Yazar "Demirci, Mehmet" seçeneğine göre listele
Listeleniyor 1 - 4 / 4
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Assessment of Epstein-Barr virus, Candida albicans, and some periodontal pathogens in rheumatoid arthritis patients with periodontitis(Kare Publ., 2023) Paksoy, Tuğçe; Ustaoğlu, Gülbahar; Taşçı, Murat; Demirci, Mehmet; Ünlü, Özge; Yaşar, Mustafa FatihOBJECTIVE: To comparatively investigate the periodontal results and microbial load in subgingival biofilm samples (SBS) in rheumatoid arthritis subjects and healthy volunteers.METHODS: One hundred twenty subjects were classified into different cohorts: healthy (H-C); periodontitis with good systemic health (H-P); rheumatoid arthritis (RA) and good periodontal health (RA-C); and periodontitis with RA (RA-P). The periodontal parameters were recorded, and SBS were collected to determine periodontal pathogens including Epstein-Barr Virus (EBV) and Candida albicans using reverse transcription-polymerase chain reaction (RT-PCR). RESULTS: Subjects that had greater disease course, determined by moderate or high disease activity scores 28 (DAS28), suffered from worse oral health conditions (higher plaque index, gingival index, bleeding on probing, probing depth, and excessive clinical attachment loss) than those with low DAS28 scores. A higher prevalence of Treponema denticola (T. denticola) was observed in the RA-P group. Cyclic citrullinated peptide was associated with the occurrence of T. denticola and Campylo-bacter rectus. DAS28 using C-reactive protein (DAS28-CRP) had a significant association with Capnocytophaga gingivalis and EBV. The duration of the RA disease was associated with the presence of T. denticola.CONCLUSION: Subgingival microbial difference could reliably discriminate RA from healthy individuals. Especially, T. denti-cola and EBV may play a key role in periodontitis associated with RA.Öğe Bolu ve yöresinde veteriner hekimlerde bruselloz ve kistik ekinokokkoz seroprevalansı(Bolu Abant İzzet Baysal Üniversitesi, 2019) Demirci, Mehmet; Ayaz, ErolBruselloz ve kistik ekinokokkoz, tüm dünyada yaygın zoonotik karakterli hastalıklardır. Ülkemiz ve yakın komşuları bu hastalıklar bakımından endemik/hiperendemik bölgelerdedirler. Bu araştırmada, bu hastalıklar yönünden Bolu ve yöresindeki istatistiki durumun ortaya konması ve diğer istatistiklerle beraber sunulması ile Bolu ve yöresinde çalışan veteriner hekimlerin bu hastalıklar açısından risk grubunda olup olmadıklarının belirlenmesi amaçlanmıştır. Bu amaçla araştırmaya katılan 72 veteriner hekim ile 384 diğer gönüllüden (Bolu ve yöresini temsilen) alınan örneklerde, Brucella Coombs Gel Test ile bruselloz, İndirekt Hemaglütinasyon Testi ile de kistik ekinokokkoz için antikor araması yapılmıştır. Araştırma sonucunda veteriner hekimlerde bruselloz prevalansı %9,72 (7/72) iken; kistik ekinokokkoz seropozitifliğine rastlanılmamıştır; diğer gönüllülerde ise bruselloz prevalansı %1,82 (7/384) ve kistik ekinokokkoz prevalansı %0,52 (2/384) olarak tespit edilmiştir. Bu sonuçlar neticesinde, Bolu ve yöresinde çalışan veteriner hekimlerin bruselloz bakımından riskli grupta yer aldığı görülmüştür. Diğer gönüllülerde ise bruselloz prevalansı Sağlık Bakanlığı verilerinin üzerinde olup; kistik ekinokokkoz prevalansı da Türkiye ortalamasının oldukça üzerindedir. Çalışmamızda; bruselloz prevalansının veteriner hekimler ile diğer gönüllüler arasındaki oranı istatistiki olarak anlamlı bulunmuştur. Diğer gönüllülerde bruselloz prevalansı ile eğitim düzeyi, yerleşim bölgesi ve pastörize edilmemiş süt ve süt ürünlerinin tüketilmesi arasında; kistik ekinokokkoz prevalansı ile de yeşilliklerin yıkanmadan tüketilmesi ve kuyu suyu içilmesi arasında istatistiki olarak anlamlı bir ilişki bulunmuştur. Bu araştırma ile, Bolu ve yöresinde brusellozun ve kistik ekinokokkozun önemli bir halk sağlığı sorunu oluşturduğu kanaatine varılmıştır.Öğe Evaluation of bacterial colonization and clinical properties of different suture materials in dentoalveoler surgery(W B Saunders Co-Elseiver Inc, 2022) Yaman, Deniz; Paksoy, Tuğçe; Ustaoğlu, Gülbahar; Demirci, MehmetPurpose: This study aimed to compare the effects of 10 different suture materials commonly used in dentoalveolar surgery on wound healing, their postoperative microbial colonization, and related clinical parameters. Methods: A total of 172 suture samples from patients who had undergone extraction of impacted third molars were included in the study. The suture materials studied were poly-glycolide-colactide, fast absorbable poly-glycolide-colactide, poly-glycolic acid-cocaprolactone, polydioxanone, silk, polypropylene, polyvinylidene difluoride, polyamide, polyester, and polytetrafluoroethylene (PTFE). The microbial colonization in all sutures and clinical parameters were evaluated after 1 week. Results: Multifilament sutures had higher bacterial colonization compared with monofilament sutures (P < .001). No dental plaque accumulation was observed in any samples of polypropylene sutures. Polydioxanone, PTFE, and poly-glycolic acid-cocaprolactone sutures exhibited less postoperative slack compared with all other sutures after 1 week. Patients with silk, polyvinylidene difluoride, and PTFE sutures had less suture-related discomfort. According to the Landry index score, monofilament sutures demonstrated superior wound healing to multifilament sutures (P = .019). In addition, nonabsorbable sutures showed significantly better wound epithelization than absorbable sutures (P < .001). Conclusions: Bacterial colonization and tissue reactions due to the surface properties of the suture affected the wound healing after dentoalveolar surgery. Multifilament sutures should not be applied for prolonged periods because of their tendency for microbial colonization. The tissue reaction to the absorbable suture materials may adversely affect wound healing. (C) 2021 The American Association of Oral and Maxillofacial Surgeons.Öğe The link between total antioxidant status, total oxidant status, arylesterase activity, and subgingival microbiota in psoriasis patients(Wiley, 2022) Paksoy, Tuğçe; Ustaoğlu, Gülbahar; Yaman, Deniz; Arıöz, Özkan; Demirci, Mehmet; Polat, MuallaBackground Studies focusing on the relationship between periodontitis and systemic diseases have suggested a possible association between these two chronic and inflammatory disorders. We aimed to comparatively investigate the salivary oxidative status, biomarker levels, clinical findings, and the microbial load on subgingival biofilm samples in psoriasis patients and controls. Methods Forty participants were allocated into four groups as follows: (1) systemically and periodontally healthy (C group); (2) systemically healthy with periodontitis (P group); (3) psoriasis (Ps) and periodontally healthy (Ps-C group); and (4) Ps with periodontitis (Ps-P group). Subgingival biofilm samples were obtained to detect the periodontopathogenic agents by Real-time PCR (qPCR). The total antioxidant status (TAS) (mmol/l), total oxidant status (TOS) (mu mol/l), and arylesterase (ARE) activity (U/L) were analyzed using saliva samples. Results The level of TOS and oxidative stress index (OSI) were significantly higher in patients with Ps-P and P compared to controls (P = 0.001, and P < 0.001, respectively). ARE levels were higher in controls compared to Ps and P (P < 0.001). The prevalences of bacteria detected in subgingival biofilm samples were similar between all groups (P > 0.05). Conclusions This study reported that psoriasis may amplify TOS and OSI, and the co-existence of psoriasis and periodontitis may aggravate oxidative stress.
