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Öğe Association of SYNTAX Score withPATIMA Index, Carotid Intima- andExtra- Media Thicknesses(2021) Coşgun, Mehmet; Cosgun, Zeliha; Güneş, Yılmaz; Sincer, Isa; Erdal, Emrah; Mansiroğlu, Aslı; Inanir, MehmetObjectives: Several risk scoring systems have been validated for cardiovascular risk prediction and prognosis. Periarterial adipose tissue intima media adventitia (PATIMA) index combining carotid intima media thickness (CIMT), carotid extra media thickness (CEMT), cardiac epicardial fat thickness (EFT), and body mass index (BMI) are related to coronary artery disease (CAD).Materials and Methods: One-hundred-twenty-four patients were categorized as low synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) (<22) (n=84) or high SYNTAX (?22) (n=40) score groups. Association of PATIMA index and its components with SYNTAX score were analyzed.Results: CIMT, CEMT, BMI, EFT, and PATIMA index were not significantly different between groups. SYNTAX score was not significantly correlated with traditional CVS risk factors (diabetes, hypertension, hyperlipidemia, smoking, age). There was a significant correlation between the PATIMA index and age (r=0.308, p=0.001) but not with other risk factors. Age was significantly correlated with CIMT (r=0.289, p=0.001) and EFT (r=0.208, p=0.02) but not with CEMT (r=0.091, p=0.313). There was a significant correlation between CIMT and CEMT (r=0.414, p<0.001) and between CIMT and EFT (r=0.267, p=0.004).Conclusion: We have found that the recently described PATIMA index and its components, CIMT, CEMT, and EFT are not associated with the severity of CAD assessed by the SYNTAX score. Furthermore, they have not correlated with classical risk factors apart from age.Öğe Catheter-directed intra-arterial thrombolysis for lower extremity arterial occlusions(2019) Güneş, Yılmaz; Sincer, İsa; Erdal, EmrahCatheter-directed intra-arterial thrombolysis (CDT) is a rational treatment method in patients with acute/subacute and even some chronic occlusions of lower extremity arteries and bypass grafts having salvageable limb ischemia. Immediate vessel patency can be achieved with an acceptable complication rate in many patients, especially those with fresh thrombus or emboli. It can be also an adjuvant treatment modality for endovascular interventions for chronic occlusions. There is no standard method of CDT including thrombolytic agent dose and technique. Selection of treatment strategy should be based on individual judgment based on viability of limb, lesion characteristics, and risks of hemorrhage.Öğe Comparison of demographical properties, Biochemical Parameters, Flow-mediated dilatation values and Carotis Intima Media Thickness of patients with Coronary Artery disease(2020) Erdal, Emrah; Gürler, Müjgan; İnanır, Mehmet; Özmen, NamıkTo compare demographic characteristics, biochemical parameters, flow-mediated dilatation (FMD) values and carotid intima-media thickness (CIMT) between older (>45 years) and younger (<45 years) patients with coronary artery disease (CAD). Materials and Methods: The present study comprised a total of 114 patients divided into four groups. For the study groups, group 1 had 30 patients with CAD <45 years of age, and group 2 had 32 patients with CAD >45 years of age. Group 3 and group 4 were used as controls, comprising 28 (<45 years) and 24 (>45 years) healthy participants, respectively. Demographic characteristics, biochemical parameters, FMD values and CIMT were recorded and compared statistically among patients. Results: The median age of patients was 47.81±14.50 years. Hereditary risk factors and hyperlipidemia were statistically significant in group 1 than those in group 3. Likewise, fasting blood glucose levels and CIMT values were statistically higher in group 1 than those in group 3. Gender distribution and hyperlipidemia were statistically significant in group 2, in contrast to those in group 4. The values of FMD was lower in group 2 than those in group 4, which seemed to be statistically significant. The values of CIMT were higher whereas platelet counts were lower in group 2 than those in group 1, both findings of which were also statistically significant. The values of CIMT and Neutrophil/Lymphocyte (N/L) ratios increased whereas the values of FMD decreased significantly as the ages of participants increased. Conclusion: The factors where CAD was more common in subjects were as follows: being over 45 years of age (2.36 times), the presence of hyperlipidemia (3.58 times), increased N/L ratios (1.6 times), a combination of increased CIMT values and age (12 times), and decreased FMD values (2 times).Öğe Could platelet distribution width predict coronary collateral development in stable coronary artery disease?(2020) Sincer, İsa; Mansıroğlu, Aslı; Erdal, Emrah; Coşgun, Mehmet; Aktaş, Gülali; Güneş, YılmazOBJECTIVE: We hypothesized that hemogram parameters should be related to the development of coronary collateral vessels. For this purpose, we aimed to compare platelet distribution width (PDW) and PDW to platelet ratio (PPR) in subjects with stable coronary artery disease having adequate or inadequate coronary collateral development. METHODS: A total of 398 patients with stable angina pectoris undergoing coronary angiography were enrolled and divided on the basis of the development of coronary collateral (CCD) (inadequate CCD (n=267) and adequate CCD (n=131). Routine complete blood count and biochemical parameters were measured before coronary arteriography. RESULTS: Mean PDW and PPR values of inadequate and adequate CCD groups were 17.5% (10–23) and 12.4% (9.8–22) %, p<0.001, respectively. In multivariate analysis, age (p=0.012, 95% CI for OR: 0.958 (0.933–0.983) and PDW (p<0.001, 95% CI for OR: 1.432 (1.252–1.618) were found to be statistically significantly different inadequate CCD group compared to adequate CCD group. Receiver operating curve (ROC) analyses revealed that a PPR value greater than 0.057 had 76% sensitivity and 51% specificity and a PDW higher than 16.2% had 80% sensitivity and 66% specificity in predicting inadequate CCD. CONCLUSION: The present study suggests that PDW and PPR may be associated with the degree of collateral development in chronic stable coronary artery disease (CAD).Öğe Does mean platelet volume decrease in the presence of coronary artery fistula?(Arquivos Brasileiros Cardiologia, 2019) Sincer, İsa; Çekici, Yusuf; Coşgun, Mehmet; Aktaş, Gülali; Güneş, Yılmaz; Erdal, Emrah; Mansıroğlu, Aslı Kurtar; İnanır, MehmetBackground: Coronary artery fistula (CAF) is an abnormal connection that links a coronary artery to a cardiac chamber or another major blood vessel. Several studies have shown the association between mean platelet volume (MPV) and cardiovascular diseases. In the literature, there is no previous study about the association between hematologic parameters and congenital CAF. For this reason, we aimed to investigate the association of MPV with CAF. Methods: 70 patients with normal coronary arteries and 50 with coronary artery fistulas were included. Routine blood and biochemical parameters were measured before the arteriography. Differences between groups for continuous variables were analyzed with t- test or Mann-Whitney test. P values < 0.05 were considered significant. Regression analysis was used to find independent predictors of CAF. Results: Baseline patient demographics, including age and clinical risk factors, were similar between the groups. Compared to the control group, median (IQR) High-density lipoprotein cholesterol (HDL) levels were significantly higher (p=0.04) and MPV levels were significantly lower in the CAF group (8.84 +/- 1.71fL vs. 10.43 +/- 1.34, p < 0.001). In the multivariate analysis, only MPV was a significant predictor of CAF (p < 0.001, 95% CI for OR: 0.438 (0.306-0.629). A negative correlation was found between MPV and fistulae in Pearson's correlation test (r: -0.454, p < 0.001). An MPV level of < 9,6 fL showed sensitivity, specificity, positive predictive value and negative predictive value of 80%, 68%, 71% and 78% respectively (AUC = 0.766, 95% CI, 0.678-0.854) for the prediction of CAF. Conclusion: The present study suggests that MPV may decrease in patients with CAF.Öğe Does periodontitis affect mean platelet volume(MPV) and plateletcrit (PCT) levels in healthy adults?(Assoc Medica Brasileira, 2020) Ustaoğlu, Gülbahar; Erdal, Emrah; İnanir, MehmetOBJECTIVE: Periodontitis may stimulate infectious and immune response and cause the development of atherogenesis, coronary heart disease, and myocardial infarction. The aim of this study was to compare the plateletcrit (PCT) and mean platelet volume (MPV) levels derived from complete blood count (CBC) tests in patients suffering from stage 3 periodontitis with those of healthy individuals without periodontal disease. METHODS: The study included 57 patients (28 females and 29 males) with Stage 3 Periodontitis and 57 volunteering individuals (31 females and 26 males) who were periodontally healthy. The age of study participants ranged from 18 to 50 years. Their periodontal condition was investigated with probing depth (PD), clinical attachment level, bleeding on probing, and plaque index. Leukocyte (WBC) and erythrocyte count (RBC), hemoglobin (Hb) and hematocrit (HCT) levels, mean corpuscular volume (MCV) and red cell distribution width (RDW), thrombocyte count, mean platelet volume (MPV), plateletcrit (PCT), and neutrophil and lymphocyte counts were evaluated based on the CBC test results of the study participants. RESULTS: PCT, WBC, Neutrophil, and MPV values were found to be significantly higher in the periodontitis group (p<0.05). There were no significant differences in RBC counts, Hb, HCT, MCV, RDW, and platelet and lymphocyte counts between the two study groups (p>0.05). CONCLUSIONS: PCT and MPV levels may be a more useful marker to determine an increased thrombotic state and inflammatory response in periodontal diseases.Öğe Echocardiographic assessment of epicardial fat tissue thickness in patients with severe periodontitis(Elsevier Espana Slu, 2020) Erdal, Emrah; İnanır, Mehmet; Ustaoğlu, Gülbahar; Sincer, İsaObjectives: This study aims to assess the thickness of epicardial fat tissue (EFT), a sign of cardiovascular risk, using echocardiography in patients with severe periodontitis. Methods: Thirty-three patients with stage III or IV periodontitis and 33 healthy participants were enrolled into the study. Epicardial fat tissue thickness was measured perpendicularly via echocardiography of the free wall of the right ventricular at end-diastole in three cardiac cycles. Body mass index (BMI) was calculated by dividing weight in kilograms by the height in meters squared. EFT to BMI ratio (EFT/BMI) was measured by dividing EFT by the BMI. Results: There was no significant difference between study patients and the control group as regards to the frequency of diabetes, hypertension, smoking, and hyperlipidemia. The EFT and EFT/ BMI ratio were significantly different in the control and periodontitis groups (0.510.17 vs. 0.77 +/- 0.16, respectively; p <0.001) (0.021 +/- 0.008 vs. 0.030 +/- 0.006, respectively; p<0.001). Pearson's correlation coefficient demonstrated a significant relationship between EFT and the clinical parameters of periodontitis (p<0.001) Conclusions: EFT thickness measured by echocardiography appears to be associated with severe periodontitis and may thus be an indirect sign of cardiovascular disease in periodontitis patients. (c) 2020 Sociedade Portuguesa de Cardiologia. Published by Elsevier Espana, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).Öğe Evaluation of electrocardiographic ventricular and atrial repolarization markers in patients with high grade varicocele(2019) Erdal, Emrah; Sincer, İsa; Gucuk, Adnan; Güneş, Yılmaz; Bostancı, Emre; İnanır, MehmetAim: Varicocele is abnormal dilation of testis veins without unclear pathophysiology. Morphological studies showed imbalance between vasoconstrictor and vasodilator mechanisms. We aimed to determine the relationship between varicocele and cardiovascular system disorders with electrocardiography (ECG) parameters. Methods: This is a prospective study which was conducted in a University Hospital between February and June 2018. Thirty patients (18-45 years old) with high grade varicocele from urology outpatient clinic and 32 healthy volunteers for the control group were recruited to the study. Results: P-min. value was significantly higher in control group than patients with high grade varicocele (p= 0.03). PR, QT and QTc intervals, PWD and P-max values were similar. Also, there were no significant differences in terms of the other ECG parameters between the groups. Conclusions: In this small prospective study we have found no association between high grade varicocele and potential electrocardiographic arrhythmia predictors namely OTd, QTc interval, PWD, Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio. Long-term follow-up and large-scale prospective studies are needed to confirm our results.Öğe Evaluation of electrocardiographic ventricular depolarization and repolarization variables in type 1 diabetes mellitus(Arquivos Brasileiros Cardiologia, 2020) İnanır, Mehmet; Güneş, Yılmaz; Sincer, İsa; Erdal, EmrahBackground: The risk of cardiovascular events and sudden death increases with type 1 diabetes mellitus (T1DM). Objective: To evaluate electrocardiographic markers of arrhythmias in T1DM patients. Methods: Electrocardiographic parameters reflecting ventricular depolarization and repolarization, namely, QT, QTc, QTd, QTdc, Tp-e, JT, and JTc intervals and Tp-e/QT and Tp-e/QTc ratios, of 46 patients diagnosed with T1DM were retrospectively analyzed and compared with 46 healthy age-, sex-, and body mass-matched controls. Correlations between T1DM duration, hemoglobin A1c (HbA1c), and ventricular repolarization variables were analyzed. P values lower than 0.05 were considered statistically significant. Results: Diabetes duration was 16.6 +/- 7.1 years, and HbA1c was 10.81% +/- 3.27% in the T1DM group. In comparison with the control group, heart rate, QTc, QTd, QTdc, Tp-e and JTc intervals, Tp-e/QT ratio (p < 0.001), and Tp-e/QTc ratio (p = 0.007) were significantly higher in T1DM patients. T1DM duration and HbA1c levels were significantly correlated with QTc, QTd, QTdc, Tp-e, and JTc intervals and Tp-e/QT and Tp-e/QTc ratios. Conclusions: In T1DM patients, potential electrocardiographic repolarization predictors were significantly increased in correlation with disease duration and HbA1c levels. These findings may contribute to the understanding of sudden cardiac death in patients with T1DM.Öğe Evaluation of electrocardiographic ventricular repolarization parameters in extreme obesity(Churchill Livingstone Inc Medical Publishers, 2019) İnanır, Mehmet; Sincer, İsa; Erdal, Emrah; Güneş, Yılmaz; Coşgun, Mehmet; Mansıroğlu, Aslı KurtarBackground and objectives: The risk of sudden death and cardiac arrhythmia increases in morbidly obese patients. We aimed to evaluate the marker of arrhythmias such as Tp-e/QT, Tp-e/QTc, Tp-e/JT and Tp-e/JTc ratios in extreme obesity. Methods: The study included 41 extremely obese patients and 41 control subjects. QTmax, QTmin, US, JT and Tp-e intervals were measured od 12-lead electrocardiographies. In addition, Tp-e/QT, Tp-e/QTc, Tp-e/JT and Tp-e/JTc rates and QTc, cQTd and JTc intervals were calculated. Results: Tp-e interval (79.2 +/- 9.7 ms (milisecond) vs. 68.6 +/- 8.1, p < 0.001), QTc interval (395.9 +/- 18.8 vs. 377.9 +/- 19.3 ms, p < 0.001), JTc interval (317.1 +/- 27.0 vs. 297.4 +/- 23.2 ms, p = 0.001), Tp-e/QT ratio (0.22 +/- 0.03vs. 0.19 +/- 0.02, p < 0.001),Tp-e/QTc ratio (0.20 +/- 0.26vs. 0.18 +/- 0.02, p = 0.001), Tp-e/JT ratio (0.29 +/- 0.04 vs. 0.25 +/- 0.03, p < 0.001), TPe/JTc ratio (025 +/- 0.04 vs. 0.23 +/- 0.03, p = 0.018), QTd (32.8 +/- 10 vs.15 +/- 6.4 ms, p < 0.001) and cQTd (70.0 +/- 30.1 vs. 313 +/- 22.4 ms, p < 0.001) were significantly higher in obese patients. Conclusion: Compared to healthy subjects potential ECG repolarization predictors were significantly increased in extremely obese patients. (C) 2018 Elsevier Inc. All rights reserved.Öğe Evaluation of electrocardiographic ventricular repolarization parameters in stable coronary artery disease(2021) Coşgun, Mehmet; Erdal, Emrah; Güneş, Yılmaz; Sincer, Isa; Mansiroğlu, AslıAim: To examine the relationship between the SYNTAX score (SS) and cardiac repolarization parameterssuch as cQTd and Tp-e values, and Tp-e/QT, Tp-e/JT, Tp-e/QTc, and Tp-e/JTc ratios in patients who havestable angina pectoris.Methods: 12-lead resting electrocardiograms (ECGs) and SS of 160 patients (51 female and 109 male)undergoing coronary angiography with the pre-diagnosis of stable angina pectoris were evaluated. Patientswith a SS below 22 were classified as Group 1 (low-SYNTAX), and those above 22 (high-SYNTAX) as Group2. Forty-four patients with normal coronary angiography were included in Group 3.Results: Mean age of the patients was 62.4±9.1 years. The heart rate, QRS, QT, cQT and JT durations betweenthe groups were similar. In addition, relatively recent ventricular repolarization indices such as Tp-e intervaland Tp-e/QT, Tp-e/JT, Tp-e/QTc, and Tp-e/JTc ratios were also not substantially different between groups.Conclusion: Several surface ECG predictors of ventricular arrhythmias, including QTd, JT and Tp-e intervalsand their ratios to QT and JT, are not significantly correlated with SYNTAX score-assessed CAD severity inpatients with stable angina pectorisÖğe Evaluation of ventricular repolarisation features with novel electrocardiographic parameters in patients with severe periodontitis(2020) İnanır, Mehmet; Erdal, Emrah; Sincer, İsa; Ustaoğlu, GülbaharIntroduction: Ventricular arrhythmic predictors in severe periodontitis may be linked with cardiovascular events and the sudden death risk. In this study, we evaluated certain electrocardiographic (ECG) ventricular arrhythmic predictors in patients with severe periodontitis. Methods: ECG parameters of 72 patients diagnosed with severe periodontitis, which are indicative of ventricular arrhythmia, were examined, and these parameters were compared with the control group.Results: Compared to the control group, QT interval (QT)(p=0.014), corrected QT (QTc) (p<0.001), QT dispersion (QTd) (p<0.001), QTdc p<0.001), JT interval (p=0.012), JTc interval (p<0.001), T peak and end interval (Tp-e) (p<0.001), Tp-e/QT ratio (p<0.001), Tp-e/QTc ratio (p<0.001), Tp-e/JT ratio (p<0.001) and Tp-e/JTc ratio (<0.001) were found to be higher in patients with severe periodontitis. Conclusion: Our study showed that arrhythmic ECG markers were significantly prolonged in patients with severe periodontitis. In future extensive prospective studies, we think that these arrhythmic predictors should be evaluated to predict malignant arrhythmias.Öğe Influence of different anti-hypertensive drugs on gingival overgrowth: cross-sectional study in a Turkish population(Wiley, 2020) Ustaoğlu, Gülbahar; Erdal, Emrah; Karaş, ZeynepObjective The purpose of this study was to evaluate the occurrence rate of drug-induced gingival overgrowth (DIGO) in patients treated with angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and calcium channel blockers (CCBs) such as amlodipine, lercanidipine, and benidipine, as well as to assess the relationship of those mentioned above with medication variables and oral hygiene. Methods Sociodemographic details, DIGO, and clinical periodontal parameters were obtained from one hundred and thirty-one patients receiving ACE inhibitors, ARBs, and CCBs for a period of at least 2 years. Results The occurrence rate of DIGO was 19.6% in patients using CCB, 12.5% in the ARB group, and 7.5% in the ACE inhibitor group. In a subgroup analysis of CCBs, DIGO was found to be 31.8% in the amlodipine group, 13.3% in the lercanidipine group, and 7.1% in the benidipine group. While there was a significant relationship between amlodipine drug dosage and DIGO, no association was found between the duration of therapy and DIGO in all CCB subgroups. Conclusion There was no difference between the groups in terms of DIGO. Duration of therapy and drug dosage did not affect the severity of DIGO in both ACE inhibitors and ARB groups.Öğe Investigation of patients with coronary slow flow in terms of periodontal health status(Assoc Medica Brasileira, 2021) Erdal, Emrah; Ustaoğlu, Gülbahar; Karaş, Zeynep; Bilgin, SatılmışOBJECTIVE: This study aims to evaluate the relationship between periodontal health status and coronary slow flow phenomenon. METHODS: One hundred and two patients who underwent coronary angiography with the diagnosis of stable angina pectoris were included in the study. Patients were divided into two groups: patients with coronary slow flow (Test group) (n=51), and patients with normal coronary angiography (Control group) (n=51). Diagnosis of slow coronary flow was made according to Beltrame criteria by coronary angiography. Demographic characteristics of the participants were recorded. The periodontal health was assessed by clinical periodontal parameters such as probing depth, clinical attachment level, gingival index, plaque index, and bleeding on probing. RESULTS: There were no significant differences between groups as regards the frequencies of hypertension, smoking (p>0.05). As for the periodontal parameters of the study groups, probing depth, gingival index, plaque index, bleeding on probing, and clinical attachment level values were statistically higher in the test group compared to the control group (p<0.05). CONCLUSIONS: Periodontitis might be accepted as one of the underlying causes of coronary slow flow. Patients with coronary slow flow should be evaluated for an underlying periodontal disease, and treatment of periodontal disease can protect against future cardiovascular events.Öğe Mechanical prosthetic aortic valve thrombosis treated with low-dose ultra slow infusion of tissue-type plasminogen activator during pregnancy(Coll Physicians & Surgeons Pakistan, 2021) Ural, Ülkü Mete; Uysal, Aybike; Erdal, EmrahSir, Prosthetic valve thrombosis (PVT) is extremely rare in patients with aortic valve replacement and can be a life-threatening condition for both the mother and fetus, if it develops in pregnant women; and it requires immediate treatment. The treatment options during pregnancy include valve replacement, surgical thrombectomy, and thrombolytic therapy.1 The surgical approach in pregnancy is associated with elevated maternal and fetal mortalityÖğe P-wave duration and dispersion in lone obesity(College of Physicians and Surgeons Pakistan, 2021) Cosgun, Mehmet; Sincer, Isa; Inanir, Mehmet; Erdal, Emrah; Mansiroglu, Asli Kurtar; Gunes, YilmazObjective: To assess P-wave duration and dispersion (PD) in morbidly obese young subjects who do not have co-associated atrial fibrillation (AF) risk factors, such as hypertension, diabetes, atrial enlargement and diastolic dysfunction. Study Design: An observational cross-sectional study. Place and Duration of Study: Bolu Abant Izzet Baysal University Medical Faculty, Turkey; and the study was conducted between October 2017 and June 2018. Methodology: P-wave duration and dispersions were determined on 12-lead surface ECG in 47 morbidly obese and 44 healthy weight subjects, aged between 21-40 years. Above mentioned risk factors were studied. The correlation between BMI, PD and Pmax were investigated by Pearson correlation analysis. Results: Average body mass index (BMI) of obese and control groups were 42.3 (8.5) vs. 19.5 (1.5) (P <0.001). Maximum P-wave duration [(Pmax), 105.3±9.8 vs. 95.6±8.5, p<0.001] and PD [27.6 (7.6) vs. 12.2(8.3), p<0.001] were statistically significantly prolonged in obese patients when compared to the normal weight group. BMI correlation with Pmax and PD (r=0.485; p<0.001 and r=0.620; p<0.001, respectively) were significant. Conclusion: Pmax and PD, which are potential electrocardiographic AF predictors, may increase in lone obese patients having no comorbidities. © 2021 College of Physicians and Surgeons Pakistan. All rights reserved.Öğe Platelet-to-lymphocyte ratio (PLR) and Plateletcrit (PCT) in young patients with morbid obesity(Assoc Medica Brasileira, 2019) Erdal, Emrah; İnanır, MehmetOBJECTIVE: To compare the complete blood counts, namely the plateletcrit (PCT) and Platelet-To-Lymphocyte Ratio (PLR) of healthy subjects and those with morbid obesity in the young population. METHODS: We included 45 patients with morbid obesity (body mass index -BMI - greater than or equal to 45 kg/m2) and 45 healthy subjects (BMI less than or equal to 25 kg/m2) in our study. Blood samples were obtained from the participants following a 12-hour fasting period. Then we evaluated the levels of hemoglobin (Hb), hematocrit (HCT), red cell distribution width (RDW), mean platelet volume (MPV), white blood cell (WBC), PLR, platelet counts, and PCT in the complete blood count. RESULTS: The morbid obesity group had significantly higher platelet counts and PCT values (p<0.001), and PLR values (p=0.033). The value of WBC was also higher in the obese group (p=0.001). MPV was lower in the obesity group but not statistically significant (p=0.815). No significant difference was found between hemoglobin and hematocrit values in these groups; but RDW valuewere higher and statistically significant in the obese group (p=0.001). CONCLUSION: PLR or PCT may be more useful as a marker in determining an increased thrombotic state and inflammatory response in morbid obesity.Öğe The relationship between epicardial fat thickness and high-grade varicocele(Makerere University, Medical School, 2020) Sincer, İsa; Erdal, Emrah; Gücük, Adnan; Bostancı, Emre; Güneş, YılmazBackground: Varicocele is abnormal dilation of testis veins. The precise mechanism of varicocele is not fully understood despite some hypothesis were suggested in the literature. Disequilibrium between constrictor and dilatator mechanism of the veins have been shown to cause varicocele. High-grade varicoceles have been also linked to endothelial dysfunction and increased vasoconstriction. Objectives: We hypothesized that epicardial fat thickness (EFT), flow-mediated dilatation (FMD) and aortic stiffness (AS) could be associated with varicocele. In the present study, we aimed to compare vascular parameters such as FMD, EFT and AS in healthy subjects and high-grade varicocele patients. Methods: The study population consisted of 35 men with high-grade varicocele and 32 age-and sex-matched control subjects younger than 45 years old. This is a cross-sectional study conducted at Bolu Abant Izzet Baysal University Hospital between May to October 2018. Results: EFT, aortic diastolic diameters (AoDD) and EFT/BMI ratio were significantly higher in control group than in patients with high-grade (p=0.012, p=0.044, p=0.026, respectively). EFT and EFT /BMI ratio were significantly and inversely correlated with presence of varicocele (r=-0.422, p=0.009; r=-0.38, p=0.026, respectively). Conclusion: The present study suggests that high-grade varicocele may be associated with decreased echocardiographic EFT but not with aortic stiffness and FMD.Öğe Relationship between risk markers for cardiovascular disease and peri-implant diseases(Springer Japan Kk, 2020) Ustaoğlu, Gülbahar; Erdal, EmrahBackground The aim of this paper is to explore the serum biochemical parameters also known as risk markers for cardiovascular system, in individuals who have received dental implant treatment, and to reveal risk factors for peri-implant diseases. Methods The study included 58 subjects with peri-implantitis, 49 subjects with peri-implant mucositis, and 49 healthy subjects. All the subjects were assessed in terms of both peri-implant clinical parameters-probing depth (PD), bleeding on probing (BOP), the type of prosthesis, gingival index (GI), keratinized mucosa width (KMW), and plaque index (PI)-and serum biochemical parameters (e.g., LDL cholesterol, HDL cholesterol, triglyceride, total cholesterol, vitamin D, uric acid, white blood cell (WBC), neutrophil, hemoglobin (Hb), and platelet counts). Results KMW was the lowest in the peri-implantitis group. Compared with the other groups, the peri-implantitis group showed significantly higher levels of triglyceride, uric acid, and WBC. The peri-implantitis group had the lowest level of vitamin D. Triglyceride and uric acid levels had positive correlations with peri-implant clinical parameters. Conclusion High levels of triglyceride and uric acid may pose a risk for both peri-implant diseases and cardiovascular diseases. Prior to dental implant surgery, patients' serum biochemical parameters should be checked.
