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    The effect of diosmin hesperidin on intestinal ischaemia - reperfusion injury
    (Acta Medical Belgica, 2004) Pehlivan, Mevlüt; Hazinedaroğlu, Selçuk Mevlüt; Kayaoğlu, Hüseyin Ayhan; Erkek, Ayhan Bülent; Keklik, T.; Canbolat, Orhan; Koçak, Suzan
    Aim : The effect of Diosmin Hesperidin on intestinal ischaemia reperfusion injury was evaluated in an experimental model in rats. Material and methods: Forty Spraque-Dawley rats were divided into 4 groups of (n = 10) (sham, sham + Diosmin Hesperidin, Reperfusion, Reperfusion + Diosmin Hesperidin). Diosmin Hesperidin oral gavage was administrated at a dose of 50 mg/kg to rats 14 and 2 hours before the operation and 30 minutes of ischaemia and 30 minutes of reperfusion was performed in the groups when appropriate. Ileum samples were resected for histopathological evaluation and tissue malondialdehyde (MDA) and myeloperoxidase (MPA) level determination. Results : Mean mucosal injury score of IR group (4,50 0,23) was significantly higher than the other groups (p < 0.05). Although mean mucosal injury score of IR + DH group was higher than sham and sham + DH groups, difference was not statistically significant (p > 0.05). Tissue MDA and MPO activities of IR group were 45,55 +/- 2.61 nmol/g/wet tissue and 1.68 +/- 0.25 U/g/wet tissue respectively and were significantly higher than the other groups (p < 0.008). Although tissue MDA and MPO activities of IR + DH group was higher than sham and sham + DH groups, differences were not statistically significant (p > 0.008). Conclusion : Diosmin Hesperidin seems to be effective in the prevention of intestinal reperfusion injury.
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    N-Acetylcysteine in intestinal reperfusion injury: an experimental study in rats
    (Wiley, 2004) Hazinedaroğlu, Selçuk M.; Dülger, Ferda; Kayaoğlu, Hüseyin A.; Pehlivan, Mevlüt; Serinsöz, Ebru; Canbolat, Orhan; Erverdi, Nezih
    Background: The aim of the present study was to investigate the effect of N-acetylcysteine on intestinal reperfusion injury. Methods: Forty Spraque-Dawley rats were divided into four groups (n = 10): sham, sham + N-acetylcysteine, reperfusion, and reperfusion + N-acetylcysteine. Thirty minutes of ischaemia +/- 30 min of reperfusion was performed under 100 mg/kg N-acetylcysteine or placebo, administered 30 min before the operation in the groups where appropriate. Ileum samples were resected for histopathologic evaluation and tissue malondialdehyde and super oxide dismutase level determination. Results: The mean mucosal injury score and malondialdehyde level of the reperfusion and reperfusion + N-acetylcysteine groups were significantly higher than that of the control and control + N-acetylcysteine group (P < 0.01, P < 0.05, respectively). Mean super oxide dismutase level of the control + N-acetylcysteine group was significantly higher than that of the other groups (P < 0.05). Conclusion: N-Acetylcysteine did not prevent intestinal reperfusion injury by means of histopathologic findings and malondialdehyde level.