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Öğe Association of SYNTAX Score withPATIMA Index, Carotid Intima- andExtra- Media Thicknesses(2021) Coşgun, Mehmet; Cosgun, Zeliha; Güneş, Yılmaz; Sincer, Isa; Erdal, Emrah; Mansiroğlu, Aslı; Inanir, MehmetObjectives: Several risk scoring systems have been validated for cardiovascular risk prediction and prognosis. Periarterial adipose tissue intima media adventitia (PATIMA) index combining carotid intima media thickness (CIMT), carotid extra media thickness (CEMT), cardiac epicardial fat thickness (EFT), and body mass index (BMI) are related to coronary artery disease (CAD).Materials and Methods: One-hundred-twenty-four patients were categorized as low synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) (<22) (n=84) or high SYNTAX (?22) (n=40) score groups. Association of PATIMA index and its components with SYNTAX score were analyzed.Results: CIMT, CEMT, BMI, EFT, and PATIMA index were not significantly different between groups. SYNTAX score was not significantly correlated with traditional CVS risk factors (diabetes, hypertension, hyperlipidemia, smoking, age). There was a significant correlation between the PATIMA index and age (r=0.308, p=0.001) but not with other risk factors. Age was significantly correlated with CIMT (r=0.289, p=0.001) and EFT (r=0.208, p=0.02) but not with CEMT (r=0.091, p=0.313). There was a significant correlation between CIMT and CEMT (r=0.414, p<0.001) and between CIMT and EFT (r=0.267, p=0.004).Conclusion: We have found that the recently described PATIMA index and its components, CIMT, CEMT, and EFT are not associated with the severity of CAD assessed by the SYNTAX score. Furthermore, they have not correlated with classical risk factors apart from age.Öğe Changes in the size of breast lesions during menstrual cycle observed by ultrasound: An initial study(Scientific Publishers of India, 2017) Dagistan, Emine; Canan, Arzu; Halicioglu, Siddika; Cosgun, Zeliha; Gurel, SafiyePurpose: We aimed to evaluate changes in size of breast lesions during menstrual phases. Material and methods: In this prospective study, 46 women aged 18-35 years old who were referred to our radiology clinic for breast sonography and had cystic or solid breast lesions larger than 5 mm were enrolled to the study. Breast ultrasound (US) was performed at two different times; one within 5 days before and one within 5 days after menstrual bleeding. Anteroposterior and transverse length of the lesions were measured. Results: In total, 145 breast lesions were detected by US. Of these lesions, 6 were visualized in premenstrual phase but were not observed in postmenstrual phase. 6 lesions different were not visualized in premenstrual, but were detected in postmenstrual phase. One hundred and twenty-three lesions were visualized by US both in luteal and follicular phases. Conclusions: Timing of breast US might cause false results and unnecessary further investigations. Therefore, we suggest that breast US in women should be performed in follicular phase of the menstrual cycle. © 2017, Scientific Publishers of India. All Rights Reserved.Öğe Could Hemogram Parameters Predict Extensive Pulmonary Involvement in SARS CoV-2 Infection?(2022) Cosgun, Zeliha; Kalfaoğlu, Melike Elif; Dağistan, Emine; Özsari, Emine; Aktaş, GülaliAim: Since the start of the pandemic, the novel coronavirus infection SARS CoV-2 has caused huge morbidity and mortality, as well as a significant economic cost. We aimed to compare clinical and laboratory findings of the SARS CoV-2 patients with mild pulmonary involvement to those in subjects with advanced pulmonary involvement. Material and Methods: In this study, the relationship between hemogram indices and pulmonary involvement in patients hospitalized for SARS CoV-2 infection at Bolu Abant Izzet Baysal University Hospital was investigated. We analyzed the thorax CT images of the subjects with SARS CoV-2 in present retrospective study. Radiological pattern of disease-related in the lungs, percentage of lung involvement, hemogram parameters, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), aspartate and alanine transaminases (AST and ALT), lactate dehydrogenase (LDH), D-dimer, ferritin, total bilirubin, albumin, creatinine kinase, serum creatinine in patients with advanced and mild pulmonary involvement were compared. Results: Advanced pulmonary involvement (greater than 50%) was positively and significantly correlated with ESR, (r=0.32, p<0.001), CRP (r=0.37, p<0.001), LDH (r=0.46, p<0.001), D-dimer (r=0.19, p<0.001), ferritin (r=0.37, p<0.001), mean platelet volume (MPV) (r=0.13, p<0.001), the neutrophil to lymphocyte ratio (NLR) (r=0.33, p<0.001) and platelet to lymphocyte ratio (PLR) (r=0.27, p<0.001). Conclusion: We suggest that MPV, PLR and NLR could be early predictors of advanced pulmonary involvement in SARS CoV-2 patients. Physicians should aware of this complication in the setting of elevated MPV, PLR or NLR levels.Öğe İdiyopatik Normal Basınçlı Hidrosefali Tanısı ile Şant Uygulanan Hastaların Tedavi ve Gözlem Sonuçları(2021) Şenol, Özgür; Dağistan, Emine; Cosgun, Zeliha; Kalfaoğlu, Melike Elif; Dağistan, YaşarAmaç İdiyopatik normal basınçlı hidrosefali (iNPH) tanısı ile orta basınçlı ventriküloperitoneal (VP) ve lumboperitoneal (LP) şant uygulanan hastaların 3 yıllık takip sırasında klinik sonuçları ve şant tedavisinde karşılaştığımız problemleri sunmayı amaçladık. Gereç ve Yöntem Çalışmaya 2013 – 2017 tarihleri arasında Nöroloji ve Nöroşirurji Anabilim Dallarına başvuran, klinik ve radyolojik olarak iNPH olarak değerlendirilen hastalar retrospektif olarak tarandı.VP ve LP şant uygulanan hastalarda başarı oranları ve komplikasyonları kayıt edildi. Bulgular Değerlendirilen 26 hastanın 19 tanesine (%73,1) VP şant, 7 tanesine (%26,9) LP şant uygulandı. 5 hastaya (%19) batın revizyonu, 2 hastaya (%11) kranial revizyonu uygulandı. Cerrahi sonrası 1 hastada (%5) subdural hematom gelişti. 3 (%11) hastada analjezik tedaviye yanıtlı, günler içerisinde düzelen baş ağrısı gelişti. Hiçbir hastada şant enfeksiyonu, şant erezyonu, işitme kaybı, görme kaybı veya sistemik enfeksiyon gibi majör komplikasyon görülmedi. Sonuç iNBH’de hastaların yaş ortalaması yüksek olmasından dolayı beyin atrofiside eşlik edebileceğinden hızlı beyin omurilik sıvısı (BOS)boşalımının kanamalara sebep olma riski göz önünde bulundurulmalıdır. Komplikasyon oranının daha düşük olması ve ayarlanabilir şantın manyetik ortamlardan çabuk etkilenmesinden dolayı öncelikle orta basınçlı VP şant ve ardından LP şant düşünülebilirÖğe Lomber Disk Hernisi ve Hemogram Parametreleri Arasında Bir Bağlantı Var mı?(2018) Kılınç, Erkan; Dağıstan, Yaşar; Dağıstan, Emine; Cosgun, ZelihaAmaç: Enflamatuvar mekanizmalar disk hernisi ile ilişkili bel ağrısının patogenezinde önemli bir rol oynamaktadır. Rutin hemogram testlerindeki yeni ve umut vadeden enflamatuvar belirteçler ortalama trombosit hacmi (mean platelet volume--MPV) ve kırmızı küre dağılım genişliğidir (red cell distribution width--RDW). Bu çalışmada lomber disk hernisinden (LDH) muzdarip hastaların MPV ve RDW değerlerinin, sağlıklı gönüllülere ve radyolojik lomber disk hernisi bulgusu olmayan siyataljili semptomatik hastalara ait değerlerle karşılaştırılması amaçlanmıştır.Gereç ve Yöntemler: Bu retrospektif kohort çalışması Abant İzzet Baysal Üniversitesi Eğitim ve Araştırma Hastanesi Nöroşirürji Anabilim Dalı'nda gerçekleştirildi. Kontrol (n=57), LDH (n=73) ve siyatalji (n=20) grupları olmak üzere toplam üç grup oluşturuldu. Grupların beyaz küre, hemoglobin, hematokrit, ortalama korpüsküler hacim, platelet sayısı ile RDW ve MPV parametreleri değerlendirildi.Bulgular: LDH, siyatalji ve kontrol gruplarının ortalama MPV değerleri sırasıyla 9,3±1,8 fL, 8,2±1,1 fL ve 8,4±1,0 fL olarak bulundu. LDH grubunun ortalama MPV değeri siyatalji ve kontrol gruplarınınkinden anlamlı derecede daha yüksekti (p=0,001). LDH, siyatalji ve kontrol gruplarının ortalama RDW değerleri sırasıyla 14,8±1,8, 13,8±1,0 ve 13,7±1,2 olarak bulundu. LDH grubunun ortalama RDW değeri de siyatalji ve kontrol gruplarınınkinden anlamlı derecede daha yüksekti (p=0,001).Tartışma ve Sonuç: Yükselmiş MPV ve RDW değerleri siyataljili hastalarda LDH'ye işaret eden güçlü indikatörler olabilir ve bu yükselmiş değerlere sahip hastalar görüntüleme çalışmalarında öncelenmelidirler. Bununla birlikte bulgularımızı destekleyen daha fazla prospektif çalışmaya ihtiyaç vardır.Öğe The Predictors of Pneumonia in Children with COVID-19(2023) Yoldaş, Meyri Arzu; Tayfur, Aslı Çelebi; Daniş, Ayşegül; Hanci, Fatma; Atasoy, Halil Ibrahim; Bolu, Semih; Cosgun, ZelihaThe purpose of this study was to evaluate the relationship between the presence of pneumonia and blood parameters in cases of Coronavirus disease (COVID-19) and to examine their predictive characteristics in terms of pneumonia. We reviewed the file records of 151 pediatric patients with a diagnosis of COVID-19 confirmed by the real time-reverse transcription polymerase chain reaction test in nasopharyngeal swabs. The patients were divided into two groups based on direct chest X-ray and computed tomography results in [Group 1 (n:41), with pneumonia findings, and Group 2 (n:110), with no pneumonia findings]. The groups’ demographic data, clinical and laboratory findings were compared. Pulmonary involvement was determined in 41 (27.1%) of the 151 patients. The [body mass index (BMI) Z-score], red blood cell distribution width (RDW), mean platelet volume (MPV), neutrophil lymphocyte ratio, passive leg raise, and D-dimer levels were significantly higher in patients with pneumonia than those without pneumonia in our study. Based on multivariate logistic regression analysis, BMI Z-score, MPV, and RDW were found to be independent risk factors of pneumonia in patients. The current study showed higher levels of blood parameters in patients with coronavirus disease 2019 (COVID -19) presenting with pneumonia than those without pneumonia. We suggest that BMI-Z score and MPV value may assist in predicting pulmonary involvement in patients with COVID-19.Öğe Relationship between osteoarthritis findings in knee radiography and meniscus lesionin magnetic resonance imaging in symptomatic knee pain cases(2021) Kalfaoğlu, Melike Elif; Cosgun, Zeliha; Dağistan, EmineAim: Knee osteoarthritis is a very common joint disease in the community. However, some meniscus lesions are asymptomatic. Studies show that a significant number of individuals with knee pain without radiographic osteoarthritis findings show meniscus injury on magnetic resonance imaging (MRI). Our study aimed to evaluate the relationship between meniscus lesions and the presence of radiographic knee osteoarthritis in individuals over 50 years of age with knee pain complaints. Methods: Radiographic and MRI results of two hundred and forty patients who applied to our hospital with the complaint of knee pain between August 2018 and January 2020 were analyzed. Radiographic grading for knee osteoarthritis was performed using the Kellgren Lawrence scale. Classification of meniscus lesions in MRI was made as per the criteria defined by the British Knee Meniscus Surgery Association. Intergroup results were evaluated statistically. Results: Osteoarthritis was detected in 110 (45.8%) of 240 knee radiographs. In 78.3% of all cases, meniscus lesions were detected in 96.4% of those with osteoarthritis and 63% of those without osteoarthritis. In patients with osteoarthritis, the prevalence of surgically targeted and possible target lesions was found to be significantly higher than those with no arthritis findings. Conclusions: According to our study results, meniscus lesions were found quite common in individuals with knee pain, especially those with osteoarthritis. Particularly in patients with radiographic osteoarthritis findings, surgical targets and possible target meniscus lesions were more common than those without osteoarthritis findings. Therefore, MRI, in addition to direct radiography, should not be overlooked when determining treatment.Öğe Sonographic examination of respiratory muscles in chronic obstructive lung disease and evaluation of the relationship with clinical severity of exacerbation(2022) Akbulut, Semiha; Cosgun, Zeliha; Özsari, Emine; Kalaycioğlu, OyaIntroduction: This study aimed to sonographically examine the fraction of thickening in the respiratory muscles during the acute exacerbation of chronic obstructive pulmonary disease (COPD) and to determine its relationship with the clinical severity of the exacerbation. Methods: This prospective study looked at 159 people over the age of 50 who were diagnosed with COPD using the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria and were admitted to the hospital because they were having an acute COPD flare-up. Ultrasonography was used to measure how thick the parasternal intercostals, pectoralis major, and diaphragm muscles were in each patient. Results: Of the patients, 63 had mild, 63 had moderate, and 33 had severe exacerbations. Parasternal intercostal and pectoralis major muscle thickening fractions were significantly higher in moderate and severe exacerbations compared to mild exacerbations, while the diaphragm muscle thickening fraction was significantly lower (p<0.001). In the severe and moderate exacerbation groups, the thickening percentages of parasternal intercostal and pectoralis major muscle were significantly higher in severe exacerbation than in moderate exacerbation (p<0.001). There was no significant difference in the diaphragm muscle thickening fraction between the two groups. Discussion and Conclusion: Ultrasonography of the respiratory muscles may provide useful information in identifying COPD patients at risk of severe exacerbation, as well as a reliable and repeatable biomarker in patient follow-up.
