Lomber Disk Hernisi ve Hemogram Parametreleri Arasında Bir Bağlantı Var mı?
Küçük Resim Yok
Tarih
2018
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Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Enflamatuvar mekanizmalar disk hernisi ile ilişkili bel ağrısının patogenezinde önemli bir rol oynamaktadır. Rutin hemogram testlerindeki yeni ve umut vadeden enflamatuvar belirteçler ortalama trombosit hacmi (mean platelet volume--MPV) ve kırmızı küre dağılım genişliğidir (red cell distribution width--RDW). Bu çalışmada lomber disk hernisinden (LDH) muzdarip hastaların MPV ve RDW değerlerinin, sağlıklı gönüllülere ve radyolojik lomber disk hernisi bulgusu olmayan siyataljili semptomatik hastalara ait değerlerle karşılaştırılması amaçlanmıştır.Gereç ve Yöntemler: Bu retrospektif kohort çalışması Abant İzzet Baysal Üniversitesi Eğitim ve Araştırma Hastanesi Nöroşirürji Anabilim Dalı'nda gerçekleştirildi. Kontrol (n=57), LDH (n=73) ve siyatalji (n=20) grupları olmak üzere toplam üç grup oluşturuldu. Grupların beyaz küre, hemoglobin, hematokrit, ortalama korpüsküler hacim, platelet sayısı ile RDW ve MPV parametreleri değerlendirildi.Bulgular: LDH, siyatalji ve kontrol gruplarının ortalama MPV değerleri sırasıyla 9,3±1,8 fL, 8,2±1,1 fL ve 8,4±1,0 fL olarak bulundu. LDH grubunun ortalama MPV değeri siyatalji ve kontrol gruplarınınkinden anlamlı derecede daha yüksekti (p=0,001). LDH, siyatalji ve kontrol gruplarının ortalama RDW değerleri sırasıyla 14,8±1,8, 13,8±1,0 ve 13,7±1,2 olarak bulundu. LDH grubunun ortalama RDW değeri de siyatalji ve kontrol gruplarınınkinden anlamlı derecede daha yüksekti (p=0,001).Tartışma ve Sonuç: Yükselmiş MPV ve RDW değerleri siyataljili hastalarda LDH'ye işaret eden güçlü indikatörler olabilir ve bu yükselmiş değerlere sahip hastalar görüntüleme çalışmalarında öncelenmelidirler. Bununla birlikte bulgularımızı destekleyen daha fazla prospektif çalışmaya ihtiyaç vardır.
Aim: Inflammatory mechanisms play a key role in the pathogenesis of back pain related to disc hernia. Mean platelet volume (MPV) and red cell distribution width (RDW) are novel and promising inflammatory markers in routine hemogram tests. In this study, we aimed to compare the MPV and RDW values of patients with lumbar disc herniation (LDH) to those of healthy subjects and symptomatic patients suffering from sciatica without radiological evidence of lumbar disc herniation.Materials and Methods: This retrospective cohort study was carried out in the Neurosurgery Department of the Abant Izzet Baysal University Education and Research Hospital. Three groups as the controls (n=57) and LDH (n=73) and sciatica (n=20) groups were designed. Hemogram parameters including white blood cell count (WBC), hemoglobin (Hb), hematocrit (Htc), mean corpuscular volume (MCV), RDW, platelet count (PLT) and MPV were evaluated for each group. Results: The mean MPVs of the LDH, sciatica, and control groups were 9.3±1.8 fL, 8.2±1.1 fL, and 8.4±1.0 fL, respectively. The mean MPV was significantly higher for the LDH group, compared to the sciatica and control groups (p=0.001). The mean RDWs of the LDH, sciatica, and control groups were 14.8±1.8, 13.8±1.0, and 13.7±1.2, respectively. The mean RDW was also significantly higher for the LDH group in comparison to the sciatica and control groups (p=0.001). Discussion and Conclusion: We think that elevated MPV and RDW values might be strong indicators of LDH in patients with sciatica and that such patients should be prioritized for imaging studies. However, further prospective studies are needed to support our results.
Aim: Inflammatory mechanisms play a key role in the pathogenesis of back pain related to disc hernia. Mean platelet volume (MPV) and red cell distribution width (RDW) are novel and promising inflammatory markers in routine hemogram tests. In this study, we aimed to compare the MPV and RDW values of patients with lumbar disc herniation (LDH) to those of healthy subjects and symptomatic patients suffering from sciatica without radiological evidence of lumbar disc herniation.Materials and Methods: This retrospective cohort study was carried out in the Neurosurgery Department of the Abant Izzet Baysal University Education and Research Hospital. Three groups as the controls (n=57) and LDH (n=73) and sciatica (n=20) groups were designed. Hemogram parameters including white blood cell count (WBC), hemoglobin (Hb), hematocrit (Htc), mean corpuscular volume (MCV), RDW, platelet count (PLT) and MPV were evaluated for each group. Results: The mean MPVs of the LDH, sciatica, and control groups were 9.3±1.8 fL, 8.2±1.1 fL, and 8.4±1.0 fL, respectively. The mean MPV was significantly higher for the LDH group, compared to the sciatica and control groups (p=0.001). The mean RDWs of the LDH, sciatica, and control groups were 14.8±1.8, 13.8±1.0, and 13.7±1.2, respectively. The mean RDW was also significantly higher for the LDH group in comparison to the sciatica and control groups (p=0.001). Discussion and Conclusion: We think that elevated MPV and RDW values might be strong indicators of LDH in patients with sciatica and that such patients should be prioritized for imaging studies. However, further prospective studies are needed to support our results.
Açıklama
Anahtar Kelimeler
Tıbbi Araştırmalar Deneysel
Kaynak
ANADOLU KLİNİĞİ TIP BİLİMLERİ DERGİSİ
WoS Q Değeri
Scopus Q Değeri
Cilt
23
Sayı
1
