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Öğe Catheter associated Staphylococcus sciliuri sepsis in a patient with acute myeloid leukemia(2006) Koçoğlu, Esra; Karabay, OğuzThe coagulase-negative bacterial species Staphylococcus sciuri is widely distributed in the natural environment. Although principally found in animals, S.sciuri is occasionally isolated from human samples. In this paper, S.sciuri bacteremia which was associated with an indwelling catheter of a patient with acute myeloid leukemia (AML) and neutropenia was presented. An empirical intravenous antibiotic therapy (meropenem, vancomycin) was initiated with the preliminary diagnosis of febrile neutropenia and catheter infection. The catalase and oxidase positive, tube coagulase negative strain isolated from three of the concurrent blood cultures and intravenous catheter culture has been identified as S.sciuri. The isolate was found resistant to penicilin and oxacilline. This case has emphasized the importance of identification of coagulase-negative staphylococci isolated from the cultures of patients with haematological malignancy.Öğe Comment on Demirbağ, et al. "Multidrug resistance of isolated microorganisms in occluded bile duct stents" (Turk J Gastroenterol 2007; 18 (1): 33-40)(2007) Koçoğlu, EsraI have read, with great interest, the article by Demirba. et al. (1) published in Turk J Gastroenterol which showed that all bile duct stents are contaminated by microorganisms, the majority of them being multidrug resistant. However, I have some comments to this article.Öğe Comparison of classical methods versus BACTEC blood culture system for culture of normally sterile body fluids(Science & Innovation, Ltd, 2015) Mengeloğlu, Zafer; Taş, Tekin; Bucak, Özlem; Koçoğlu, Esra; Küçükbayrak, AbdulkadirBackground - Presence of microorganisms in sterile body sites leads to life-threatening infections. For early and accurate diagnosis of those infections, cultures of the sterile fluids have to be done. These cultures can not always detect the causative agents due to insufficent number or fastidious growing of the probable microorganisms in the material. Objectives - In this study, it was aimed to compare sterile body fluid cultures which had been processed with both conventional culture methods and BACTEC automatized blood culture system retrospectively. Material and Methods - A total of 138 body fluid cultures were compared retrospectively from the laboratory records. Results - Amongst the specimens, 122 cultures were negative. Nine of the rest 16 specimens were positive with both culture methods and seven cultures were positive with BACTEC only. None of the specimens which were negative in BACTEC system revealed positive with the conventional method. BACTEC detected significantly higher number of positivity (P<0.001). No significant difference was found between the methods due to contamination (P=0.183). Conclusion - In conclusion, our study shows that inoculation of the sterile body fluid specimens into blood culture bottles and incubation of them in BACTEC system as well as culturing with conventional methods increase the detection rate of probable causative agents.Öğe Comparison of toxin genes in staphylococcus aureus isolates obtained from patients and carriers(Carbone Editore, 2013) Mengeloğlu, Fırat Zafer; Çiçek, Ayşegül Çopur; Koçoğlu, Esra; Taş, Tekin; Bucak, Özlem; Güçkan, RıdvanIt is important to have information about virulence characteristics of S. aureus isolates obtained from the nasal cultures of carriers in terms of the capability to cause severe infections. In the present study, S. aureus isolates obtained from carriers and isolates obtained from clinical specimens, and which were determined as causative agents of infection, were compared in terms of the genes of staphylococcal enterotoxiiz A and 8 (sea and seb), TSST-I (tst), and PVL (pv1). A total of 44 S. aureus strains isolated from clinical specimens and 44 carrier isolates were tested for the genes with polyinerase chain reaction method. As the results, the most common gene was sea with a rate of 45.5% (40188). This gene was found in 34.1% (15144) of the carrier isolates and in 56.8% (25144) of the clinical group. Furthermore, the presence of the sea gene was found to be significantly higher in the clinical isolates than in the carriers' (P=0.032). The tst, seb, and pvl genes were positive at rates of 18.2% (16188). 4.5% (4188), and 5.7% (5188), respectively. No significant differences were found between the groups according to positivity rates of the tst, seb, and pvl genes (p>0.05 for each gene) To our knowledge, differences between carrier isolates and clinical isolates in terms of toxin genes have not been investigated before the present study. The presence of sea at a significantly higher rate in clinical isolates shows the need for advanced molecular analysis on this topic.Öğe Could thrombocyte parameters be an inflammatory marker in the brucellosis?(Medical Association of Zenica-Doboj Canton, 2013) Küçükbayrak, Abdülkadir; Taş,Tekin; Tosun, Mehmet; Aktaş, Gülali; Alçelik, Aytekin; Hakyemez, İsmail Necati; Koçoğlu, EsraAim To investigate links between platelet parameters mean platelet volume (MPV), platelet count (PC), platelet distribution width (PDW), platelet mass (PM) and brucella tube agglutination titers (BSTAT) in patients with brucellosis. Initially, PC, MPV, PM and PDW calculations were compared between periods before and after treatment. The correlation between inlammation markers (erythrocyte sedimentation rate, ESR, white blood cell count, WBC, and C reactive protein, CRP) and platelet parameters was subsequently investigated. Methods This self-controlled study included 40 patients who had positive BSTAT at least at a titer of 1/160. Platelet parameters and inlammation values (CRP, ESR) at the time of positive BSTAT at least at a titer of 1/160 (pre-treatment) were compared with control of the same parameters at the time when BSTAT became negative or when the titers reduced 4 folds (post-treatment). Results Mean platelet volume values (7.90+1.96) were signiicantly elevated in post treatment period when compared to pre treatment (7.58+1.96), (p= 0.023). Post treatment CRP, ESR and PC were signiicantly reduced when compared to pretreatment values (p=0.000, p=0.000 and p=0.025, respectively). In the pretreatment period, a direct correlation between ESR and PC values (r=0.036, p=0.025), and inverse correlations between ESR with MPV (r=-0.337, p=0.038) was found. A dependent predictive factor in multivariate logistic regression analysis for BSTAT was not found. Conclusion We suggest that PC and MPV may be inlammatory markers in brucellosis.Öğe Coxiella Burnetii seroprevalence in the rural part of Bolu, Turkey(2009) Karabay, Oğuz; Koçoğlu, Esra; Baysoy, Gökhan; Konyalıoğlu, SelamiAim: This study was performed to determine the seroprevalence of Coxiella burnetii in the rural part of Bolu, a city located in the western part of the Black Sea region of Turkey. Materials and Methods: The study population was chosen by cluster sampling to represent the rural population of the city. Serum samples were collected from the 9 rural districts of Bolu. Blood samples were taken to the laboratory while stored at 4 °C in ice-cooled boxes. The sera were then stored at −20 °C until testing. The presence of IgG antibodies against C. burnetii phase-II antigens in the sera was determined using IFA. Results: The study included 293 cases and C. burnetii phase-II IgG was positive in 61 of the subjects (20.8%). The seroprevalence of C. burnetii was 23.8% (59/248) among the participants above 18 years of age and 4.4% (2/45) among those younger than 18 years of age (P < 0.01). There was a significant relationship between C. burnetii seropositivity and direct contact with the birth products of farm animals (P < 0.001); however, there was not a significant difference between genders. Conclusions: Although the seroprevalence rate was high, Q fever was underreported and unrecognized in rural Bolu. We conclude that Q fever must be considered in patients with a suitable clinical course in this region.Öğe Decreased superoxide dismutase activity after ECT and correlation between higher oxidant levels and poor response to ECT in depression(2010) Virit, Osman; Dalkılıç, Alican; Bulut, Mahmut; Bülbül, Feridun; Altındağ, Abdurrahman; Koçoğlu, EsraObjective: The literature regarding effects of electroconvulsive therapy (ECT) on oxidative metabolism (OM) reports conflicting changes in oxidant and antioxidant status in animal studies. The goal of this first human study was to investigate the changes in oxidants and antioxidants in plasma of depressed patients after ECT. Methods: Fourteen unipolar and two bipolar patients were included in the study. The blood samples were obtained within one hour before the 1st and within one hour after the 7th ECT sessions. Oxidants malondialdehyde (MDA), nitric oxide (NO), and xanthine oxidase (XO) and antioxidant superoxide dismutase (SOD) were measured in the plasma. Results: Before the 1st and after the 7th ECT sessions, the Hamilton Depression Rating Scale (HDRS) scores were 32.63 ± 9.54 and 16.50 ± 7.22, respectively (t=7.92, df=15, p<0.001). After the 7th ECT, SOD values were significantly lower than pre-ECT SOD values (p<0.05, Z= -3,459). There were no significant difference between pre-and post-ECT values of MDA, NO, and XO (p>0.05). However, pre-ECT SOD values were significantly and positively correlated with pre-ECT HDRS scores (r=0.641, p=0.007). Conclusion: The decrease in antioxidant enzyme SOD after ECT may damage the neurons by increasing oxidative stress. Thus, possible benefits of antioxidant supplementation during ECT should be investigated. Additionally, higher pre-ECT oxidant levels may predict a poor response to ECT in depression.Öğe Determination of anti-nuclear antibody pattern distribution and clinical relationship(Professional Medical Publications, 2014) Mengeloğlu, Zafer; Taş, Tekin; Koçoğlu, Esra; Aktaş, Gülali; Karabörk, ŞeydaBackground and Objectives: Autoantibodies are innmunglobulins occurred directly against autoantigens that are known as endogen antigens. Autoinnmune disease is an occasion that the body begins a fight against its own cells and tissues. The antibodies that are created by the body against its own cell nuclei are called as anti-nuclear antibodies (ANA), and one of the methods used for detection and pattern of ANA is indirect immunofluorescence test (IIF). In the present study, it was aimed to determine the rate of ANA positivity and patterns of the positive specimens, and to investigate the relationship between ANA positivity and diseases in patients. Methods: ANA test results of a total of 3127 patients admitted during March 2010 to December 2012 were evaluated retrospectively. ANA test (HEp 20-10, EUROIMMUN, Germany) was used in dilution of 1:100 in IIF test. Results: A total of 494 (15.8%) resulted as ANA positive. ANA positivity rate was significantly higher in female patients than the male ones (p < 0.001). The most frequent ANA patterns were coarse speckled pattern (154 patients, 31.2%), nucleolar pattern (89 patients, 18.0%), fine speckled pattern (57 patients, 11.5%), and speckled pattern (48 patients, 9.7%). ANA positivity was most commonly determined in rheumatoid arthritis (RA) (42 patients, 8.5%), systemic lupus erythematosus (SLE) (29 patients, 5.9%), and rheumatoid vasculitis (RV) (28 patients, 5.7%). The most frequent symptoms or findings were joint pain (127 patients, 26.0%) and anemia (28 patients, 5.7%). ANA positivity rates were found to be significantly higher in patients with RA (p < 0.001), with SLE (p < 0.001), and with Raynaud phenomenon (p=0.001) in comparison to the controls. Amongst the most frequent diseases evaluated, no significant differences were found between the control groups and the groups of RV (p=0.089), multiple sclerosis (p=0.374), and Sjogren syndrome (p=0.311) in terms of ANA positivity rates. Conclusions: The present study is the first study reporting the positivity rate and distribution of ANA in Bolu located in northwestern Turkey. Information about the pattern types and the distribution of the patterns according to the diseases and symptoms contribute in diagnosis of autoimmune diseases. It is observed that clinical diagnosis has been supported significantly by ANA test according to data of our study.Öğe Distribution of bla(OXA) genes in acinetobacter baumannii strains : a multicenter study(Ankara Microbiology Soc, 2013) Çiftci, İhsan Hakkı; Aşık, Gülşah; Karakeçe, Engin; Öksüz, Lütfiye; Yağcı, Server; Koçoğlu, EsraAcinetobacter baumannii is the most important agent of nosocomial infections within the Acinetobacter genus. This gram-negative coccobacillus is intrinsically resistant to many antibiotics used in antimicrobial therapy, and capable of developing resistance including carbapenems. The objective of this study was to develop a multiplex real time polymerase chain reaction (qPCR) kit for OXA subgroups in A.baumannii, and to investigate the distribution of OXA subgroups in A.baumannii strains isolated from geographically different regions of Turkey. A total of 834 A.baumannii clinical isolates collected from different state and university medical centers in 13 provinces (Afyonkarahisar, Ankara, Bolu, Elazig, Erzurum, Isparta, Istanbul, Kahramanmaras, Konya, Sakarya, Van) between 2008-2011, were included in the study. The isolates were identified by conventional methods and automated systems [Vitek2 (bioMerieux, ABD) and Phoenix (BD Diagnostic, MD)]. The susceptibility profiles of the isolates were studied with automated systems and standard disc diffusion method. All samples were subjected to qPCR to detect bla(OXA-51-like), bla(OXA-23-like) and bla(OXA-58-like) genes. A conventional PCR method was also used to detect bla(OXA-24-like) gene. The resistance rates observed during the study period were as follows: 96.8% for amoxicillin-clavulanate, 86.8% for ciprofloxacin, 74.7% for gentamicin, 71.7% for amikacin, 73.5% for cefaperozone-sulbactam, 72.1% for imipenem and 73% for meropenem. Six hundred and two (72.2 %) isolates were resistant to both imipenem and meropenem. Colistin was found to be the most effective antibiotic against A.baumannii isolates with 100% susceptibility rate. All isolates were positive for bla(OXA-51-like) gene, however bla(OXA-24-like) gene could not be demonstrated in any isolate. Total positivity rates of bla(OXA-23-like) and bla(OXA-58-like) genes were found as 53.7% and 12.5%, respectively, while these rates were 74.4% and 17.3% in carbapenem-resistant isolates, respectively. Twenty-five isolates were positive-for both bla(OXA-23-like) and bla(OXA-58-like) genes. All of the carbapenem-resistant isolates have OXA type genes like with the exception of bla(OXA-24-like) gene. The positivity rates for bla(OXA-23-like) and bla(OXA-58-like) genes varied for each center. In addition, there was a decrease in the frequency of bla(OXA-58-like) gene, however both bla(OXA-23-like) gene and carbapenem resistance rates increased during the study period. In conclusion, high rates of resistance to carbapenems were also remarkable but A.baumannii strains keep on sensitivity to colistin. Both bla(OXA-23-like) and bla(OXA-58-like) genes were shown to be widespread in carbapenem-resistant A.baumannii clinical isolates. However, bla(OXA-23-like) gene positive strains were increased throughout the study. Currently, multiplex qPCR is the best way for rapid diagnosis of resistant bacteria for prevention of hospital-acquired infections. The multiplex qPCR kit developed in this study could be useful for rapid diagnosis and identify the frequencies of bla(OXA-23-like), bla(OXA-51-like) and bla(OXA-58-like) genes in carbapenem-resistant A.baumannii clinical isolates.Öğe Effect of inhaled budesonide on oropharyngeal, Gram-negative bacilli colonization in asthma patients(Asian Pacific Society of Respirology, 2007) Talay, Fahrettin; Karabay, Oğuz; Yılmaz, Fahrettin; Koçoğlu, EsraBackground and Objective: The effect of inhaled budesonide on oropharyngeal Gram-negative bacilli colonization (OGNBC) in asthmatic patients was investigated. Methods: Oropharyngeal cultures were obtained from asthmatic patients attending the hospital respiratory outpatient clinic, at baseline and 1 month after treatment with 800 mu g/day of inhaled budesonide. Cultures were evaluated for OGNBC and compared with those of healthy controls. Results: A total of 148 cultures (74 from asthma patients, 74 from healthy controls) were evaluated. Six cultures (8.1%) from healthy controls, eight cultures (10.8%) from asthma patients obtained before treatment and 20 cultures (27.0%) obtained after treatment were positive for OGNBC (P < 0.05). Gender, age, presence of atopy and the degree of illness were not found to be related to the presence of OGNBC in and healthy control cultures. In the cultures obtained from the patients after treatment, OGNBC was higher in patients > 50 years and in those with FEV1 < 70% (P < 0.05). Nine (18.8%) of 48 patients < 50 years compare with 11 (42.3%) of the 26 patients > 50 revealed OGNBC (P < 0.05). OGNBC were observed in 18.9% of the patients with FEV1 = 70% and in 47.6% of those with FEV1 < 70% (P < 0.05). Conclusions: The increased rate of OGNBC in asthma patients treated with inhaled budesonide was found to be related to increased age and lower level of FEV1. Further studies with larger numbers of patients are required for the interpretation of this colonization in the course of lower respiratory infections in these patients.Öğe The effect of triamcinolone acetonide aqueous nasal spray on the nasal carriage of Staphylococcus aureus(Ocean Side Publications Inc, 2006) Yılmaz, Fahrettin; Karabay, Oğuz; Talay, Fahrettin; Köybaşı, Serap; Koçoğlu, EsraBackground: In this study we aimed to investigate the effect of triamcinolone acetonide aqueous (TAA) intranasal spray that was used for 2 months to treat allergic rhinitis (AR) on the nasal carriage of Staphylococcus aureus (NCSA). Methods: A total of 125 adult AR patients (study group) and 133 healthy individuals (control group) were enrolled for the study. The 14 subjects were diagnosed with AR after a detailed history, physical examination, and prick testing. The AR subjects were administered TAA in a daily dosage of a 220-mu g intranasal route. Nasal cultures were obtained on the 1st (baseline), 55th, and 60th days, and the subjects in the last two cultures of whom S. aureus was detected were accepted as NCSA. Results: After all exclusion criteria were used, 110 AR and 114 control group subjects were enrolled in the study. Based on the culture results that were obtained on the 55th and 60th days, 10 (%9.1) patients from the study group and 18 (%15.7) individuals from the control group were defined to be NCSA (p>0.05). Conclusion: We conclude that the use of TAA treatment for AR does not increase the prevalence of NCSA. However, additional studies with a larger series are required to explain the effects of steroids on nasal colonization of S. aureus.Öğe Effects of intranasal phototherapy on nasal microbial flora in patients with allergic rhinitis(Iranian Scientific Society Medical Entomology, 2013) Yıldırım, Yavuz Selim; Apuhan, Tayfun; Koçoğlu, EsraThe objective of this study was to investigate the effect of intranasal phototherapy on nasal microbial flora in patients with allergic rhinitis. This prospective, self-comparised, single blind study was performed on patients with a history of at least two years of moderate-to-severe perennial allergic rhinitis that was not controlled by anti-allergic drugs. Thirty-one perennial allergic rhinitis patients were enrolled in this study. Before starting the test population on their intranasal phototherapy, the same trained person took a nasal culture from each subject by applying a sterile cotton swab along each side of the nostril and middle meatus. Each intranasal cavity was irradiated three times a week for two weeks with increasing doses of irradiated. At the end of the intranasal phototherapy, nasal cultures were again obtained from the each nostril The study found that after intranasal phototherapy, the scores for total nasal symptoms decreased significantly but bacterial proliferation was not significantly different before and after phototherapy. We have shown that intranasal phototherapy does not change the aerobic nasal microbial flora in patients with perennial allergic rhinitis.Öğe Effects of lycopene in intestinal ischemia reperfusion injury via intestinal immunoglobulin A(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2021) İkiz, Özgür; Kahramansoy, Nurettin; Erkol, Hayri; Koçoğlu, Esra; Fırat, TülinBackground: Intestinal ischemia causes an inflammatory response that may become intense by reperfusion and result in bacterial translocation. Intestinal immunoglobulin A is known to be a barrier against bacterial translocation. Lycopene is a compound with antioxidant and anti-inflammatory properties. We hypothesized that lycopene has positive effects in ischemia-reperfusion of the intestine through the intestinal IgA. Material and methods: Twenty-eight Wistar albino rats were separated into four groups: sham, control, lycopene-administered-before-ischemia (L-pre), and lycopene-administered-after-reperfusion groups. Histopathologic changes, intestinal immunoglobulin A levels, and bacterial translocation were evaluated after the ischemia-reperfusion period of 0.5-12 h. Results: Histopathologic changes, intestinal immunoglobulin A, and bacterial translocation levels in the L-pre group were similar to those in the sham group. Administration of the lycopene after reperfusion showed just a slight protective effect. However, the L-pre group had significantly fewer histopathologic changes when compared with changes in the control (P = 0.011). Intestinal immunoglobulin A level in the L-pre group was found to be higher than that in the control group (P = 0.014). Bacterial translocation levels in the blood and mesenteric lymph nodes, in the L-pre group, were lower than those in the control group (P = 0.0027 and P = 0.0097, respectively). Conclusions: Lycopene limited intestinal damage, reduced loss of intestinal immunoglobulin A and decreased bacterial translocation when administered before the ischemia-reperfusion injury.Öğe Effects of septoplasty on nasal and oropharyngeal microbial flora(Academic Journals, 2011) Apuhan, Tayfun; Koçoğlu, Esra; Yıldırım, Yavuz Selim; Şimşek, Tuğçe; Kazaz, Hasan; Gök, ÜzeyirWe characterized the changes in oropharyngeal and nasal flora of the patients with a deviated nasal septum before and after septoplasty. Patients who underwent septoplasty for nasal septal deviation were included in this study. Nasal and oropharyngeal cultures were taken with a sterile cotton swab preoperatively and one month after septoplasty. Antimicrobial susceptibility testing was performed using the disc method. Fifty-nine patients with a deviated nasal septum were included in the study: 29 women and 30 men, whose ages ranged from 18 to 40 years. There was no significant difference between the preoperative and postoperative (one month after surgery) isolated bacteria of the nasal and oropharyngeal regions. Septoplasty did not change the nasal and oropharyngel microbial flora in patients who underwent septoplasty for nasal septal deviation.Öğe Efficacy of moxifloxacin compared to teicoplanin in the treatment of implant-related chronic osteomyelitis in rats(Wiley, 2010) Özturan, Kutay Engin; Yücel, İstemi; Koçoğlu, Esra; Çakıcı, Hüsamettin; Güven, MelihTreatment of implant-related chronic osteomyelitis is often difficult and usually consists of implant removal, extensive surgical debridement, and prolonged antibiotic use This study was performed to assess the efficacy of moxifloxacin compared to a glycopeptide, teicoplanin in chronic implant-related methicillin-sensitive Staphylococcus aureus (MSSA) osteomyelitis The left femoral medullar cavities of 60 Wistar male rats were contaminated with 100 mu l of 10(8) cfu/ml methicillin-sensitive S aureus (ATCC 29213) and Kirschner wires were placed into the medulla of the femur Alter 6 weeks, rats were randomly divided into five groups In two groups, the Kirschner wires were removed Experimental groups were as follows group 1 contaminated, Kirschner wire inside, received teicoplamn, group 2 contaminated, Kirschner wire removed, received teicoplanin, group 3 contaminated, Kirschner wire inside, received moxifloxacm; group 4 contaminated, Kirschner wire removed, received moxifloxacm, group 5 contaminated, Kirschner wire inside, no antibiotics (control group) Groups 1 and 2 received teicoplanin (20 mg/kg once daily), whereas groups 3 and 4 received moxifloxacin (10 mg/kg twice daily) intraperitoneally for 28 days At the end of the treatment, animals were sacrificed by inhalation anesthesia with ether and femora were retrieved and bacterial counts (cfu/g) were determined Bacterial counts in all study groups were significantly reduced relative to the control The decrease of bacterial counts was more prominent in group 4 compared to group 1 (p = 0 001) and group 2 = 0 003) Moxifloxacin therapy is an effective alternative to teicoplamn for chronic implant-related MSSA osteomyelitis (C) 2010 Orthopaedic Research Society Published by Wiley Periodicals, Inc J Orthop Res 28 1368-1372, 2010Öğe Evaluation of psychiatric morbidity and quality of life in inactive HbsAg carriers(Academic Journals, 2011) Küçükbayrak, Abdulkadir; Canan, Fatih; Alçelik, Aytekin; Aktaş, Gülali; Koçoğlu, Esra; Taş, TekinHepatitis B virus (HBV) infection develops in forms from asymptomatic carrier to cirrhosis. There are several studies examining the quality of life of patients with HBV in literature. However, only two studies have investigated the psychiatric morbidity in hepatitis B patients. In this study, we evaluated psychiatric morbidity and quality of life in inactive HbsAg carriers. This case-controlled study was performed among 26 healthy volunteers as control group and 31 inactive HbsAg carriers. Seven (22.5%) of our Hepatitis B patients were found to have an Axis I psychiatric diagnosis. For the carriers, the diagnoses made were major depression (3 patients), major depression with conversion disorder (1 patient), moderate depressive disorder (1 patient), cyclothymic disorder (1 patient), and obsessive-compulsive disorder (1 patient). No significant difference was found between carriers and controls in terms of quality of life scores and anxiety and depression scores. According to these findings, the patients with hepatitis should undergo psychiatric evaluation by a specialist. Also, physicians should be aware that emotional and psychiatric support is not necessary for all of the patients with hepatitis B.Öğe Frequency of nasal helicobacter pylori carriage among cooks(Pakistan Medical Assoc, 2013) Karabay, Oğuz; Güçlü, Ertuğrul; Koçoğlu, Esra; Özdemir, Davut; Şencan, İrfanObjective: To investigate the frequency of nasal helicobacter pylori carriage among cooks living in Bolu, Ardahan and Sakarya province of Turkey. Methods: A total of 54 cooks (10 from Bolu, 29 from Ardahan and 15 from Sakarya) were enrolled. Nasal helicobacter was tested using polymerase chain reaction. Results: Helicobacter pylori was detected in only one cook. Conclusion: Nasal Helicobacter pylori colonisation ratio in cooks in Turkey was found to be very low. Presumably hand hygiene compliance lowered the frequency.Öğe Helicobacter pylori and kindergarten toys(2011) Karabay, Oğuz; Koçoğlu, Esra; Sandıkçı, Özlem; Öğütlü, Aziz; Tuna, NazanHelicobacter pylori (H. pylori) is prevalent throughout the world. It is an infection acquired usually at school age, and lasts lifelong if left untreated. Numerous studies have been conducted concerning the prevalence, contamination routes and risk factors of H. pylori. Its prevalence varies according to age and country (1). How H. pylori is acquired and the contamination routes are clearly not known at present. The commonest route for contamination is oral-oral or fecal-oral. The prevalence has been reported to be high in places with poor hygienic conditions and in crowded living conditions, such as in nurseries, kindergartens and rehabilitation centers, leading to contamination via the fecal-oral route. Various substances, either alive or inorganic, can play a role in H. Pylori contamination. However, there are numerous sources that might play a role in contamination in childhood, which have not yet been investigated. Do the toys shared among children play a role in H. pylori contamination? As far as we know, this is the first study that aims to investigate the role of shared kindergarten toys in H. pylori contamination (2,3).Öğe Huzurevi sakinlerinde bakteriüri sıklığı ve risk faktörleri(2007) Koçoğlu, Esra; Karabay, Oğuz; İnce, NevinGiriş: Asemptomatik bakteriüri huzurevlerinde kalan yaşlılarda toplumda yaşayan yaşlılara göre daha fazladır. Bu çalışmanın amacı, Bolu'da huzurevinde kalan yaşlılar arasında asemptomatik bakteriürinin sıklığı ve ilişkili risk ortaya çıkarmaktır. Yöntem ve Gereç: Huzurevinde kalan 42 kişi ziyaret edilerek çalışma için yazılı onayları alınmıştır. Toplam iki hasta çalışma dışı kalmıştır. Kalan 40 kişiden 6'sının idrar yolu infeksiyonu şikayeti olduğu için çalışma dışı bırakılmıştır. Huzurevinde kalan yaşlılardan 24 saat ara ile steril kaplar içinde toplanan iki idrar örneğinin kültürü yapılmış ve 10(5)cfu/ml ve daha fazla üremesi olanlar pozitif olarak değerlendirilmiştir. Bulgular: Yaş ortalaması 74.9 olan 40 hastadan altısının idrar yolu infeksiyonu şikayeti olduğundan çalışma dışı bırakılmıştır ve kalan 34 yaşlıda asemptomatik bakteriüri sıklığı %17.6 ve en sık izole edilen etken Escherichia coli olarak bulunmuştur. Yaş, cinsiyet, uygunsuz antibiyotik kullanımı, inkontinans, diyabet ve invaziv ürolojik girişimlerle ile ASB arasında anlamlı ilişki saptanmamıştır. Sonuç: Sonuç olarak asemptomatik bakteriürinin 60 yaş üzerinde sık rastlanan bir durum olduğu ve tedavi amacıyla antibiyotik uygulanmasına gerek olmadığı, ancak konunun daha geniş serilerle araştırılmasının uygun olacağı kanısına varılmıştır.Öğe Huzurevi sakinlerinde dermatofit infeksiyonları(2007) Koçoğlu, Esra; Göksügür, Nadir; Karabay, Oğuz; Özbostancı, Betül; İnce, Nevin; Parlak, Ali HaydarYaşlı nüfusun önemli sağlık sorunlarından biri olan mantar infeksiyonları birçok malzemenin ortak kullanıldığı kapalı topluluklarda sık görülmektedir. Huzurevi sakinlerinde mantar infeksiyonlarının sıklığının bilinmesi ve takibi infeksiyon yayılımını ve olası komplikasyonları engelleyecektir. Bu araştırmada huzurevinde kalan yaşlılarda dermatofitoz sıklığı ile buna neden olan etkenlerin sıklığının belirlenmesi amaçlandı. Huzurevlerinde kalan 80 kişiye ulaşılarak dermatolojik muayeneleri yapılarak 65 şüpheli lezyondan alınan kazıntı örneklerinin mikroskopik değerlendirmesi ve mikolojik kültürleri yapıldı. Alınan örneklerden 23'ünde (% 35,4) direkt mikroskobide mantar elemanları görüldü. Toplam 17(% 26,2) kültürde üreme oldu. Bunların altısında (% 35,3) Trichophyton rubrum, beşinde (% 29,5) Epidermophyton floccosum, iki örnekte (% 11,8) Fusarium spp., iki örnekte (% 11,8) Candida spp. ve birer örnekte (% 5,8) Trichophyton tonsurans ve Trichophyton mentagrophytes üredi. Bu bulgular doğrultusunda huzurevlerinde yaşayan yaşlı insanlardaki dermatofitoz sıklığı ve etken dağılımının diğer yaşlı popülasyondan farklı olmadığı, huzurevlerinin ek bir risk oluşturmadığı kanısına varıldı.
