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Öğe Comparison of microporous polysaccharide hemospheres and Ankaferd Blood Stopper in a rabbit epistaxis model(Springer, 2016) Yurttaş, Veysel; Şereflican, Murat; Terzi, Elçin Hakan; Özyalvaçlı, Gülzade; Kazaz, HasanThe aim of this study was to evaluate the histopathological impact, effectiveness, and safety of two hemostatic agents, Ankaferd Blood Stopper (ABS) and microporous polysaccharide hemospheres (MPH), in an experimental rabbit epistaxis model. Rabbits were randomly assigned, using a computerized random number generator, to the following three groups of six animals: group 1 (control, irrigated with saline); group 2 (ABS-treated); and group 3 (MPH-treated). In all groups, a standardized rabbit epistaxis model was used. Hemostasis time and extent of nasal bleeding were measured to compare the hemostatic effect of ABS and MPH among groups. Septums were removed for histopathological analysis, 7 days after the procedure. ABS reduced hemostasis time to 104.2 s and amount of bleeding to 20.5 mg. MPH reduced hemostasis time to 71.7 s and amount of bleeding to 11.5 mg. Mean bleeding time in wounds administered ABS and MPH was significantly shorter compared with wounds administered isotonic saline solution (p = 0.004). ABS and MPH application decreased bleeding significantly compared with the control group (p = 0.004). Bleeding time and amount in the MPH group was significantly reduced compared with the ABS group (p = 0.013 and p = 0.004, respectively). There was no significant difference in the histopathological evaluation results between the ABS, MPH, and control groups. Our data indicate that both ABS and MPH represent safe, effective, and fast-acting hemostatic agents in the management of epistaxis. MPH was more effective than ABS in terms of hemostasis time and amount of bleeding.Öğe Effect of n-butyl-2-cyanoacrylate on the tensile strength and pressure resistance of tracheal anastomoses ex vivo(Sage Publications Ltd, 2015) Biçer, Yusuf Özgür; Köybaşı, Serap; Kazaz, Hasan; Seyhan, SinanObjectives To investigate the effects of n-butyl-2-cyanoacrylate on tracheal anastomoses in terms of increased tension and intraluminal pressure ex vivo. Study Design Ex vivo experimental study. Setting Tertiary referral center (Department of Otolaryngology). Subjects and Methods Thirty sheep tracheas were used. Four cartilage rings were resected from the tracheas that were 20 cm in length. End-to-end anastomoses were performed by using Vicryl only (group 1), Vicryl and n-butyl-2-cyanoacrylate (group 2), and n-butyl-2-cyanoacrylate only (group 3). The amount of force to break off the anastomosis and the amount of intraluminal pressure to arouse air leakage through the anastomosis were measured. Results The mean force required to break off was 171.9 29.7 N in group 1, 164.8 +/- 26 N in group 2, and 13.52 +/- 2 N in group 3. The mean force required to break off in group 3 was significantly lower than those in groups 1 and 2 (P = .008 and P = .008, respectively). The mean pressure required to cause air leakage was 49.6 +/- 9.1 mm Hg in group 1, 113 +/- 14.4 mm Hg in group 2, and 15 +/- 4.2 mm Hg in group 3. Group 2 was found to be more resistant to intraluminal pressure than groups 1 and 3 (P = .008 and P = .008, respectively). Conclusion n-Butyl-2-cyanoacrylate had no significant effect on tensile strength. However, its application on the suture line provided extra pressure resistance ex vivo. We believe that further studies need to be conducted to investigate its long-term effects and histological impact on tracheal anastomoses in vivo.Öğe Effects of septoplasty on nasal and oropharyngeal microbial flora(Academic Journals, 2011) Apuhan, Tayfun; Koçoğlu, Esra; Yıldırım, Yavuz Selim; Şimşek, Tuğçe; Kazaz, Hasan; Gök, ÜzeyirWe characterized the changes in oropharyngeal and nasal flora of the patients with a deviated nasal septum before and after septoplasty. Patients who underwent septoplasty for nasal septal deviation were included in this study. Nasal and oropharyngeal cultures were taken with a sterile cotton swab preoperatively and one month after septoplasty. Antimicrobial susceptibility testing was performed using the disc method. Fifty-nine patients with a deviated nasal septum were included in the study: 29 women and 30 men, whose ages ranged from 18 to 40 years. There was no significant difference between the preoperative and postoperative (one month after surgery) isolated bacteria of the nasal and oropharyngeal regions. Septoplasty did not change the nasal and oropharyngel microbial flora in patients who underwent septoplasty for nasal septal deviation.Öğe High sensitivity C-reactive protein levels in chronic rhinosinusitis and allergic rhinitis(2011) Yıldırım, Yavuz Selim; Apuhan, Tayfun; Koçoğlu, Mücahide Esra; Şimşek, Tuğçe; Kazaz, HasanAmaç: Bu çalışmada alerjik rinitli, nazal polipli ve polipsiz kronik rinosinüzitli (KRS) hastaların periferik kanlarındaki yüksek duyarlılıklı C-reaktif protein (hs-CRP) düzeyleri arasındaki ilişki değerlendirildi. Hastalar ve Yöntemler: Çalışmaya dahil edilen 100 hasta; alerjik rinitli hastalar (grup 1), nazal polipli KRS’li hastalar (grup 2), nazal polipsiz KRS’li hastalar (grup 3) ve sigara içmeyen kontroller (grup 4) olmak üzere 25’er kişilik dört gruba ayrıldı. Tüm hastalara detaylı semptom sorgulaması, fizik muayene, tam kan sayımı ve paranazal sinüs radyografileri yapıldı. Tüm hastalarda hs-CRP düzeyleri semi kantitatif olarak, lateks ile güçlendirilmiş immünonefelometrik yöntem ile ölçüldü. Bulgular: Yüksek duyarlılıklı-CRP düzeyleri açısından grup 1, grup 2 ve grup 3 ile kontrol grubu arasında istatistiksel olarak anlamlı farklılık yoktu (sırasıyla; p=0.861, p=0.7196 ve p=0.127). Sonuç: Alerjik rinit, nazal polipli KRS ve nazal polipsiz KRS gruplarında periferik kan hs-CRP düzeyleri kontrol grubu ile karşılaştırıldığında istatistiksel anlamlı farklılık saptanmadı.Öğe Nazal septum cerrahisinde kullanılan hidroksiapatitin histolojik ve fonksiyonel etkilerinin bir tavşan modelinde araştırılması(Bolu Abant İzzet Baysal Üniversitesi, 2014) Kazaz, Hasan; Biçer, Yusuf ÖzgürÖZET Hasan K. Nazal septum cerrahisinde kullanılan hidroksiapatitin histolojik ve fonksiyonel etkilerinin bir tavşan modelinde araştırılması. Abant İzzet Baysal Üniversitesi Tıp Fakültesi, Kulak Burun Boğaz Baş ve Boyun Cerrahisi, Tıpta Uzmanlık Tezi, Bolu, 2014. Amaç Hidroksiapatit 20 yılı aşkın süredir tıp alanında kullanılan bir biyomateryaldir. Rinoplastide augmentasyon materyali olarak kullanıldığına dair bilgiler mevcuttur. Fakat septoplastide kullanımıyla ilgili yeterli bilgi yoktur. Araştırmamızda hidroksiapatitin nazal septum cerrahisinde kullanımının histolojik ve fonksiyonel etkilerini bir tavşan modeli kullanarak araştırmayı hedeflendi. Metod Ağırlıkları 1.8 ile 2.8 kg arasında değişen 24 adet Yeni Zellanda tavşanı kullanıldı. Denekler her biri 8 tavşandan oluşan 3 gruba ayrıldı. Grup 1'de septum ön ucundan yaklaşık 1×0.5cm'lik kıkırdak çıkarılıp kıkırdağa herhangi bir işlem yapılmadan tekrar yerine yerleştirildi. Grup 2'de septumun ön ucundan 1×0.5cm 'lik kıkırdak çıkarılarak yerine aynı boyutta hidroksiapatit plaka yerleştirildi. Grup 3'deki deneklerde ise septumun ön ucundan 1×0.5cm'lik kıkırdak çıkarıldı ve aynı boyuttaki hidroksiapatit plakayla yan yana gelecek şekilde çıkarıldığı yere yerleştirildi. Denekler 3 ay boyunca takip edildi ve bu esnada periyodik olarak muayene bulguları kaydedildi. Deney sonunda denekler sakrifiye edilip septumun ilgili bölgesi makroskopik olarak değerlendirilip histolojik incelemeye alındı. Bulgular Grup 1'den alınan örneklerde inflamasyon bulguları çok hafifti ya da yoktu. Grup 2 ve 3 de grup 1'dekinden daha fazla inflamasyona rastlandı. Grup 1'deki inflamasyon şiddetindeki bu fark istatistiksel olarak anlamlıydı. (p=0.005) İnflamasyon şiddeti Grup 3'te, Grup 2'de olduğundan daha fazlaydı. Fakat bu fark istatistiksel olarak anlamlı değildi. (p=0,161) Grup 2 deki deneklere ait örnekler değerlendirildiğinde tüm greftlerin rejeksiyona uğradığı tespit edildi. Hem hidroksiapatit hem de kıkırdağın birlikte yerleştirildiği Grup 3'teki deneklerden elde edilen örnekler incelendiğinde ise 3 denekte hidroksiapatit plakanın atılmamış olduğu, 5 denekte ise atılmış olduğu tespit edildi. Grup 2 ve Grup 3 greft materyalinin atılımı açısından karşılaştırıldığında iki grup arasında 1. ay, 2.ay ve 3.ayda istatistiksel olarak anlamlı fark olmadığı görüldü.(Sırasıyla p=0.50, p=0.31, p=0.10). Sonuç Çalışmamızın sonucunda elde ettiğimiz veriler hidroksiapatitin kullanıldığı haliyle tavşan septumunda allogreft olarak kullanımının oldukça zor olduğunu göstermektedir. Özellikle daha ince ve daha geniş gözenekli hidroksiapatit plakalarla yapılacak hayvan deneylerinin yol gösterebileceği düşünülmüştür.Öğe Outcomes from cyanoacrylate use in tracheal anastomosis in a rat model(Sage Publications Ltd, 2015) Biçer, Yusuf Özgür; Köybaşı, Serap; Seyhan, Sinan; Fırat, Tülin; Kazaz, HasanObjectives We aimed to investigate the histologic effects of N-butyl-2-cyanoacrylate (NBCA) and metacryloxisulfolane (MS) comonomer on tracheal anastomosis in vivo on a rat model of tracheal resection and end-to-end anastomosis. Study Design Animal experiment. Rat model of tracheal resection and end-to-end anastomosis. Setting Animal laboratory. Subjects and Methods Tracheal resection and end-to-end anastomosis were performed in 28 Wistar albino rats. Rats were randomly divided into 2 groups: control (n = 14), in which anastomoses were performed with 8/0 Vicryl, and study (n = 14), in which NBCA and MS comonomer was used in addition to 8/0 Vicryl to perform anastomosis. Seven rats from each group were sacrificed on day 7 and the remaining on day 28 for gross and histologic examination. Results Indurations at the site of anastomoses were detected in all rats of study group. Slight narrowing at the site of anastomosis was observed in 8 rats of the study group and in only 1 of the control group. The difference was significant on day 28 (P = .021). The inflammatory cell infiltration was significantly increased in the study group on day 28 (P = .022). Epithelial regeneration was found to be worse in the study group on day 28 (P = .022). Conclusions The use of NBCA and MS comonomer increased the inflammation in rat tracheal anastomosis with respect to inflammatory cell count and epithelial regeneration. So the use of NBCA and MS comonomer in tracheal surgery cannot be recommended yet in the light of our data.Öğe Vitamin A, Vitamin D, Zinc and Iron Levels in Children Undergoing Adenoidectomy and Placement of Tympanostomy Tubes(Duzce Univ, 2014) Apuhan, Tayfun; Bugdayci, Guler; Simsek, Tugce; Kazaz, HasanObjectives: Adenoidectomy and the placement of tympanostomy tubes are among the most commonly performed surgical procedures in ear nose and throat clinics. Systemic and local causes have been implicated in the pathophysiology leading to these procedures. The aim of this study was to investigate a possible association between levels of vitamin A, vitamin D, iron, and zinc need to undergoing adenoidectomy and placement of tympanostomy tubes. Material and Methods: Demographic and disease- specific data were obtained from 31 Turkish children undergoing adenoidectomy and the placement of tympanostomy tubes, and 14 controls. Blood samples were taken for measurement of vitamin A, zinc, iron, and 25- hydroxy vitamin D (25[OH] D). All measurements were done in the same laboratory by the same researcher. Results: The study group comprised 13 (41.9%) girls and 18 (58.1%) boys, and the control group 7 (50%) girls and 7 (50%) boys. There were no statistically significant differences between study and control groups in plasma 25(OH) D, iron, zinc, or vitamin A levels (p> 0.05). Conclusions: This pilot study did not show an association between serum vitamin D, iron, zinc, and vitamin A and the need to have an adenoidectomy and placement of tympanostomy tubes.
