Yazar "Pehlivan, Murat" seçeneğine göre listele

Listeleniyor 1 - 8 / 8
  • Küçük Resim Yok
    Öğe
    Analytical performance evaluation of siemens sysmex CS-2500 and sekisui CP-3000
    (Clin Lab Publ, 2022) Pehlivan, Mine Büşra; Pehlivan, Murat; Ceylan, Celal; Alışık, Murat; Yis, Özgür Mehmet; Buğdaycı, Güler
    Background: Automatic coagulation analyzers have been used in the last 50 years and have been developed considerably. Newly developed tests and methods cannot be conducted in routine laboratories without evaluating their performance. Therefore, their performance must be evaluated and approved before being used routinely. The aim of this study is to evaluate the analytical performance of Sysmex Coagulation System-2500 (CS-2500) and Sekisui CP- 3000 automatic coagulation analyzer (CP-3000). Methods: For APTT, PT, and D-dimer tests, reference range verification study, a method comparison study was performed in both analyzers in accordance with CLSI protocols, and precision and accuracy were evaluated using internal and external quality control samples. In the evaluation of precision and accuracy, CV% and bias% values were calculated. Bland-Altman, Passing-Bablok regression analysis, and correlation coefficient were used in the comparison study. Results: The CV% values calculated for APTT and PT in both analyzers were found to be below the CLSI recommendation of 5%. D-dimer test results meet the quality criteria recommended by CLSI. Accuracy for both analyzers was within the acceptable limits. The reference ranges recommended by the manufacturer have been veryfied. Regression equations for APTT, PT, and D-dimer are y = -3.313 + 1.188x, y = -0.0399 + 1.048x, and y = 0.155 + 0.655x, respectively, and r values were 0.904, 0.978, and 0.974, respectively. Conclusions: CS-2500 and CP-3000 analyzers are suitable for laboratory use for routine coagulation. Since the CP-3000 device is newly used in our country, it needs to be supported by more comparison studies.
  • Küçük Resim Yok
    Öğe
    Analytical Performance Evaluation of Siemens Sysmex CS-2500 and Sekisui CP-3000
    (Clin Lab Publ, 2022) Pehlivan, Mine B.; Pehlivan, Murat; Ceylan, Celal; Alisik, Murat; Yis, Ozgur M.; Bugdayci, Guler
    Background: Automatic coagulation analyzers have been used in the last 50 years and have been developed considerably. Newly developed tests and methods cannot be conducted in routine laboratories without evaluating their performance. Therefore, their performance must be evaluated and approved before being used routinely. The aim of this study is to evaluate the analytical performance of Sysmex Coagulation System-2500 (CS-2500) and Sekisui CP-3000 automatic coagulation analyzer (CP-3000). Methods: For APTT, PT, and D-dimer tests, reference range verification study, a method comparison study was performed in both analyzers in accordance with CLSI protocols, and precision and accuracy were evaluated using internal and external quality control samples. In the evaluation of precision and accuracy, CV% and bias% values were calculated. Bland-Altman, Passing-Bablok regression analysis, and correlation coefficient were used in the comparison study. Results: The CV% values calculated for APTT and PT in both analyzers were found to be below the CLSI recommendation of 5%. D-dimer test results meet the quality criteria recommended by CLSI. Accuracy for both analyzers was within the acceptable limits. The reference ranges recommended by the manufacturer have been veryfied. Regression equations for APTT, PT, and D-dimer are y =-3.313 + 1.188x, y =-0.0399 + 1.048x, and y = 0.155 + 0.655x, respectively, and r values were 0.904, 0.978, and 0.974, respectively. Conclusions: CS-2500 and CP-3000 analyzers are suitable for laboratory use for routine coagulation. Since the CP-3000 device is newly used in our country, it needs to be supported by more comparison studies. (Clin. Lab. 2022;68:xx-xx. DOI: 10.7754/Clin.Lab.2021.210606)
  • Küçük Resim Yok
    Öğe
    Analytical Performance Evaluation of Siemens Sysmex CS-2500 and Sekisui CP-3000
    (Clin Lab Publ, 2022) Pehlivan, Mine B.; Pehlivan, Murat; Ceylan, Celal; Alisik, Murat; Yis, Ozgur M.; Bugdayci, Guler
    Background: Automatic coagulation analyzers have been used in the last 50 years and have been developed considerably. Newly developed tests and methods cannot be conducted in routine laboratories without evaluating their performance. Therefore, their performance must be evaluated and approved before being used routinely. The aim of this study is to evaluate the analytical performance of Sysmex Coagulation System-2500 (CS-2500) and Sekisui CP- 3000 automatic coagulation analyzer (CP-3000). Methods: For APTT, PT, and D-dimer tests, reference range verification study, a method comparison study was performed in both analyzers in accordance with CLSI protocols, and precision and accuracy were evaluated using internal and external quality control samples. In the evaluation of precision and accuracy, CV% and bias% values were calculated. Bland-Altman, Passing-Bablok regression analysis, and correlation coefficient were used in the comparison study. Results: The CV% values calculated for APTT and PT in both analyzers were found to be below the CLSI recommendation of 5%. D-dimer test results meet the quality criteria recommended by CLSI. Accuracy for both analyzers was within the acceptable limits. The reference ranges recommended by the manufacturer have been veryfied. Regression equations for APTT, PT, and D-dimer are y = -3.313 + 1.188x, y = -0.0399 + 1.048x, and y = 0.155 + 0.655x, respectively, and r values were 0.904, 0.978, and 0.974, respectively. Conclusions: CS-2500 and CP-3000 analyzers are suitable for laboratory use for routine coagulation. Since the CP-3000 device is newly used in our country, it needs to be supported by more comparison studies.
  • Küçük Resim Yok
    Öğe
    Analytical performance evaluation of siemens sysmex CS-2500 and sekisui CP-3000 (vol 68, 2022)
    (Clin Lab Publ, 2022) Pehlivan, Mine Büşra; Pehlivan, Murat; Ceylan, Celal; Alışık, Murat; Yis, Özgür Mehmet; Buğdaycı, Güler
    Background: Automatic coagulation analyzers have been used in the last 50 years and have been developed considerably. Newly developed tests and methods cannot be conducted in routine laboratories without evaluating their performance. Therefore, their performance must be evaluated and approved before being used routinely. The aim of this study is to evaluate the analytical performance of Sysmex Coagulation System-2500 (CS-2500) and Sekisui CP- 3000 automatic coagulation analyzer (CP-3000). Methods: For APTT, PT, and D-dimer tests, reference range verification study, a method comparison study was performed in both analyzers in accordance with CLSI protocols, and precision and accuracy were evaluated using internal and external quality control samples. In the evaluation of precision and accuracy, CV% and bias% values were calculated. Bland-Altman, Passing-Bablok regression analysis, and correlation coefficient were used in the comparison study. Results: The CV% values calculated for APTT and PT in both analyzers were found to be below the CLSI recommendation of 5%. D-dimer test results meet the quality criteria recommended by CLSI. Accuracy for both analyzers was within the acceptable limits. The reference ranges recommended by the manufacturer have been veryfied. Regression equations for APTT, PT, and D-dimer are y = -3.313 + 1.188x, y = -0.0399 + 1.048x, and y = 0.155 + 0.655x, respectively, and r values were 0.904, 0.978, and 0.974, respectively. Conclusions: CS-2500 and CP-3000 analyzers are suitable for laboratory use for routine coagulation. Since the CP-3000 device is newly used in our country, it needs to be supported by more comparison studies.
  • Küçük Resim
    Öğe
    Atropa belladonna and associated anticholinergic toxic syndrome: a case report
    (Univ Udayana, 2017) Karagöz, İbrahim; Bilgi, Murat; Boduç, Elif; Pehlivan, Murat; Solmaz, Kübra
    Atropa belladonna causes poisoning by its anticholinergic effects. Excessive ingestion of this plant may cause peripheral anticholinergic effects, and moreover, a more severe clinical picture can be seen due to its central effects which can result in lethargy, coma or even death. In this article, we aimed to present a case with Atropa belladonna intoxication and to emphasize that Atropa belladonna poisoning should be kept in mind in cases with anticholinergic findings.
  • Küçük Resim
    Öğe
    Effects of anaemia on TAVR outcomes
    (Taylor & Francis Ltd, 2019) Şener, Yusuf Ziya; Okşul, Metin; Pehlivan, Murat
    We have read with great interest the paper published by Kanjanahattakij et al. which was about the effects of anaemia on transfemoral aortic valve replacement (TAVR) outcomes. Authors depicted that anaemia is related with increased long term mortality rates but not with short term mortality rates defined as deaths occured in first month after TAVR.
  • Küçük Resim Yok
    Öğe
    İyi ve kötü kontrollü tip 2 diabetes mellitus'lu hastalarda total antioksidan status (TAS), total oksidan status (TOS) düzeyleri ve metabolik parametrelerin değerlendirilmesi
    (Bolu Abant İzzet Baysal Üniversitesi, 2020) Pehlivan, Murat; Aktaş, Gülali
    Diyabet yaşadığımız yüzyılın en önemli sağlık sorunlarından biri olarak kabul edilmektedir. Diyabetli sayısının her geçen gün artması, diyabetle ilişkili sağlık sorunlarının toplum sağlığını ve ülke ekonomilerini ciddi derecede etkilemesi bu düşünceyi desteklemektedir. Diyabet ve komplikasyonları gelişiminde serbest oksijen radikalleri ile antioksidan sistem arasındaki denge önemli rol oynamaktadır. Dr. Erel tarafından yeni bir kalorimetrik ölçüm tekniğiyle genel antioksidan seviyeyi tespit etmek amacıyla total antioksidan status (TAS) kiti ve genel oksidan seviyeleri tespit etmek amacıyla total oksidan status (TOS) kiti geliştirilmiştir. Bu çalışmada iyi kontrollü tip 2 diyabetli hastalardaki TAS ve TOS düzeyleri ile metabolik parametreleri kötü kontrollü tip 2 diyabetli hastalardaki TAS ve TOS düzeyleri ile metabolik parametrelerle karşılaştırmayı amaçladık. Üniversitemiz hastanesi İç Hastalıkları polikliniklerine Mart 2019 ile Eylül 2019 tarihleri arasında tip 2 diyabet teşhisiyle başvuran kötü ve iyi kontrollü hastalar çalışmaya dahil edildi. Demografik veriler ve antropometrik ölçümler, tansiyon ve nabız verileri, TAS-TOS sonuçları, metabolik parametreler, böbrek ve karaciğer fonksiyon testleri, tam kan ve anemi parametreleri, diyabetin mikrovasküler ve makrovasküler komplikasyonları varlığı, tedaviye uyum, diyet ve egzersiz alışkanlıkları kaydedildi. İyi ve kötü kontrollü tip 2 diyabetik hastaların verileri karşılaştırıldı. Çalışmaya 96 kötü diyabetik kontrollü ve 43 iyi diyabetik kontrollü olmak üzere toplam 139 hasta alındı. Demografik veriler ve antropometrik ölçümler açısından her iki grup arasında fark izlenmedi. Kötü kontrollü tip 2 diyabet grubunda ortalama HbA1c %9.1 ve açlık kan glukozu 169 mg/dL iken iyi kontrollü tip 2 diyabet grubunda ortanca HbA1c %6.4 ve açlık kan glukozu 113 mg/dL olup glisemi kontrolü açısından gruplar arasında belirgin fark mevcuttur (HbA1c için p<0.001; açlık kan glukozu için p<0.001). Çalışmamızda TOS düzeyi kötü kontrollü tip 2 diyabetlilerde iyi kontrollü tip 2 diyabetiklere kıyasla belirgin yüksek (p=0.002), TAS düzeyi ise belirgin düşük saptandı (p<0.001). Kötü kontrollü tip 2 diyabetiklerin %47.9'unda ve iyi kontrollü tip 2 DM hastalarının %27.9'unda mikrovasküler komplikasyon varlığı saptandı (p=0.027). Alt grup analizinde ise retinopati, nefropati ve nöropati sıklığı açısından iyi ve kötü kontrollü diyabetikler arasında anlamlı fark izlenmedi. Kötü kontrollü tip 2 diyabet hastalarının %17.7'sinde makrovasküler komplikasyon varlığı saptanırken, iyi kontrollü tip 2 diyabet grubunda bu oran %14 olarak tespit edildi ve gruplar arasında istatistiksel anlamlı fark izlenmedi. İyi kontrollü ve kötü kontrollü diyabetiklerde diyet uyumu sırasıyla %58.1 ve %34.4 olarak saptandı (p=0.027). Kötü kontrollü diyabetik bireylerde oksidatif sistemdeki oksidan– antioksidan dengesinde oksidasyon lehine bozulma olup mikrovasküler komplikasyon gelişiminde oksidatif stresin rolü olduğu düşünülmektedir. Tip 2 DM hastalarında TOS düzeyleri mikrovasküler komplikasyon ve morbidite için prediktif bir test olarak kullanılabilir. TAS düzeyi 1.37 mmol Trolox Eq/L'nin üzerinde olduğunda %74 sensitivite ve %53 spesifite ile iyi diyabetik kontrolü öngörmektedir. TOS düzeyi ise 3.97 ?mol H2O2 Eq/L'nin üzerinde olduğunda %60 sensitivite ve %53 spesifite ile kötü diyabetik kontrolü öngörmektedir. Anahtar Kelimeler: Antioksidan, Diyabet komplikasyonları, HbA1c, Mikrovasküler Komplikasyonlar, Oksidant, Tip 2 Diabetes Mellitus
  • Küçük Resim Yok
    Öğe
    Nadir bir olgu: Jackhammer özofagus
    (2020) Gürler, Müjgan; Pehlivan, Murat; Can, Güray; Kayhan, Meral Akdoğan
    Jackhammer özofagus, özofagus manometri incelemelerinin ortalama %4’ünde saptanan peristaltik hiperkontraktil motilite bozukluğudur. Tanısı çoğunlukla disfaji, bazen göğüs ağrısı veya gastroözofageal reflü şikayetleri ile başvuran hastalarda konur. Disfaji semptomu, alt özofageal sfinkterdeki güçlü kasılmalar, özofageal çıkış darlığı ve yüksek distal kontraktil integral ile ilişkilidir. Jackhammer özofagus tedavisi ile ilgili net bir konsensüs bulunmamaktadır. Asid maruziyetinin azaltılması semptom ve motor bozukluğunu azalttığı gösterilmiştir. Ağırlıklı semptomlar göğüs ağrısı ve disfaji için ise nöromodülatörler ile düz kas gevşeticileri verilebilir. Ağır refrakter olgularda özofageal Botulinum toksini enjeksiyonu ve POEM gibi endoskopik yöntemlerin yanında Heller myotomi gibi cerrahi seçenekler de düşünülebilir. Vakamızda Botulinum enjeksiyonu ve kalsiyum kanal blokeri ile klinik yanıt elde edilmiştir.