Yazar "Kandemir, Hakan" seçeneğine göre listele

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  • Küçük Resim
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    Carbazole substituted BODIPY dyes :synthesis, photophysical properties and antitumor activity
    (Elsevier Sci Ltd, 2015) Şengül, İbrahim Fazıl; Okutan, Elif; Kandemir, Hakan; Astarcı, Erhan; Çoşut, Bünyemin
    In this study, two different BODIPYs containing carbazole groups at the mesa position were designed and synthesized. All compounds were fully characterized by elemental analysis, FT-IR, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, H-1 and C-13 NMR spectroscopy. The photophysical properties of the new compounds were investigated by means of absorption and fluorescence spectroscopies in dilute dichloromethane solutions. We were also interested in the biological activity of these two novel carbazole-linked BODIPYs, particularly concerning their ability to inhibit human colon cancer HT29 cell lines. The photophysical studies revealed strong donor acceptor interaction between carbazole and BODIPY and follow the order compound 5 > compound 4. Also, preliminary assay showed that compound 5 possessed higher cytotoxic activity than compound 4, with IC50 values of 8.3 ng/mL and 21.7 ng/mL respectively. (C) 2015 Elsevier Ltd. All rights reserved.
  • Küçük Resim
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    Synthesis of novel pyrrolo[3,2-c]carbazole and dipyrrolo[3,2-c: 2 ',3 '-g]carbazole derivatives
    (Georg Thieme Verlag Kg, 2016) Şengül, İbrahim Fazıl; Astarcı, Erhan; Kandemir, Hakan
    Pyrrolocarbazole and dipyrrolocarbazoles have been synthesized via the Hemetsberger indole synthesis, starting from 9-ethyl carbazole-3-carbaldehyde and 9-ethylcarbazole-3,6-dicarbaldeyde, respectively. The pyrrolocarbazole structures were confirmed through H-1 NMR, C-13 NMR, IR, mass spectrometry and single crystal X-ray diffraction techniques. The targeted compounds showed potent in vitro cytotoxicity against human colon cancer HT29 cells.