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Öğe Acanthamatous Ameloblastoma of the Body of the Mandible: Case Report(2015) Toptaş, Orçun; Akkaş, İsmail; Ozan, Fatih; Boran, ÇetinAmeloblastomlar çenenin lokal agresif lezyonlarıdır. Anatomik bölge, klinik tablo ve histopatolojik farklılıklara göre farklı alt tipler tanımlanabilir. Bu olguda mandibula gövdesinde enükleasyon ve küretaj ile tedavi edilen unikistik akantamöz ameloblastom sunulmuştur. Unikistik ameloblastom çenenin nadir lezyonlarından olmasına rağmen mandibula gövdesinde görülebilmektedir.Öğe Ağız kuruluğu(2014) Akkaş, İsmail; Toptaş, Orçun; Ozan, FatihTükürük, sindirim, konuşma ve yutma işlemlerinin kolaylaştırılması ve antimikrobiyal ve kayganlaştırıcı etkisi ileoral dokuların korunmasında görev alan önemli bir vücutsıvısıdır. Subjektif ağız kuruluğu veya kserostomi genellikle azalmış tükürük akımı ve daha nadir olarak da psikolojik faktörler ile alakalıdır. Tükürük akımının azalmasınaneden olan başlıca sebepler dehidratasyon, bazı ilaçlar,baş ve boyun bölgesine uygulanan radyoterapi ve Sjögrensendromu gibi bazı özel sistemik hastalıklardır. Tükürükbezi hipofonksiyonuna sahip hastalar birçok oral patolojiyönünden risk altındadırlar ve uygun semptomatik ve önleyici yaklaşımlar ile tedavi edilmeleri önemlidir. Bu makalede ağız kuruluğunun değerlendirilmesi, semptomlarıngiderilmesi ve önlenmesi güncel literatürler eşliğinde anlatılmaktadır.ANAHTARKELİMELER: Ağız kuruluğu; ağız sağlığı; tükürükbezleri; tükrük salgısı azlığıKAYNAKGÖSTERMEKİÇİN: Akkaş İ, Toptaş O, Özan F. Ağız kuruluğu. Acta Odontol Turc 2014;31(1):54-60[Abstract in English is at the end of the manuscript]Öğe Does stinging nettle (urtica dioica) have an effect on bone formation in the expanded inter-premaxillary suture?(Pergamon-Elsevier Science Ltd, 2016) Irgın, Celal; Çörekçi, Bayram; Ozan, Fatih; Halıcıoğlu, Koray; Toptaş, Orçun; Yıldırım, Arzu Birinci; Türker, Arzu; Yılmaz, FahriObjective: To determine whether systemically given stinging nettle (SN) has an effect on bone formation in response to expansion of the rat inter-premaxillary suture. Materials and methods: A total of 28 male Wistar albino rats were randomly divided into 4 equal groups: control (C), only expansion (OE), SN extract given only during the expansion and retention periods (SN group; a total of 17 days), and SN extract given during the nursery phase before expansion (a period of 40 days) and during the expansion and retention periods (N + SN group; a total of 57 days). After the 5-day expansion period was completed, the rats in the OE, SN, and N + SN groups underwent 12 days of mechanical retention, after which they were sacrificed, and their premaxilla were dissected and fixed. A histologic evaluation was done to determine the number of osteoblasts, osteoclasts, and capillaries, as well as the number and intensity of inflammatory cells and new bone formation. Results: Statistically significant differences were found between the groups in all histologic parameters except the ratio of intensities of inflammatory cells. New bone formation and the number of capillaries were significantly higher in the SN groups than in the other groups. The statistical analysis also showed that the numbers of osteoblasts, osteoclasts, and capillaries were highest in the N + SN group. Conclusion: Systemic administration of SN may be effective in accelerating new bone formation and reducing inflammation in the maxillary expansion procedure. It may also be beneficial in preventing relapse after the expansion procedure. (C) 2016 Elsevier Ltd. All rights reserved.Öğe Dynamic assessment of Capparis spinosa buds on survival of periodontal ligament cells using a real-time cell analysis method(Medknow Publications & Media Pvt Ltd, 2015) Ozan, Fatih; Ozan, Ülkü; Oktay, Elif Aybala; Toptaş, Orçun; Özdemir, HakanBackground: Tooth avulsion is the most severe type of traumatic dental injuries and it results in the complete displacement of the tooth out of its socket in alveolar bone. Reimplantation of the tooth is considered to be a best treatment modality due to its biological and psychological advantages. Its prognosis depends on the extra alveolar time, the storage medium, and the patients general health. Objective: The aim of this study was to evaluate the effect of Capparis spinosa (C. spinosa) in maintaining the viability of human periodontal ligament (PDL) cells using a real-time cell analysis method. Materials and Methods: Periodontal ligament cells were obtained from healthy human third molars extracted for orthodontic purposes. The storage media tested were: Dulbeccos Modified Eagle Medium (DMEM), C. spinosa, Hanks Balanced Salt Solution (HBSS), and light milk. A real-time cell analyzer system was used to evaluate cell viability. After seeding cell suspensions into the wells of the E-plate 96, PDL cells were treated with each of tested media and monitored for every 5 min for 26 h. Statistical analysis of the data was accomplished using one-way analysis of variance complemented by the Tukey test. The level of significance was set at P < 0.05. Results: Dulbeccos Modified Eagle Medium (control) and C. spinosa groups had significantly higher cell index values compared with the HBSS and light milk (P < 0.05). Although, C. spinosa showed better results than DMEM (control), but this difference was not found statistically significant. Conclusion: Capparis spinosa can be a suitable, alternative storage medium for avulsed teeth.Öğe Effects of energy drinks on soft tissue healing(Lippincott Williams & Wilkins, 2014) Tek, Mustafa; Toptaş, Orçun; Akkaş, İsmail; Kazancıoğlu, Hakkı Oğuz; Fırat, Tülin; Ezirganlı Şeref; Ozan, FatihThe aim of the present study was to investigate the effects of an energy drink (ED) on soft tissue wound healing in the rat model. Thirty-six male Wistar albino rats were randomly divided into 2 groups. A full-thickness paravertebral linear incision wound model was created. The experimental group (EG) received an ED (Red Bull), and the control group (CG) received water. Red Bull (3.57 mL/kg/d) was administered to the rats by the oral gavage method on the day before the skin incision and continued for 14 days. The rats were sacrificed (n = 6 in each group) on the 3rd, 7th, and 14th day of the study. Sections were obtained from excised linear wound healing site and stained with hematoxylin-eosin and Masson trichrome for morphological analysis. To assess angiogenesis on the sections, immunohistochemical studies were carried out using vascular endothelial growth factor antibody and alpha smooth muscle actin Ab-1. The breaking strength of the wound healing site was measured in Newtons using a tensiometer. Morphological analysis showed that collagen deposition in the wound areas was statistically higher in the EG compared with that of the CG at both the third and seventh days (P < 0.05). Re-epithelialization on healing sites in the EG was statistically higher than in the CG on the seventh day (P < 0.05). The results of the immunohistochemical studies indicated that the numbers of new blood vessels in the wound healing sites of the EG were significantly higher at the 7th and 14th days when compared with the CG (P < 0.05). The breaking strength of the wound healing sites was also significantly higher on the 7th and 14th days in the EG (P < 0.05). The results demonstrate that ED accelerates soft tissue wound healing and that its effect may be due to increased collagen deposition, re-epithelialization, and new blood vessel formation in the wound.Öğe Evaluation of cytotoxic effect of garlic on human gingival fibroblasts: A Preliminary study(2013) Ozan, Fatih; Özdem, Muhsin; Ozan, Ülkü; Şençimen, Metin; Akın, Zübeyde PolatÇalışmamızda insan diş eti fibroblastları üzerine sarımsak özütünün sitotoksisitesi araştırıldı. %12.5, 6.25, 3.12, 1.5 ve 0.6’lık derişimlerde olmak üzere 5 farklı sarımsak çözeltisi hazırlandı. Klorheksidin glukonat ve sarımsağın insan dişeti fibroblastları üzerine olan sitotoksik etkileri 24. saatte agar difüzyon metodu ile değerlendirildi. % 6.25, 3.12 ve 1.5’lik derişimlerdeki sarımsak çözeltileri her hangi bir sitotoksik etki göstermemiştir. %12.5’luk derişimdeki sarımsak çözeltisi sitotoksik etki göstermiştir, bu etki klorheksidin glukonatın gösterdiğinden daha az bulunmuştur. Bu ön çalışmadan elde edilen verilere göre sarımsak çözeltisi ile hazırlanacak uygun solüsyonlar ağız sağlığının elde edilmesi yönünde gelecekte kullanılabilir.Öğe The importance of CBCT imaging to determine the characteristics of a bone sequestrum in a case of chronic osteomyelitis(2013) Akkaş, İsmail; Tozoğlu, Sinan; Çağlayan, Fatma; Ozan, FatihChronic osteomyelitis may show a suppurative course with abscess or fistula formation and sequestration at some stages, and persist for a variable period up to many years with intermittent exacerbation. The importance of imaging in osteomyelitis is threefold: to localize the condition, to find out its extent, and to assess the response after treatment. Conventional multislice computed tomography is a useful method of preoperative assessment, but it is not considered as the initial choice for imaging in osteomyelitis because of its reported lack of sensitivity in bone marrow disease. The Cone Beam Computed Tomography (CBCT) is used in dentistry to image high- contrast objects such as teeth and bone and it is particularly important for several applications including treatment planning for dental implants and evaluating dental and osseous diseases in the jaws and temporomandibular joints. However, CBCT provides a lower dose, lower cost alternative to conventional CT that promises to improve the practice of oral and maxillofacial radiology. In this case report the management of a patient with persistent suppurative osteomyelitis and its treatment assisted by Cone Beam Computed Tomography (CBCT) are presented.Öğe Intraosseous epidermoid cyst associated with impacted mandibular wisdom teeth: an uncommon entity(Journal of Clinical and Diagnostic Research, 2014) Toptaş, Orçun; Akkaş, İsmail; Tek, Mustafa; Ozan, Fatih; Boran, ÇetinEpidermoid and dermoid cysts of the jaws are seen rarely. The formation theories of the intraosseous epidermoid cyst (IEC) are not clear. The radiographic appearance is similar with unilocular cysts. Surgical enucleation is the suggested treatment method for epidermoid cysts. This case report presents bilateral mandibular intraosseous epidermoid cysts with impacted wisdom teeth which is the first documented case in the literature.Öğe Mandibular üçüncü molarların angulus kırığı oluşumu üzerine etkisi(2013) Akkaş, İsmail; Tozoğlu, Sinan; Ozan, FatihBu makalenin amacı, mandibular 3. molar dişe sahip olan ve olmayan bireylerde mandibula angulus kırığı oluşma riskinin belirlenmesidir. Bu amaçla, “mandibular third molars” ve “angle fractures” anahtar kelimeleri kullanılarak PUBMED/MEDLINE veri tabanında literatür taraması gerçekleştirildi. Birbirine benzer istatiksel analiz yapmış ve mandibula angulus kırıkları ile beraber kontrol grubu olarak kabul edilebilecek şekilde diğer mandibula kırıklarını çalışmalarına dâhil etmiş 9 adet makaleden elde edilen veriler istatiksel olarak değerlendirildi. Bu makalelerdeki retrospektif kohort çalışmadaki vaka sayısı 6466 ve mandibula angulus kırığı sayısı 1769’idi. Çalışmalardaki rölatif risk değerleri, 1,2 ile 3,6 arasında hesaplandı. Ayrıca rölatif risk ortalamasının 2,14 olduğu belirlendi (%95 güven aralığı 1,92–2,39). Sonuç olarak mandibular 3. molar dişe sahip olan bireylerin olmayanlara göre ortalama 2 kat daha fazla mandibula angulus kırığı oluşma riskine sahip oldukları bulundu.Öğe Oral mikroorganizmalara karşı propolisin antimikrobiyal etkinliği(2015) Ozan, Ülkü; Ozan, Fatih; Er, KürşatÇeşitli amaçlarla halk hekimliğinde binlerce yıldır doğalürünler kullanılmaktadır. Bu ürünlerin arasında, patojenikmikroorganizmalar üzerine antimikrobiyal aktivitesi çok iyiolan propolis, son zamanlarda çok fazla ilgi çekmektedir.Propolis içeriği, arının gezdiği alanlardaki floraya ve toplandığı zamana göre oldukça farklılık ve zenginlik göstermektedir. Kimyasal bileşimlerindeki farklılıklara rağmen,tüm propolis ürünleri belirgin biçimde antimikrobiyal etkinlik göstermektedir. Bunlar, farmakolojik olarak aktif moleküller flavonoidler, fenolik asitler ve esterler olaraksayılabilir. Son zamanlarda yapılan çalışmalardan elde edilen verilere göre propolis, ağızdaki patojenik mikroorganizmalar üzerine belirgin inhibisyon göstermektedir.Antimikrobiyal ajanlara karşı mikroorganizmaların dirençgeliştirmeleri, geliştirdikleri direnç mekanizmalarını bakteriler arası ilişki ile birbirlerine aktarmaları ve diğer yan etkileri de göz önünde bulundurulduğunda ağız boşluğuhastalıklarının tedavisinde yeni tedavi yöntemleri oldukçaönem arz etmektedir,Öğe Periodontally Accelerated Molar Distalization With Miniscrew Assisted Memory Screw: A Pilot Study(Aves Press Ltd, 2013) Corekci, Bayram; Irgin, Celal; Halicioglu, Koray; Hezenci, Yasin; Dursun, Saffet; Ozan, FatihObjective: To examine the treatment effects of a miniscrew assisted memory screw system supported by piezoincision for the noncompliance molar distalization of maxillary first molars in patients with Class II malocclusion. Materials and Method: Nine subjects with skeletal Class I dental Class II malocclusion were treated. An anchorage unit was prepared using two miniscrew that were placed just behind a line connecting the first premolars at the mesial contact point. The memory expansion screw (500 g), and two miniscrews placed parallel to the occlusal plane provided stable, 4-point support for the appliance. Piezoincision was performed immediately after the appliance as cemented. Four midlevel incisions were made under local anesthesia between the roots of the teeth on the buccal side of the maxillary alveolar bone from the mesial first premolar to the second molar. A 3-mm piezoelectrical corticotomy was then performed by inserting the tip of Piezotome into each of these openings. Screw activation was started the following day. Skeletal and dental changes were measured on cephalograms, and dental casts were obtained before and after distalization. Results: Upper first molars were successfully distalized in approximately 4.6 months and the mean distalization at the end was 4.98 mm. The average distal tipping of the upper first molars was 7.75 degrees. No statistically significant changes were noted in the sagittal position of the maxilla or in the position of the upper incisors as a result of treatment. The maxillary first molars also moved palatinally (1.13 mm), but no significant distal rotation occurred. Conclusion: This system provided an efficient distalization method for posterior teeth and showed no anchorage loss. Molar tipping and palatal movement were observed as side effects in the patients.Öğe Systemic propolis stimulates new bone formation at the expanded suture : a histomorphometric study(E H Angle Education Research Foundation, Inc, 2013) Altan, Burcu Ayşe; Kara, İsa Muhammed; Nalçacı, Ruhi; Ozan, Fatih; Erdoğan, Şerif MuharremObjective: To investigate the effects of systemically given propolis on the expanded premaxillary suture in a rat study model. Materials and Methods: The 24 rats were randomly divided into three groups only expansion (OE), expansion plus propolis (PRO), and nonexpansion (control) groups. After the 5-day expansion period was completed, the OE and PRO groups underwent 12 days of mechanical retention. At the end of this period, the animals were euthanatized and their pre-maxillae were dissected and fixed. Histomorphometric examination was performed to determine the number of osteoclasts, osteoblasts, and capillaries as well as the intensity of inflammatory cells and amount of new bone formation. Results: Statistical analysis showed that the intensities of inflammatory cells, number of osteoblasts, and amount of new bone formation were greater in the PRO group than in the other groups. The PRO group also had more osteoclasts and new capillaries. Conclusion: Systemic use of propolis may hasten new bone formation at the expanded suture in rats. (Angle Orthod. 20-13;83:286-291.)Öğe Yanan ağız sendromu(2014) Toptaş, Orçun; Akkaş, İsmail; Ozan, FatihYanan ağız sendromu, dili ya da diğer ağız içi dokuları etkileyen ağrı veya iğneleyici his veren karmaşık bir rahatsızlıktır. Bu durum sistemik ve lokal nedenlere bağlı ortaya çıkabildiği gibi sağlıklı bireylerde de görülebilir. Yanan ağız sendromunun etyolojisinde birçok faktör bulunmaktadır. Yaş ve cinsiyet de prevalansta önemli rol oynamaktadır. Literatürde birçok tedavi yöntemi sunulmuş olmasına kar- şın henüz ortak bir tedavi seçeneğinde uzlaşılamamıştır. ANAHTAR KELİMELER: Allerji; ağız sağlığı; diyabet; endokrin; galvanizm; mantar hastalıkları; psikolojik; tükürük bezi.
