stable coronary artery disease?(2020) Sincer, İsa; Mansıroğlu, Aslı; Erdal, Emrah; Coşgun, Mehmet; Aktaş, Gülali; Güneş, YılmazOBJECTIVE: We hypothesized that hemogram parameters should be related to the development of coronary collateral vessels. For this purpose, we aimed to compare platelet distribution width (PDW) and PDW to platelet ratio (PPR) in subjects with stable coronary artery disease having adequate or inadequate coronary collateral development. METHODS: A total of 398 patients with stable angina pectoris undergoing coronary angiography were enrolled and divided on the basis of the development of coronary collateral (CCD) (inadequate CCD (n=267) and adequate CCD (n=131). Routine complete blood count and biochemical parameters were measured before coronary arteriography. RESULTS: Mean PDW and PPR values of inadequate and adequate CCD groups were 17.5% (10–23) and 12.4% (9.8–22) %, p<0.001, respectively. In multivariate analysis, age (p=0.012, 95% CI for OR: 0.958 (0.933–0.983) and PDW (p<0.001, 95% CI for OR: 1.432 (1.252–1.618) were found to be statistically significantly different inadequate CCD group compared to adequate CCD group. Receiver operating curve (ROC) analyses revealed that a PPR value greater than 0.057 had 76% sensitivity and 51% specificity and a PDW higher than 16.2% had 80% sensitivity and 66% specificity in predicting inadequate CCD. CONCLUSION: The present study suggests that PDW and PPR may be associated with the degree of collateral development in chronic stable coronary artery disease (CAD).Öğe Dating thrombus organization with eosinophil counts in deep venous thrombosis(Elsevier, 2021) Mansıroğlu, Aslı Kurtar; Sincer, İsa; Coşgun, Mehmet; Güneş, YılmazObjective: It is known that eosinophils (EOS) are essential for thrombus formation. Studies have demonstrated the association of EOS with coronary artery disease, stent thrombosis, coronary collateral development, and vasospastic angina. However, there is little data about the association of hemogram parameters, especially EOS counts, with deep venous thrombosis (DVT) subgroups. Methods: The present study comprised 243 patients diagnosed with DVT (of whom 86 were acute, 72 were indeterminate, and 85 were chronic) and 75 control patients. Medical records of all the patients were reviewed, and relevant data were collected retrospectively. The baseline characteristics, as well as hemogram and biochemistry parameters, were recorded. Results: The patients with DVT had significantly lower median EOS count yet higher median neutrophil to lymphocyte ratio (NLR) than those of control patients (P <.001). Similarly, acute DVT patients had lower EOS count yet higher NLR values compared with those of indeterminate and chronic DVT patients. However, EOS count was not significantly different between chronic DVT and control groups. While NLR ratio was significantly correlated with acute DVT (r = 0.34; P <.001), Spearman's correlation test revealed that EOS count was inversely correlated with the presence of acute DVT (r = –0.52; P <.001). Conclusions: Low EOS count may lead the physician to a higher probability of acute DVT rather than indeterminate and chronic DVT.Öğe Differential value of eosinophil count in acute coronary syndrome among elderly patients(Taylor & Francis Ltd, 2019) Sincer, İsa; Güneş, Yılmaz; Mansıroğlu, Aslı Kurtar; Aktaş, GülaliWe aimed to search eosinophil (EOS) counts in elderly acute coronary syndrome (ACS) subjects and to investigate its value for discrimation between unstable angina pectoris (UAP) and myocardial infarction (MI) [non-ST elevation MI (NSTEMI) or ST elevation MI (STEMI)]. The patients were divided into three groups regarding the diagnosis: patients with UAP (63), with NSTEMI (154), and with STEMI (73). General characteristics such as gender, age, systolic and diastolic blood pressure were obtained from patients' files. Complete blood count and biochemical parameters were measured before coronary angiography. EOS was found significantly higher in UAP (0.134 (0.002-0.746) u/mm(3)) compared to NSTEMI (0.085(0.001-0.601) u/mm(3)) and STEMI (0.020(0.001-0.479) u/mm(3)) groups. Kruskal-Wallis test with Bonferroni-corrected Mann-Whitney U-test revealed that EOS count was significantly different between UAP and NSTEMI (p < .001), UAP and STEMI (p < .001) and NSTEMI and STEMI (p < .001) groups. A receiver operating curve (ROC) analysis revealed that a cut-off >0.083 u/mm(3) EOS value had a sensitivity of 79% and specificity of 57% for determination of ACS as UAP (AUC = 0.686, 95% CI, 0.617-0.755). In the present study, we detected an inverse relationship between the number of blood eosinophil count and the severity of ACS subgroups in elderly patients with higher counts in UAP than MI groups.Öğe Does mean platelet volume decrease in the presence of coronary artery fistula?(Arquivos Brasileiros Cardiologia, 2019) Sincer, İsa; Çekici, Yusuf; Coşgun, Mehmet; Aktaş, Gülali; Güneş, Yılmaz; Erdal, Emrah; Mansıroğlu, Aslı Kurtar; İnanır, MehmetBackground: Coronary artery fistula (CAF) is an abnormal connection that links a coronary artery to a cardiac chamber or another major blood vessel. Several studies have shown the association between mean platelet volume (MPV) and cardiovascular diseases. In the literature, there is no previous study about the association between hematologic parameters and congenital CAF. For this reason, we aimed to investigate the association of MPV with CAF. Methods: 70 patients with normal coronary arteries and 50 with coronary artery fistulas were included. Routine blood and biochemical parameters were measured before the arteriography. Differences between groups for continuous variables were analyzed with t- test or Mann-Whitney test. P values < 0.05 were considered significant. Regression analysis was used to find independent predictors of CAF. Results: Baseline patient demographics, including age and clinical risk factors, were similar between the groups. Compared to the control group, median (IQR) High-density lipoprotein cholesterol (HDL) levels were significantly higher (p=0.04) and MPV levels were significantly lower in the CAF group (8.84 +/- 1.71fL vs. 10.43 +/- 1.34, p < 0.001). In the multivariate analysis, only MPV was a significant predictor of CAF (p < 0.001, 95% CI for OR: 0.438 (0.306-0.629). A negative correlation was found between MPV and fistulae in Pearson's correlation test (r: -0.454, p < 0.001). An MPV level of < 9,6 fL showed sensitivity, specificity, positive predictive value and negative predictive value of 80%, 68%, 71% and 78% respectively (AUC = 0.766, 95% CI, 0.678-0.854) for the prediction of CAF. Conclusion: The present study suggests that MPV may decrease in patients with CAF.Öğe Echocardiographic assessment of epicardial fat tissue thickness in patients with severe periodontitis(Elsevier Espana Slu, 2020) Erdal, Emrah; İnanır, Mehmet; Ustaoğlu, Gülbahar; Sincer, İsaObjectives: This study aims to assess the thickness of epicardial fat tissue (EFT), a sign of cardiovascular risk, using echocardiography in patients with severe periodontitis. Methods: Thirty-three patients with stage III or IV periodontitis and 33 healthy participants were enrolled into the study. Epicardial fat tissue thickness was measured perpendicularly via echocardiography of the free wall of the right ventricular at end-diastole in three cardiac cycles. Body mass index (BMI) was calculated by dividing weight in kilograms by the height in meters squared. EFT to BMI ratio (EFT/BMI) was measured by dividing EFT by the BMI. Results: There was no significant difference between study patients and the control group as regards to the frequency of diabetes, hypertension, smoking, and hyperlipidemia. The EFT and EFT/ BMI ratio were significantly different in the control and periodontitis groups (0.510.17 vs. 0.77 +/- 0.16, respectively; p <0.001) (0.021 +/- 0.008 vs. 0.030 +/- 0.006, respectively; p<0.001). Pearson's correlation coefficient demonstrated a significant relationship between EFT and the clinical parameters of periodontitis (p<0.001) Conclusions: EFT thickness measured by echocardiography appears to be associated with severe periodontitis and may thus be an indirect sign of cardiovascular disease in periodontitis patients. (c) 2020 Sociedade Portuguesa de Cardiologia. Published by Elsevier Espana, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).Öğe Effect of new oral anticoagulants on platelet indices in non-valvular atrial fibrillation patients(Springer Medizin, 2021) Düzen, İrfan Veysel; Oğuz, Elif; Çekici, Yusuf; Yavuz, Fethi; Vuruşkan, Ertan; Sincer, İsa; Poyraz, Fatih; Alıcı, Hayri; Yüksek, Ümit; Demirtaş, Abdullah Orhan; Sucu, MuratNew-generation oral anticoagulants (NOACs) are now preferred as a first-line treatment in the management of atrial fibrillation for prevention of thromboembolic complications. Mean platelet volume (MPV), one of the indicators of increased platelet activity, is also associated with an increased stroke risk in atrial fibrillation patients. The aim of this study was to evaluate changes in MPV, platelet distribution width (PDW) and plateletcrit following use of NOACs. The study included 116 patients with non-valvular atrial fibrillation without previous NOAC use. Complete blood counts, biochemical analyses and echocardiography were performed for all patients. No significant differences were observed in MPV or other platelet indices at 6 months compared to baseline. Our results indicate that MPV and other platelet indices are not affected by NOAC use in non-valvular atrial fibrillation patients.Öğe Evaluation of electrocardiographic ventricular and atrial repolarization markers in patients with high grade varicocele(2019) Erdal, Emrah; Sincer, İsa; Gucuk, Adnan; Güneş, Yılmaz; Bostancı, Emre; İnanır, MehmetAim: Varicocele is abnormal dilation of testis veins without unclear pathophysiology. Morphological studies showed imbalance between vasoconstrictor and vasodilator mechanisms. We aimed to determine the relationship between varicocele and cardiovascular system disorders with electrocardiography (ECG) parameters. Methods: This is a prospective study which was conducted in a University Hospital between February and June 2018. Thirty patients (18-45 years old) with high grade varicocele from urology outpatient clinic and 32 healthy volunteers for the control group were recruited to the study. Results: P-min. value was significantly higher in control group than patients with high grade varicocele (p= 0.03). PR, QT and QTc intervals, PWD and P-max values were similar. Also, there were no significant differences in terms of the other ECG parameters between the groups. Conclusions: In this small prospective study we have found no association between high grade varicocele and potential electrocardiographic arrhythmia predictors namely OTd, QTc interval, PWD, Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio. Long-term follow-up and large-scale prospective studies are needed to confirm our results.Öğe Evaluation of electrocardiographic ventricular depolarization and repolarization variables in type 1 diabetes mellitus(Arquivos Brasileiros Cardiologia, 2020) İnanır, Mehmet; Güneş, Yılmaz; Sincer, İsa; Erdal, EmrahBackground: The risk of cardiovascular events and sudden death increases with type 1 diabetes mellitus (T1DM). Objective: To evaluate electrocardiographic markers of arrhythmias in T1DM patients. Methods: Electrocardiographic parameters reflecting ventricular depolarization and repolarization, namely, QT, QTc, QTd, QTdc, Tp-e, JT, and JTc intervals and Tp-e/QT and Tp-e/QTc ratios, of 46 patients diagnosed with T1DM were retrospectively analyzed and compared with 46 healthy age-, sex-, and body mass-matched controls. Correlations between T1DM duration, hemoglobin A1c (HbA1c), and ventricular repolarization variables were analyzed. P values lower than 0.05 were considered statistically significant. Results: Diabetes duration was 16.6 +/- 7.1 years, and HbA1c was 10.81% +/- 3.27% in the T1DM group. In comparison with the control group, heart rate, QTc, QTd, QTdc, Tp-e and JTc intervals, Tp-e/QT ratio (p < 0.001), and Tp-e/QTc ratio (p = 0.007) were significantly higher in T1DM patients. T1DM duration and HbA1c levels were significantly correlated with QTc, QTd, QTdc, Tp-e, and JTc intervals and Tp-e/QT and Tp-e/QTc ratios. Conclusions: In T1DM patients, potential electrocardiographic repolarization predictors were significantly increased in correlation with disease duration and HbA1c levels. These findings may contribute to the understanding of sudden cardiac death in patients with T1DM.Öğe Evaluation of electrocardiographic ventricular repolarization parameters in extreme obesity(Churchill Livingstone Inc Medical Publishers, 2019) İnanır, Mehmet; Sincer, İsa; Erdal, Emrah; Güneş, Yılmaz; Coşgun, Mehmet; Mansıroğlu, Aslı KurtarBackground and objectives: The risk of sudden death and cardiac arrhythmia increases in morbidly obese patients. We aimed to evaluate the marker of arrhythmias such as Tp-e/QT, Tp-e/QTc, Tp-e/JT and Tp-e/JTc ratios in extreme obesity. Methods: The study included 41 extremely obese patients and 41 control subjects. QTmax, QTmin, US, JT and Tp-e intervals were measured od 12-lead electrocardiographies. In addition, Tp-e/QT, Tp-e/QTc, Tp-e/JT and Tp-e/JTc rates and QTc, cQTd and JTc intervals were calculated. Results: Tp-e interval (79.2 +/- 9.7 ms (milisecond) vs. 68.6 +/- 8.1, p < 0.001), QTc interval (395.9 +/- 18.8 vs. 377.9 +/- 19.3 ms, p < 0.001), JTc interval (317.1 +/- 27.0 vs. 297.4 +/- 23.2 ms, p = 0.001), Tp-e/QT ratio (0.22 +/- 0.03vs. 0.19 +/- 0.02, p < 0.001),Tp-e/QTc ratio (0.20 +/- 0.26vs. 0.18 +/- 0.02, p = 0.001), Tp-e/JT ratio (0.29 +/- 0.04 vs. 0.25 +/- 0.03, p < 0.001), TPe/JTc ratio (025 +/- 0.04 vs. 0.23 +/- 0.03, p = 0.018), QTd (32.8 +/- 10 vs.15 +/- 6.4 ms, p < 0.001) and cQTd (70.0 +/- 30.1 vs. 313 +/- 22.4 ms, p < 0.001) were significantly higher in obese patients. Conclusion: Compared to healthy subjects potential ECG repolarization predictors were significantly increased in extremely obese patients. (C) 2018 Elsevier Inc. All rights reserved.Öğe Evaluation of endothelial dysfunction in COVID-19 with flow-mediated dilatation(Arquivos Brasileiros Cardiologia, 2022) Mansıroğlu, Aslı Kurtar; Seymen, Hande; Sincer, İsaBackground: Inflammation is known to play a crucial role in many diseases, including COVID-19. Objective: Using flow-mediated dilatation (FMD), we aimed to assess the effects of inflammation on endothelial function in COVID-19 patients. Methods: This study was conducted with a total of 161 subjects, of whom 80 were diagnosed with COVID-19 within the last six months (comprising 48 women and 32 men with a mean age of 32.10 +/- 5.87 years) and 81 were healthy controls (comprising 45 women and 36 men with a mean age of 30.51 +/- 7.33 years). We analyzed the findings of transthoracic echocardiography and FMD in all subjects. All results were considered statistically significant at the level of p < 0.05. Results: The echocardiography and FMD of the COVID-19 group were performed 35 days (range: 25-178) after diagnosis. There was no statistically significant difference in echocardiographic parameters. Differently, FMD (%) was significantly higher in the control group (9.52 +/- 5.98 vs. 12.01 +/- 6.18, p=0.01). In multivariate analysis with the forward stepwise model, FMD was significantly different in the control group compared to the COVID-19 group (1.086 (1.026 - 1.149), p=0.04). A Spearman's correlation test indicated that FMD (r=0.27, p=0.006) had a weak positive correlation with the presence of COVID-19. Conclusion: Our findings point to COVID-19-induced endothelial dysfunction, as assessed by FMD, in the early recovery phase.Öğe Evaluation of ventricular repolarisation features with novel electrocardiographic parameters in patients with severe periodontitis(2020) İnanır, Mehmet; Erdal, Emrah; Sincer, İsa; Ustaoğlu, GülbaharIntroduction: Ventricular arrhythmic predictors in severe periodontitis may be linked with cardiovascular events and the sudden death risk. In this study, we evaluated certain electrocardiographic (ECG) ventricular arrhythmic predictors in patients with severe periodontitis. Methods: ECG parameters of 72 patients diagnosed with severe periodontitis, which are indicative of ventricular arrhythmia, were examined, and these parameters were compared with the control group.Results: Compared to the control group, QT interval (QT)(p=0.014), corrected QT (QTc) (p<0.001), QT dispersion (QTd) (p<0.001), QTdc p<0.001), JT interval (p=0.012), JTc interval (p<0.001), T peak and end interval (Tp-e) (p<0.001), Tp-e/QT ratio (p<0.001), Tp-e/QTc ratio (p<0.001), Tp-e/JT ratio (p<0.001) and Tp-e/JTc ratio (<0.001) were found to be higher in patients with severe periodontitis. Conclusion: Our study showed that arrhythmic ECG markers were significantly prolonged in patients with severe periodontitis. In future extensive prospective studies, we think that these arrhythmic predictors should be evaluated to predict malignant arrhythmias.Öğe Is ionizing radiation a risk factor for anxiety in employees?(Assoc Medica Brasileira, 2020) Mansıroğlu, Aslı Kurtar; Erer, Murat; Coşgun, Mehmet; Sincer, İsa; Güneş, YılmazOBJECTIVE: Workers describe many physical and mental symptoms when working in radiation areas. This study aimed to assess these symptoms in radiation workers using the Beck Anxiety Inventory (BAI). METHODS: A total of 42 radiation workers (22 males and 20 females, mean age 34 +/- 7 years) and 47 control subjects (22 males and 27 females, mean age 31 +/- 8 years) who work in non-radiation areas in the hospital were included in the study. All participants anonymously filled out the Beck Anxiety Inventory (BAI) questionnaire. RESULTS: The demographic data of workers were not significantly different between groups. In the BAI, the dizzy or lightheaded (p =0.01), terrified (p= 0.01), unsteady (p=0.02), heart-pounding and racing (p=0.02) items were significantly higher in the radiation-exposed group compared to the control group. vertical bar The BAI score was also significantly higher in the radiation-exposed group (11.1 +/- 6.8 vs. 8.7 +/- 3.8, p =0.04) CONCLUSION: These results suggest the possibility that radiation may play a role in the psychometric properties of workers. The effects of radiation on the health of employees need to be further investigated and understood.
