Yazar "Khan, Faheem Ahmed" seçeneğine göre listele

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    Bioinformatics tools make plant functional genomics studies easy
    (Springer International Publishing, 2017) Sameeullah, Muhammad; Aslam, Noreen; Khan, Faheem Ahmed; Aasim, Muhammad
    In the era of omics with the huge available data sets in field of genomics, transcriptomics, proteomics, metabolomics and phenomics need the quick access and efficiently use of the information to validate the functions for the particlular gene family or the gene of interest in the plant cell. Therefore, user-friendly bioinformatics tools are utmost important for the students, researchers, and scientists to carry out successful functional genomics experiments. Here we describe the free available online databases and tools that can be utilized without prior deep knowledge of bioinformatics. The access to genomics, transcriptomics, metabolomics, and phenomics tools will be beneficial for designing of intelligent experiments. Keywords Functional genomics Gene expression Comparative genomics Metabolomics Bioinformatics tools
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    CRISPR/Cas9-mediated immunity in plants against pathogens
    (Caister Academic Press, 2017) Sameeullah, Muhammad; Khan, Faheem Ahmed; Özer, Göksel; Aslam, Noreen; Gürel, Ekrem; Karadeniz, Turan
    Global crop production is highly threatened due to pathogen invasion. The huge quantity of pesticides application, although harmful to the environment and human health, is carried out to prevent the crop losses worldwide, every year. Therefore, understanding the molecular mechanisms of pathogenicity and plant resistance against pathogens is important. The resistance against pathogens is regulated by three important phytohormones, viz. salicylic acid (SA), jasmonic acid (JA) and ethylene (ET). Here we review the possible role of CRISPR technology to understand the plant pathogenicity by mutating genes responsible for pathogen invasion or up-regulating the phytohormones genes or resistant genes. Thus hormone biosynthesis genes, receptor and feeding genes of pathogens could be important targets for modifications using CRISPR/Cas9 following multiplexing tool box strategy in order to edit multiple genes simultaneously to produce super plants. Here we put forward our idea that the genes would be either mutated in case of plant receptor protein targets of pathogens or up-regulation of resistant genes or hormone biosynthesis genes will be better choice for resistance against pathogens.
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    Crispr/cas9-mediated immunity in plants against pathogens
    (Caister Academic Press, 2018) Sameeullah, Muhammad; Khan, Faheem Ahmed; Özer, Göksel; Aslam, Noreen; Gurel, Ekrem; Waheed, Mohammad Tahir; Karadeniz, Turan
    Global crop production is highly threatened due to pathogen invasion. The huge quantity of pesticides application, although harmful to the environment and human health, is carried out to prevent the crop losses worldwide, every year. Therefore, understanding the molecular mechanisms of path-ogenicity and plant resistance against pathogens is important. The resistance against pathogens is regulated by three important phytohormones, viz. salicylic acid (SA), jasmonic acid (JA) and ethylene (ET). Here we review the possible role of CRISPR technology to understand the plant pathogenicity by mutating genes responsible for pathogen invasion or up-regulating the phytohormones genes or resistant genes. Thus hormone biosynthesis genes, receptor and feeding genes of pathogens could be important targets for modifications using CRISPR/Cas9 following multiplexing tool box strategy in order to edit multiple genes simultane-ously to produce super plants. Here we put forward our idea that the genes would be either mutated in case of plant receptor protein targets of pathogens or up-regulation of resistant genes or hormone bio-synthesis genes will be better choice for resistance against pathogens. © 2018, Caister Academic Press. All rights reserved.
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    CRISPR/Cas9-mediated Immunity in Plants Against Pathogens
    (Mdpi, 2018) Sameeullah, Muhammad; Khan, Faheem Ahmed; Ozer, Goksel; Aslam, Noreen; Gurel, Ekrem; Waheed, Mohammad Tahir; Karadeniz, Turan
    Global crop production is highly threatened due to pathogen invasion. The huge quantity of pesticides application, although harmful to the environment and human health, is carried out to prevent the crop losses worldwide, every year. Therefore, understanding the molecular mechanisms of pathogenicity and plant resistance against pathogens is important. The resistance against pathogens is regulated by three important phytohormones, viz. salicylic acid (SA), jasmonic acid (JA) and ethylene (ET). Here we review the possible role of CRISPR technology to understand the plant pathogenicity by mutating genes responsible for pathogen invasion or up-regulating the phytohormones genes or resistant genes. Thus hormone biosynthesis genes, receptor and feeding genes of pathogens could be important targets for modifications using CRISPR/Cas9 following multiplexing tool box strategy in order to edit multiple genes simultaneously to produce super plants. Here we put forward our idea that the genes would be either mutated in case of plant receptor protein targets of pathogens or up-regulation of resistant genes or hormone biosynthesis genes will be better choice for resistance against pathogens.
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    Need of cost-effective vaccines in developing countries: what plant biotechnology can offer?
    (Springer International Publishing Ag, 2016) Waheed, Mohammad Tahir; Sameeullah, Muhammad; Khan, Faheem Ahmed; Syed, Tahira; Ilahi, Manzoor
    To treat current infectious diseases, different therapies are used that include drugs or vaccines or both. Currently, the world is facing an increasing problem of drug resistance from many pathogenic microorganisms. In majority of cases, when vaccines are used, formulations consist of live attenuated microorganisms. This poses an additional risk of infection in immunocompromised patients and people suffering from malnutrition in developing countries. Therefore, there is need to improve drug therapy as well as to develop next generation vaccines, in particular against infectious diseases with highest mortality rates. For patients in developing countries, costs related to treatments are one of the major hurdles to reduce the disease burden. In many cases, use of prophylactic vaccines can help to control the incidence of infectious diseases. In the present review, we describe some infectious diseases with high impact on health of people in low and middle income countries. We discuss the prospects of plants as alternative platform for the development of next-generation subunit vaccines that can be a cost-effective source for mass immunization of people in developing countries.
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    Recent developments in therapeutic protein expression technologies in plants
    (Springer, 2015) Fahad, Shah; Khan, Faheem Ahmed; Pandupuspitasari, Nuruliarizki Shinta; Ahmed, Muhammad Mahmood; Liao, Yu Cai; Sameeullah, Muhammad
    Infectious diseases and cancers are some of the commonest causes of deaths throughout the world. The previous two decades have witnessed a combined endeavor across various biological sciences to address this issue in novel ways. The advent of recombinant DNA technologies has provided the tools for producing recombinant proteins that can be used as therapeutic agents. A number of expression systems have been developed for the production of pharmaceutical products. Recently, advances have been made using plants as bioreactors to produce therapeutic proteins directed against infectious diseases and cancers. This review highlights the recent progress in therapeutic protein expression in plants (stable and transient), the factors affecting heterologous protein expression, vector systems and recent developments in existing technologies and steps towards the industrial production of plant-made vaccines, antibodies, and biopharmaceuticals.
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    Suppressing photorespiration for the improvement in photosynthesis and crop yields: A review on the role of S-allantoin as a nitrogen source
    (Academic Press Ltd- Elsevier Science Ltd, 2019) Fahad, Shah; Khan, Faheem Ahmed; Pandupuspitasari, NuruliarizkiShinta; Hussain, Saddam; Khan, Imtiaz Ali; Sameeullah, Muhammad
    Environmental variations resulting in biotic and abiotic stresses demand adaptive changes in the photosynthetic machinery. To cope with these challenges, plant scientists are constantly striving to enhance photosynthetic activity. The photorespiration pathway, which fixes O-2 and releases CO2 in C-3 plants, competes with photosynthesis. One method to increase yield would be to enhance photosynthesis by engineering the photorespiratory pathway. To date, three engineered photorespiratory pathways have been produced, of which two have been proven experimentally in the model plant, Arabidopsis thaliana. These approaches might be helpful in enhancing crop resilience to future environmental challenges. In partially photorespiratory suppressed plants, it is hypothesized that a gene cluster may have formed between bacterial glycolate dehydrogenase (GDH), glyoxylate carboligase (GCL), and tartronic semi aldehyde (TSR) genes with Arabidopsis allantoin degradation genes like Arabidopsis allantoinase (AtALN) to utilize S-allantoin as a source of nitrogen. Observations of the use of allantoin as an exclusive source of nitrogen or energy by Arabidopsis and Escherichia coli led us to propose a genetic switch control model between nitrogen assimilation and energy producing pathways in partially photorespiratory suppressed plants.
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    Suppressing photorespiration for the improvement in photosynthesis and crop yields: A review on the role of S-allantoin as a nitrogen source (vol 237, pg 644, 2019)
    (Academic Press Ltd- Elsevier Science Ltd, 2019) Fahad, Shah; Khan, Faheem Ahmed; Pandupuspitasari, NuruliarizkiShinta; Hussain, Saddam; Khan, Imtiaz Ali; Sameeullah, Muhammad
    The affiliation for the author “Elsayed Fathi Abd_Allah” has changed.