Yazar "Aksoy, Fadullah" seçeneğine göre listele

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  • Küçük Resim
    Öğe
    The Effects of Montelukast on Random Pattern Skin Flap Survival: An Experimental Study in Rats
    (Elsevier Science Inc, 2008) Gideroğlu, Kaan; Yılmaz, Fahrettin; Aksoy, Fadullah; Buğdaycı, Güler; Çakıcı, Hüsamettin; Hapa, Onur
    BACKGROUND: A variety of methods to improve skin flap survival, including the use of pharmacologic agents, have been intensively investigated. Decreasing neutrophil-mediated inflammation and tissue injury has been reported to be effective in improving flap survival. Montelukast is a selective reversible cysteinyl leukotriene receptor-1 antagonist that has been found to have protective effects against renal ischemia reperfusion injury and burn-induced oxidative injury of the skin in rats. However, its effects on skin flap survival have not been previously reported. OBJECTIVE: The aim of this study was to investigate the effects of montelukast on neutrophil-mediated random pattern skin flap survival. METHODS: Mate Sprague-Dawley rats weighing 230 to 250 g were randomly divided into 2 groups-the montelukast-treated group and the control group. Caudally based rectangular random pattern skin flaps 3 x 9 cm were elevated on the backs of the rats. The flaps were sutured into their original places. In the montelukast group, 1 mL of solution containing 10 mg/kg montelukast was administered intraperitoneally (IP) 30 minutes before surgery and then daily for 6 days. In the control group, I mL of saline was administered IP 30 minutes before surgery and then daily for 6 days. To observe the effects of montelukast, myeloperoxidase (MPO) activity, an index of tissue neutrophil infiltration, was measured from extracted skin tissue 12 hours after flap elevation. Flap viability was evaluated 7 days after surgery by measuring necrotic flap area and total flap area. RESULTS: Sixteen rats (mean [SD] weight, 240.6 [6.6] g) were equally divided between the 2 groups. All rats survived throughout the study period. Mean (SD) MPO activity in flap tissue was significantly lower in the montelukast group than in the control group (14.57 [2.33] vs 21.28 [4.86] U/g protein; P = 0.005). The percentage of necrotic flap area was significantly lower in the montelukast group than in the control group (17.17 [7-95] vs 37.51 [10.72]; P = 0.001). CONCLUSION: This small, experimental, in vivo animal study found that montelukast was associated with both lower MPO activity and a lower percentage of necrotic random pattern skin flap area. Future studies are needed to clarify these findings. (Curr Ther Res Clin Exp. 2008;69:459-465) (C) 2008 Excerpta Medica Inc.
  • Küçük Resim
    Öğe
    Laryngeal tuberculosis
    (2008) Taşkın, Ümit; Yılmaz, Fahrettin; Elbistanlı, Suphi; Aksoy, Fadullah; Karaaslan, Osman
    Tüberküloz son yıllarda yeniden çok önemli bir sağlık sorunu haline gelmiştir. Akciğer dışı organ tüberkülozu giderek önem kazanmakta ve yeni olguların yaklaşık %15'ini oluşturmaktadır. Larinks tüberkülozu ender görülen akciğer dışı organ tüberkülozlarından biridir ve günümüzde tüberkülozun laringeal tutulumu tüm tüberküloz olgularının %1'inden daha azdır. Genellikle erkeklerde ve sigara içenlerde görülmesi, ses kısıklığı semptomu vermesi ve endoskopik muayenede kitle görünümü nedeniyle larinks tümörleri ile karışabilir. Hemen daima akciğer tüberkülozunun bir komplikasyonu olarak ortaya çıkmaktadır. Tüberkülozun yaygınlaştığı günümüzde boğaz ağrısı, kulak ağrısı ve ses kısıklığı gibi yakınmalarla gelen hastaların ayırıcı tanısında larinks tüberkülozu da göz önünde bulundurulmalıdır. Kesin tanıya ulaşmak için mikrobiyolojik ve histopatolojik örnekler alınmalıdır. Bu yazıda bir larinks tüberkülozu olgusunu literatür eşliğinde sunmayı amaçladık.
  • Küçük Resim
    Öğe
    Montelukast protects axial pattern rat skin flaps against ischemia/reperfusion injury
    (Academic Press Inc Elsevier Science, 2009) Gideroğlu, Kaan; Yılmaz, Fahrettin; Aksoy, Fadullah; Buğdaycı, Güler; Sağlam, İbrahim; Yılmaz, Fahri
    Background. Recent studies have shown that neutrophils play an important role in the pathogenesis of reperfusion injury. Using an inferior epigastric artery skin flap as a flap ischemia/reperfusion (I/R) injury model, we investigated whether the administration of montelukast sodium, a selective reversible cysteinyl leukotriene 1 (Cy5LT1) receptor antagonist, decreases neutrophil infiltration and promotes flap survival. Methods. Eighteen rats were used and randomly divided into three groups (n = 6 for each group). Group I was the sham group and did not undergo ischemic insult; rather, normal saline (1mL) was administrated intraperitonealy (i.p.) 30 min before surgery and continued for 6 d. Group II (control) and Group III (montelukast) underwent 12 h of ischemic insult. For Group II, normal saline (1mL) was injected i.p. 30 min before the surgery and immediately before reperfusion, and this continued for 6 d. In Group III, 1mL of montelukast (10mg/kg) was injected i.p. and continued for 6 d. Malondialdehyde (MDA) and glutathione (GSH) levels and myeloperoxidase (MPO) enzyme activities were investigated. Histological evaluation was made to investigate the tissue neutrophil count. Survival areas were assessed at 7 d postoperatively. Results. Group III (montelukast- treated) showed a significantly higher survival rate than Group II (control) (P = 0.029) but a lower survival rate than Group I (sham). Histological and biochemical assays corroborated this data. Conclusion. This study suggests that montelukast CysLT1 receptor antagonist montelukast reversed I/R-induced oxidant responses and improved flap survival by inhibiting neutrophil infiltration and balancing oxidant and antioxidant status. (C) 2009 Elsevier Inc. All rights reserved.