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Öğe Co-morbidity of migraine and major depression in the Turkish population(Sage Publications Ltd, 2003) Keçeci, Hulusi; Dener, Şefik; Analan, E.The aim of the present study was to estimate the co-morbidity of migraine and major depression in the Turkish population. The households were selected randomly from all district areas. The study included 947 subjects aged greater than or equal to 18 years. The diagnosis of migraine was made according to the criteria of the International Headache Society. The diagnosis of major depression was made according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria. Migraine was identified in 163 subjects. Major depression was identified in 155 subjects, and in 53 subjects with migraine. The lifetime prevalence of major depression was approximately three times higher in persons with migraine in this Turkish population.Öğe Diyabetik nöropatili hastaların nöropatik ağrı ve depresyon tedavisinde, antidepresan ve antiepileptik kullanımı: bir karşılaştırma(2011) Değirmenci, Yıldız; Keçeci, Hulusi; Karaman, Handan Işın ÖzışıkAmaç: Bu çalışmada, diyabetik nöropati (DN) hastalarında antidepresan olan amitriptilin ve venlafaksin SR ile antiepileptik olan lamotirijin ve okskarbazepinin ağrı ve depresyon üzerindeki etkilerinin araştırılması amaçlanmıştır. Gereç ve Yöntemler: Diyabetik nöropati tanısı konmuş hastalara nöropatik ağrı değerlendirmesine yönelik vizüel analog skala (VAS) ve Short-McGill ağrı anketi (SMAA) ile birlikte depresyon değerlendirmesinde kullanılan Beck Depresyon Envanteri (BDE) uygulanmasını takiben, rastgele ve randomize bir şekilde lamotrijin (2x50 mg/gün), okskarbazepin (2x300 mg/gün), amitriptilin (25 mg/gün) ve venlafaksin SR (75 mg/gün) tedavi rejimlerinden biri başlanmıştır. Hastalar 15 günlük aralarla toplam 6 kez kontrole çağrılmış ve her kontrolde VAS skorları ölçülmüştür. 6. ve son kontrolde ise VAS’a ek olarak SMAA ve BDE skorları ölçülmüştür. Bulgular:Tüm gruplarda, tedavi öncesi ve tedavi sonrası son BDE ve SMAA değerleri arasında istatistiksel olarak anlamlı farklılık saptanmıştır (p<0.05). Başlangıç VAS skorları benzer olan tüm tedavi gruplarında, 15. ve 30. ve 90. günlerde yapılan değerlendirmelerde VAS skorlarının tüm gruplar arasında istatistiksel olarak anlamlı farklılık gösterdiği saptanmıştır (p<0.05). Sonuç olarak lamotirijin ve okskarbazepin depresyon üzerinde amitriptilin ve venlafaksin SR kadar etkili olduğu bulunmuştur. Sonuç: Ağrılı DN ve eşlik eden depresyon varlığında antiepileptik ve antidepresanların benzer etkili olmaları tedavi alternatiflerinin arttırılması ve tedavinin kişiselleştirilmesine katkıda bulunması açısından önemlidir.Öğe Electrodermal activities and autonomic nervous system in behcet's patients(Springer-Verlag, 2002) Akyol, Melih; Turaçlar, Uğur; Keçeci, Hulusi; Özçelik, Sedat; Marufihah, Mehmet; Erdal, S.; Polat, MuratBehcet's disease is often a progressive disorder. In some cases, there is a possibility of subclinical involvement without neurologic signs and symptoms. The autonomic nervous system is affected in Behcet's disease. The aim of the present study was to investigate autonomic nervous system functions in Behcet's patients by analyzing electrodermal activities. A total of 16 patients and 16 healthy volunteers were accepted for the study. Skin potential recordings were taken at room temperature in a quiet place within a Faraday's cage. The mean values of basal skin potentials and skin potential responses in the patients' group were reduced when compared with those of the control group (p=0.0001). There was no difference between the groups regarding the mean values of latencies (p=0.09). The findings suggest that electrodermal activities may reflect autonomic nervous system dysfunction in Behcet's patients, and the measurement of electrodermal activities may be useful for the assessment of autonomic nervous system involvement in Behcet's disease.Öğe Epidemiological and clinical characteristics of migraine in Sivas, Turkey(Wiley, 2002) Keçeci, Hulusi; Dener, ŞefikObjective.-To investigate the epidemiology of migraine in Sivas, Turkey, including its prevalence, clinical characteristics, and impact according to age, sex, and socioeconomic status. Methods.-Thirteen hundred twenty subjects were personally interviewed by a neurologist. Each household member with headache was asked questions regarding their headaches including age at onset, frequency, duration, character, location, severity, aggravating and ameliorating factors, and prodromal and associated symptoms. Migraine diagnoses were determined in accordance with the classification criteria of the International Headache Society. Results.-Migraine was identified in 173 subjects (45 males and 128 females), and lifetime prevalence of migraine was 7.9% (95% CI, 5.66 to 10.1) in males and 17.1% (95% CI, 14 to 20) in females. Aura was reported by 1.4% of males and 3.3% of females. Conclusion.-Migraine prevalence in Turkey is similar to that reported in Europe and the United States.Öğe Habituation and dishabituation of P300(Lippincott Williams & Wilkins, 2006) Keçeci, Hulusi; Değirmenci, Yıldız; Atakay, SelçukObjective: We aimed to see the consequences of habituation and posthabituation by means of repeatedly measuring the effects over a longer period. Method: The study was performed on 27 healthy volunteers. The event-related potentials were recorded from the Fz, the Cz, and the Pz electrode sites. The rare tone-frequent tone probability ratio was 20%. All subjects were asked to press a button when they heard a rare tone. The test was continued until 20 artifact-free rare tones were averaged, which was accepted as I trial block. After 10 trial blocks were obtained in a sequential manner, the test was completed. Result: This study has indicated that P300 amplitudes decrease with repeated stimulations, that is, there is a habituation period. As the test continues, the speed of amplitude decrease slows down and after a while it even starts to increase: that is, a dishabituation occurs. Conclusions: It is very likely that this habituation relates to a period of learning and dishabituation relates to a period of mental fatigue. In these processes, changes of amplitude and latency values reflect changes in amount of neuronal activation.Öğe Habituation of auditory event-related potentials in patients with Behcet's disease(2004) Keçeci, Hulusi; Kavak, Ayşe; Akyol, Melih; Değirmenci, Yıldız; Anul, HüseyinBehcet's disease is a progressive and/or relapsing-remitting multisystem inflammatory disorder. Involvement of the central nervous system occurs in 10%-29% of cases with Behcet's disease. The aim of the present study was to assess the effect of repetitive auditory stimulations on event-related potentials (ERP) in patients with Behcet's without neurologic manifestations. The study was performed in 14 patients with Behcet's disease and 14 healthy volunteers. ERPs were recorded from Fz, Cz and Pz. The auditory ERPs test was continued until 20 artefact-free rare tones were averaged, which was accepted as one trial block. After six blocks were obtained in a sequential manner, the test was completed. According to the results of the present study, P300 latency changed in different manners over trial blocks in the two groups. P300 latency values showed a progressive increase in the controls; however this was not determined in the Behcet's group. Thus, habituation was not observed in the patient group. Because of the lack of habituation related to P300 latency, it may be thought that there is an insidious pathologic process in Behcet's disease without neurologic manifestation. © Springer-Verlag Italia 2004.Öğe Hormone replacement therapy in hypothyroidism and nerve conduction study(Elsevier France-Editions Scientifiques Medicales Elsevier, 2006) Keçeci, Hulusi; Değirmenci, YıldızObjectives. - To evaluate the electrodiagnostic evidence of peripheral nerve dysfunction in patients with hypothyroidism before and after hormone replacement treatment. Materials and methods. - Forty patients aged above 18 years diagnosed with hypothyroidism were included in our study. Patients with FT4 levels below 11.6 pmol/l and TSH levels above 4.2 IU/ml were accepted as hypothyroidic. Electrodiagnostic evaluation was performed at the onset of the study and after 3 months. Electrodiagnostic evaluation included motor and sensory nerve conduction studies, and F wave. Results. - The differences between pre- and post-treatment FT4, FT3 and TSH values were found to be statistically significant. At the onset, electrophysiological evaluation revealed carpal tunnel syndrome in 15 patients and polyneuropathy in seven patients; whereas 18 patients were found normal in these respects. After treatment, the electrodiagnostic evaluation revealed that 35 patients were normal, while only two patients had carpal tunnel syndrome and three patients had polyneuropathy. The differences between before and after treatment values of median motor distal latency and amplitude, median sensorial nerve conduction velocity, tibia[ motor nerve conduction velocity and sural. sensory nerve conduction velocity were found to be statistically significant. Conclusion. - The results of the control evaluation after treatment demonstrated that the findings related to entrapment neuropathy and polyneuropathy in hypothyroid patients can be reversible in a period of 3 months if appropriate hormone replacement treatment can be obtained. Especially in the treatment of entrapment neuropathy in hypothyroidism, the chance of medical treatment must be given to patients before considering surgical treatment.
