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  • Küçük Resim Yok
    Öğe
    Carotis lntima Media Thickness in Female Patiens with Subclinical Hypothyroidism
    (Galenos Yayincilik, 2010) Onder, Elif; Aydin, Yusuf; Gungor, Adem; Celbek, Gokhan; Kir, Seher; Yildinm, Hayriye Ak; Demirin, Hilmi
    Objective: Recent studies have shown that subclinical hypothyroidism (SCH) has similar cardiovascular risks with clinical hypothyroidism (CH). We evaluated carotis intima media thickness (CIMTI-indicator of early changes in atherosclerotic process-in female patients, who have either CH or SCH, with similar age and demographic features. Materials and Methods: In this study, we included 81 female patients admitted to internal medicine and endocrinology outpatient clinic, diagnosed with CH (30) or SCH (51) according to their laboratory findings and who hove not previously received treatment and 38 healthy women. BMI (body moss index), sistolic and diastolic blood pressure, triglycerides (TG), total cholesterol (TC), LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), vitamin B-12, folate, homocysteine, high-sensitive C-reactive protein (Hs CRP), and CIMT were measured in all participants Results: There was not a statistical difference between the groups in TG, TC, HDL-C, LDL-C, vitamin B-12, and folate levels (p>0.05). On the other hand, SCH and CH groups differed statistically significantly from the control group for Hs CRP (p=0.011), homocysteine (p<0.001), and CIMT values. Additionally, age was found to be the most important factor for increase in CIMT when multiple linear regression analysis was performed. Conclusions: Lack of difference between CH patients and SCH patients in respect to Hs CRP, homocystein, and CIMT shows that inflammation and increase in CIMT starts during SCH period. Hence, we think that the increase in CIMT in SCH patients when TSH levels are higher than the normal range is a clinically important sign of early cardiovascular diseases.
  • Küçük Resim Yok
    Öğe
    Neutrophil - lymphocyte ratio in patients with ankylosing spondylitis
    (2014) Özşahin, Mustafa; Demirin, Hilmi; Uçgun, Taner; Ermiş, Mehmet Fatih; Admış, Özlem; Ataoğlu, Safinaz
    Amaç: Bu çalışmanın amacı, ankilozan spondilit (AS) hastalarındaki inflamasyon ile nötrofil -lenfosit oranı (NLO) arasındaki ilişkiyi belirlemektir. Yöntem: Ankilozan spondilit tanılı 40 hasta ve 30 sağlıklı gönüllü çalışmaya dahil edildi. Tüm veriler yatan ve poliklinik hasta kayıt veritabanından elde edildi. Tüm olguların Bath Ankilozan Spondilit Hastalık Aktivite İndeksi (BA S- DAI), tam kan sayımı (TKS), CRP ve ESH’ı da kapsıyan ayrı ntılı fizik muayene ve laboratuvar bulguları kaydedildi. Lenfosit ve nötrofil sayısı otomatik TKS’nin bir parçası olarak ölçüldü. Bulgular : Akut-faz reaktanı olan CRP ve ESH kontrol gr ubuna göre hasta grubunda anlamlı olarak daha yüksekti (p 0.05). Sonuç : Bu çalışmada NLO düzeylerinin AS hastalarında sağlıklı bireylere göre anlamlı olarak yüksek olmadığı görüldü. Bu sonuç NLO’nun AS hastalarında sistemik in flamasyonu değerlendirmede uygun bir ölçü birimi olmad ığını götermektedir. Bizim elde ettiğimiz bu ön sonuçların daha ileri çalışmalarla tamamlanması gerektiğine inanıyoruz.
  • Küçük Resim
    Öğe
    Relationship of maternal serum resistin and visfatin levels with gestational diabetes mellitus
    (Taylor & Francis Ltd, 2014) Karataş, Ahmet; Işıkkent, Nilüfer Tuncay; Özlü, Tülay; Demirin, Hilmi
    Introduction: Adiponectin, resistin and visfatin are thought to play role in the pathophysiology of gestational diabetes (GDM). In this study, we aimed to investigate the association of maternal second trimester serum resistin and visfatin levels with GDM. Materials and methods: Screening and diagnosis for GDM was performed between the 24-28th gestational weeks. About 40 women diagnosed with GDM and 40 non-diabetic women constituted the study and control groups, respectively. Groups were compared for second trimester maternal serum resistin, visfatin and HbA1c levels, HOMA-IR and postpartum 75 g OGTT results. Results: Mean serum resistin (p = 0.071) and visfatin (p = 0.194) levels were similar between the groups. However, mean BMI (p = 0.013), HOMA-IR (p = 0.019), HbA1c (p<0.0001) and birth weight (p = 0.037) were significantly higher in GDM group compared to controls. Type 2 diabetes and impaired glucose tolerance were detected in 2 (5%) and 7 (20%) women in the GDM group, respectively, with 75 g OGTT performed at the postpartum 6th week. Resistin levels of patients with GDM and postpartum glucose intolerance were higher than those with GDM but no postpartum glucose intolerance (p = 0.012). Visfatin levels in the GDM group showed a positive correlation with biparietal diameter, head circumference, abdominal circumference and femur length (p<0.05). Conclusion: Maternal serum resistin and visfatin levels are unchanged in GDM. In patients with GDM, second trimester resistin levels may be predictive for postpartum glucose intolerance and second trimester visfatin levels may be related with fetal biometric measurements. Further larger studies are needed.