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  • Küçük Resim
    Öğe
    Histopathological effects of intranasal phototherapy and nasal corticosteroids in allergic rhinitis in a rabbit model
    (Elsevier Science Sa, 2015) Yurttaş, Veysel; Şereflican, Murat; Erkoçoğlu, Mustafa; Terzi, Elçin Hakan; Kükner, Aysel; Oral, Mesut
    Allergic rhinitis is one of the most common health problems and has a major effect on quality of life. Although new-generation antihistamines and nasal steroids are the main treatment options, complete resolution cannot be obtained in some patients. Besides common side effects such as nasal irritation and epistaxis, the use of these drugs is controversial in some patients, such as pregnant or breastfeeding women. These findings highlight the need for new treatment options. Although phototherapy has been successfully used in the treatment of atopic dermatitis, which is an IgE-mediated disease and shares several common pathogenic features with allergic rhinitis, there are limited studies about its role in the treatment of allergic rhinitis. In this study, we aimed to evaluate and compare the histopathological effects of intranasal phototherapy (Rhinolight) and nasal corticosteroid treatment on the nasal mucosa in allergic rhinitis in a rabbit model and we found that both treatment options significantly reduced inflammation in the nasal mucosa without increasing apoptosis of mucosal cells. (C) 2015 Elsevier B.V. All rights reserved.
  • Küçük Resim
    Öğe
    Is middle ear pressure effected by nasal packings after septoplasty?
    (Aves, 2015) Şereflican, Murat; Yurttaş, Veysel; Oral, Mesut; Yılmaz, Beyhan; Dağlı, Muharrem
    OBJECTIVE: To investigate the effects of different types of nasal packings on middle ear pressure in patients undergoing septoplasty. MATERIALS and METHODS: Sixty patients who were suffering from nasal obstruction and who had to undergo septoplasty because of nasal septal deviation were included in the study. After the septoplasty, Merocel packings and internal nasal splints were intraoperatively applied in thirty patients each. Middle ear pressure was evaluated by tympanometry. Tympanometric peak pressures were used for this aim. Acoustic impedance measurements were performed in both ears, and the average values of the two ears were calculated. Tympanometric measurements were performed for patients during the preoperative period and on the 2nd and 5th postoperative days. RESULTS: There were 30 (5 females, 25 males; average age 23 years) patients in the internal nasal splint group and 30 (8 females, 22 males; average age 26 years) patients in the anterior Merocel packing group. When the values obtained by acoustic impedancemetry before the operation and on the postoperative 5th day were compared, there was no statistically significant difference between the groups. The middle ear pressure significantly decreased in the anterior Merocel packing group compared with that in the internal nasal splint group. The intragroup comparison of the acoustic impedance measurements of the internal nasal splint group revealed no significant difference between the preoperative acoustic impedance values and the values obtained on the postoperative 2nd day. CONCLUSION: Cannulated silicone intranasal splints are better in terms of patient comfort after an intranasal surgery without effecting eustachian tube function.
  • Küçük Resim Yok
    Öğe
    Parkinson hastalığında servikal vestibüler evoked myojenik potansiyeller
    (Bolu Abant İzzet Baysal Üniversitesi, 2017) Oral, Mesut; Yurttaş, Veysel
    Amaç: Parkinson Hastalığı (PH)'nın yaşam kalitesini önemli ölçüde etkileyen özelliklerinden biri olan Postural instabilitenin nedeni tam olarak bilinmemektedir. Bu çalışmada postüral instabilite de vestibüler sistemin rolünü servikal vestibüler evoked myojenik potansiyel (cVEMP) testi ile değerlendirmeyi amaçladık. Materyal ve Metod: Çalışmaya herhangi bir nörolojik veya otolojik hastalığı olmayan, 30 (23 erkek, 7 kadın) PH olgusu ve 30 (22 erkek, 8 kadın), sağlıklı gönüllü dahil edildi. PH olanların yaşları 50-87 arasında değişmekte olup, ortalama 66±9,2'dir. Kontrol grubunun yaşları ise 48-80 arasında ve ortalama 62±7,8'dir. PH olgularının ortalama hastalık süresi 4,8±3,1 (1-13) yıl olarak saptandı. Vaka grubununda 15 kişi Hoehn-Yahr evre I, 15 kişi Hoehn-Yahr evre II ve 6 kişi Hoehn-Yahr evre III olarak değerlendirildi. Her iki gruptaki bireylerin tümünde bilateral cVEMP kayıtlamaları yapıldı. Bulgular: Kontrol grubunun tümünden bilateral normal bifazik VEMP cevapları (P13-N23) elde edildi. PH grubunun, 11 (% 36,6)'inde ünilateral, 5 (% 16,6)' inde bilateral VEMP cevabı alınmadı. 14 (%46,6) hastadan bilateral VEMP yanıtı elde edildi. PH ortalama P13 latansı istatistiksel olarak anlamlı şekilde kontrol grubundan daha uzun bulundu. Ortalama yanıt amplitüdü de istatistiksel olarak anlamlı şekilde kontrol grubundan daha düşük bulundu. N23 latansları açısından her iki grup arasında istatistiksel olarak anlamlı bir fark bulunmadı. Sonuç: Çalışmamızda Parkinson hastalarından elde edilen anormal VEMP cevaplarının postüral instabiltenin sakkülokolik refleks arkı ile ilgili olabileceği düşünülmüştür. Anahtar Kelimeler: Vestibüler Evoked Myojenik Potansiyel, Parkinson hastalığı, Vestibülokollik refleks