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Öğe Alterations in placental pendrin expression in pre-eclampsia(Taylor & Francis Ltd, 2014) Karataş, Ahmet; Erdem, Havva; Albayrak, Mustafa; Oktay, Murat; Özlü, Tülay; Dönmez, Melahat EmineIntroduction: Pendrin is an integral membrane protein and plays a key role in extracellular fluid volume and blood pressure control. We aimed to investigate the relationship between pendrin immunostaining intensity in normal and pre-eclamptic placental tissue. Methods: Fifty-six placental tissues, of which 26 were in pre-eclamptic, and 30 were in control group were evaluated by immunohistochemical staining. Positive immunostaining was evaluated using a semiquantitative score: 0, negative; +, mild; ++, moderate; and +++, intense. Results: There was more positive immunstaining in the pre-eclamptic placenta compared to the controls (p<0.001). A significant positive correlation was observed between immunostaining level and diastolic blood pressure (r = 0.533, p = 0.005) in the pre-eclamptic group. However, no significant correlation was observed between any condition and immunostaining level in the control group. Conclusions: Placentas in the pre-eclamptic group were significantly more immunostained with pendrin than were those in the control group. In addition, a positive correlation between immunostaining intensity with pendrin and both systolic and diastolic blood pressure were observed. Pendrin may play a role in the mechanism of severe hypertension in women with pre-eclampsia.Öğe Are insulin resistance and serum resistin levels increased in women with idiopathic hirsutism?(Verduci Publisher, 2014) Erkan, Müşerref; Albayrak, Mustafa; Karataş, Ahmet; Keskin, Fatih; Aydın, YusufOBJECTIVE: To investigate the insulin resistance and serum resistin levels in women with idiopathic hirsutism compared to controls and women with polycystic ovary syndrome (PCOS). PATIENTS AND METHODS: Three groups of women including 23 women with idiopathic hirsutism, 28 women with PCOS and 28 non-hirsute women serving as controls were included into the study. The Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), serum fasting insulin and resistin levels were compared between the groups. RESULTS: There were no statistically significant differences regarding the age, BMI and waist circumferences between the groups. Mean and median fasting blood glucose, fasting insulin, HOMA-IR, serum resistin levels were statistically similar between the groups (p = 0.966, p = 0.378, p = 0.409 and p = 0.784, respectively). There were no correlations between the resistin, HOMA-IR, fasting insulin levels and BMI in any of the three groups. CONCLUSIONS: Insulin resistance and serum resistin levels do not appear to be increased in women with idiopathic hirsutism compared to controls at similar BMI's and waist circumferences.Öğe Can anti–adhesive efficacy of sodium hyaluronate and carboxymethylcellulose membrane be improved further by colchicine and collagenase?(2011) Sarohan, Aziz Rodan; Albayrak, Mustafa; Somunkiran, Aslı; Özdemir, Ismail; Iskender, Abdulkadir; Yalçin, Gülbin Sezen; Özaydin, IsmetAmaç: Cerrahi sonrası intraperitoneal adezyonların oluşumunu önlemede kollajenaz ve kolşisinin etkinliklerini deneysel hayvan modelinde histopatolojik değerlendirme ile araştırmaktır. Gereç ve Yöntem: Çalışmada 40 adet dişi Wistar Albino cinsi rat kullanıldı. Ratlar, kontrol, seprafilm, kolşisin-seprafilm, kollajenaz-seprafilm olmak üzere dört gruba ayrıldı. Laparotomi ile sağ proksimal uterin horn antimezosalpingeal yüzde bisturi aracılığı ile 0.5 cm’lik bir kesi oluşturuldu. Takiben kesi üstüne deneklerin grubuna uygun olarak 0.5 cm’lik Seprafilm; 2 mg Kolşisin emdirilmiş 0.5 cm’lik Seprafilm; 1?g kollajenaz emdirilmiş 0.5 cm’lik Seprafilm yerleştirilerek batın kapatıldı. Kontrol grubuna herhangi bir ajan uygulanmadı. Ratlar 20 gün sonra sakrifiye edilerek makroskopik ve histopatolojik değerlendirmeleri yapıldı. Histopatolojik inceleme Kanbour-Shakir kriterlerine göre yapıldı. Bulgular: Histopatolojik olarak değerlendirilen beş parametrenin toplamı ile elde edilen histolojik toplam skorun kolşisin-seprafilm grubunda en düşük olduğu görüldü. Kolşisinseprafilm grubunun total histolojik skoru ile kontrol, seprafilm ve kollajenaz-seprafilm gruplarının ortalama histolojik skorları arasında istatistiksel olarak anlamlı ölçüde farklılık bulundu (p<0.05). Sonuç: Batın içi operasyonlarda kolşisinin uzun süre lokal olarak etki etmesini sağlayacak bir metod ile kullanımı, cerrahi sonrası adezyon oluşumunu hem makroskopik hem de histolojik olarak azaltmaktadır. Bu deneysel çalışmadan elde edilen umut verici sonuçların araştırılacağı daha geniş kapsamlı çalışmalara ihtiyaç vardır.Öğe Can maternal height predict shorter cervical length in asymptomatic low-risk pregnant women?(Elsevier Science Bv, 2011) Albayrak, Mustafa; Özdemir, İsmail; Koç, Önder; Coşkun, EsraObjective: To evaluate the association between maternal height and cervical length in the first and second trimesters in low-risk asymptomatic pregnant women. Study design: Maternal height and cervical length of 146 asymptomatic women with singleton pregnancies at low risk for preterm birth were measured during the first and second trimesters. Preterm birth was defined as birth before <37 gestational weeks. Correlations between maternal height and cervical length measurements were determined using Pearson correlation analysis. The women were also divided into three groups based on height percentiles: <25% (Group I), 25-75% (Group II) and >75% (Group III). Cervical lengths were compared among groups. Correlations between cervical length and maternal height and statistically significant differences in cervical length among height percentile groups were the main outcomes. Results: Maternal height was positively but weakly correlated with first and second trimester cervical lengths (p = 0.047, r = 0.167 and p = 0.039, r = 0.197 respectively). The mean first trimester cervical lengths were significantly different between the groups (p = 0.04). There were no significant differences, however, in the mean second trimester cervical lengths among the three groups although the difference was close to significance (p = 0.06). Conclusion: Although our results indicate a relationship between maternal height and cervical length in our population, maternal height seems to have only limited value in identifying women to be screened for shorter cervical length in a low risk asymptomatic population. (C) 2011 Elsevier Ireland Ltd. All rights reserved.Öğe Circulating oxidized low-density lipoprotein and paraoxonase activity in preeclampsia(Karger, 2005) Uzun, Hafize; Benian, Ali; Madazlı, Rıza; Topçuoğlu, Mehmet Ata; Aydın, Seval; Albayrak, MustafaPreeclampsia is one of the most frequent complications of pregnancy, however, little is known about its etiology. The objective of this study was to investigate the association of oxidized low-density lipoprotein ( oxLDL) and paraoxonase (PON1) activity in women with either preeclampsia or normotensive (NT) pregnancy. The study groups included 41 pregnant women with preeclampsia and 33 normotensive pregnant women. In all patients maternal serum total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides (TGs) were measured using enzymatic methods. Serum PON1 activities and malondialdehyde (MDA) concentrations were measured by spectrophotometric methods, and oxLDL was measured by enzyme-linked immunoassay ( ELISA). Serum concentrations of lipid parameters ( TC, LDL, VLDL, and TGs) were significantly higher in preeclampsia compared with NT controls ( p < 0.001, p < 0.05, p < 0.05, and p < 0.001, respectively). Serum concentrations of MDA and oxLDL were significantly higher, while PON1 activity was significantly lower in preeclampsia compared with NT controls ( p < 0.001, p < 0.001, and p < 0.001, respectively). A positive correlation was detected between oxLDL and MDA ( r = 0.876), and a negative correlation was detected between both MDA and oxLDL and PON1 ( r = - 0.837 and r = - 0.759, respectively). Our data demonstrate that preeclampsia is associated with increased oxLDL and decreased PON1 activity. Elevated oxidative stress, oxLDL, dyslipidemia and decreased PON1 activities may cause vascular endothelial damage and contribute to the pathophysiology of preeclampsia.Öğe Comparison of the diagnostic efficacy of the two rapid bedside immunoassays and combined clinical conventional diagnosis in prelabour rupture of membranes(Elsevier Science Bv, 2011) Albayrak, Mustafa; Özdemir, İsmail; Koç, Önder; Ankaralı, Handan; Özen, OrhanObjective: Diagnosis of prelabour rupture of membranes (PROM) may be challenging. Conventional diagnostic methods such as speculum examination, ferning pattern, and pH detection are not satisfactorily accurate. Two relatively new, commercially available rapid bedside immunoassay strip tests, for placental alpha microglobulin-1 (PAMG-1) and insulin-like growth factor binding protein-1 (ILGFBP-1), are alleged to be more accurate. We compared the diagnostic efficacy of PAMG-1 and ILGFBP-1 immunoassay tests and combined conventional clinical diagnostic methods in PROM. Study design: 167 pregnant women with signs and/or symptoms of PROM were prospectively evaluated with a combination of conventional clinical tests including speculum examination, nitrazine, ferning pattern, and pooling, in addition to PAMG-1 and ILGFBP-1 immunoassays. Differences in sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of the diagnostic methods were compared. Results: Although the PAMG-1 assay was more accurate, the PAMG-1 immunoassay, ILGFBP-1 immunoassay, and combined conventional clinical diagnosis were, in fact, all highly accurate with no significant difference in sensitivity, specificity, PPV, NPV, or accuracy. Conclusion: Both rapid bedside strip tests may be used in clinical practice with similar efficacy in diagnosing PROM, particularly as a backup when diagnosis is still in doubt following a combination of conventional diagnostic methods. (C) 2011 Elsevier Ireland Ltd. All rights reserved.Öğe Early neonatal outcomes in patients with late preterm birth(2013) Karataş, Ahmet; Albayrak, Mustafa; Keskin, Fatih; Biyik, Ismail; Okur, Mesut; Güneş, Cemalettin; Köse, Seyit AliObjective: Preterm deliveries increased in many countries in recent years. However, despite fetal lung maturity, substantial neonatal morbidity may occur even after 34 weeks of gestation. The aim of this study was to evaluate neonatal morbidity and mortality in women with late preterm births. Design: Retrospective. Setting: Duzce University School of Medicine, Departments of Obstetrics and Gynecology and Pediatrics. Patients: Medical records of 291 pregnant women and newborns born between the 340/7-366/7 weeks of gestation were reviewed. Interventions: The whole population is first divided into two groups as depending on the presence of PPROM or not; and then also divided into-three groups based on the gestational age at delivery as 340/7-346/7 week (Group 1), 350/7-356/7 week (Group 2), and 360/7-366/7 week (Group 3). Main outcome measures: Groups were compared with respect to neonatal complications related to prematurity and early membrane rupture. Results: Of the 291 neonates included in the study, 85 were delivered preterm due to PPROM, 206 were non-PPROM group, and 76 were in group 1, 108 were in group 2, and 107 were in group 3. Sepsis rate was higher in group 1 and 2 compared to group 3 (p=0.016, p=0.029). NICU stay period was longer in group 1 and group 2 than group 3 (p=0.028, p=0.015 respectively). Newborns in group 1 had significantly longer hospital stay than group 3 (p=0.010), and total hospital stay period were significantly higher in newborns with sepsis. Conclusions: The late-preterm infants especially in earlier weeks represent a significantly higher risk category for neonatal complications, and they have a significantly longer NICU and hospital stay period.Öğe EARLY NEONATAL OUTCOMES IN PATIENTS WITH LATE PRETERM BIRTH(Galenos Publ House, 2013) Karatas, Ahmet; Albayrak, Mustafa; Keskin, Fatih; Biyik, Ismail; Okur, Mesut; Gunes, Cemalettin; Kose, Seyit AliObjective: Preterm deliveries increased in many countries in recent years. However, despite fetal lung maturity, substantial neonatal morbidity may occur even after 34 weeks of gestation. The aim of this study was to evaluate neonatal morbidity and mortality in women with late preterm births. Design: Retrospective. Setting: Duzce University School of Medicine, Departments of Obstetrics and Gynecology and Pediatri Clinics. Patients: Medical records of 291 pregnant women and newborns born between the 340/7-366/7 weeks of gestation were reviewed. Interventions: The whole population is first divided into two groups as depending on the presence of PPROM or not; and then also divided into-three groups based on the gestational age at delivery as 34(0/7)-34(6/7) week (Group 1), 35(0/7)-35(6/7) week (Group 2), and 36(0/7)-36(6/7) week (Group 3). Main outcome measures: Groups were compared with respect to neonatal complications related to prematurity, and early membrane rupture. Results: Of the 291 neonates included in the study, 85 were delivered preterm due to PPROM, 206 were non-PPROM group, and 76 were in Group 1, 108 were in Group 2, and 107 were in Group 3. Sepsis rate was higher in Group 1 and 2 compared to Group 3 (p=0.016, p=0.029). NICU stay period was longer in Group 1 and Group 2 than group 3 (p=0.028, p=0.015 respectively). Newborns in Group 1 had significantly longer hospital stay than Group 3 (p=0.010), and total hospital stay period were significantly higher in newborns with sepsis. Conclusions: The late-preterm infants especially in earlier weeks represent a significantly higher risk category for neonatal complications, and they have a significantly longer NICU and hospital stay period.Öğe Effects of hormone replacement therapy on plasma and tissue fibrinolytic activity in a rat model of surgically induced menopause(Canadian Soc Clinical Investigation, 2014) Topçuoğlu, Mehmet Ata; Albayrak, Mustafa; Erman, Hayriye; Balcı, Huriye; Karakuş, MesutPurpose: The purpose of this study was to analyze the effects of estrogen deficiency and hormone replacement therapy (HRT) on fibrinolytic activity in a rat mode of surgically induced menopause. Methods: Twelve-week-old, sexually mature female Sprague-Dawley rats, each weighing 200-250 g, were randomly divided into four groups: (1) sham- operated group, (2) ovariectomy group, (3) ovariectomy group followed by oral administration of daily 17 beta-estradiol (0.02 mg/kg/day) (E2) + norethisterone acetate (0.01 mg/kg/day), and (4) ovariectomy group followed by oral administration of daily 17 beta-estradiol (0.01 mg/kg/day) + drospirenone (0.02 mg/kg/day). Tissue plasminogen activator (tPA) antigen, plasminogen activator inhibitor-1 (PAI- 1) antigen, and PAI-1/tPA levels were measured as markers of fibrinolysis in plasma and liver and brain tissue. Results: Compared with sham-operated rats, ovariectomized rats showed higher levels of fibrinolytic activity; however, the increased fibrinolytic activity in plasma and liver tissue was significantly reduced by HRT regimens. No change was observed in the levels of fi brinolytic activity in brain tissue. Conclusions: HRT showed beneficial effects by decreasing fibrinolytic activity related to surgically induced menopause. Short-term HRT treatment was associated with a shift in the procoagulant-anticoagulant balance toward a procoagulant state.Öğe Evaluation of chromosomal abnormalities and common trombophilic mutations in cases with recurrent miscarriage(Makerere Univ, Fac Med, 2014) Karataş, Ahmet; Eröz, Recep; Albayrak, Mustafa; Özlü, Tülay; Çakmak, BülentBackground: Recurrent miscarriage (RM) is a frequent obstetric problem. Its' pathophysiology is poorly understood. Infections, genetic, endocrine, anatomic and immunologic problems have been suggested as causes for RM. Objective: To evaluate the frequency of chromosomal abnormalities and 3 common thrombophilic mutations in couples with RM. Methods: A retrospective data collection was performed for the results of the cytogenetic analysis of the couples and Methylenetetrahydrofolate Reductase (MTHFR) C677T, Factor V Leiden (FVL) G1691A and Prothrombin (PTm) G20210A mutations of the mother in 142 couples suffering from RM. Results: Prevalence of FVL, MTHFR, and PTm gene mutations were similar between cases shaving 2 or >= 3 abortions (P=0.528; P=0.233; P=0.375). In patients with FVL, MTHFR and PTm gene mutations, the OR's of having >= 3 abortions when compared to having 2 abortions were 1.515 (95% CI: 0.414-5.552), 0.573 (95% CI: 0.228-1.441), and 2.848 (95% CI: 0.355-22.871). All cases with PTm mutation had >= 3 abortions and all abortions occurred between 6-8 gestational weeks. Conclusion: Chromosomal abnormalities and thrombophilic mutations (especially PTm) seem to have an important role in RM. Additional larger studies involving investigation of more genes that may have a role in pregnancy are needed to assess this association.Öğe Geç preterm doğum olgularında erken neonatal sonuçlar(2013) Karataş, Ahmet; Albayrak, Mustafa; Keskin, Fatih; Bıyık, İsmail; Okur, MesutAmaç: Preterm doğumlar son zamanlarda birçok ülkede artış göstermiştir. Fetal akciğerin gelişmiş olmasına rağmen, 34. gebelik haftasından sonra bile ciddi yenidoğan morbiditesi meydana gelebilir. Bu çalışmanın amacı, geç preterm doğum olgularında neonatal morbidite ve mortaliteyi araştırmaktır. Planlama: Retrospektif Ortam: Düzce Üniversitesi Tıp Fakültesi, Kadın Hastalıkları-Doğum ve Pediatri Kliniği Hastalar: 340/7-366/7 gebelik haftasında doğum yapan 291 gebe kadın ve yenidoğanlar incelendi. Girişim: Çalışmaya dahil edilen olgular PPROM varlığı ya da yokluğuna göre öncelikle iki gruba ayrıldı. Daha sonra gruplar, tekrar gebelik haftasına göre kendi içlerinde, 340/7-346/7 hafta olanlar(grup 1),350/7-356/7 hafta olanlar (grup 2), 360/7-366/7 hafta olanlar(grup 3) şeklinde üçe ayrıldı. Değerlendirme parametreleri: Gruplar prematürite ve erken membran rüptürü ile ilişkili yenidoğan komplikasyonları açısından karşılaştırıldı. Sonuç: Çalışmaya dahil edilen ikiyüz doksanbir olgunun 85'i PPROM nedeniyle erken doğum yapmıştı. 206'sı PPROM olmayan gruptaydı ve 76'sı 1. grup, 108'i 2. grup, 107'si de 3. grupta yer aldı. Sepsis oranı, birinci ve ikinci grupta üçüncü gruba göre daha yüksekti (p:0.016, p:0.029). Yenidoğan yoğunbakım ünitesinde (YDYB) kalış süresi 3. gruba oranla, 1. ve 2. grupta daha yüksekti (sırasıyla p:0.028, p:0.015). Birinci gruptaki yenidoğanlar, üçüncü gruptakilere göre anlamlı olarak daha uzun hastanede kalış süresine sahipti (p=0.010), ve toplam hastanede kalış süresi sepsisli yenidoğanlarda anlamlı olarak daha yüksekti. Yorum: Özellikle daha erken gebelik haftalarında olan geç preterm yenidoğanlar, yenidoğan komplikasyonları için anlamlı olarak daha fazla risklidirler, aynı zamanda anlamlı olarak yenidoğan yoğun bakım ve hastanede daha uzun kalış süresine sahiptir.Öğe Hormonal Modulation of the Proinflammatory Cytokines, Leptin and Plasminogen Activator Inhibitor-1 in Healthy Postmenopausal Women(Galenos Yayincilik, 2008) Topcuou, M. Ata; Uzun, Hafize; Aydin, Seval; Albayrak, Mustafa; Vehid, Suphi; Zeybek, Gorkem; Topcuoglu, DenizIn this study we aimed to determine the levels of TNF-alpha, IL-6, IL-1 beta, PAI-1, leptin in healthy premenopausal and postmenopausal subjects who were evaluated before and after hormone replacement therapy (HRT). Twenty premenoposal woman with regular cycles and 45 postmenopausal women were included in the study. Twenty-five of the postmenopausal women received conjugated estrogen (CCE) + medroxyprogesterone acetate (MPA) and the other 20 received 17-beta estradiol + norethisterone acetate (NETA). The levels of the above identified cytokines in these two treatment groups were compared with that of the healthy pemenopausal group as well as with each other before and after 6 months of HRT. IL-1 levels were significantly higher in the postmenopausal group before HRT when compared to the premenopausal group. Levels of IL-1 were elevated even more after 6 months of HRT. IL-6 was significantly higher in postmenopausal group before HRT compared to the premenopausal group. After 6 months of HRT there was no significant decrease in levels of IL-6. TNF-alpha was significantly higher in postmenopausal group before HRT compared to the premenopausal group. No significant decrease was seen after HRT. PAI-1 was significantly higher in the postmenaposal group before HRT compared to the premenopausal group. After 6 months of HRT, there was a significant decrease in levels of PAI-1. Leptin levels were not different between the premenopausal and the postmenopausal groups (p=0.97). But leptin levels were higher in the postmenopausal group after receiving HRT for 6 months. Menopausal status and HRT may be the causative factor of biochemical proinflammatory response, lepitn. fibrinolytic process and coagulation in healthy postmenopausal women.Öğe Maternal serum soluble HLA-G levels in missed abortions(Mdpi, 2013) Keskin, Fatih; Karataş, Ahmet; Albayrak, Mustafa; Bıyık, İsmail; Erkan, MüşerrefBackground and Objective. It is unclear how immune tolerance develops to a semiallograft fetus in pregnancy. Human leukocyte antigen G (HLA-G) expressed by extravascular trophoblasts plays an important role in the recognition of the gestational tissues as self and the development of immune tolerance against the gestational tissues by the maternal immune system. The soluble form of the HLA-G (sHLA-G) molecule in the maternal serum is also reported to contribute to the prevention of rejection during pregnancy. The aim of the study was to compare the maternal serum sHLA-G levels of the women with missed abortions and control subjects with uncomplicated pregnancies. Material and Methods. The prospective cross-sectional study involving 40 with missed abortions and 40 control women, matched by age, gestational age, and body mass index, was carried out. The study group consisted of the women with singleton pregnancies, who were diagnosed with a missed abortion. Only the patients who were confirmed to have an uncomplicated term delivery during follow-up were included in the control group. The serum sHLA-G level was compared between the groups. Results. There was no significant difference in the mean serum sHLA-G levels in terms of gravidity (P=0.761) and a history of abortion (P=0.379) in the control group. The median serum sHLA-G level in the missed abortion group was significantly lower compared with the control group (16.8 [8.5-35.8] vs. 26 [11-135] U/mL, P<0.001). All the women in the control group had uncomplicated term deliveries. Conclusion. Our results showed that the women with missed abortions had significantly lower serum sHLA-G levels compared with the healthy pregnant controls, which may have potentially played a role in the impairment of physiological immunological tolerance during pregnancy. However, the determination of the exact role and the potential clinical utility of maternal serum sHLA-G for the detection/ prediction of a missed abortion risk requires further detailed studies.Öğe Oxytocin versus sustained-release dinoprostone vaginal pessary for labor induction of unfavorable cervix with Bishop score >= 4 and >= 6: A randomized controlled trial(Wiley, 2013) Koç, Önder; Duran, Bülent; Özdemirci, Şafak; Albayrak, Mustafa; Koç, ÜmmügülsümAim To compare the efficacy and safety of high-dose intravenous oxytocin and sustained-release dinoprostone vaginal pessaries for cervical ripening and labor induction in pregnant patients at term with poor Bishop scores. Material and Methods Women at term with a Bishop score 4 and 6 were randomized into two groups to undergo induction of labor with either high-dose oxytocin administered intravenously (n=90) or dinoprostone-only vaginal pessary without oxytocin augmentation (n=90). The main outcome measures were rate of cesarean delivery, induction to delivery interval, number of deliveries achieved within 4, 8, 12, and 16h of labor induction, maternal complications during induction, fetal outcome, and total hospital stay. In this study, per-protocol analysis was performed. Results There were fewer cesarean deliveries with oxytocin compared to dinoprostone-only groups (7/79 vs 14/89); however, the difference was not statistically significant. The inductiondelivery intervals (7.9h vs 12.0h, P<0.001; and 5.7 vs 10.4h, P<0.001; oxytocin vs dinoprostone-only for primiparous and multiparous patients, respectively) were significantly shorter in oxytocin-induced patients compared to dinoprostone-only. A significantly higher percentage of patients delivered in the oxytocin group compared to the dinoprostone-only group in 4, 8, 12, 16, and 20h. Conclusion Intravenous oxytocin is effective to stimulate labor at term for patients with Bishop scores 4 and 6, with a shorter time interval from induction to vaginal delivery.Öğe Post-partum haemorrhage from the lower uterine segment secondary to placenta praevia/accreta: Successful conservative management with Foley balloon tamponade(Wiley, 2011) Albayrak, Mustafa; Özdemir, İsmail; Koç, Önder; Demiraran, YavuzProfuse bleeding from the lower uterine segment secondary to placenta praevia/accreta during caesarean delivery is a challenging problem in obstetrics. We present our experiences using intrauterine Foley balloon tamponade for the conservative management of post-partum haemorrhage from the lower uterine segment. Intraoperative haemostasis was achieved in all women who were unresponsive to other conservative methods. Foley balloon tamponade may be considered in the management of lower uterine segment bleeding at caesarean delivery.
