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Öğe Anaplastic large cell lymphoma in a patient with rheumatoid arthritis(Springer Heidelberg, 2011) Beş, Cemal; Beş, Z. Senem; Vardı, Şeref; Soy, MehmetIt is known that patients with rheumatoid arthritis (RA) have an increased risk for non-Hodgkin's lymphomas in comparison with the general population. Although increased risk of lymphoma is attributed to the disease activity, the drugs used in the therapy of RA may also cause increased risk of malignancy. Herein, we report on an RA patient who developed non-Hodgkin's lymphoma after methotrexate therapy and review the literature about it. A 74-year-old man with RA had been treated with low-dose methotrexate and subsequently developed anaplastic large cell lymphoma of the T-cell phenotype. Anaplastic large cell lymphoma has been reported rarely in rheumatoid arthritis.Öğe Bronchocentric granulomatosis in a patient with rheumatoid arthritis(Springer Heidelberg, 2012) Beş, Cemal; Kılıçgün, Ali; Talay, Fahrettin; Yılmaz, Fahri; Soy, MehmetBronchocentric granulomatosis is an uncommon entity which has no specific clinical, radiological and immunological features. It is usually diagnosed at morphological examination of biopsy or resected lung material. Aetiology of bronchocentric granulomatosis is unclear. A 49-year-old female patient, who was followed up with diagnosis rheumatoid arthritis in our outpatient clinic, presented with right lobe nodular lesion in chest radiography. Right thoracotomy and wedge resection was performed. Pathological examination revealed bronchocentric granulomatosis. Bronchocentric granulomatosis has been rarely reported in rheumatoid arthritis. This case might be a proof that bronchocentric granulomatosis may be one of the respiratory manifestations of rheumatoid arthritis.Öğe The effect of TNF? blockers on psychometric measures in treatment resistant ankylosing sponylitis patients: A pilot study(Elsevier France-Editions Scientifiques Medicales Elsevier, 2011) Arısoy, Özden; Beş, Cemal; Çifci, Çiğdem; Sercan, Mustafa; Soy, MehmetThere is a high co-morbidity between chronic inflammatory disorders and depression1. Proinflammatory cytokines like TNFα seems to play a central role in the pathogenesis of these disorders and its neutralization provides a potent treatment for inflammatory disorders2. Trying et al (2006) showed that a TNF-α blocker -etanercept- caused at least a 50% improvement in depression scores in psoriasis patients.3 These observations together with the theoretical background led to the hypothesis that TNF-α blockers may reverse depressive symptoms associated with chronic inflammatory disorders.Öğe Emphysematous pyelonephritis caused by Klebsiella oxytoca in a patient with diabetic nephropathy(Nobel Ilac, 2010) Beş, Cemal; Okutur, Kerem; Şeber, Selçuk; Paksoy, Fatma; Borlu, FatihA 50-year-old woman with a 30 years history of diabetes mellitus and has been diagnosed with diabetic nephropathy for the last 4 years presented with abdominal pain, nausea and vomiting. Abdominal ultrasonography revealed a hyperechogenic air image at right kidney and with the aid of subsequently performed abdominal tomography type 2 emphysematous pyelonephritis diagnosis was made. Klebsiella oxytoca was isolated in blood culture and with appropriate antibiotic therapy and subsequent percutenous drainage the patient made a full recoveryÖğe Erythema nodosum associated with granulomatous mastitis: report of two cases(Springer Heidelberg, 2010) Beş, Cemal; Soy, Mehmet; Vardı, Şeref; Şengül, Neriman; Yılmaz, FahriGranulomatous mastitis is a rare breast disease characterized by chronic inflammation. Clinical presentation of granulomatous mastitis usually mimics malignancy or infection. Coincidence of granulomatous mastitis and erythema nodosum is a quite rare feature. In this paper, we aimed to present two young women with granulomatous mastitis accompanied by erythema nodosum and successfully treated with corticosteroids. Granulomatous mastitis should be kept in the mind for differential diagnosis of erythema nodosum.Öğe Exon 2: Is it the good police in familial mediterranean fever?(2019) Bilge, Nazife Şule Yaşar; Solmaz, Dilek; Şenel, Soner; Emmungil, Hakan; Kılıç, Levent; Beş, CemalObjective: Familial Mediterranean fever (FMF) is the most common autoinflammatory disease. Most of the identified disease-causing mutations are located on exon 10. As the number of studies about the effect of the exonal location of the mutation and its phenotypic expression is limited, we aimed to investigate whether the exonic location of the Mediterranean fever (MEFV) mutation has an effect on the clinical manifestation in patients with FMF. Methods: Study population was derived from the main FMF registry that included 2246 patients from 15 different rheumatology clinics. We categorized the mutations according to their exon locations and retrieved the clinical and demographic information from the database. Results: Patients having the MEFV mutations on exon 2 or 10 (n:1526) were divided into three sub- groups according to the location of the MEFV mutations: Group 1 (exon 2 mutations), Group 2 (exon 10 mutations), and Group 3 (both exon 2 and exon 10 mutations). Group 2 patients were of a signifi- cantly younger age at onset, and erysipel-like erythema, arthritis, amyloidosis, and a family history of FMF were more common in this group. Conclusion: Patients with FMF and exon 10 mutations show more severe clinical symptoms and out- come. Exon 2 mutations tend to have a better outcome.Öğe Hip osteonecrosis in Cushing's disease treated with bone-preserving procedures(Springer Tokyo, 2009) Güven, Melih; Ünay, Koray; Beş, Cemal; Poyanlı, Oğuz; Akman, BudakÖğe Joint and nail involvement in Turkish patients with psoriatic arthritis(Springer-Verlag GmbH Germany, part of Springer Nature, 2008) Soy, Mehmet; Karaca, Nuran; Ümit, Elif Uğur; Beş, Cemal; Pişkin, SüleymanPsoriatic arthritis is an autoimmune, chronic, systemic inflammatory disorder characterized by the association of arthritis with psoriasis. In this paper, we explore the characteristics of joint and nail involvement in Turkish patients with psoriatic arthritis. Forty patients with psoriasis (M/F, 18/22) and 49 (M/F, 25/24) subjects with psoriatic arthritis were included in the study. Clinical characteristics of the patients were recorded. The distribution of the subjects with arthritis: (according to the clinical and radiological findings): polyarticular, 65%; oligoarticular, 23%; isolated axial involvement, 7.7%; arthritis mutilans, 3.8%; sacroiliitis, 19%. Nail involvement was significantly higher among patients with arthritis; i.e., 91 versus 32%; (P < 0.05). There were no correlation between the skin involvement pattern and the arthritis type (P > 0.05). Nevertheless, no relation was observed between the psoriasis duration and arthritis (P > 0.05). Nail involvement is a frequent feature of the psoriatic arthritis which may be a useful finding for differential diagnosis of psoriatic arthritis from other inflammatory arthropathies.Öğe Pseudoxanthoma elasticum with mallory-weiss syndrome: Case report(Ortadogu Ad Pres & Publ Co, 2012) Paksoy Türköz, Fatma; Ulaş, Turgay; Beş, Cemal; Özkan, Koray; Sakız, Damlanur; Dal, Mehmet Sinan; Borlu, FatihPseudoxanthoma elasticum is a multi-systemic, genetic disorder of the connective tissue characterized by progressive calcification and fragmentation of elastic fibers in skin, retina, gastrointestinal and cardiovascular systems. Skin changes generally manifest in adulthood and rarely in childhood. Upper gastrointestinal hemorrhage occurs in some cases and is frequently resistant to nonsurgical methods of treatment. As the prognosis of pseudoxanthoma elasticum is related to the involvement of extracutaneous organs, early recognition of the disease is important to take preventive measures and to decrease the morbidity. Herein, we presented a case of pseudoxanthoma elasticum with Mallory-Weiss syndrome, who had repetitive and massive upper gastrointestinal bleeding. To our knowledge, there is no reported case of pseudoxanthoma elasticum with Mallory-Weiss syndrome in the literature.Öğe Serious menstrual bleeding associated with use of TNF alpha blocker: two cases(Springer Heidelberg, 2012) Beş, Cemal; Soy, MehmetMenstrual disorders associated with the use of TNF alpha blocker have been rarely reported. Herein, we reported two cases aged 31 and 41, presenting with excessive menstrual bleeding occured after adalimumab administration which was subsequently discontinued.Öğe Serum levels of visfatin, resistin and adiponectin in patients with psoriatic arthritis and associations with disease severity(Wiley-Blackwell, 2016) Dikbaş, Oğuz; Tosun, Mehmet; Beş, Cemal; Tönük, Şükrü Burak; Akşehirli, Özge Yılmaz; Soy, MehmetAim: Psoriatic arthritis (PsA) is an inflammatory form of arthritis typically associated with psoriasis and/or psoriatic nail disease. Adipocytokines were once thought to influence development of (only) insulin resistance and diabetes mellitus. However, it is now clear that adipocytokines play important roles in development of the inflammation associated with either autoimmune or auto-inflammatory disorders. In the present study, we measured changes in the serum levels of adiponectin, resistin and visfatin, and the associations of such changes with the extent of disease activity and insulin resistance in PsA patients. Material and methods: A total of 67 subjects (28 with PsA and 39 healthy controls) without hypertension or diabetes mellitus were enrolled. Adiponectin, resistin and visfatin levels, and the extent of insulin resistance (assayed using the homeostasis model [HOMA-IR]), were measured in all subjects. Assessment of PsA disease activity was done with the Disease Activity Index for Psoriatic Arthritis (DAPSA). Results: Psoriatic arthritis patients had considerably higher serum levels of adiponectin, resistin and visfatin than did healthy controls (all P < 0.05). In the logistic regression analysis, the following variables may contribute to complex pathogenesis of PsA: adiponectin (P = 0.001, OR = 3.1, 95% CI = 1.6-6.0), resistin (P = 006, OR = 1.8, 95% CI = 1.2-2.9) and visfatin (P = 0.031, OR = 3.9, 95% CI = 1.1-13.9). In contrast, we have not detected any correlation between DAPSA and adipocytokine serum levels (P > 0.05). Conclusion: There is no correlation between adipocytokines and disease activity. Although serum adiponectin, resistin and visfatin levels are higher in patients with PsA, pathophysiological significance of the result has to be evaluated with more extensive studies.Öğe Steroid-induced bicondylar osteonecrosis of both femurs in a patient with Behcet's disease(Clinical & Exper Rheumatology, 2010) Polat, Mualla; Beş, Cemal; Güven, Melih; Çakar, Murat; Soy, Mehmet[No Abstract Available]Öğe An unusual cause of a cystic lesion with an osteochondral defect in the talus intraosseous lipoma(Amer Podiatric Med Assoc, 2011) Atay, Evren Fehmi; Güven, Melih; Çakar, Murat; Başsorgun, Cumhur İbrahim; Akman, Budak; Beş, CemalAn intraosseous lipoma is a rare benign bone lesion that proliferates from mature lipocytes. It occurs most frequently in the lower limb, particularly in the calcaneus. The talus is an unusual location for this rare lesion. A review of the literature produced only two reports with talar intraosseous lipomas under the name of intraosseous lipomatosis, which described multiple lipomas in different areas. We describe a 38-year-old male patient who had an isolated intraosseous lipoma with an osteochondral defect in the talus and was treated with autologous osteochondral graft transplantation by medial malleolar osteotomy. He could walk with full weightbearing without any assistance at the end of 12 months. Intraosseous lipoma localized in the talus may be confused radiologically with other bone lesions, especially with unicameral bone cyst, if it is associated with an osteochondral defect. Autologous osteochondral graft transplantation is a successful treatment method for talar intraosseous lipoma. (J Am Podiatr Med Assoc 101(3): 269-274, 2011)Öğe Werner's syndrome: a quite rare disease for differential diagnosis of scleroderma(Springer Heidelberg, 2010) Beş, Cemal; Vardı, Şeref; Güven, Melih; Soy, MehmetWerner's syndrome (WS) is an autosomal recessive disorder characterized by premature aging. The main features of the disease are scleroderma-like skin appearance, premature atherosclerosis, short stature, diabetes mellitus, early osteoporosis and early aging. Herein, we describe a patient with WS, who has scleroderma-like skin changes and discuss the literature about WS as a disease in the differential diagnosis of systemic sclerosis.
