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    Association between novel inflammatory markers derived from hemogram indices and metabolic parameters in type 2 diabetic men
    (Taylor & Francis Ltd, 2019) Bilgin, Satılmış; Aktaş, Gülali; Koçak, M. Zahid; Atak, Burçin M.; Kurtkulağı, Özge; Duman, Tuba T.; Şavlı, Haluk
    Aim: Hemogram indices were proposed as novel inflammatory markers in chronic conditions and inflammation has substantial role in the pathogenesis of type 2 diabetes mellitus (T2DM). We aimed to observe hemogram parameters of type 2 diabetic male subjects with various age groups in well and poorly controlled subsets. Methods: Data of type 2 diabetic men enrolled to the study were recorded from patient files of the institution. Study population were grouped into three according to the age. Group A was consisted of patients younger than 55 years, Group B was consisted of patients aged between 55 and 64 years, and Group C was consisted of patients aged 65 years or older. Data of the study groups were compared. Results: Study population was consisted of 130 subjects; 44 in Group A and 43 in each of Groups B and C. Median red cell distribution width (RDW) (p = .04), mean RDW to platelet ratio (RPR) (p = .006), median mean platelet volume to platelet ratio (MPR) (p = .02) levels of the study groups were statistically different. HbA1c level was significantly and positively correlated with RDW (r = 0.45, p < .001), neutrophil to lymphocyte ratio (NLR) (r = 0.47, p < .001), mean platelet volume to lymphocyte ratio (MLR) (r = 0.35, p < .001), MPR (r = 0.26, p = .003), and RPR (r = 0.37, p < .001) levels. Conclusion: Elevated RDW, NLR, MLR, MPR, and RPR levels in diabetic men should trigger the measurement of HbA1c since each were strongly correlated with HbA1c level. Moreover, elevated RDW, NLR, MLR, and RPR could be marker of worse diabetic control in men with T2DM.
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    A case of sitagliptin-induced mild acute pancreatitis
    (Coll Physicians & Surgeons Pakistan, 2018) Koçak, Mehmet Zahid; Aktaş, Gülali; Erkuş, Edip; Duman, Tuba T.; Atak, Burçin M.; Şahin, Deniz; Şavlı, Haluk
    Acute pancreatitis (AP) is characterised by inflammatory destruction of the gland due to early activation of the pancreatic proteolytic enzymes. Drug-induced AP accounts for only 0.1-2 % of AP.1 One of these drugs is dipeptidyl peptidase-4 inhibitor (DPP-4i). Association between AP and Sitagliptin, a DPP-4i, was initially described in a transgenic rat model.2 We aim to present a case of AP in a diabetic elderly, which was likely associated with Sitagliptin treatment.
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    Type 2 diabetes mellitus is more commonly well controlled in younger men compared to older men
    (Taylor & Francis Ltd, 2019) Koçak, M. Zahid; Aktaş, Gülali; Duman, Tuba T.; Atak, Burçin M.; Bilgin, Satılmış; Kurtkulağı, Özge; Şavlı, Haluk
    Aims: Type 2 Diabetes Mellitus (T2DM) is nearly epidemic worldwide. Greater skeletal muscle mass in men is protective against the development of T2DM compared to women, however, nutritional diversity, stress levels and other factors also affects this situation. In present retrospective study, we aimed to observe diabetic control level, metabolic parameters and general characteristics of type 2 diabetic men and to compare these values in middle aged and elderly diabetic population. Methods: The male patients with T2DM that admitted to the outpatient internal medicine clinics of our institution between November 2018 and April 2019 were included to the study. According to the age, study population divided into two groups; either younger than 60 years (group I) and 60 years or older (group II). Study parameters were compared between study groups. Results: Fasting plasma glucose (FPG) and glycated Hb level (HbA1c) of group I were lower than those of the group II (p = 0.004 for FPG and p = 0.048 for HbA1c). Control level of T2DM was defined as well controlled in 20 (29%) patients in group I and 5 (10.9%) patients in group II (p = 0.02). Conclusion: Physicians should aware that well controlled T2DM is more common among younger diabetic men compared to older men and try to enhance diabetic regulation level in elderly men by interventions that aimed to improve skeletal muscle or by pharmacologic agents.