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Bilateral acute depigmentation of the iris determined in two cases after COVID-19 infection
(Wolters Kluwer Medknow Publications, 2023) Soydan, Adem; Kaymaz, Abdulgani
Bilateral acute depigmentation of the iris (BADI) is a rare disease characterized by iris atrophy. Although it can be self-limiting, it is sometimes progressive and can lead to glaucoma and severe vision loss. Two female patients were admitted to our clinic because of a change in iris color following coronavirus disease 2019 (COVID-19) infection. After the exclusion of other etiologies in the eye examination, BADI was diagnosed in both cases. Thus, it was shown that COVID-19 may also be involved in the etiology of BADI.
Evaluation and comparison of optical coherence tomography angiography (OCTA) parameters in normal and moderate myopic individuals
(Elsevier, 2024) Toprak, Güvenç; Ulaş, Fatih; Kaymaz, Abdulgani; Soydan, Adem; Kaplan, Abdulfatih; Alkan, Yunus; Özdemir, Buse; Bayrak, Abdullah
Objective: The objective of this study was to evaluate and compare Optical Coherence Tomography Angiography (OCTA) parameters in patients with moderate myopia and healthy individuals retrospectively. Methods: A total of 80 male individuals aged 18-20 years were included in the study with 40 moderate myopic and 40 healthy persons. All participants underwent detailed ocular examination including refraction, intraocular pressure (IOP), visual acuity, biomicroscopy, OCTA measurement and optic biometry measurement. Retinal, retinal nerve fiber layer and choroidal layer thicknesses were evaluated in mu m with the help of the software available in the OCTA device. Results: The mean axial length (24.32 +/- 0.53 mm) was statistically significantly higher in the moderate myopic group (24.32 mm) compared to the healthy group (23.33 +/- 0.61 mm) (p < 0.001). Spherical equivalent (SE) was found as -3.79 +/- 0.91 D in the moderate myopic group and -0.22 +/- 0.32 D in the healthy group (p < 0.05). The mean superficial foveal mean density (FovSupMVD) and the mean deep foveal mean density (FovDepMVD) were statistically significantly lower in the moderate myopic group than in the healthy group (both, p < 0.001). The mean retinal temporal thickness (RTt) was statistically significantly lower in the moderate myopic group (p = 0.017). There was a mild negative correlation between axial length and FovSupMVD, FovDepMVD in myopes. In axial length ROC analysis, the cutoff value for moderate myopes was found to be 24.15 mm. Mean superficial foveal mean density (FovSupMVD) and mean deep foveal mean density (FovDepMVD), mean retinal temporal thickness (RTt) were significantly lower in the group above 24.15 mm axial length compared to the group below 24.15 mm axial length (all three, p < 0.001). Foveal avascular zone was significantly higher in the group above 24.15 mm axial length (p = 0.016) Conclusion: The results of our study indicate that the mean axial length and spherical equivalent were significantly higher, while retinal temporal thickness, the mean superficial foveal mean density and the mean deep foveal mean density were significantly lower in patients with myopia up to -6.0 D compared to the healthy individuals.
Evaluation of retina and retinal nerve fiber layer thicknesses with vitamin b12 deficiency
(Wiley-Blackwell, 2016) Doğan, Ümit; Türkoğlu, Şule Aydın; Ulaş, Fatih; Soydan, Adem; Kaymaz, Abdulgani; Eroğlu, Tarık; Ağca, Sümeyra
Aim: We aimed to compare the retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) thickness of B12 vitamin deficiency patients with healthy controls using optical coherence tomography (OCT). Methods: Forty-six patients (27 females / 19 males) diagnosed with B12 vitamin deficiency and 46 healthy controls (26 females / 20 males) with similar age and sex were included in the study. RNFL thickness of global, superotemporal, temporal, inferotemporal, superonasal, nasal and inferonasal sectors and GCL thickness and volume measurements of central, superior, inferior, temporal, and nasal sectors were performed using Spectralis-OCT device in all cases. Results: The mean age of the patient group was 42.17±15.34 years, while that of the control group was 44.21±12.34 years (p=0.528). Mean serum vitamin B12 levels were measured as 163,47±19,80 pg/ml in the patient group and 311,80±76,30 pg/ml in the control group (p <0,01). There was no statistically significant difference between the global RNFL thicknesses of the two groups (p> 0,05). However, statistically non-significant thinning was observed in the superotemporal and global RNFL thickness of the group with B12 vitamin deficiency (p values are 0,140 and 0,171, respectively). There was also no statistically significant difference between GCL thicknesses and volumes of the two groups (p> 0.05). Conclusions: No significant reduction was observed in RNFL and GCL thicknesses of adult subjects with B12 vitamin deficiency compared with healthy controls. Keywords: Ganglion cell layer; optical coherence tomography; retinal nerve fiber layer; vitamin B12 deficiency.
Evaluation of retinal and choroidal thickness in various age groups
(2018) Çelik, Fatih; Ulaş, Fatih; Kaymaz, Abdulgani; Özsoy, Ercan
Aim: To evaluate retinal and choroidal thickness of healthy individuals in various age groups with optical coherence tomography (OCT) and enhanced depth imaging (EDI)-OCT technique . Material and methods: Totally 149 healthy patients aged between 0 and 69 years from seven different decades were included in this study. The retinal and choroidal thickness of the central area (fovea) and of the nasal and temporal points at a distance of 1500 ?m from this central point were measured in the right eye with an OCT device (Heidelberg, Germany) in all subjects. The subjects with any ocular or systemic pathology and the subjects with a spherical refractive error more than 3 D or a cylindrical refractive error more than 1 D were excluded. The measurements of right eyes of the subjects were used in the statistical analysis and the P value less than 0.01 was considered to be significant. Results: The mean retinal thickness measurements were 326.61±16.89 µm at the temporally, 218.72±19.06 µm centrally and 351.32±17.74 µm nasally, with no statistically significant difference between the age groups (p?0.01). The mean choroidal thickness measurements were 299.01±72.38 µm temporally, 332.34±78.08 µm centrally and 258.30±71.80 µm nasally. There were statistically significant differences in central and temporal choroidal thickness between age groups (p?0.01). Conclusion: A statistically significant decrease was present in the choroidal thickness but not in the retinal thickness with age.
Evaluation of subjects with a moderate cup to disc ratio using optical coherence tomography and Heidelberg retina tomograph 3: impact of the disc area
(Medknow Publications & Media Pvt Ltd, 2015) Ulaş, Fatih; Doğan, Ümit; Kaymaz, Abdulgani; Çelik, Fatih; Çelebi, Serdal
The aim was to evaluate subjects with a moderate cup to disc ratio using optical coherence tomograph (OCT) and Heidelberg retina tomograph (HRT) 3. Settings and Design: We included 80 patients with early glaucoma and 80 nonglaucomatous subjects with moderate cup/disc ratio (range of 0.5-0.8) to this cross-sectional study. Subjects and Methods: We compared results of color-coded algorithms of HRT 3 (Moorfields regression analysis [MRA] and Glaucoma probability score [GPS]) and OCT. All outputs are classified into three categories: Within normal limits (WNLs), borderline and outside normal limits (ONLs). Diagnostic accuracies of algorithms were determined using the highest sensitivity criteria. Results: The sensitivities of global MRA, GPS and OCT were 0.75, 0.925 and 0.725, respectively, in average disc area group and 0.85, 1.0 and 0.425, respectively, in large disc area group. The specificities of global MRA, GPS and OCT were 0.55, 0.15 and 0.85, respectively, in average disc area group and 0.425, 0.025 and 0.80, respectively, in large disc area group. Area under receiver operating characteristic curve (AUROC) of global MRA, GPS and OCT were 0.667, 0.617 and 0.792, respectively, in average disc area group and 0.746, 0.576 and 0.627, respectively, in large disc area group. AUROC of global MRA and OCT combination in the average and large disc area groups were 0.828 and 0.825, respectively. Conclusions: In contrast to GPS and OCT algorithms, diagnostic performance of MRA algorithm increased in large disc area group. Combining MRA and OCT algorithms produced satisfactory diagnostic performance in subjects with an average and large disc area.
Evaluation of the acute effects of cigarette smoking on the eye of non-Smoking healthy young male subjects by optical coherence tomography angiography
(Taylor & Francis Ltd, 2020) Kaymaz, Abdulgani; Ulaş, Fatih; Toprak, Güvenç; Uyar, Enes; Çelebi, Serdal
Purpose: Investigation of the acute effects of cigarette smoking on the eye using optical coherence tomography angiography (OCTA) on young healthy non-smoking male subjects. Materials and methods: The right eye of 25 healthy non-smoking male subjects were included in this study. Selected parameters of the macular and circumpapillary vasculature were measured, including macular flow indices, foveal avascular zone, vessel densities of macula and optic disc using OCTA. The measurements of the subjects were performed on the first day without smoking at 0 min, 5 min, 30 min and 60 min. Measurements were repeated at the same regime on the second day after smoking. Paired samples t-test and repeated measures one-way analysis of variance test was used for the statistical analysis. Results: The repeated measures analysis of variance test using the Bonferroni adjustment demonstrated a significant change for superficial and deep foveal vessel density, flow area of choriocapillaris, and circumpapillary capillary density following smoking (range of p value was <0.001-0.004). Intraocular pressure, foveal avascular zone area, flow area of outer retina and foveal non-flow area of superficial layer measurements did not have any significant changes following smoking (range of p value was 0.192-0.812). Conclusion: In non-smoking cases, even smoking only one cigarette significantly decreased the vessel density parameters at the acute period. Even though there was an increase in measured parameters shortly after smoking, it had lessened when compared to non-smokers, even one hour following smoking.
Evaluation of the effect of Carvacrol on retinal neovascularization in rats
(2021) Kaymaz, Abdulgani; Erimşah, Sevilay
Objectives: To compare the effect of intraperitoneal administered Carvacrol with bevacizumab in anoxygen-induced retinopathy (OIR) model in rats.Materials and Methods: Twenty-eight newborn rats were included in the study and the OIR model wascreated with the 50/10% oxygen style. The study consisted of 4 groups and each rat in the groups receivedan intraperitoneal injection of 0.01 mL once on the postnatal 14th day. While the OIR model was not createdin Group I (control group), it was created for Groups II, III, and IV. Groups I and II were injected with 0.9%NaCl solution, Group III with bevacizumab, and Group IV with carvacrol. The rats were sacrificed on thepostnatal 18th day.Results: Histopathological and immunohistochemical studies showed that the number of retinal vascularendothelial cells (RVECs) and nuclear factor (NF)-?B levels decreased similarly in Group III and Group IVcompared to Group II. RVECs values for Group I, Group II, Group III and Group IV were measured as1.26±0.80, 27.10±3.63, 7.54±1.38, and 6.22±1.22, respectively and it differed significantly between groups(p<0.001). Likewise, NF-?B levels were recorded as 0.61 ± 0.30, 4.36±0.65, 2.68±0.44, and 2.85±0.58,respectively and it differed significantly between groups (p<0.001). On the other hand, RVECs and NF-?Blevels were similar between Group III, and Group IV (p values were 0.58 and 0.91, respectively).Conclusions: The study demonstrated that carvacrol significantly reduced retinal pathologicalneovascularizations, RVECs, and NF-?B levels. Moreover, the observed effects were comparable to those ofbevacizumab.
Glokom olgularında dört farklı cihazla ölçülen göz içi basınçlarının karşılaştırılması ve merkezi kornea kalınlığı ile ilişkileri
(Bolu Abant İzzet Baysal Üniversitesi, 2013) Kaymaz, Abdulgani; Çelebi, Serdal
ÖZET Abdulgani Kaymaz, Glokom Olgularında Dört Farklı Cihazla Ölçülen Göz İçi Basınçlarının Karşılaştırılması ve Merkezi Kornea Kalınlığı ile İlişkileri. Uzmanlık Tezi, Bolu, 2013. Glokom göz içi basıncı (GİB) artışı, optik sinir başında (OSB) çukurlaşma ve atrofi, ilerleyici görme alanı kaybı ile seyreden bir optik nöropatidir. Glokomda artmış GİB; tanı, sınıflandırma ve hastalık takibinde yol gösteren en önemli göstergedir. Bu nedenle GİB'nin doğru ve güvenilir ölçümü gereklidir. Glokomun seyri boyunca görmede meydana gelen fonksiyonel kaybı perimetri ile tespit etmek mümkündür. Ancak, saptanabilir görme alanı (GA) kaybı meydana gelmeden önce, önemli oranda hücre kaybı gerçekleşmektedir. Bu nedenle, araştırmacılar glokomun erken tanısını sağlayacak daha yeni ve güvenilir yöntemleri araştırmaktadır. Çalışmamızda glokom tanısı almış olgularda; Goldmann aplanasyon tonometresi (GAT), Tonopen tonometre (Tonopen Avia) ve nonkontakt tonometreler (NKT) (Canon TX-10 ve TX-20P) ile ölçülen GİB değerlerini kıyaslayarak, bu cihazlarla ölçülen GİB?nin merkezi kornea kalınlığı (MKK) ile ilişkilerini araştırdık. Toplam 67 hastanın 37`si erkek (% 55,2), 30`u kadın (% 44,8) olup, yaş ortalaması 64,09±8,017 idi. Primer açık açılı glokomlu (PAAG) hasta sayısı 46 (% 68,7), psödoeksfoliyatif glokomlu (PEG) hasta sayısı 21 (% 31,3) idi. Çalışmamızda NKT TX-10 ve TX-20P GİBstd (Merkezi kornea kalınlığına göre düzeltilmemiş Canon TX-20P GİB ölçümü) cihazları ile ölçülen GİB sonuçlarıyla MKK arasında istatistiksel olarak anlamlı orta düzeyde ilişki saptandı (sırasıyla TX-10 r=0,285, p=0,019, TX-20P GİBstd r=0,326, p=0,007). NKT TX-20P GİBcor (Merkezi kornea kalınlığına göre düzeltilmiş Canon TX-20P GİB ölçümü), Tonopen ve GAT ile ölçülen GİB değerleri ile MKK arasında istatistiksel olarak anlamlı ilişki saptanmadı (TX-20P GİBcor p=0,825, Tonopen p=0,980 ve GAT p=0,740). GAT ile Tonopen (p=0,705) ve TX-10 ile Tonopen (p=0,104) cihazlarıyla ölçülen GİB değerleri arasında istatistiksel olarak anlamlı fark saptanmadı. Sonuç olarak NKT cihazları ve Tonopen ile ölçülen GİB değerleri GAT ile ölçülen değerlere göre daha yüksek saptanmıştır. Canon TX-10 ve Tonopen ile ölçülen GİB değerleri GAT ile ölçülene göre hafif yüksek olmasına rağmen (sırasıyla yaklaşık olarak 1,5 mmHg ve 1,8 mmHg), % 95?lik güvenilirlik aralığı değerleri (sırasıyla 5,5 mmHg ve 5,6 mmHg) klinik olarak kabul edilemeyecek düzeylerdeydi. Canon TX-20 GİBstd ve TX-20P GİBcor ile ölçülen GİB değerleri, GAT ile ölçülen GİB değerlerine göre oldukça yüksek değerler vermekte (sırasıyla yaklaşık olarak 3 mmHg ve 3,5 mmHg) ve bu değerler klinik olarak kabul edilebilir düzeylerde değildir. MKK ile GAT, Tonopen ve Canon TX-20P GİBcor ile ölçülen GİB değerleri arasında ilişki saptanmadı (p>0,05). NKT Canon TX-10 ve NKT Canon TX-20P GİBstd ile ölçülen GİB değerleriyle MKK arasında pozitif yönde orta derecede korelasyon saptandı (sırasıyla TX-10 r=0,285, p=0,019, TX20-Pstd r=0,326, p=0,007). Anahtar Kelimeler: Glokom, Goldmann aplanasyon tonometresi, tonopen tonometre, nonkontakt tonometre, merkezi kornea kalınlığı.
Glokomlu olgularda dört farklı tonometreyle ölçülen göz içi basınç ölçüm sonuçlarının karşılaştırılması ve merkezi kornea kalınlığı ile ilişkileri
(2014) Kaymaz, Abdulgani; Çelebi, Serdal; Ulaş, Fatih; Doğan, Ümit
Amaç: Glokomlu olgularda dört farklı tonometreyle ölçülen göz içi basınçlarının (GİB)karşılaştırılması ve merkezi kornea kalınlığı (MKK) ile ilişkilerinin araştırılması. Gereç ve Yöntem: Çalışmamızda glokom tanısı almış olguların Goldmann aplanasyon tonometresi (GAT), Tonopen tonometre (Tonopen Avia) ve nonkontakt tonometreler (NKT) (Canon TX-10 ve TX-20P) ile GİB ölçümleri ve ultrasonik pakimetre cihazı ile MKK ölçümleri yapıldı. Bulgular: Çalışmaya katılan 67 glokomlu olgunun yaş ortalaması 64,09±8,017 idi. Çalışmamızda Canon TX-10 ve TX-20P GİBstd (MKK'ye göre düzeltilmemiş Canon TX-20P GİB ölçümü) ile ölçülen GİB sonuçlarıyla MKK arasında istatistiksel olarak anlamlı orta düzeyde ilişki saptandı (sırasıyla TX-10 r=0,285, p=0,019, TX-20P GİBstd r=0,326, p=0,007). NKT TX-20P GİBcor (MKK'ye göre düzeltilmiş Canon TX-20P GİB ölçümü), Tonopen ve GAT ile ölçülen GİB değerleri ile MKK arasında istatistiksel olarak anlamlı ilişki saptanmadı (TX-20P GİBcor p=0,825, Tonopen p=0,980 ve GAT p=0,740). Canon TX-10 ve Tonopen ile ölçülen GİB değerleri GAT ile ölçülene göre hafif yüksek olmasına rağmen (sırasıyla 1,5 ve 1,8 mmHg) % 95’lik güven aralığı değerleri (sırasıyla 5,5 ve 5,6 mmHg) klinik olarak kabul edilemeyecek düzeylerdeydi. Canon TX-20P GİBstd ve TX-20P GİBcor değerleri GAT ile ölçülen GİB değerlerine göre klinik olarak kabul edilemeyecek düzeylerde yüksekti (sırasıyla 3 ve 3,5 mmHg). Sonuç: GAT, Canon TX-10, Canon TX-20P ve Tonopen ölçüm sonuçları birbirlerinin yerlerine kullanılmamalıdır.
Have problems been experienced in the treatment of eye patients during the COVID-19 pandemic?
(2021) Kaymaz, Abdulgani; Soydan, Adem
To investigate whether there are delays in the treatment of patients with eye diseases during the Covid-19 pandemic. Two hundred patients were included in the study. The problems experienced in the treatment of the patients due to the pandemic and the cause of these problems were investigated. The number of patients whose treatment was delayed was 84 and the mean delay time in treatment was 4.51±2.16 months. The patients who delayed the treatment the most were patients with glaucoma, retinal vascular occlusion, cataract, diabetes mellitus, age-related macular degeneration, and hypertension (86%, 75%, 64%, 53%, 43%, 33%, respectively). The rate of patients presenting due to decreased visual acuity was 24%. It was observed that 39% of all patients had coronaphobia. It is obvious that pandemic disrupts the treatment process of many diseases, including eye diseases. It will be beneficial to create new treatments and follow-up protocols for chronic eye diseases for pandemic periods.
Investigating the effects of carvacrol in rats using oxygen-induced retinopathy model
(Wolters Kluwer Medknow Publications, 2021) Kaymaz, Abdulgani; Ulaş, Fatih; Çetinkaya, Ayhan; Erimşah, Sevilay
Purpose: Investigating the effects of intraperitoneal carvacrol administration in rats using the oxygen-induced retinopathy (OIR) model. Methods: A total of 28 newborn Sprague Dawley rats were used and the OIR model was created using the 50/10% oxygen model. The study composed of four groups in total. While the OIR model was not used in Group I (control group), it was created for Groups II, III, and IV. About 0.01 mL carvacrol, bevacizumab, or 0.9% NaCl was administered intraperitoneal (IP) to the rats in all groups on postnatal day (PND) 14 as follows: Group I and Group II were administered 0.9% NaCl, Group III was administered bevacizumab, and Group IV was administered carvacrol. On PND 18, rats were sacrificed and their right eyes were enucleated. Results: Histopathological and immunohistochemical studies showed that the number of vascular endothelial cells (VECs), vascular endothelial growth factor (VEGF), and tumor necrosis factor-alpha (TNF-alpha) decreased similarly in Group III and Group IV compared with Group II. VECs values for Group I, Group II, Group III, and Group IV were measured as 0 +/- 0, 26.45 +/- 4.57, 7.75 +/- 1.98, and 5.78 +/- 1.72, respectively, and it differed significantly between groups (P < 0.001). Likewise, VEGF levels were observed as 0.06 +/- 0.01, 3.31 +/- 0.53, 2.47 +/- 0.44, and 2.49 +/- 0.52, respectively, and it differed significantly between groups (P < 0.001). TNF-alpha levels were recorded as 0.06 +/- 0.01, 3.58 +/- 0.38, 2.46 +/- 0.49, and 2.29 +/- 0.25, respectively, and it differed significantly between groups (P < 0.001). VECs, VEGF, and TNF-alpha were similar between Group III and IV (range of P values were 0.486-0.998). Conclusion: The study demonstrated that carvacrol significantly reduced retinal pathological angiogenesis, NV, VEC nuclei count, VEGF, and TNF-alpha levels. Moreover, the observed effects were comparable to those of bevacizumab.
Investigation of the effect of quercetin in an experimental oxygen-induced retinopathy model
(2021) Kaymaz, Abdulgani; Ulaş, Fatih; Erimşah, Sevilay; Öztabag, Cansu Kara
Aim: To investigate of the effect of intraperitoneal (IP) quercetin and bevacizumab on oxygen-inducedretinopathy (OIR) model in rats.Methods: In the study, 28 newborn rats were used. The OIR model was performed with the 50/10% oxygentechnique. The study consisted of four groups as a control group (Group I) and OIR groups (Group II, III, andIV). IP injection applied to all groups on the postnatal day (PND) 14. Groups I and II were performed 0.9%NaCl, Group III was performed IP bevacizumab, and Group IV was performed IP quercetin. All animals weresacrificed on PND 18.Results: Based on the data obtained from immunohistochemical and histopathological examinations, thenumber of vascular endothelial cell (VEC), vascular endothelial growth factor (VEGF), and tumor necrosisfactor-? (TNF-?) levels were significantly reduced in Group III and IV compared to Group II. VECs levelswere 0±0, 32.69±5.77, 2.92±0.63, and 3.64±0.36 in Group I, Group II, Group III, and Group IV, respectively(p<0.001). Likewise, VEGF values were 0.15±0.01, 7.57±1.80, 2.45±0.45, and 2.46±0.49, respectively(p<0.001). As well as TNF-? values were 0.06±0.01, 8.22±2.24, 2.32±0.32, and 2.29±0.26 in Group I, GroupII, Group III, and Group IV, respectively (p<0.001). There was no significant difference between Group IIIand Group IV in terms of VEC, VEGF and TNF-? values (range of p values was 0.96-1.00).Conclusion: The results of the present study showed that quercetin administration significantly reduced theVEC number and suppressed VEGF and TNF-?. Quercetin's anti-inflammatory and anti-angiogenesis effectwas found to be similar to bevacizumab.
Investigation of the relationship between eye involvement and systemic diseases in patients with COVID-19
(2021) Kaymaz, Abdulgani; Üçgül, Rukiye Kiliç
Investigation of whether there is a relationship between eye involvement and systemic diseases in patients diagnosed with Coronavirus Disease-2019 (COVID-19). Onehundred and tenpatients who admitted to our hospital and were diagnosed with COVID-19 by Polymerase Chain Reaction (PCR) and chest computed tomography (CT)were included in the study. The demographic characteristics and existing systemic diseases of the patients were questioned. Whether the patients had ocular involvementassociated with COVID-19 was investigated. The patients with eye involvement were examined in terms of systemic diseases and the drugs they used. Sixty oneof thepatients were male and 49 were female. Eight (7.3%) of the 110 patients had ocular involvement. Six of these 8 patients had no comorbid diseases. Two patients withadditional systemic disease had a common diagnosis of chronic kidney disease. The mean age of those with ocular involvement (44.88 ± 21.97 years) was lower than theaverage age of the total group (52.29 ± 22.93 years). The most common additional systemic disease in patients with COVID-19 was hypertension (26.4%).All patients hadconjunctival hyperemia. Five of the patients had epiphora, 5 had secretion, 4 had burning-stinging and 2 had ocular pain.3 of the patients were smokers.In 2 patients, thefirst finding of COVID-19 started with eye complaints.One of the patients with ocular involvement had a history of previous Fuchs uveitis. Although eye involvement inCOVID-19 patients is not common, it may appear as the first finding. Detection of patients with eye involvement may be beneficial in terms of early diagnosis, treatmentand prevent transmission. In addition, the relationship between comorbid diseases and eye involvement may be important in terms of prognosis.
Investigation of the short-term effects of water drinking test on the eye using optical coherence tomography angiography in young healthy male subjects
(Taylor & Francis Ltd, 2022) Soydan, Adem; Ulaş, Fatih; Kaymaz, Abdulgani; Toprak, Güvenç; Uyar, Enes; Çelebi, Serdal
Purpose To evaluate the acute effects of the water drinking test (WDT) on the eye using optical coherence tomography angiography (OCTA) on healthy young male subjects. Methods The study included 25 eyes of 25 male subjects. Selected parameters of the retinal vasculature were measured, including macular flow indices, foveal avascular zone, and vessel densities (VDs) of the macula using OCTA. The measurements were taken on the first day without drinking water at 0 min, 30 min and 60 min, then repeated on the second day before drinking water at 0 min, and after drinking water at 30 min and 60 min. The Paired Samples t-test and repeated measures One-way analysis of variance test were used in the statistical analyses. Results The repeated measures analysis of variance test using Bonferroni adjustment demonstrated a significant increase in superficial and deep foveal VD following WDT (p < 0.001 for both). Intraocular pressure, retinal nerve fibre layer thickness, foveal avascular zone, flow area of choriocapillaris, flow area of outer retina, foveal non-flow area of superficial layer, and retinal thickness measurements showed no significant changes following WDT. Conclusions WDT is associated with temporary flow modifications in superficial and deep foveal vascular plexus in young male subjects.
Management of cataracta membranacea in a geriatric patient
(Elsevier Inc, 2013) Erdurmuş, Mesut; Kaymaz, Abdulgani; Önder, Halil İ.; Yılmaz, Ayhan; Soydan, Adem
An 80-year-old woman presented to our clinic with blurred visual in her right eye. On ophthalmoscopic examination, the visual acuity was counting fingers at 50 cm in the right eye and 20/50 in the left eye. Slitlamp biomicroscopy showed fibrous adhesion of the anterior and posterior capsules and absence of lens material in the right eye. Anterior capsule wrinkling was also observed. The left eye had an anterior chamber intraocular lens (IOL) following complicated cataract surgery. Intraocular pressures were within normal limits in both eyes. Cataracta membranacea was diagnosed, and vitrectomy probe-assisted capsular opening, anterior vitrectomy, and sulcus-fixated foldable IOL implantation were performed. At the last follow-up visit, the corrected visual acuity in the right eye improved to 20/50. The aim of this report is describe the oldest patient in the literature with cataracta membranacea and to discuss its management with the aid of current knowledge.
Optik düşük koherensli refl ektometri kullanılan katarakt hastalarında göz içi lens gücü hesaplama formüllerinin karşılaştırılması
(2017) Ulaş, Fatih; Kaymaz, Abdulgani; Soydan, Adem; Uyar, Enes; Doğan, Ümit
Amaç: Optik düşük koherens refl ektometri cihazı ile çeşitli biyometrik formüller kullanılarak hesaplanan tahmini postoperatif refraksiyon doğruluklarının karşılaştırılması. Gereç ve Yöntemler: Tüm gözler aksiyel uzunluklarına göre kısa (<22.0 mm), ortalama (22.0-24.5 mm) ve uzun (>24.5 mm) olmak üzere 3 gruba ayrıldı. Beş farklı formül için (Haigis, Hoffer Q, SRK/T, Holladay 1 ve SRK II) Ortalama hata ve ortalama mutlak hata (OMH) değerleri hesaplandı ve karşılaştırıldı. Bulgular: Gözlerin %88,7'si 1 D ve %98,3'ü ise 2 D ortalama mutlak hata içindeydi. Kısa gözlerde Haigis, Hoffer Q, SRK/T, Holladay 1 ve SRK II formülleri için OMH değerleri sırasıyla, 0.37±0.28 D, 0.32±0.29 D, 0.42±0.30 D, 0.41±0.25 D ve 0.46±0.33 D idi. Ortalama gözlerde OMH değerleri sırasıyla, 0.52±0.47 D, 0.51±0.46 D, 0.53±0.46 D, 0.51±0.45 D ve 0.58±0.50 D idi. Uzun gözlerde ise OMH değerleri sırasıyla, 0.52±0.47 D, 0.51±0.46 D, 0.53±0.46 D, 0.51±0.45 D ve 0.58±0.50 D idi. Sonuç: Haigis, Hoffer Q, SRK/T ve Holladay 1 formülleri tüm aksiyel uzunluk gruplarında SRK II formülünden daha öngörülebilir refraktif sonuçlar verdi.
Santral retinal ven tıkanıklığı ve maküla ödeminde patogenez
(2019) Ulaş, Fatih; Uyar, Enes; Kaymaz, Abdulgani
Santral retinal ven tıkanıklığı (SRVT) yaygın görülen bir retinal vasküler hastalıktır. Fakat SRVT patogenezi tam olarak bilinmemektedir. SRVT gelişiminde çeşitli sistemik ve lokal risk faktörleri rol oynamaktadır. SRVT maküler ödem (MÖ) ve neovaskülarizasyona neden olarak görmeyi olumsuz etkileyebilmektedir. MÖ, maküler bölgede sıvı ve protein birikmesi sonucu oluşmaktadır. MÖ patofizyolojisi oldukça karmaşık bir süreçtir ve MÖ gelişiminde birçok faktör etkili olmaktadır. Bu derlemede SRVT ve SRVT nedeniyle oluşan MÖ patogenezi tartışılmıştır.
Topical vancomycin is more efficient than povidone-ıodine treatment in controlling bacterial growth in methicillin-resistant staphylococcus aureus keratitis model in rabbits
(Taylor & Francis Inc, 2024) Alkan, Yunus; Kaymaz, Abdulgani; Behçet, Mustafa; Bayrak, Abdullah
Purpose: To evaluate the efficacy of topical vancomycin and povidone iodine (PI) application on methicillin-resistant Staphylococcus aureus (MRSA) keratitis model in rabbits. Methods: MRSA keratitis was induced by injecting 0.1 mL MRSA containing 1000 colony-forming units (CFU) into central cornea of right eyes of 24 New Zealand White rabbits. Animals were divided into four groups (n = 6): control (treated with balanced salt solution), 50 mg/mL topical vancomycin, 5% topical PI, and combination; examined before and after treatment, and corneal tissues were harvested for analysis at 9th hour of treatment. Results: Bacterial load was determined as: 7.63 +/- 0.82 log10 CFU/g in control group, 6.95 +/- 1.66 log10 CFU/g in PI group, 4.67 +/- 0.77 log10 CFU/g in combination group, and 4.33 +/- 0.71 log10 CFU/g in vancomycin group (p = 0.001). Median of total clinical score increased significantly from 7 [range: 5-8] to 11.5 [range: 11-15] (p = 0.001) in control group, did not change (6 [range: 5-8] to 7 [range: 5-7]; p = 0.695) in vancomycin group, increased significantly from 7 [range: 5-8] to 12.5 [range: 10-14] (p < 0.001) in PI group, increased significantly from 6.5 [range: 5-7] to 8 [range: 7-9] in combination group (p = 0.002). Post-treatment clinical scores for chemosis, conjunctival injection, iritis, hypopyon, epithelial erosion, and corneal infiltrate were significantly lower in vancomycin-treated groups compared to others (p < 0.05). In PI-treated groups, especially scores for chemosis, conjunctival injection, epithelial erosion and corneal infiltrate were significantly higher than vancomycin (p < 0.05). Conclusion: Topical vancomycin significantly inhibited bacterial growth in MRSA keratitis. However, PI was ineffective in controlling this growth; additionally, exerted toxic effect on ocular surface. When vancomycin was combined with PI, no additional increase in efficacy of treatment was detected compared to only vancomycin.
Yaşa Bağlı Makula Dejenerasyonunda Yeni Tedavi Yaklaşımlarında Polifenoller
(2022) Kurt, Akif Hakan; Öztabag, Cansu Kara; Kaymaz, Abdulgani
Yaşa bağlı makula dejenerasyonu (YBMD), dünya çapında milyonlarca insanı etkileyen bir retina hastalığıdır. Gözün retina pigment epiteli (RPE) ve fotoreseptörlerinin nörodejenererasyonu sonucu görme kaybı ile karakterize multifaktöriyel bir hastalıktır. 65 yaş üstü kişilerde geri dönüşü olmayan görme bozukluğunun önde gelen sebepleri arasında yer alan, YBMD’nin prevalansı hızla artmasına karşın, oluşan görme kaybının etkin bir tedavisi yoktur. Güncel çalışmalar ile, YBMD’nin farmakoterapisi hala istenen düzeyde olmasa da antioksidan tedaviler ile hastalığın seyri yavaşlatılmaktadır. Bir çok meyve ve sebzede bulunan polifenollerin antikanser, anti-inflamatuar, antiapoptotik özelliklerinin yanı sıra antioksidan özelliğe de sahip olması YBMD’nin önlenmesi için bir umut olmuştur. Son zamanlarda, polifenollerin YBMD’nin önlenmesinde rolü olduğuna işaret eden çalışmalar yayınlanmıştır. Güçlü antioksidan özelliğe sahip polifenollerin oksidatif hasara karşı doğrudan reaktif oksijen türlerini (ROS) süpürme dışında, kronik inflamasyon ve apoptotik yolaklar üzerinden nöroprotektif etkisi olduğunu gösteren çalışmalar da bu görüşü desteklemektedir. Bu derleme yazısında polifenollerin YBMD gibi retina hastalıklarının önlenmesinde ki rolü ve etkin tedavi yaklaşımları irdelenmiştir.

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