DSpace Arşivi :: by Yazar "Akdeniz, Hayrettin" değerine göre listeleniyor

Yazar "Akdeniz, Hayrettin" seçeneğine göre listele

Listeleniyor 1 - 19 / 19

Are we aware of q fever enough? Experience from a single centre
(2019) Gözdaş, Hasan Tahsin; Sırmatel, Fatma; Karabörk, Şeyma; Akdeniz, Hayrettin
ABSTRACT BACKGROUND: Q fever is a zoonosis caused by Coxiella burnetii. The main clinical presentations are pneumonia and hepatitis. However, it can be difficult to recognise Q fever due to many different clinical presentations. In this study, we aimed to increase the awareness of Q fever by presenting clinical and laboratory features of Q fever cases from our institution. MATERIAL and METHODS: Patients with a diagnosis of Q fever in our hospital database were evaluated retrospectively. Patient characteristics as well as clinical and laboratory values at presentation were recorded. RESULTS: A total of six patients were included in this study. Various clinical presentation was observed such as fever, anorexia and malaise as the most common symptoms. The most common laboratory abnormality was CRP elevation as being detected in all patients followed by LDH and transaminase elevations. both were found in four patients. CONCLUSION: Serological methods used to diagnose Q fever are not routinely performed, so Q fever cases can be missed easily. We believe that Q fever should be investigated further in patients from endemic regions who did not give adequate response to nonspesific antibiotic treatment.
Asymmetric dimethylarginine levels in patients with cutaneous anthrax: a laboratory analysis
(Bmc, 2014) Sünnetçioğlu, Mahmut; Mengeloğlu, Zafer; Baran, Ali İrfan; Karahocagil, Mustafa; Tosun, Mehmet; Küçükbayrak, Abdülkadir; Akdeniz, Hayrettin
Background: Asymmetric dimethylarginine (ADMA), the main endogenous inhibitor of nitric oxide synthase, is considered to be associated with endothelial dysfunction. High ADMA levels have been shown to be related with disorders causing vascular inflammation such as hypertension, hypercholesterolemia, atherosclerosis, chronic heart failure, stroke and sepsis. Cutaneous anthrax (CA) is a serious infectious disease which may cause vasculitis. The aim of the study was to investigate the serum ADMA levels in patients with CA. Methods: A total of 35 serum samples of the patients with CA and 18 control sera were tested for ADMA levels using ADMA ELISA kit (Immunodiagnostik AG, Bensheim, Germany). Results: ADMA levels were found to be significantly higher in the patients group than the controls (p < 0.001). In addition, ADMA levels were found to be positively associated with sedimentation rates (R = 0.413; p = 0.026), and inversely associated with international normalized ratio (INR) levels (R = -0.46; p = 0.011). A cut-off value of 0.475 of ADMA had a sensitivity of 74.3%, specificity of 77.8%, and accuracy of 75.5% in the diagnosis of CA. Conclusion: Although the exact mechanism still remains unclear, ADMA levels could be related to immune activation in CA. In addition, these data might suggest the higher ADMA levels in patients could be due to the perivascular inflammation and vasculitis in CA.
Brucellosis presented with fever and generalized maculopapular rash
(Erciyes Univ Sch Medicine, 2020) Gözdaş, Hasan Tahsin; Sırmatel, Fatma; Akdeniz, Hayrettin
Background: Brucellosis is a multisystemic zoonosis that can affect all body organs and systems. Musculoskeletal system is the most affected system; however, cutaneous involvement is quite rare. Case Report: A 31-year-old male who was previously healthy was admitted with fever and generalized maculopapular rash for the last three days before his admission to the hospital. He was eventually diagnosed with brucellosis based on the clinical history and epidemiological features. Brucellosis treatment was administered for six weeks and the patient recovered completely. Conclusion: In endemic regions, brucellosis should be included in the differential diagnosis of the patients presenting with fever and generalized maculopapular rash.
A case of colistin-induced fixed drug eruption
(2013) Hakyemez, İsmail Necati; Küçükbayrak, Abdülkadir; Yıkılgan, Aslıhan Burcu; Bolaç, Elif Sultan; Yıldız, Nebil; Boran, Çetin; Akdeniz, Hayrettin
Fiks ilaç erüpsiyonu (FİE) etyolojisinde başta antimikrobiyaller olmak üzere çeşitli ilaçlar rol almaktadır. Klinik görünümü, ilaca bağlı gelişen bir reaksiyon için oldukça tipiktir. Literatürde, kolistine bağlı gelişen fiks ilaç erüpsiyonu olgusu bildirilmemiştir. Acinetobacter pnömonisi nedeniyle kolistin kullanılan 83 yaşındaki bir erkek hastada ortaya çıkan fiks ilaç erüpsiyonu, çok nadir görülmesi açısından sunulmuştur. FİE ayırıcı tanısında kolistinin yer alabileceği akılda tutulmalıdır
Determining immunoassay cutoff value using Western blot results to predict hepatitis C infection in blood donors with low-titer anti-HCV reactivity
(Springer, 2013) Küçükbayrak, Abdulkadir; Çakmak, Saadet; Hakyemez, Ismail Necati; Taş, Tekin; Akdeniz, Hayrettin
Since the 1990s, blood donors have been scanned for anti-hepatitis C virus (anti-HCV) antibodies, which can be defined by enzyme immunoassay as a screening test. In this population, false-reactive ratios have been high. Recently, some authors have aimed to find a cutoff value for anti-HCV different from those established by test manufacturers to predict HCV infection. In this study, 321 patients, after two repeating tests, had reactive results in s/co < 10 titers on anti-HCV test. The patients were 29.6 % (n=95) in women and 70.4 % (n=226) in men. The patients were classified into three groups by Western blot (WB) results (PS, positive; NG, negative; and ID, indeterminate). The average anti-HCV titer of the whole group was 2.61 +/- 1.96. Anti-HCV titers of subgroups were 2.43 +/- 1.95 in NG, 4.93 +/- 2.53 in PS, and 2.50 +/- 1.65 in ID (p< 0.001). There was a significant difference between NG and PS and between PS and ID subgroups (p< 0.001). There was a positive correlation between WB and anti-HCV titers in all patients (r=0.298, p< 0.001), in women (r=0.282, p< 0.001), and in men (r=0.337, p=0.002). According to receiver operator characteristic curve analysis, the cutoff value of anti-HCV titer to predict hepatitis C infection was > 2.61 s/co, with 74.1 % sensitivity and 71.6 % specificity (area under the curve, 0.820; 95 % confidence interval, 0.753 to 0.887). We suggest that an effective cutoff value for anti-HCV other than that established by the manufacturer cannot be assigned to predict hepatitis C infection for blood donors in low-prevalence areas.
The effect of brucellosis on women's health and reproduction
(Aras Part Medical Int Press, 2015) Kurdoğlu, Mertihan; Çetin, Orkun; Kurdoğlu, Zehra; Akdeniz, Hayrettin
Due to its potential harmful effects on the general health and reproductive life of the women, in the light of available literature, it was aimed to review the effect of human brucellosis on women's health and reproduction. Data from 75 reports belonging to the years 1917 through 2015, obtained via a search on various internet sources by the words "Brucella", "brucellosis," "women's health," "human pregnancy," "human reproduction," "abortion," "preterm birth," "intrauterine fetal demise," and "intrauterine fetal death" were used to characterize basic microbiological features together with the risk factors, clinical presentations and complications of the human brucellosis related to various aspects of reproductive well-being. A high rate of spontaneous abortion was a more consistent finding rather than high rates of preterm delivery and intrauterine fetal death in pregnant women with brucellosis. The occurrence of abortion was not associated with the magnitude of serum agglutination titre or the clinical type of disease. The novel replication profiles of Brucella in human trophoblasts give insights into the pathogenesis of infectious abortion. Brucellosis is a risk factor for women's general health and reproduction as well as for many obstetric complications during pregnancy, of which spontaneous abortion is the mostly known. In order to prevent the disease and these complications, education of the women, especially the poor ones of childbearing age with low educational level is strongly advised. When the infected women present for medical care, an appropriate antimicrobial therapy should be started promptly.
Efficacy of daptomycin on experimental methicillin-resistant staphylococcus aureus keratitis in rabbits
(Mary Ann Liebert, Inc, 2013) Mengeloğlu, Fırat Zafer; Küçükbayrak, Abdulkadir; Bucak, Yasin Yucel; Erdurmuş, Mesut; Taş, Tekin; Özyalvaçlı, Gülzade; Bayram, Recep; Bucak , Özlem; Akdeniz, Hayrettin
Purpose: We aimed to compare the efficacy of topical daptomycin (DAP) with that of vancomycin (VA) in the treatment of keratitis caused by methicillin-resistant Staphylococcus aureus (MRSA). Methods: One hundred colony-forming unit MRSA bacteria were injected intrastromally into both corneas of 28 rabbits. Sixteen hours after injection, the rabbits' eyes were treated with 1 drop of topical DAP (10 or 50mg/mL), VA (50mg/mL), or isotonic saline for 19 doses. Their eyes were examined for clinical severity before and after treatment. Results: The minimum inhibitory concentration values of VA and DAP against the bacterial strain were found to be 2 and 0.5g/mL, respectively. The mean pre- and post-treatment clinical scores of the eyes did not differ significantly among the groups. However, the mean difference between the post- and pretreatment clinical scores was significantly lower in the 50mg/mL DAP group than in the other groups (P=0.042). A marked decrease in bacterial load was detected in all treatment groups compared to the control group (P=0.002). Although there were no significant differences in bacterial load among the treatment groups, the 50mg/mL DAP group showed the greatest decrease. The mean % epithelial erosion rate tended to be higher in the 50mg/mL VA group than in the other groups (P=0.31). Conclusions: Topical DAP significantly reduced the bacterial load and showed activity against MRSA comparable to that of fortified VA in this experimental model.
Erythrocytes parameters in the course of brucellosis
(2013) Küçükbayrak, Abdülkadir; Taş, Tekin; Tosun, Mehmet; Aktaş, Gülali; Hakyemez, İsmail Necati; Mengeloğlu, Fırat Zafer; Akdeniz, Hayrettin
Amaç: Bruselloz hastalarında tüm eritrosit parametrelerini değerlendirmek ve bu parametreler ile inflamatuar belirte çler arasındaki ilişkiyi araştırmak. Yöntem: Çalışmaya brusella tüp aglütinasyon pozitif toplam 55 hasta alındı. Hastaların yaş ve cinsiyetleri, brusella tüp aglütinasyon testi sonuçları, eritrosit sedimantasyon hızları, C-reaktif protein ve eritrosit parametreleri ile ilgili veriler laboratuvar kayıtlarından incelendi. Bulgular: Hastalarda ortalama yaş 45,4 ± 18,1 ve kadın/erkek oranı 25/30’du. Tedavi sonrası hemoglobin, hematokrit, ortalama eritrosit hacmi, ortalama eritrosit hemoglobin ve ortalama eritrosit hemoglobini konsantrasyon değerleri tedavi öncesi değerlere gore anlamlı olarak daha yüksek bulundu. Sonuç: Eritrosit parametrelerinin değerlendirilmesi aneminin ve brusellozla ilişkili doğasının anlaşılmasında fayda sağlaya- bileceği düşünülmüştür.
Evaluation of patients with Tularemia in Bolu province in northwestern Anatolia, Turkey
(J Infection Developing Countries, 2014) Mengeloğlu, Zafer; Duran, Arif; Hakyemez, İsmail Necati; Ocak, Tarık; Küçükbayrak, Abdülkadir; Akdeniz, Hayrettin; Taş, Tekin
Introduction: Tularemia is a zoonotic disease caused by Francisella tularensis. Here we present an epidemic occurring in Bolu province, located in northwestern Anatolia in Turkey, and some features of the cases. Methodology: The data was provided by the Bolu Provincial Health Directorate. All of the antibody response tests were studied in the National Health Institute (formerly named Refik Saydam Hygiene Department), the reference laboratory of the Ministry of Health of the Turkish Republic. A total of 393 individuals were tested by microagglutination test (MAT) for tularemia between 2006 and 2011. A total of 218 patients whose demographical data were available were included in the study; 83 were accepted as the patient group and 135 were the controls. Of the patients, 31 (37.3%) were male and 52 (62.7%) were female. Results: Fever (p < 0.001), URTI symptoms (p = 0.047), conjunctivitis (p = 0.004), and rash (p = 0.026) were significantly higher in the patient group. A positive association was found between MAT and fever (r = 0.324; p < 0.001), and a negative association was found between MAT and both lymphoadenopathy (r = -0.25; p = 0.013) and chills (r = -0.218; p = 0.035). Higher MAT titers were detected in oropharyngeal tularemia (r = 0.306; p = 0.003). Conclusions: In conclusion, tularemia must be considered in differential diagnosis in patients presenting with fever and LAP in non-endemic regions. Furthermore, water sources and contact with rodents must be investigated.
Foodborne botulism in Turkey, 1983 to 2017
(Taylor & Francis Ltd, 2019) Karsen, Hasan; Ceylan, Mehmet Reşat; Bayındır, Hasan; Akdeniz, Hayrettin
Objective: The aim of this study is to assess the epidemiology of foodborne botulism cases which were seen and published in Turkey. Material and Methods: This study covers the cases and outbreaks of botulism that have been identified and published in any region of Turkey, between 1983 and 2017. This systematic review was performed in accordance with the guidelines for performing and reporting systematic reviews and meta-analyses. The search was done on PubMed and Google in English and Turkish languages. Demographic features of the cases, nutritional sources, the development process of the disease, clinical symptoms and signs, the duration of hospitalization, treatment and mortality rates were analyzed. Results: Totally 95 patients (57 female and 38 male) were assessed from the published. The food which caused the majority of intoxication cases was canned green beans, and all the foods were home-canned goods. There cords showed that botulism antitoxin was given to 56 patients. The time from exposure to illness onset was 26.9 h. While 18 patients died at the end of follow-up and treatment (mortality 19%), 77 patients were discharged with full recovery. Conclusion: Among 95 botulism cases, spread in Turkey over the last 35 years, the predominant source of toxin was home-canned food and green beans, in particular. Since community and emergency room physicians may be the first to treat patients with any type of botulinum intoxication, they must know how to diagnose and treat this rare but potentially lethal disease.
High asymmetric dimethylarginine (ADMA) levels in patients with Brucellosis
(Springer/Plenum Publishers, 2014) Mengeloğlu, Zafer; Sünnetçioğlu, Mahmut; Tosun, Mehmet; Küçükbayrak, Abdülkadir; Ceylan, Mehmet Reşat; Akdeniz, Hayrettin
Asymmetric dimethylarginine (ADMA) is the main endogenous inhibitor of nitric oxide synthase and is considered to be associated with endothelial dysfunction. Brucellosis, a zoonotic disease caused by Brucella spp., can manifest as vasculopathy. The present study was performed to investigate the relationship between ADMA and brucellosis. Serum samples from 39 patients with an accurate diagnosis of brucellosis and from 18 healthy control individuals were included in this study. ADMA levels were significantly higher in the patient group than the controls (P < 0.001). Receiver operating characteristic (ROC) curve analysis indicated that ADMA level a parts per thousand yen0.61 had a sensitivity of 79.5 %, specificity of 88.9 %, positive predictive value of 93.9 %, and negative predictive value of 66.7 %. This is the first report of an association between brucellosis and high levels of ADMA. In conclusion, ADMA levels should be tested in brucellosis cases and that further studies to clarify the mechanism underlying the association between ADMA and brucellosis are required.
Mean platelet volume is not a predictive marker of histopathological changes of the liver in patients with chronic hepatitis B
(Elsevier Masson, Corporation Office, 2013) Taş, Tekin; Küçükbayrak, Abdülkadir; Kurt, Mevlüt; Mengeloğlu, Zafer; Özyalvaçlı, Gülzade; Gürel, Kamil; Akdeniz, Hayrettin
Non-invasive fibrosis tests are correlated with necroinflammatory actvity of liver in patients with chronic hepatitis B
(Societa Editrice Universo, 2014) Özyalvaçlı, Gülzade; Küçükbayrak, Abdülkadir; Kurt, Mevlüt; Gürel, Kamil; Güneş, Öznur; Üstün, Cemal; Akdeniz, Hayrettin
Background. The gold standarda method used for assessing necroinflammatory activity and fibrosis in the liver is a liver biopsy which has many disadvantages. Therefore, many investigators have been trying to develop non-invasive tests for predicting liver fibrosis score (LFS) of these patients. The aim of this study is to describe the relationship between certain non-invasive fibrosis markers with LFS and histological activity index (HAI) detected histopathologically by liver biopsy in chronic hepatitis B patients. Materials and Methods. A total of 54 patients who had undergone a liver biopsy with the diagnosis of chronic HBV infection were included in the study. Ishak scoring was used for the evaluation of liver fibrosis, and a modified Knodell HAI was used for demonstration of necroinflammation. In this study, non-invasive fibrosis tests were calculated as described in previous studies. Results. Histological acitivity index was positively correlated with age, age/platelet index, cirrhosis discriminant score (CDS), AST/ platelet ratio index (APRI), AST/platelet/GGT/AFP index (APGA), fibro-quotient (Fibro-Q), Goteburg University Cirrhosis Index (Guci), and Platelet/Age/Phosphatase/AFP/AST index (PAPAS). When divided into two groups according to HAI, Guci and APGA were found significantly different both in >4 and >4 HAI groups than the other group. In ROC analysis performed for LFS; PAPAS, APGA, FFI and APRI were the markers having the highest AUC levels, and in ROC analysis performed for HAI; Guci, APRI and APGA were the markers with the highest AUC levels. Conclusion: APRI, APGA and GUCI tests may be helpful in prediction of necroinflammatory scores in the liver.
Noninvasive models to predict liver fibrosis in patients with chronic hepatitis B: a study from Turkey
(Kowsar Publ, 2017) Korkmaz, Pınar; Demirtürk, Neşe; Batırel, Ayşe; Yardımcı, Ahmet Cem; Çağır, Ünal; Sırmatel, Fatma; Akdeniz, Hayrettin
Background: Manynoninvasive methods, including aspartateaminotransaminase (AST)/alanineaminotransaminase (ALT) ratio (AAR), AST-to-platelet ratio index (APRI), Bonacini cirrhosis discriminant score (CDS), fibrosis-4 (FIB4) index, and age-platelet index (API), have been described to determine the stage of hepatic fibrosis. However, thesemethodsare developed for patients with chronic hepatitisC(CHC) andproduce conflicting results in the prediction of liver fibrosis in patients with chronic hepatitis B (CHB). Objectives: The aim of this study was to evaluate the relationship between 7 noninvasive models, including AAR, APRI, CDS, API, FIB-4, neutrophil-to-lymphocyte ratio (NLR), and red cell distribution width (RDW)-to-platelet ratio (RPR) in patients with CHB. Methods: The study population included all patients with CHB, undergoing liver biopsy to determine HBsAg and HBV DNA positivity in more than 6 months. Results: A total of 2520 treatment-naive CHB patients from 40 different centers were included in the study. In total, 62.6% of the patients were male, and the mean age was 40.60 +/- 12.34 years (minimum, 18 years; maximum, 77 years). The Ishak fibrosis score was >= 3 in 29.8% of the patients, indicating significant fibrosis. The mean API, APRI, CDS, NLR, FIB4, and RPR scores in the noninvasive models were significantly different between the groups with significant and low fibrosis (P < 0.05). All the noninvave models (API, APRI, AAR, CDS, NLR, RPR, and FIB4) were found to be significant in the discrimination of cirrhosis (P < 0.05). In the multiple logistic regression analysis, CDS, albumin, alkaline phosphatase (ALP), total bilirubin, neutrophil count, NLR, mean platelet volume (MPV), and FIB4 were independent indices for cirrhosis. Conclusions: In the present study, the role of noninvasive tests in the prediction of liver fibrosis stage and cirrhosis was evaluated in a large cohort of CHB patients. Overall, noninvasive models are gradually becoming more promising. Accordingly, the need for liver biopsy can be reduced with a combination of noninvasive methods in the future.
Nosocomial acinetobacter baumannii infections and changing antibiotic resistance
(Professional Medical Publications, 2013) Hakyemez, İsmail Necati; Küçükbayrak, Abdülkadir; Taş, Tekin; Yıkılgan, Aslıhan Burcu; Akkaya, Akcan; Yaşayacak, Aliye; Akdeniz, Hayrettin
Objectives: In the intensive care setting, Acinetobacter baumannii causes ventilator-associated pneumonia and other nosocomial infections that are difficult to treat. Objective of this study was to investigate nosocomial A. baumannii infections and its changing antibiotic resistance. Methods: A total of 56 patients diagnosed with A. baumannii infections between January 2009 and December 2011 were included in the study. Diagnosis for nosocomial infections was established according to the CDC (Centers for Disease Control and Prevention) criteria. Identification of the agents isolated was carried out using conventional methods and VITEK 2 automated system, while antibiotic sensitivity testing was performed through VITEK 2 AST-N090 automated system. Results: The most common infection was nosocomial pneumonia by 43%, among which 46% were ventilator-associated pneumonia. Considering all years, the most effective antibiotics on the isolated strains were found as colistin, tigecycline, imipenem and meropenem. However resistance to imipenem and meropenem was observed to increase over years. Conclusion: The issue of increased resistance to antibiotics poses difficulty in treatment of A. baumannii infections which in turn increases the rate of mortality and cost. In order to prevent development of resistance, antibiotics must be used in an appropriate way in accompanied with proper guidance.
Oje kullanımının eldeki bakteriyel üreme üzerine etkisi
(Bilimsel Tıp Yayınevi, 2021) Yiğit, Ümmühan; Soysal, Ganime Esra; Özarslan, Talat Oğulcan; İlçe, Arzu; Sırmatel, Fatma; Akdeniz, Hayrettin
Giriş: İnfeksiyonların önlenmesinde ameliyathane ve yoğun bakım gibi özellikli birimlerde çalışanların el hijyeninin sağlanması oldukça önemli, en etkili ve en ucuz yöntemdir. Bu çalışma; ameliyathane ve yoğun bakımlarda hemşirelerin oje kullanımının ellerdeki bakteriyel üreme üzerine etkisini belirlemek amacıyla planlandı. Materyal ve Metod: Çalışmanın evrenini bir ilde bulunan eğitim araştırma ve devlet hastanesinin yoğun bakım ünitelerinde ve ameliyathanelerinde çalışan hemşireler oluşturdu. Çalışma yoğun bakımlarda 43, ameliyathanelerde 29 olmak üzere çalışmaya katılmayı kabul eden toplamda 72 hemşirede gerçekleştirildi. Araştırmaya katılanların el florası üzerindeki bakteri kolonizasyonunu ölçmek için hemşirelerinden önce ojesiz hijyenik el yıkama sonrası ilk örnek, oje sürüldükten 24 saat sonra hijyenik el yıkama sonrası ikinci örnek ve oje sürüldükten 72 saat sonra hijyenik el yıkama sonrası üçüncü örnek alındı. Hemşirelerin tırnak ve ellerinden alınan örnekler kanlı agar besiyerlerine ekilerek sonuçlar değerlendirildi. Bulgular: Hemşirelerden üç aşamada alınan örneklerde, toplam üreyen koloni sayısı açısından bakıldığında gruplar arası hem sağ ve sol el, hem de sağ ve sol tırnaklarda, istatistiksel olarak anlamlı bir fark olmadığı görüldü (p≥ 0.05). Alınan örneklerde koagülaz negatif stafilokok (KNS), Staphylococcus aureus, Bacillus spp., Enterococcus spp., Streptococcus pyogenes, Acinetobacter spp., Klebsiella spp., Candida spp. ve Non-candida mantar türlerinin ürediği tespit edildi. Bu türler arasında en sık üreyen mikroorganizmanın KNS olduğu görüldü. Ayrıca üreyen toplam koloni sayıları açısından yoğun bakım ve ameliyathaneler karşılaştırıldığında sağ el, sağ ve sol tırnaklarda fark görülmezken, sol elde üreyen toplam koloni sayısı ameliyathanede çalışan hemşirelerde anlamlı şekilde daha yüksek bulundu (p≤ 0.05). Sonuç: Ameliyathane ve yoğun bakım hemşirelerinde bütünlüğü bozulmamış oje kullanımının 72 saate kadar eldeki bakteriyel üreme üzerine etkisinin olmadığı bulundu.
The role of hematological parameters in estimating nosocomial sepsis
(Modestum Ltd., 2019) Gözdaş, Hasan Tahsin; Gel, Keziban Türken; Yasayacak, Aliye; Kesgin, Makbule Tokur; Akdeniz, Hayrettin
Background: Sepsis is a systemic inflammatory condition with high mortality rate. It is important to estimate nosocomial sepsis in order to manage the patients earlier. The aim of this study was to investigate the role of hematological parameters in estimating nosocomial sepsis. Material and Methods: A retrospective examination was conducted on 121 nosocomial sepsis patients between 01 January 2014 and 30 June 2017. Neutrophil to lymphocyte ratio (NLR) and C-reactive protein (CRP) of the patients at the onset of sepsis were compared with baseline values. Results: The mean CRP level of the cohort at admission was 55±5.4 mg/dL and 139.2±6.2 mg/dL at the onset of sepsis (p<0.001). The mean NLR at admission was 10.64±10.6 and 13.69±14.5 at the onset of sepsis (p=0.037). In contrast, the differences in white blood cell, and mean platelet volume values at admission and sepsis onset were not statistically significant (p>0.05). Significant correlation was found between CRP and NLR values at both admission (r=0.365, p<0.001) and at the onset of sepsis (r=0.261, p=0.004). Conclusion: We concluded that the NLR is a useful marker in estimating nosocomial sepsis especially when considered together with CRP. © 2019 by the authors; licensee Modestum Ltd., UK.
Seroprevalence of human fascioliasis in Van province, Turkey
(Aves, 2015) Cengiz, Zeynep Taş; Yılmaz, Hasan; Dülger, Ahmet Cumhur; Akdeniz, Hayrettin; Karahocagil, Mustafa Kasım
Background/Aims: Fasciola hepatica is a rare zoonotic parasite that infects the liver of many mammals including humans. The aim of this study was to determine the seroprevalence of fascioliasis in Van province by ELISA (antibody detection) on the assumption that not all cases could be detected by stool examination alone. Materials and Methods: A total of randomly selected 1,600 patients, directed from affiliated outpatient clinics to Yuzuncu Yil University Medical Faculty Parasitology Laboratory, were enrolled in the study. Their mean age was 4.44 +/- 19.00 years. Blood samples were collected from all the patients, and their stool samples were examined. For the stool examination, native-lugol and sedimentation (in formalin-ethyl acetate) methods were employed. ELISA for F. hepatica was performed on the blood samples from all patients. Seropositive patients were treated with triclabendazole. Results: F. hepatica was detected by ELISA in 89 (5.6%) of the 1,600 patients, but eggs were identified on the stool examination in only 29 (1.8%) patients. The prevalence of F. hepatica was higher in females (7.2%) than in males (4.2%) and was higher in the >= 36-year age group (6.7%) than in the <= 35-year age group (4.4%). Abdominal pain (93.3%), fatigue (88.8%), and weight loss (69.7%) were the most common symptoms. Eosinophilia was present in 89.9% of the patients. All seropositive patients had a history of eating raw aquatic plants. Conclusion: Stool examination alone is not sufficient to diagnose F. hepatica. Serological tests such as ELISA must be used together with stool examination.
Ventilatör ilişkili pnömoni sıklığı risk faktörleri ve etkenleri
(2012) Bilici, Adnan; Karahocagil, Mustafa Kasım; Yapıcı, Kubilay; Göktaş, Uğur; Yaman, Görkem; Akdeniz, Hayrettin
Gereç ve Yöntem: Ventilatör ilişkili pnömoni (VİP), invaziv Mekanik Ventilasyon (MV) uygulanan hastalarda gelişen ve yoğun bakım ünitelerinde sık karşılaşılan, mortalite hızı yüksek bir hastane enfeksiyonudur. Bu çalışmada Yüzüncü Yıl Üniversitesi Tıp Fakültesi Anesteziyoloji ve Reanimasyon Yoğun Bakım Ünitesinde Eylül 2008-Aralık 2009 tarihleri arasında VİP sıklığı, risk faktörleri, etkenleri ve antibiyotiklere duyarlılıkları araştırılmıştır. Bulgular: Hasta günü ile ilişkili ventilatör kullanımı ve 1000 ventilatör gününde gerçekleşen VİP oranı sırasıyla 0.77 ile 31.6 atak/1000 ventilatör günü olarak bulunmuştur. VİP olgularında sıklık sırasına göre; Acinetobacter baumannii % 31, Pseudomonas spp. % 20.6, Klebsiella spp. % 17.2, S. aureus % 15, E. coli % 9.2, S. epidermidis % 3.5, E. faecium % 1.1, E. cloacae % 1.1 ve M. morganii % 1.1 oranında izole edilmiştir. Klinik uygulamada sorun oluşturabilecek bazı antibiyotik direnç profilleri elde edilmiştir. P. aeruginosa suşlarında imipenem direnci % 61.1, siprofloksasin direnci % 55.5, seftazidim direnci % 55.5, amikasin direnci % 44.5, S. aureus suşlarında metisilin direnci % 84.6, A. baumannii suşlarında imipenem direnci % 59.3 olarak saptanmıştır. Sonuç: Ampirik tedavide kullanılacak antibiyotiklerin ünitenin mikrobiyolojik flora ve antibiyotik direncine göre yönlendirilmesi, etken izolasyonu sonrasında ise; tedavinin antibiyotik duyarlılık sonucuna göre dar spektrumlu antibiyotik ile modifiye edilmesi hedeflenmelidir.

Yazar "Akdeniz, Hayrettin" seçeneğine göre listele

Sayfa Başına Sonuç

Sıralama seçenekleri