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Öğe Assessment of aortic stiffness by transthoracic echocardiographic in young COVID-19 patients(Wolters Kluwer Medknow Publications, 2022) Mansiroglu, Asli Kurtar; Disikirik, Tuba; Seymen, Hande; Cosgun, Mehmet; Sincer, IsaBackground: Deteriorated aortic elasticity is part of the atherosclerotic process. Inflammation is an underlying factor in both COVID-19 and atherosclerosis. Aims and Objectives: Using aortic elastic properties, we aimed to assess the subclinical indicators of susceptibility to inflammatory atherosclerosis in patients with COVID-19. Materials and Methods: Out of 194 participants included in this study, 100 were diagnosed with COVID-19 in the last 6 months (60 women and 40 men with a mean age of 34.13 ± 6.45 years) and 94 were healthy controls (55 women and 39 men with a mean age of 30.39 ± 7.21 years). We analyzed transthoracic echocardiographic and aortic stiffness parameters in all participants. Results: Values of systolic blood pressure (110 [85-140] vs. 110 [80-140], P = 0.037) and pulse pressure (PP) (37 [25-55] vs. 40 [25-55], P < 0.01) were significantly different between the groups. As for laboratory parameters, levels of glucose (97.89 ± 20.23 vs. 92.00 ± 9.95, P = 0.003) and creatinine (0.80 ± 0.13 vs. 0.75 ± 0.09, P = 0.003) were significantly higher in the COVID-19 group. Echocardiographic parameters showed that both groups differed significantly in diastolic aortic diameter (2.42 ± 0.28 vs. 2.31 ± 0.35, P = 0.017), aortic strain (9.66 [1.20-31.82] vs. 12.82 [2.41-40.11], P = 0.025), aortic distensibility (0.502 [0.049-2.545] vs. 0.780 [0.120-2.674], P < 0.01), and aortic stiffness (16.67 [4.19-139.43] vs. 11.71 [3.43-65.21], P = 0.006). Conclusion: Measurement of aortic stiffness is a simple, practical yet inexpensive method in COVID-19 patients, and therefore, may be used as an early marker for COVID-19-induced subclinical atherosclerosis. © 2022 Wolters Kluwer Medknow Publications. All rights reserved.Öğe Evaluation of endothelial dysfunction in COVID-19 with flow-mediated dilatation(Arquivos Brasileiros Cardiologia, 2022) Mansıroğlu, Aslı Kurtar; Seymen, Hande; Sincer, İsaBackground: Inflammation is known to play a crucial role in many diseases, including COVID-19. Objective: Using flow-mediated dilatation (FMD), we aimed to assess the effects of inflammation on endothelial function in COVID-19 patients. Methods: This study was conducted with a total of 161 subjects, of whom 80 were diagnosed with COVID-19 within the last six months (comprising 48 women and 32 men with a mean age of 32.10 +/- 5.87 years) and 81 were healthy controls (comprising 45 women and 36 men with a mean age of 30.51 +/- 7.33 years). We analyzed the findings of transthoracic echocardiography and FMD in all subjects. All results were considered statistically significant at the level of p < 0.05. Results: The echocardiography and FMD of the COVID-19 group were performed 35 days (range: 25-178) after diagnosis. There was no statistically significant difference in echocardiographic parameters. Differently, FMD (%) was significantly higher in the control group (9.52 +/- 5.98 vs. 12.01 +/- 6.18, p=0.01). In multivariate analysis with the forward stepwise model, FMD was significantly different in the control group compared to the COVID-19 group (1.086 (1.026 - 1.149), p=0.04). A Spearman's correlation test indicated that FMD (r=0.27, p=0.006) had a weak positive correlation with the presence of COVID-19. Conclusion: Our findings point to COVID-19-induced endothelial dysfunction, as assessed by FMD, in the early recovery phase.Öğe Normal koroner arterler saptanan sigara içen ve içmeyen hastaların elektrokardiyografik aritmi parametrelerinin değerlendirilmesi(Bolu Abant İzzet Baysal Üniversitesi, 2023) Seymen, Hande; İnanır, MehmetGiriş ve Amaç: Sigara içiciliği, kardiyovasküler hastalıklar için en önemli önlenebilir risk faktörü olup; kardiyovasküler etkileri üzerine yapılan çalışmalar ağırlıkla ateroskleroz üzerine olup, aritmi üzerine etkileriyle ilgili daha sınırlı veri mevcuttur. Çalışmamıza normal koroner arterlere sahip sigara içen ve içmeyen hastaları dahil ederek ateroskleroz sürecinden bağımsız olarak sigaranın elektrokardiyografik aritmi parametrelerine olan etkisini göstermeyi hedefledik. Gereç ve Yöntem: Bu çalışma, tek merkezli, randomize olmayan, prospektif bir çalışmadır. Çalışmaya konvansiyonel koroner anjiografi veya koroner bilgisayarlı tomografi anjiografi normal koroner arterler saptanan sigara içicisi 48 hasta ve sigara içmeyen 50 hasta alınmıştır. QRS süresi, QT intervali, JT intervali, Tp-e intervali, Tp-e/QT, Tp-e/QTc, Tp-e/JTc oranları hesaplanmıştır. QTc, QTdc ve JTc intervalleri Fridericia formülü kullanılarak hesaplanmıştır. Bulgular: Sigara içenlerde içmeyenlere kıyasla Tp-e/JT oranı artmış olarak tespit edilmiştir (p değeri: 0.04) Diğer parametrelerde iki grup arasında anlamlı fark izlenmemiştir. Sonuç ve Öneriler: Muhtemelen sigaranın aritmi üzerine olan esas etkisi ateroskleroz ortaya çıktıktan sonra başlamaktadır. Sigaranın ateroskleroz sürecinden bağımsız olarak aritmi üzerine olan etkisini göstermek için daha yüksek hasta sayısı içeren çok merkezli çalışmalara ihtiyaç vardır.Öğe The right ventricle systolic force ratio could predictthe severity of the tricuspid regurgitation-RIVIERA ratio(Wiley, 2023) Acar, Emrah; İzci, Servet; Dönmez, İbrahim; Yılmaz, Mehmet Fatih; Özgül, Neryan; Seymen, Hande; Özcan, Eda; Güneş, YılmazPurpose: For assessing the severity of tricuspid regurgitation (TR), there is no gold standard. We developed a parameter, the right ventricular systolic force ratio-RIVIERA, using the continious wave Doppler analysis of TR and pulsed-wave analysis of the right ventricle outflow tract. We hypothesized that the RIVIERA would facilitate the ability to identify severe TR in clinical settings.Materials and Methods: We obtained data from routine transthoracic echocardiograms. All records reporting no or mild TR (n = 732), moderate TR (n = 584), and severe TR (n = 519) TR were reanalyzed to measure vena contracta (VC) width, TR jet area, effective regurgitant orifice (EROA) derived with the proximal isovelocity surface area method, the RIVIERA, and right-sided chamber volumes.Results: Significant linear trends were demonstrated for right atrial volume index, end-diastolic volume index, RVOT velocity time integral, TR jet area, TR-Vmax, TR-VTI, TR acceleration, VC width, EROA with increasing TR severity. Independent predictors of severe RT included RIVIERA <4.8, VC width =0.7 cm, TR jet area > 10 cm(2), and EROA =0.4 cm(2).Conclusion: The RIVIERA is a feasible, effective, and independent predictor of severe TR that enhances established techniques for estimating TR severity. For clinical decision-making and management, accurate measurement and classification of TR severity are essential. Therefore, it should be thought about include the RIVIERA in the integrative method to assessing TR severity.
