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Öğe Acute Hepatitis C Infection Developing in the Offspring Born to an Anti-HCV- Positive Mother: A Case Report(Aves, 2009) Sirmatel, Fatma; Midikli, Durdane; Sirmatel, Ocal; Gursoy, Bensu; Duygu, FaziletAcute hepatitis C developed one month after delivery in a child whose mother was an inactive carrier of HCV and had given birth by normal vaginal delivery. Acute hepatitis C was diagnosed after one month in the child by serological, biochemical and ultrasonographic tests. Although the patient had high liver enzyme levels (ALT 245 IU/L, AST 123 IU/L), and positivity for both anti HCV (by ELISA) and HCV-RNA viral load (by PCR), the mother was an inactive HCV carrier. The patient was breasfed by the mother and showed spontaneous clearence without antiviral treatment after two years. Women should be examined for HCV before pregnancy in regions with medium HCV risk levels, and need to be enlightened regarding this issue. Also, considering that 20-25% of acute hepatitis C cases show spontanous clearance within 6-12 months on follow up, unnecessary treatment can be prevented.Öğe Evaluation of total oxidative level and total antioxidant capacity in cases with chronic viral hepatitis(Aves, 2009) Sırmatel, Fatma; Duygu, Fazilet; Çelik, Hakim; Selek, Şahabettin; Sırmatel, Öcal; Gürsoy, Bensu; Eriş, Fatma NurObjective: Oxidative stress is described as an instability between production of free radicals from cells and antioxidant defence of the body. The aim of the study was to investigate the correlation of total antioxidant capacity (TAC) and total oxidative level (TOL) with the severity of the disease and reliability of these parameters in the follow up of response to treatment in cases with chronic viral hepatitis (CVH). Methods: Between January 2004-March 2006, 73 cases with CVH were included in the study. The ages of the patients ranged from 15 to 70 years. Diagnosis of CVH was confirmed by clinical serological, and biochemical markers. The cases were divided into two groups: Group 1 as HBsAg-positive or anti-HCV-positive but HBV DNA or HCV RNA-negative and Group 2 as proven CVH. TAC, lipid hydroperoxide (LOOH), and TOL of the sera were studied according to Erel method, and statistically evaluated by 2 test in all the cases. Results: TAC, LOOH and TOL were found statistically significantly different between two groups. Average values of TAC were 1.8 +/- 0.5 mmol Trolox-Eqv./L and 1.0 +/- 0.15 mmol Trolox-Eqv./L in Group 1 and Group 2 (p=0.0001) respectively. Average values of LOOH were 5.3 +/- 2.8 mu mol H2O2 in Group 1 and 10.6 +/- 10.1 mu mol H2O2 in Group 2 (p=0.002). Average values of TOL were 10.2 +/- 5.9 mu mol H2O2 Eqv./L in Group 1 and 18.5 +/- 16.6 mu mol H2O2 Eqv./L in Group 2 (p=0.004). Conclusions: TAC was found higher, and TOL and LOOH were found lower in Group 1 than Group 2. The evaluation of plasma TAC, TOS ve LOOH levels may be important activation markers for the follow up of CVH.Öğe Sağlıklı kan donörlerinde Hepatit B virus, Hepatit C virus ve Hepatit D virus seroprevalansı(2012) Sırmatel, Fatma; Yetkin, Gülay İmadoğlu; Eriş, Fatma Nur; Tekin, Süda Koruk; Duygu, Fazilet; Karaağaç, Leman; Dinçer, SevimAmaç: İki farklı yörede bulunan Araştırma ve Uygulama Hastanesi Kan bankasına başvuran sağlıklı kan donörlerinde kronik viral hepatit etkenleri olan HBV, HCV ve HDV seroprevalansı EIA yöntemi ile araştırıldı. Bu çalışmanın amacı, batı ve güneydoğu Anadolu bölgelerinin kronik viral hepatit seroprevalansını sağlıklı kan donörlerinde saptamak ve yöresel farklılığı literatür eşliğinde irdelemektir. Gereç ve Yöntemler: Bu çalışma iki gruptan oluşmaktadır. Birinci grup 2004-2006 yılları arasında Şanlıurfa, ikinci grup 2007-2009 yılları arasında Bolu’da Üniversite Hastanesi Kan Bankasında yapılmıştır. Çalışma olguları sağlıklı kan donörlerinden, gönüllülük ilkesine göre seçilmiştir. Donörlerin kronik viral hepatit göstergelerinden HBsAg / anti-HCV makro EIA (Abbott, Axyms, UK), anti-HDV testleri mikro EIA (Abbot, UK) yöntemi ile çalışıldı. Tüm olguların yaşları, meslekleri, bulaş olabilecek özgeçmişleri ve doğum yerleri ayrıntılı olarak sorgulanmıştır. Bul gu lar: Birinci grupta: toplam 19.250 gönüllü sağlıklı kan dönoründe 565 olguda HBsAg (%2,9) ve 104 olguda anti-HCV (%0,5) pozitif olarak bulundu. HBsAg pozitif olan toplam 194 olgunun beşinde anti-HDV (%2,5) olumlu bulundu. İkinci grupta ise toplam 2012 kan dönoründe sırası ile HBsAg 24 (%1,19), anti-HCV 5 (%0,24) olguda pozitif bulunurken, anti-HDV olumluluğuna rastlanılmamıştır. So nuç: Güneydoğu ve batı bölgesinde iki farklı şehir populasyonları karşılaştırıldığı zaman kronik viral hepatit etkenlerinin batı bölgesinde anlamlı olarak daha az olduğu görülmüştür. Daha önceleri güneydoğuda bölgesinde kronik viral hepatit seroprevalansı daha yüksek iken son yıllarda düşüş göstermesi ve özellikle batı bölgesinde anti-HDV pozitifliğinin olmaması dikkat çekici bulunmuştur. Kronik viral hepatitlerin seropozitifliğinin azalmasında rutin aşılama, eğitim ve bilgilendirim programları ile gerçekleştiği katına varılmıştır.Öğe Seroprevalance of Hepatitis B Virus, Hepatitis C Virus and Hepatitis D Virus in Healthy Blood Donors(Galenos Publ House, 2012) Sirmatel, Fatma; Yetkin, Gulay; Eris, Fatma Nur; Koruk, Suda Tekin; Duygu, Fazilet; Karaagac, Leman; Dincer, SevimObjective: Training and research Hospital in the two different region, healthy volunteer blood donors were admitted to Blood Bank which serological markers to chronic viral hepatitis HBV, HCV and HDV seroprevalance was investigated by EIA. The aim of this study is to determine seropositivity indicating chronic hepatitis through west and southeast regions and to debate the difference between two regions according to literature. Materials and Methods: This study was performed in two groups. First group was enrolled in Sanliurfa between 2004-2006 years, whereas second group was programmed in Bolu between 2007-2009 years. Both of them were taken University Hospital Blood Bank. Healthy blood donors were chosen on a voluntary basis. The serological markers of donors HBV and HCV were studied by macro EIA (Abbott Axsym UK), whereas HDV markers in the sera of patients with HBsAg positive by micro EIA (Abbott UK). All the patients' ages, professions, birth places and history of transmission were questioned in detail. Results: In the first group; 565 (2.9%) HBsAg and 104 (0.5%) anti-HCV positive cases were found in a total of 19.250 healthy blood donors. Only 194 HBsAg positive cases were followed and monitories in which 5 (2.5%) ones of all were found to be anti-HDV positive. In the second group including 2012 blood donors, HBsAg and anti-HCV positivity were found respectively 24 (1.19%) and 5 (0.24%) besides no anti-HDV positivity. All subjects' mean age was 33.9(between 18-71 years). Conclusion: When comparing population of both Southeast and West cities in aspect of chronic viral hepatitis markers, it is found to be significantly less in West. Previously chronic viral hepatitis seroprevalance is higher in the Southeast region to show decline in recent years and especially in the western region has a remarkable absence of and anti-HDV positivity. We assume that the decrease in the rate seropositivity of chronic viral hepatitis is due to routine immunization and education programs.
