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Öğe Comparison of dexmedetomidine and midazolam for monitored anesthesia care combined with tramadol via patient-controlled analgesia in endoscopic nasal surgery: A prospective, randomized, double-blind, clinical study(Elsevier, 2007) Karaaslan, Kazım; Yılmaz, Fahrettin; Gülcü, Nebahat; Çolak, Cemil; Şereflican, Murat; Koçoğlu, HasanBackground: Monitored anesthesia care (MAC) may be applied for septoplasty or endoscopic sinus surgery in which an adequate sedation and analgesia without respiratory depression are desired for comfort of both the patient and the surgeon. Several combinations with different agents have been used for this purpose in these patients. However, analgesic properties for these agents have not been reported. Objective: The aim of this study was to investigate the analgesic and sedative effects of dexmedetomidine or midazolam infusion combined with tramadol that was used via patient-controlled analgesia (PCA), and to document the effects of these drugs on early cognitive functions. Methods: This prospective, randomized, double-blind, clinical study enrolled patients undergoing septoplasty or endoscopic sinus surgery at the Abant Izzet Baysal University Hospital, Bolu, Turkey, between February and September 2006. Patients were randomly allocated in a 1: 1 ratio into I of 2 groups: the dexmedetomidine group (group D) patients received IV dexmedetomidine I mu g/kg for 10 minutes followed by continuous infusion of 0.5 mu g/kg center dot h(-1); and the midazolam group (group M) patients were administered a loading dose of IV midazolam 40 mu g/kg for 10 minutes followed by infusion at the rate of 50 mu g/kg center dot h-1. A I-minute bolus dose of IV tramadol (1.5 mg/kg) was administered in both groups 10 minutes after the administration of the primary drug, and continued via infusion using a PCA device. After baseline measurements, systolic arterial pressure (SAP), diastolic arterial pressure (DAP), mean arterial pressure (MAP), heart rate (HR), oxygen saturation, and rate of respiration were recorded after the loading dose of study drug, after the bolus tramadol dose, at 10-minute intervals during the operation, and twice in the recovery rooms; 5 minutes after arrival and 5 minutes before discharge. Verbal rating score (VRS) and Ramsay sedation score were determined at baseline (after surgery was started), every 10 minutes thereafter until the end of the operation, and 2 times during recovery. All patients were assessed with the Wechsler Memory Scale-Revised at baseline (preoperatively) and 4 hours after the operation. Results: Seventy patients were enrolled in the study and randomly assigned to I of 2 groups: group D (sex, male/fernale, 23/12; mean [SEM] age, 32.53 [2.07] years; mean [SEM] weight, 73.03 [2.41] kg) or group M (sex, male/female, 21/14; mean [SEM] age, 34.43 [1.83] years; mean [SEM] weight, 67.90 [2.32] kg). All hemodynamic parameters (SAP, DAP, MAP, HR) were significantly higher in group M compared with group D from the onset of the surgery to discharge time (P < 0.05). Pain and sedation scores were similar in both groups, but the amount of PCA-administered rescue tramadol was significantly higher in group M (P = 0.001). A higher, though not statistically significant, prevalence of adverse events (ie, hypotension, bradycardia, and perioperative nausea and vomiting) were observed in group D. Postoperative logical verbal memory and digit span values were significantly higher in group D when compared with group M (P < 0.05). Postoperative digit span and visual reproduction scores were significantly higher than preoperative values in group D (P < 0.05). Postoperative personality functioning scores were significantly higher than preoperative values in group M (P < 0.05). Conclusions: Based on VRS, Ramsay sedation scores, and surgeon and anesthesiologist satisfaction scores, dexmedetomidine or midazolam combined with tramadol PCA provided adequate analgesia and sedation in these adult patients undergoing septoplasty or endoscopic sinus surgery with MAC. A significantly larger amount of rescue tramadol was used by group M, suggesting that a better analgesic effect was achieved with dexmedetomidine. (Curr Ther Res Clin Exp. 2007;68:69-81) Copyright (C) 2007 Excerpta Medica, Inc.Öğe Comparison of histopathological effects of thymoquinone and local nasal corticosteroids in allergic rhinitis in a rabbit model(Karger, 2016) Yurttaş, Veysel; Şereflican, Murat; Erkoçoğlu, Mustafa; Dağlı, Muharrem; Terzi, Elçin Hakan; Fırat, Tülin; Seyhan, SinanBackground/Aims: In this study, we aimed to evaluate the histopathological effects of thymoquinone treatment of the nasal mucosa in a rabbit model of allergic rhinitis, and we compared its effects with those of nasal mometasone furoate. Methods: A total of 24 male New Zealand rabbits were used. The animals were randomly assigned to one of four groups. Group 1 received no treatment, while group 2 underwent ovalbumin (OVA) sensitization only. Group 3 was the study group; after OVA sensitization, the rabbits were treated with intranasal thymoquinone. The group 4 rabbits received mometasone furoate for 7 days after OVA sensitization. Mucosal structures were stained with hematoxylin and eosin, while toluidine blue was used to stain mast cells. Apoptosis was evaluated using a TUNEL assay. Results: In the positive control groups, including the thymoquinone and intranasal mometasone furoate groups, intraepithelial and submucosal inflammation and goblet cell hypertrophy were significantly decreased compared to group 2 (p < 0.001). The cilial structure was normal, as was the chondrocyte structure in both treatment groups. Conclusion: This is the first study to evaluate the histopathological effects of thymoquinone in an allergic rhinitis model. Thymoquinone reduced allergic inflammation and may be valuable for treating allergic rhinitis. However, additional studies are needed. (C) 2016 S. Karger AG, BaselÖğe Comparison of microporous polysaccharide hemospheres and Ankaferd Blood Stopper in a rabbit epistaxis model(Springer, 2016) Yurttaş, Veysel; Şereflican, Murat; Terzi, Elçin Hakan; Özyalvaçlı, Gülzade; Kazaz, HasanThe aim of this study was to evaluate the histopathological impact, effectiveness, and safety of two hemostatic agents, Ankaferd Blood Stopper (ABS) and microporous polysaccharide hemospheres (MPH), in an experimental rabbit epistaxis model. Rabbits were randomly assigned, using a computerized random number generator, to the following three groups of six animals: group 1 (control, irrigated with saline); group 2 (ABS-treated); and group 3 (MPH-treated). In all groups, a standardized rabbit epistaxis model was used. Hemostasis time and extent of nasal bleeding were measured to compare the hemostatic effect of ABS and MPH among groups. Septums were removed for histopathological analysis, 7 days after the procedure. ABS reduced hemostasis time to 104.2 s and amount of bleeding to 20.5 mg. MPH reduced hemostasis time to 71.7 s and amount of bleeding to 11.5 mg. Mean bleeding time in wounds administered ABS and MPH was significantly shorter compared with wounds administered isotonic saline solution (p = 0.004). ABS and MPH application decreased bleeding significantly compared with the control group (p = 0.004). Bleeding time and amount in the MPH group was significantly reduced compared with the ABS group (p = 0.013 and p = 0.004, respectively). There was no significant difference in the histopathological evaluation results between the ABS, MPH, and control groups. Our data indicate that both ABS and MPH represent safe, effective, and fast-acting hemostatic agents in the management of epistaxis. MPH was more effective than ABS in terms of hemostasis time and amount of bleeding.Öğe The effect of adenoidectomy operation made on patients with adenoid hypertrophy on cardiovascular risk reduction(Lippincott Williams & Wilkins, 2015) Şereflican, Murat; Yurttaş, Veysel; Erdem, FatmaÖğe The effect of desflurane on postoperative olfactory memory(Verduci Publisher, 2016) Yıldız, İsa; Bayır, Hakan; Sağlam, İbrahim; Şereflican, Murat; Bilgi, Murat; Yurttaş, Veysel; Demirhan, Abdullah; Koçoğlu, HasanOBJECTIVE: In this study, we investigated the effects of desflurane 6%, on olfactory memory. PATIENTS AND METHODS: This is a prospective clinical study performed with 40 patients aged 18-60 who had elective surgery and American Society of Anesthesiologists (ASA) physical status I-III. The Brief Smell Identification Test (BSIT) was used for evaluating patients' olfactory memories before and after the surgery. Patients received standard general anesthesia protocol and routine monitoring. For induction, 1.5 mg/kg of fentanyl, 2 mg/kg of propofol, and 0.5 mg/kg of rocuronium bromide were administered. Anesthesia was maintained with the inhalational of anesthetic desflurane (6%). The scores are recorded 30 minutes before the surgery and when the Aldrete Recovery Score reached 10 in the postoperative period. Preoperative and postoperative results were compared and p-values <0.05 were considered statistically significant. RESULTS: The patients' mean age was 41.1 +/- 12.0. Preoperative total correct answer rate to odorous substances was 92.7%, and postoperative rate was 92.1%. Percentage of the odor substance identification by the patients revealed no statistically significant difference when pre and post-operative rates have been compared (p-value > 0.05). CONCLUSIONS: We have observed for the first time in the literature that general anesthesia using desflurane (6%) did not affect short-term olfactory memory. Further studies will be necessary to confirm our findings with larger sample size.Öğe The effect of mean platelet volume on the patients with nasal polyps(Univ West Indies Faculty Medical Sciences, 2016) Erdur, Ömer; Şereflican, Murat; Yurttaş, Veysel; Erdem, FatmaThe Editor, Sir, With great eagerness, we have read the study in your journal entitled “Mean platelet volume in nasal polyps” by Aktas et al (1). We would like to make some comments about this study. In recent years, many studies, which state there is a significant relation between the decrease of mean platelet volume (MPV) and inflammatory burden of several diseases, have been published (2–4). Besides this, some studies that search for the relation between nasal polyps and MPV have been reported (1, 5). In the results of these studies, there are conflicting comments about the effect of MPV value to nasal polyps. Although a good number of assertive results have been announced in these studies, sufficient usage area of MPV value measurement has not occurred in the follow-up and treatment of patients clinically as there is no fully standardized method of this parameter.Öğe The effect of melatonin on tinnitus with respect to sleep and depression : a randomized clinical trial(Aves, 2012) Köybaşı, Serap; Boztaş, Mehmet Hamid; Biçer, Yusuf Özgür; Serin, Erdinç; Süslü, Ahmet Emre; Funda, Yasemin Ongun; Şereflican, MuratObjective: In this study we aimed to investigate the psychological status of tinnitus patients as well as the sleep quality and their relation to handicap caused by tinnitus using various scales. Additionally, serum melatonin levels and the effectiveness of melatonin treatment were studied. Study Design: Prospective, double blind, randomized controlled trial Materials and Methods: Patients were divided randomly into two groups as study (melatonin, n=13) and placebo (control, n=11) groups. Tinnitus Handicap Inventory (THI), Symptom Check List (SCL), Hospital Anxiety and Depression Scale (HAD), Beck Depression Inventory (BDI), Pittsburg Sleep Qualty Index (PSQI) were applied. After filling the scales and giving the venous blood sample for melatonin measurements the patients were instructed to take one tablet (placebo or 3 mg melatonin) before sleep every night. After 8 weeks, second order scales were filled and melatonin measurements were repeated. Results: Serum melatonin levels were between 1-260 pg/ml; the mean was 38,7 pg/ml. The correlation of melatonin levels with THI and tinnitus duration was not significant. THI was found to correlate with different measures of the PSQI, HAD, and BDI in both groups. Statistical analysis failed to show any significant difference within and between groups in respect of anxiety, depressive symptoms and sleep as well as melatonin and handicap levels. When the groups were assessed according to the THI severity (mild/moderate to severe;THI2); in the control group there was significant differences in PSQI(1) and PSQI(1) (p=0.0008, p=0.18), NAD(1), HAD(2) (0.002, 0.03), HAD Depression(1-2) (0.0, 0.006) BDI (p=0.007) PSQI(2 sleep) (disturbance) (P=0.018) parameters. However, in the melatonin group it was found that there were significant differences in SCL2 (sleep) (latency), PSQI(2) (sleep) (duration) and total PSQI(2) parameters. (p=0.022, 0.027, 0.006 respectively) Conclusion: Patients with higher handicap may benefit melatonin in respect of sleep latency and duration as well as sleep quality comparing with the patients taking placebo. Moreover, melatonin efficiency may be related to its antidepressive effect.Öğe The effect of septoplasty operation for nasal septum deviation to cardiovascular risk reduction(Lippincott Williams & Wilkins, 2015) Şereflican, Murat; Yurttaş, Veysel; Erdem, FatmaÖğe The effect of topical lidocaine plus dexamethasone on postoperative analgesia in septoplasty surgery(Allied Acad, 2016) Yıldız, İsa; Bayır, Hakan; Şereflican, Murat; Demirhan, Abdullah; Yurttaş, Veysel; Bilgi, MuratIntroduction: This study has aimed to research the analgesic effects of lidocaine and dexamethasone infiltration in the merocel pack which is being used as nose pack for patients who had septoplasty operation. Materials and Methods: Sixty patients are included in randomized double blind study. The patients are divided into 3 groups as lidocaine (group L), lidocaine + dexamethasone (group LD) and dexamethasone (group D). The prepared medications are infiltrated in Merocel Pack that has been placed in both nostrils after the operation. The NRS impacts and side effects are examined in postoperative 15th minute and 1st, 2nd, 4th, 8th, 12th and 24th hours. Moreover, the total tramadol consumption between hours 0-1, 0-12 and 12-24 are recorded. Results: The study is finalized with 57 patients. The postoperative patients satisfaction did not demonstrate a significant difference among the groups by means of NRS levels. Group D has consumed more analgesics than group LD in the first 12 hours with regards to the total tramadol consumption. Conclusion: We observed that lidocaine or dexamethasone infiltrated in Merocel Pack provides analgesic effects for pain control following septoplasty whereas the total analgesia consumption is reduced when dexamethasone is combined with lidocaine.Öğe Evaluation of mean platelet volume and neutrophil to lymphocyte ratio as a diagnostic indicator in patients with recurrent aphthous stomatitis(2016) Şereflican, Murat; Şereflican, Betül; Tuman, Bengü; Göksügür, Nadir; Kesgin, Selcan; Yurttaş, VeyselAmaç: Rekürren aftöz stomatit (RAS) oral mukozanın tekrarlayan,ağrılı ülserlerle karakterize, kronik inflamatuar bir hastalığıdır. Sıkgörülen bir durum olmasına karşın etyolojisi ve patogenezi tam olarak bilinmemektedir. Etyolojisinin idiyopatik veya multifaktöryel olduğu belirtilmektedir. Ortalama trombosit hacmi (MPV) trombositaktivasyonunu gösteren, nötrofil lenfosit oranı (NLR) ise kronik inflamasyon göstergesi olan ve her ikisi de rutin tam kan tetkiklerindeölçülebilen değerlerdir. Bu çalışmanın amacı RAS'lı ve kontrol grubuhastalardaki MPV ve NLR değerlerini araştırmaktır. Yöntem:Bu çalışmaya 39 RAS'ı bulunan ve 34 kontrol grubu hastadahil edildi. Bulgular:Hasta ve kontrol grubu karşılaştırıldığında MPV, ESR, CRP,vitamin B12 değerlerinin hasta grubunda kontrol grubuna göre anlamlı derecede yüksek çıktı ve NLR, WBC, hemoglobin, nötrofil, lenfositdeğerleri arasında her iki grup arasında anlamlı fark bulunmadı. Sonuç:Ortalama trombosit hacminin, RAS'lı hastalarda tanısal birgösterge olabileceği ortaya konulduÖğe Evaluation of olfactory memory after sevoflurane anesthesia: is really short-term memory influenced?(Scientific Publishers India, 2016) Bayır, Hakan; Yıldız, İsa; Yoldaş, Hamit; Karagöz, İbrahim; Kurt, Adem Deniz; Şereflican, MuratObjective: Olfactory disorders can negatively effect the quality of life. Few clinical studies and case reports have investigated the relationship between anesthesia and olfactory dysfunction. The aim of this study was to investigate the effect of sevoflurane on olfactory memory with Brief-Smell Identification Test (TM) in patients used sevoflurane. Patients and Methods: This, prospective, clinical study was performed on 60 ASA physical status I-II patients, between 18-65 years of age who were scheduled for expected surgery duration of 40-120 minutes. All patients were preoperatively informed about Brief-Smell Identification Test. For induction 2 mg.kg(-1)propofol, 0.5 mg.kg(-1) rocuronium and 1 mu g.kg(-1) iv fentanyl were administered. Anesthesia was maintained with the inhalational of anesthetic sevoflurane (2%). Brief-Smell Identification Test scores are recorded 30 minutes before the surgery and when the Aldrate Recovery Score reached 10 in the postoperative period. Preoperative and postoperative results were compared and p-values<0.05 were considered statistically significant. Results: The patients mean age were 47.1 +/- 13.8. There was no statistically significant difference between the mean preoperative and intraoperative HR and MAP values. Preoperative total correct answer rate to odorous substances was 85.4%, and postoperative rate was 84.5%. Percentage of the odor identification by the patients revealed no statistically significant difference when pre and post-operative rates were compared (P>0.05).Öğe An evaluation on the role of MPV on idiopathic sudden hearing loss etiology(Springer, 2015) Şereflican, Murat; Yurttaş, Veysel; Erdem, FatmaÖğe Giant Chondroid Syringoma of the breast(Wiley-Blackwell, 2015) Şereflican, Betül; Kızıldağ, Betül; Kurt, Özlem Kar; Şereflican, Murat; Göksügür, Nadir; Boran, ÇetinÖğe Gorlin-Goltz sendromu(2017) Şereflican, Betül; Tuman, Bengü; Şereflican, Murat; Halıcıoğlu, Sıddıka; Özyalvaçlı, Gülzade; Bayrak, SevalGorlin-Goltz sendromu oldukça nadir görülen otozomal baskın kalı- tımlı çoklu sistemik bir hastalıktır. Bazal hücreli karsinom, çene kistleri, frontal belirginleşme, vertebra anomalileri gibi iskelet anomalileri; palmoplantar çukurlanma ve falks serebri kalsifikasyonuyla belirgindir. Medulloblastom, fibrom, rabdomyom, leiomyosarkom vb. tümörlere eğilim vardır. Tanı büyük ve küçük klinik ve radyolojik ölçütlere dayanmaktadır. Erken tanı ve tedavi, bu sendromun uzun dönemde sekellerini azaltmada büyük önem taşımaktadır. Bu yazıda saçlı deride çok sayıda kahverengi-siyah papül ve plaklarla kliniğimize başvuran ve Gorlin-Goltz sendromu düşünülen 15 yaşında erkek çocuk hasta sunuldu. Hastanın özgeçmişinde medulloblastom nedeniyle cerrahi rezeksiyon yapıldığı ve sonrasında kraniyal radyoterapi aldığı, ayrıca tek taraflı retinoblastom öyküsü vardı. Olgu, Gorlin-Goltz sendromu ve retinoblastom birlikteliğinin dizinde daha önce tanımlanmaması ve radyoterapi sonrası gelişebilecek bazal hücreli karsinomlara dikkat çekmek amacıyla sunuldu.Öğe Gorlin-Goltz syndrome(Aves, 2017) Şereflican, Betül; Tuman, Bengü; Şereflican, Murat; Halıcıoğlu, Sıddıka; Özyalvaçlı, Gülzade; Bayrak, SevalGorlin-Goltz syndrome is a rare multisystemic disease inherited in an autosomal dominant pattern. It is characterized by numerous basal cell carcinoma of the skin, jaw cysts, and skeletal anomalies such as frontal bossing, vertebral anomalies, palmoplantar pits, and falx cerebri calcification. There is a tendency to tumors including medullablastoma, fibroma, rabdomyoma, leiomyosarcoma etc.. The diagnosis is based on major and minor clinical and radiologic criteria. Early diagnosis and treatment are of utmost importance in reducing the severity of long-term sequelae of this syndrome. In this article, we present a 15-year-old boy who was admitted to our clinic with brown-black papules and plaques on his scalp and was thought to have Gorlin-Goltz syndrome. He had a history of medulloblastoma that was treated with surgical resection followed by cranial radiotherapy and unilateral retinoblastoma. We present this case, because association of Gorlin-Goltz syndrome and retinoblastoma has not been described previously in the literature and we aimed to draw attention to radiation-induced basal cell carcinomas.Öğe The histopathological and electrophysiological effects of thymoquinone and methylprednisolone in a rabbit traumatic facial nerve paralysis model(W B Saunders Co-Elsevier Inc, 2016) Şereflican, Murat; Yurttaş, Veysel; Özyalvaçlı, Gülzade; Terzi, Elçin Hakan; Türkoğlu, Şule Aydın; Yıldız, SerpilObjective: We aimed to determine the effects of methylprednisolone and thymoquinone on nerve healing in a traumatic facial nerve paralysis animal model. Subjects and methods: Twenty-four rabbits were randomly divided into 4 groups: group I: control group received no medication and no trauma; group II: sham group received no medication after facial nerve trauma group III: 5 mg/kg/day thymoquinone administered; group IV: 1 mg/kg/day methylprednisolone administered. An initial electrophysiological assessment was performed in all the animals. The buccal branch of the facial nerve was then clipped to form a traumatic facial paralysis model. The drugs were administered for two weeks once a day. At the end of the second month, the electrophysiological assessments were performed and the distal part of the traumatic facial nerve were dissected and examined under light microscopy. Results: Best nerve regeneration was observed in the control and the thymoquinone groups, respectively, whereas the weakest regeneration was determined in the sham group. Thymoquinone and methylprednisolone significantly increased nerve recovery, as measured by histopathological scores and electrophysiological assessment. In the thymoquinone group, due to postoperative amplitude, axon diameter and thickness of myelin sheath values were significantly further increased nerve regeneration compared to that of the methylprednisolone group and these values were dose to those of the values of the control group. Conclusion: Thymoquinone was slightly better than methylprednisolone for functional nerve recovery. The neuroprotective effect of thymoquinone was attributed to its antioxidant and anti-inflammatory effects. Thymoquinone can have a new treatment option to ameliorate the nerve jollity. (C) 2016 Elsevier Inc. All rights reserved.Öğe Histopathological effects of intranasal phototherapy and nasal corticosteroids in allergic rhinitis in a rabbit model(Elsevier Science Sa, 2015) Yurttaş, Veysel; Şereflican, Murat; Erkoçoğlu, Mustafa; Terzi, Elçin Hakan; Kükner, Aysel; Oral, MesutAllergic rhinitis is one of the most common health problems and has a major effect on quality of life. Although new-generation antihistamines and nasal steroids are the main treatment options, complete resolution cannot be obtained in some patients. Besides common side effects such as nasal irritation and epistaxis, the use of these drugs is controversial in some patients, such as pregnant or breastfeeding women. These findings highlight the need for new treatment options. Although phototherapy has been successfully used in the treatment of atopic dermatitis, which is an IgE-mediated disease and shares several common pathogenic features with allergic rhinitis, there are limited studies about its role in the treatment of allergic rhinitis. In this study, we aimed to evaluate and compare the histopathological effects of intranasal phototherapy (Rhinolight) and nasal corticosteroid treatment on the nasal mucosa in allergic rhinitis in a rabbit model and we found that both treatment options significantly reduced inflammation in the nasal mucosa without increasing apoptosis of mucosal cells. (C) 2015 Elsevier B.V. All rights reserved.Öğe In reference to snoring and carotid artery intima-media thickness(Wiley, 2015) Şereflican, Murat; Erdem, Alim; Erdem, FatmaÖğe Is middle ear pressure effected by nasal packings after septoplasty?(Aves, 2015) Şereflican, Murat; Yurttaş, Veysel; Oral, Mesut; Yılmaz, Beyhan; Dağlı, MuharremOBJECTIVE: To investigate the effects of different types of nasal packings on middle ear pressure in patients undergoing septoplasty. MATERIALS and METHODS: Sixty patients who were suffering from nasal obstruction and who had to undergo septoplasty because of nasal septal deviation were included in the study. After the septoplasty, Merocel packings and internal nasal splints were intraoperatively applied in thirty patients each. Middle ear pressure was evaluated by tympanometry. Tympanometric peak pressures were used for this aim. Acoustic impedance measurements were performed in both ears, and the average values of the two ears were calculated. Tympanometric measurements were performed for patients during the preoperative period and on the 2nd and 5th postoperative days. RESULTS: There were 30 (5 females, 25 males; average age 23 years) patients in the internal nasal splint group and 30 (8 females, 22 males; average age 26 years) patients in the anterior Merocel packing group. When the values obtained by acoustic impedancemetry before the operation and on the postoperative 5th day were compared, there was no statistically significant difference between the groups. The middle ear pressure significantly decreased in the anterior Merocel packing group compared with that in the internal nasal splint group. The intragroup comparison of the acoustic impedance measurements of the internal nasal splint group revealed no significant difference between the preoperative acoustic impedance values and the values obtained on the postoperative 2nd day. CONCLUSION: Cannulated silicone intranasal splints are better in terms of patient comfort after an intranasal surgery without effecting eustachian tube function.Öğe Otorhinolaryngologic Manifestations in Obstructive Sleep Apnea(2016) Şereflican, Murat; Kar, Özlem KurtIntroduction: In this study, we aimed to evaluate the patients with obstructive sleep apnea syndrome (OSAS) for otorhinolaryngological manifestations. Methods: A total of 347 patients who were diagnosed to have OSAS by polysomnography between April 2010 - September 2015 were included in the study. Data of patients, which were collected from patient registry records on hospital computer automation system, were analyzed, retrospectively. Results: A total of 117 otorhinolaryngological manifestations diagnosed in all of the OSAS patients. According to the polysonographic findings, 26 of these patients had simple snoring while 30 had mild OSAS, 20 had moderate OSAS and 41 had severe OSAS. When the OSAS group (mild-moderate-severe) (n=91) was examined, 68 patients had nasal septum deviation, 28 had inferior concha hypertrophy, 23 had tongue base hypertrophy, 20 had tonsillar hypertrophy and 33 had elongated soft palate. When the simple snoring group was examined, 20 patients had nasal septum deviation, 8 had inferior concha hypertrophy, 5 had tongue base hypertrophy, 3 had tonsillar hypertrophy and 4 had elongated soft palate. When both groups were compared, it was seen that the only significant difference was that the OSAS group had higher values in terms of elongated soft palate (p˂ 0.05). When OSAS group was examined, nasal septum deviation and concha hypertrophy were the most commonly coexisting conditions among all otorhinolaryngologic diagnosis (12.09%). Similarly, in OSAS group, nasal septum deviation, tongue base hypertrophy and elongated soft palate were the most commonly coexisting diagnosis (8.79%).There was only 1 patient having all the otorhinolaryngologic diagnosis (1.1%). Conclusion: Obstructive sleep apnea syndrome cause severe morbidity and mortality. Otorhinolaryngological pathologies have an important role in the physiopathology of OSAS and early diagnosis has a great importance in reducing mortality and morbidity.
