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    Green one-pot multicomponent synthesis, biological evaluation and theoretical investigations of some novel beta-acetamido ketone derivatives as potent cholinesterase inhibitors
    (Pergamon-Elsevier Science Ltd, 2020) Chibane, Adil Ziadi; Boulcina, Raouf; Boulebd, Houssem; Bensouici, Chawki; Yıldırım, Muhammet; Debache, Abdelmadjid
    A series of novel beta-acetamido ketones have been prepared via a four-component condensation between aromatic aldehydes, enolizable ketones, acyl chloride and acetonitrile in the presence of 10 mol% of phenylboronic acid as a catalyst. The expected products have been obtained in good to excellent yields. In addition, in vitro cholinesterase inhibitory activity of title compounds has been studied and the results indicated that some compounds exhibited remarkable BChE activity. In order to gain insights into the molecular structure and chemical reactivity of the synthesized beta-acetamido ketones, density functional theory (DFT) calculations were also carried out. (C) 2020 Elsevier Ltd. All rights reserved.
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    A silver nanoparticles-catalyzed efficient three-component synthesis of polysubstituted 4h-chromenylphosphonates and their antioxidant activity
    (Taylor & Francis Inc, 2018) Mahdjoub, Sara; Boulcina, Raouf; Yıldırım, Muhammet; Lakehal, Sihem; Boulebd, Houssem; Debache, Abdelmadjid
    A simple and efficient protocol for one-pot three-component synthesis of structurally diverse dialkyl 2-amino-3-cyano-4H-chromen-4-ylphosphonates from the condensation of salicylaldehydes, malononitrile, and trialkyl phosphite using silver nanoparticles as catalyst in ethanol at reflux has been developed. Selected new compounds were evaluated for their antioxidant activity by free radical screening using 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. Among the compounds employed, 5a, 5b, and 5h showed promising DPPH radical scavenging activities compared to the experimental standards at low concentration (100 mu g/mL) after 24h incubation. [GRAPHICS] .