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    Dyskeratosis congenita associated with three malignancies
    (European Acad Dermatology & Venereology, 2003) Baykal, Can; Kavak, Ayşe; Gülcan, P.; Büyükbabani, Nesimi
    Dyskeratosis congenita is a rare inheritable disorder characterized by abnormalities of the skin, nails and oral mucosa. Aplastic anaemia resulting from bone marrow hypoplasia is a frequent cause of death. Squamous cell carcinoma developing from leukoplakia and visceral malignancies are other complications of the disease. We report here a case of dyskeratosis congenita in a man who developed three neoplasias of different systems over a period of many years. Squamous cell carcinoma and gastric adenocarcinoma manifested 17 years after the man was diagnosed with Hodgkin's disease.
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    HLA in alopecia areata
    (Blackwell Science Ltd, 2000) Kavak, Ayşe; Baykal, Can; Özarmağan, Güzin; Akar, Uğur
    Background The aim of this study was to investigate the human leukocyte antigen (HLA) characteristics of Turkish alopecia areata patients, and the correlation of the HLA profile with age of onset, severity and duration of the disease, presence of ophiasis, and family history. Methods A total of 88 patients with alopecia areata, alopecia totalis, or alopecia universalis were compared with 100 healthy controls. HLA typing was performed by the Terasaki microlymphocytotoxicity method. Results The frequency of HLA-A1, HLA-B62(15), HLA-DQ1, and HL4-DQ3 was significantly higher in patients than in controls. HL4-DR16 was significantly less common in patients than in the control group, and we concluded that this allele might have a protective role for alopecia areata. Juvenile onset and severe involvement were related with HLA-Cw7 and HLA-DR1, respectively. The HLA profile was independent of the existence of long-standing disease, presence of ophiasis, and a positive family history. Conclusions In HLA-alopecia areata association, ethnic differences may play a role.
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    Lipedematous scalp: A rare entity
    (Wiley, 2008) Kavak, Ayse; Yuceer, Deniz; Yildirim, Uemran; Baykal, Can; Sarisoy, Hasan Tahsin
    Lipedematous scalp is characterized by increased subcutaneous thickness of the scalp without any hair change. A 50-year-old female presented with thickening of the scalp without alopecia. She had no disorder other than hypertension. Monthly sonographic measurements without any treatment showed a resolution tendency in some areas and an increased thickness in others. We discuss the characteristics of this rare and possibly underestimated entity, including differential diagnoses.
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    Nevoid hyperkeratosis of the nipple and areola: a distinct entity
    (Mosby-Elsevier, 2002) Baykal, Can; Büyükbabani, Nesimi; Kavak, Ayşe; Alper, Murat
    Although nevoid hyperkeratosis of the nipple and areola was initially described in 1923, there are only case reports or reviews, about it; no large series have been documented to date. The clinical features of the reported cases in the literature are not uniform, and it is questioned whether nevoid hyperkeratosis of the nipple and areola is a distinct clinicopathologic entity or a clinical presentation of various dermatoses. We describe 7 cases with hyperkeratotic nevoid lesions localized on the nipple and areola with different clinical features. None of them had any other associated dermatologic or systemic disease. Histopathologic examination was performed in 6 patients. Four of them had common histopathologic features suggesting a distinct entity, namely, nevoid hyperkeratosis of the nipple and areola; 2 of them had histopathologic features consistent with seborrheic keratosis. Seborrheic keratosis presents as sharply demarcated papules or plaques, whereas nevoid hyperkeratosis of the nipple or areola presents as a plaque diffusely involving the nipple or the areola.
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    Palmoplantar keratoderma and oral leucoplakia with cutaneous horn of the lips
    (Blackwell Publishing Ltd, 2002) Baykal, Can; Savcı, N.; Kavak, Ayşe; Kurul, Semra
    The inherited palmoplantar keratodermas (PPK) may be associated with a wide variety of other ectodermal abnormalities. The coexistence of PPK and leucoplakia may indicate the increased risk of oesophageal carcinoma in adult life. Cutaneous horn may develop over benign, precancerous, as well as malignant lesions, and frequently may be associated with actinic keratoses and Bowen's disease. On the other hand, the relationship of cutaneous horn and leucoplakia has been the subject of only a single case report. We present a case of PPK and diffuse oral leucokeratosis associated with relapsing cutaneous horn of the lips.