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An alternative method for anatomy training: Immersive virtual reality
(Wiley, 2020) Kurul, Ramazan; Ögün, Muhammed Nur; Narin, Ayşe Neriman; Avcı, Şebnem; Yazgan, Beyza
The aim of this study was to investigate the effect of immersive three-dimensional (3D) interactive virtual reality (VR) on anatomy training in undergraduate physical therapy students. A total of 72 students were included in the study. The students were randomized into control (n = 36) and VR (n = 36) group according to the Kolb Learning Style Inventory, sex, and Purdue Spatial Visualization Test Rotations (PSVT-R). Each student completed a pre-intervention and post-intervention test, consisting of 15 multiple-choice questions. There was no significant difference between the two groups in terms of age, sex, Kolb Learning Style Inventory distribution, and the PSVT-R (P > 0.05). The post-test scores were significantly higher compared to pre-test scores in both the VR group (P < 0.001) and the control group (P < 0.001). The difference between the pre-test and post-test results was found to be significantly higher in favor of the VR group (P < 0.001). In this study, anatomy training with a 3D immersive VR system was found to be beneficial. These results suggest that VR systems can be used as an alternative method to the conventional anatomy training approach for health students.
Antibodies against vimentin -an early biomarker of ischemia?
(Wiley, 2017) Türkoğlu, Şule Aydın; Ögün, Muhammed Nur; Karabörk, Şeyda; Orallar, Hayriye Soytürk; Yıldız, Serpil
[No Abstract Available]
Association between hemogram parameters and survival of critically Ill patients
(Sage Publications Inc, 2019) Karagöz, İbrahim; Aktaş, Gülali; Yoldaş, Hamit; Yıldız, İsa; Ögün, Muhammed Nur; Bilgi, Murat; Demirhan, Abdullah
Aim: Recently, hemogram parameters, such as mean platelet volume (MPV), had been proposed as novel inflammatory and prognostic factors. In present retrospective analysis, we aimed to determine and compare MPV of survived and dead patients whom admitted to intensive care unit (ICU) of our institution. Methods: We recorded hemogram parameters and other laboratory data and demographic characteristics of patients treated in ICU. Patients are divided into 2 groups-dead patients and survived patients. Laboratory data of survived patients compared to those of dead patients. Results: Age, gender, and other laboratory variables were not significantly different between dead and survived patients. On the other hand, MPV of survived patients was significantly higher than that of the dead patients (P = .001). Conclusion: We think that elevated MPV levels in an ICU patient should alert clinicians for worse outcome. Physicians should be more careful in the management of these patients.
Association between neutrophil-to-lymphocyte ratio and mortality in neurological intensive care unit patients
(Coll Physicians & Surgeons Pakistan, 2019) Ögün, Muhammed Nur; Yakşi, Elif
Objective: To investigate the effect of neutrophil-lymphocyte ratio (NLR) on survival and mortality in patients who were interned in the Neurology Intensive Care Unit (NICU). Study Design: A cohort study. Place and Duration of Study: Tertiary referral hospital in Bolu, Turkey, between February 2016 and November 2017. Methodology: Demographic data, hemogram and other laboratory parameters of the patients who were treated in NICU were retrospectively recorded. The patients who had a history of hematologic disease and/or premorbid use of corticosteroids were excluded from the study. Patients were divided into two groups: surviving and dead patients. MannWhitney U-test, Independent sample t-test or Chi-square test was used to compare the data between the groups, including demographic parameters, NLR and other blood parameters. Results: A total of 120 patients were studied. There was no significant difference in age, gender, hemoglobin (Hb), platelet (PLT), and erythrocyte distribution width (RDW) between the two groups. On the other hand, The NLR values [(3.9 (0.9-48) vs. 11.9 (0.9-69, p <0.001))], C-reactive protein [CRP=(25.6 mg/dL (0.1-250) vs. 57.7 mg/dL (1.2-337, p <0.002)] and white blood cell [WBC=(8.9 mu/mm(3) (3-59.8) vs. 12.4 p/mm 3 (5-41.3), p <0.002)] were significantly higher in dead patients compared to survived patients. Conclusion: Elevated NLR ratio in NICU patients may be considered as a poor prognostic factor. Clinicians should be more cautious in the follow-up of these patients.
The association of antiphospholipid antibodies in patients with multiple sclerosis
(Carbone Editore, 2018) Türkoğlu, Şule Aydın; Ögün, Muhammed Nur; Karabörk, Şeyda; Yıldız, Nebil; Yıldız, Serpil
Aim: Antiphospholipid syndrome (APS) is one of the most common acquired causes of arterial and venous thrombosis. The diagnosis is made based on the presence of antiphospholipid antibodies (APA), anticardiolipin antibodies (aCLA), lupus anticoagulant (LA), and anti-beta 2-glycoprotein I antibody levels and clinical criteria. Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating disease of the central nervous system. From time to time, MS and APS can cause diagnostic confusion for clinical and cranial involvement. We aimed to investigate the frequency of APA in patients with and without MS after being admitted for a differential diagnosis of MS. Materials and methods: The laboratory values for vasculitis/MS differential diagnosis for the last 14 months were analyzed in this retrospective cross-sectional study. The patients were categorized into those who were diagnosed as having MS and those who were not (MS-like) based on the McDonald criteria. The patients' APA IgG and IgM antibodies, aCLA IgG and IgM, and LA values were recorded. Correlation regarding the Expanded Disability Status Scale (EDSS) scores of the patients with MS was investigated. P<0.05 was considered statistically significant. Results: Of 125 patients, 42 had MS and 83 had MS-like illnesses. LA was found negative in 21 (50%) patients and positive in 21 (50%) patients in the MS group. LA was found negative in 26 (31%) patients and positive in 57 (69%) patients in the MS-like group. The difference between the groups was statistically significant (p=0.04). There were positive APA values in 1 patient, and positive aCLA values in 3 patients in the MS group, and positive APA values in 3 patients, and positive aCLA values in 4 patients in the MS-like group. This difference between the groups was not statistically significant (p=0.9). There was no correlation found between EDSS and LA in the patients with MS. Conclusion: The prevalence of antiphospholipid antibodies in MS is a controversial topic. Our study had a higher prevalence of LA in the patients with MS than in the normal population but lower than in the MS-like group. APS should be taken into consideration in the differential diagnosis of patients with MS-like conditions.
Can action research arm test predict functional independence in addition to motor functions in stroke patients?
(2020) Ögün, Muhammed Nur; Kurul, Ramazan
Objective: To investigate the ability of the Action Research Arm Test (ARAT) scores to predict functional independence in the evaluation of upper extremity motor functions in stroke patients. Methods: A total of 59 patients with stroke with a mean age of 61.10±9.12 were included in this study. Forty-one (69.5%) of the patients were male, and 18 (30.5%) were female. After obtaining the demographic data of the patients who were followed up in the stroke outpatient clinic after the stroke, upper extremity functions were evaluated using ARAT test, and functional independence was evaluated with Performance Assessment of Self Care Skills (PASS) and Functional Independence Scale (FIM) tests. The data were retrospectively evaluated and recorded. Results: The mean stroke duration was 15.38±7.16 months. According to Spearman correlation test results, there was no correlation between ARAT and PASS (p=0.902), PASS-BADL (Basic activities of daily living) (p=0.480), PASS-IADL (Instrumental activities of daily living) (p=0.524) and between ARAT and FIM (p=0.451), FIM Motor (p=0.393), and FIM Cognitive (p=0.553). There was a weak correlation between the FIM and the PASS scores (r=0.278, p=0.033). Conclusion: ARAT scores routinely used in the evaluation of upper extremity motor functions were not correlated with functional independence. In addition to the ARAT test, functional independence scales may be appropriate for the evaluation of upper extremity motor functions.
Cerebrospinal fluid levels of interleukin-17 and interleukin-34 in patients with neuro-behcet’s syndrome
(Springer, 2019) Ögün, Muhammed Nur; Karabörk, Şeyda; Önerli, Merve; Türkoğlu, Şule Aydın; Yıldız, Serpil
Behcet's disease (BD) is a rather rare chronic multisystemic vasculitic disease. Clear neurological involvement is observed in up to 49% of patients with BD. Cytokines play a pivotal role in the pathogenesis of BD. Data on the cerebrospinal fluid (CSF) levels of cytokines in patients with Neuro-Behcet's disease (NBD) are limited. We measured the CSF levels of Interleukin (IL)-17A, IL-17F, and IL-34 in 7 patients with NBD (median age of 38 years). Eleven control subjects were of a median age of 42 years. There was no significant difference in the male-to-female ratio and age between the NBD and control groups (P > 0.05). There was also no significant difference in biochemical values of CSF between NBD patients and control subjects. The CSF levels of IL-17 was significantly higher in patients with active NBD compared to the control (P < 0.05), whereas the CSF levels of IL-34 showed no difference compared to the control group (P > 0.05). This is the first study investigating the CSF levels of IL-34 in patients with NBD. Further studies with a larger sample size are required to confirm the role and values of the IL-34 levels in NBD.
Clinic and demographic profile of patients with active epilepsy: experience from a tertiary care hospital in Turkey
(Wiley, 2018) Başaran, Şehnaz; Ögün, Muhammed Nur
[No Abstract Available]
Disfajik inmeli bireylerde kullanılan kompansatuvar postürün yutma üzerine etkisi
(2018) Yakşi, Elif; Kurul, Ramazan; Avcı, Şebnem; Ögün, Muhammed Nur
Amaç: Bu çalışmanın amacı inme sonrası disfaji görülen bireylerde kullanılan postüral adaptasyon manevralarının bireylerin yutması üzerine etkisini incelemektir. Gereç ve Yöntem: Fonksiyonel oral alım skalasına göre disfaji görülen 64 inmeli birey bu çalışmaya dahil edilmiştir. Bireylerin yutma becerileri Teat-10 testi ile baş nötral pozisyonda ve etkilemiş tarafa rotasyon yaptırılarak 2 kez değerlendirilmiştir. Bulgular: Etkilenen arter bölgelerine göre yutma bozukluk şiddetlerinde belirgin farklılık olduğu bulunmuştur(p<0.05). Pozisyonlama sonrası yapılan yutma değerlendirmesi sonuçlarında nötral pozisyona göre yutmalarının anlamlı düzeyde değiştiği gözlenmiştir(p<0.05). Sonuç: Bu çalışmada chin tuck postürüne ek olarak başın etkilenen tarafa rotasyonunun inmeli disfajik bireylerde yutma fonksiyonları üzerine olumlu etkisi bulunmuştur.
Effect of leap motion based 3D immersive virtual reality usage on upper extremity function in ischemic stroke patients
(Assoc Arquivos Neuro- Psiquiatria, 2019) Ögün, Muhammed Nur; Kurul, Ramazan; Yaşar, Mustafa Fatih; Türkoğlu, Şule Aydın; Avcı, Şebnem; Yıldız, Nebil
Immersive virtual reality (VR) is a technology that provides a more realistic environmental design and object tracking than ordinary VR. The aim of this study was to investigate the effectiveness of immersive VR on upper extremity function in patients with ischemic stroke. Sixty-five patients with ischemic stroke were included in this randomized, controlled, double-blind study. Patients were randomly divided into VR (n = 33) and control (n = 32) groups. The VR group received 60 minutes of the upper extremity immersive VR rehabilitation program and the control group received 45 minutes of conventional therapy and 15 minutes of a sham VR program. Rehabilitation consisted of 18 sessions of therapy, three days per week, for six weeks. The outcome measures were the Action Research Arm Test (ARAT), Functional Independence Measure (AM), Fugl-Meyer Upper Extremity Scale (FMUE) and Performance Assessment of Self-Care Skills (PASS). In both the VR and control groups all parameters except the PASS improved over time. However independent t-test results showed that all of the FMUE, ARAT, FIM and PASS scores were significantly higher in the VR group compared with the control (p < 0.05). The minimal clinically important difference (MCID) scores of the FMUE and ARAT were higher than the cut-off MCID scores described in the literature in the VR group, whereas the AM scores were below the cut-off MCID scores. All scores in the control group were below the cut-off scores. Immersive VR rehabilitation appeared to be effective in improving upper extremity function and self-care skills, but it did not improve functional independence.
The effect of vortioxetine on penicillin-induced epileptiform activity in rats
(Assoc Arquivos Neuro- Psiquiatria, 2019) Ögün, Muhammed Nur; Çetinkaya, Ayhan; Beyazçiçek, Ersin
Vortioxetine is a multimodal antidepressant agent that modulates 5-HT receptors and inhibits the serotonin transporter. It is indicated especially in cases of major depressive disorder related to cognitive dysfunction. There are many studies investigating the effects of antidepressants on the seizure threshold and short-term epileptic activity. However, the effect of vortioxetine on epileptic seizures is not exactly known. Our aim was to investigate the effects of vortioxetine on penicillin-induced epileptiform activity. Twenty-seven Wistar rats were divided into three groups: sham-control group, positive control group (diazepam), and vortioxetine group. After a penicillin-induced epilepsy model was formed in each of the three groups of animals, 0.1 ml of saline was administered to the control group, 0.1 ml (10 mg/kg) vortioxetine was administered in the vortioxetine group, and 0.1 mL (5 mg/kg) of diazepam was administered in the positive control group, intraperitoneally. The epileptic activity records were obtained for 120 minutes after the onset of seizure.There was no significant difference in spike wave activity between the vortioxetine and diazepam groups, whereas this was significantly reduced in the vortioxetine group compared with the controls. The administration of vortioxetine at a dose of 10 mg/kg immediately after the seizure induction significantly decreased the spike frequencies of epileptiform activity compared with the control group. No significant difference was found between the vortioxetine and positive controls.This study showed that vortioxetine reduces the number of acutely-induced epileptic discharges. Vortioxetine may be an important alternative for epileptic patients with major depressive disorder-related cognitive dysfunction.
Effects of estrogen and progesterone on the neurogenic inflammatory neuropeptides: Implications for gender differences in migraine
(Springer, 2020) Çetinkaya, Ayhan; Kılınç, Erkan; Çamsarı, Çağrı; Ögün, Muhammed Nur
Neurogenic inflammation including calcitonin gene-related peptide (CGRP) and substance-P (SP) release plays a pivotal role in migraine pathogenesis. Prevalence of migraine is similar to 3 folds higher in women than in men, but its underlying mechanisms remained unclear. We investigated the effects of female sex hormones estrogen and progesterone on CGRP and SP in in-vivo and ex-vivo in rats of both sexes. For in-vivo experiments, male, female and ovariectomized rats were separated into four groups (n = 7) as control, estrogen, progesterone and estrogen + progesterone, respectively. Groups received daily intraperitoneal vehicle, 17 beta-estradiol, progesterone and 17 beta-estradiol + progesterone for 5 days, respectively. For ex-vivo experiments in both sexes, isolated trigeminal ganglia and hemiskull preparations were divided into four groups (n = 6 or 8), respectively, as in-vivo groups, and administered the same test substances. CGRP and SP contents in plasma and superfusates were determined using ELISA. In in-vivo experiments, 17 beta-estradiol decreased CGRP levels in males and SP levels in ovariectomized rats. Progesterone increased both CGRP and SP levels in females. Their combination decreased both CGRP and SP levels in males, and only SP levels in ovariectomized rats. In ex-vivo experiments, 17 beta-estradiol reduced CGRP release in males and SP release in females in trigeminal ganglia. While progesterone increased CGRP release in trigeminal ganglia, it reduced SP release from hemiskulls in both sexes. Their combination restored progesterone-mediated changes in neuropeptides releases in both trigeminal ganglia and hemiskulls in both sexes. Estrogen alleviates neurogenic inflammation through modulation of CGRP and SP release. Progesterone has dual effects on these neuropeptides in different sites associated with migraine pain.
Evaluation of the relationship between computed tomography angiography collateral scores and clinical outcome
(Assoc Arquivos Neuro- Psiquiatria, 2024) Yabalak, Ahmet; Ögün, Muhammed Nur; Önalan, Ayşenur; Yılmaz, Murat; Tokmak, Hilmiye; Ersoy, Sadettin; Bilgili, Fatma
Background The relationship between collateral circulation and prognosis after endovascular treatment in anterior circulation strokes has been reported in many studies. Objective In this study, we aimed to compare the predictive power of clinical outcome by comparing five different collateral scores that are frequently used. Methods Among the patients who underwent endovascular treatment in our clinic between November 2019 and December 2021, patients with premorbid mRS < 3, intracranial ICA and/or MCA M1 occlusion, and a pre-procedural multiphase CTA examination were included in the study. Demographic, technical, and duration information about the procedure, major events after the procedure, and clinical outcomes at 3 months were recorded. The mCTA, Tan, Maas, Miteff, and rLMC collateral scores of the patients were evaluated. Results Clinical outcome at 3 months were good in 37 of the 68 patients included in the study (mRS <= 2). Only the mCTA and rLMC collateral scores were statistically significantly higher in those with a good clinical outcome. Significant correlation with 3-month mRS was detected only in mCTA and rLMC scores. Although rLMC and mCTA collateral scores showed a statistically significant association with prognosis, they were not sufficient to be an independent predictor of prognosis. Conclusion mCTA and rLMC were found to have the highest predictive power of clinical outcome and the highest correlation with the 3-month clinical outcome. Our study suggests that it would be beneficial to develop a new scoring system over multiphase CTA, which combines regional and temporal evaluation, which are the strengths of both collateral scoring.
Evde sağlık hastalarında D vitamini düzeyleri
(2018) Dilekçi, Erdal; Dilekçi, Esra Nur Ademoğlu; Demirkol, Muhammed Emin; Ögün, Muhammed Nur
Amaç: Bu çalışmada mobilize olamayan, güneş ışığından faydalanamayan ve malnütrisyonun sık görüldüğü evde sağlık hastalarında, serum albümin ve 25-hidroksi D (25[OH]D) vitamini düzeylerini incelenmeyi amaçladık. Gereç ve Yöntem: Bu çalışmaya Ocak 2017 ve Temmuz 2017 tarihleri arasında Bolu ilinde evde sağlık hizmetleri tarafından takipli, evden dışarıya çıkamayan ve tümü aile bireyleri tarafından bakılan yatağa bağımlı 57 evde bakım hastası dahil edildi. Kontrol grubu HBYS’de kayıtlı 42 sağlıklı bireyden oluşturuldu. Kişilerin demografik verileri ve kan değerleri takip dosyalarından retrospektif olarak elde edildi. Tüm hastalarda ve kontrol grubunda serum 25(OH) D, kalsiyum ve albümin düzeyleri incelendi. Bulgular: Evde sağlık hastalarının yaş ortalaması 77.7 ± 14.01 yıl, kontrol grubunun yaş ortalaması 74.2 ± 17.03 yıl idi. Serum 25(OH) D düzeyleri hasta grubunda 11.77 ± 9.07 ng/dL, kontrol grubunda 22.62 ± 7.41 ng/dL idi (p<0.001). Serum kalsiyum ve albümin düzeyleri hasta grubunda kontrol grubuna göre istatistiksel olarak anlamlı derecede daha düşüktü (p<0.001). Sonuç: Evde sağlık hizmeti kapsamında takip edilen hastalar malnütrisyon ve D vitamini eksikliği açısından risk altında olup hastaların bu açıdan takibi ve tedavisi önem teşkil etmektedir. Bu konudaki bulgularımızı doğrulamak için ileri çalışmalara ihtiyaç vardır.
Eyes are mirror of the brain: Comparison of multiple sclerosis patients and healthy controls using OCT
(Taylor & Francis Ltd, 2019) Doğan, Ümit; Ulaş, Fatih; Türkoğlu, Şule Aydın; Ögün, Muhammed Nur; Ağca, Sümeyra
Objective: To evaluate the thickness of choroid and retinal nerve fiber layer (RNFL) in multiple sclerosis (MS) patients with and without optic neuritis using enhanced depth imaging optical coherence tomography (EDI-OCT).Methods: In this cross-sectional study, both eyes of 52MS patients [n=104 eyes; 62 eyes of MS patients without optic neuritis (MS-NON) and 42 eyes of MS patients with optic neuritis (MS-ON)] and only one eye of 36 healthy control subjects (n=36 eyes) were evaluated. Complete ophthalmologic examination and EDI-OCT scanning were completed for all participants. Choroidal thickness measurements were executed at three different points.Results: Choroidal thickness measurements were similar between MS patients and healthy control subjects. However, the mean subfoveal choroidal thickness was increased significantly in MS-ON group (399.1382.91 mu m) compared to MS-NON group (342.71 +/- 82.46 mu m; p=0.004). Mean RNFL thickness was significantly reduced in MS patients (90.42 +/- 13.31 mu m) compared to healthy controls (101.18 +/- 10.75 mu m; p<0.001). Moreover, temporal RNFL thickness was significantly thinner in MS-ON group (54 +/- 14.50 mu m) than MS-NON group (62.15 +/- 15.88 mu m; p=0.01). In MS patients, temporal RNFL thickness was correlated with both Expanded Disability Status Score (r=0.383; p<0.001) and longer disease duration (r=-0.202; p=0.04).Conclusion: The results of the present study suggest that RNFL thickness can be used as an important parameter while following up with MS patients. However, more studies using EDI-OCT are required with larger MS patient groups and automated method.
Informed consent in diagnostic and therapeutic lumbar puncture: Are patients aware of the risks?
(2019) Ögün, Muhammed Nur; Önerli, Merve; Türkoğlu, Şule Aydın; Yıldız, Serpil
Objective: To determine whether the type of informed consent (verbal or written and verbal) influenced the awareness of patients about the risks of lumbar puncture (LP). Materials and Methods: An “informed consent form” was given to the patients in group 1 24 h before the procedure, and the patients were requested to read and sign the form. The informed consent form was given to patients in group 2, and then, a neurologist verbally explained the complications mentioned in the form to the patients. After the procedure, patients in both groups were asked whether they were aware of the complications mentioned in the consent form. Results: We included 43 patients (group 1, n=23 and group 2, n=20) in the study; 14% (n=6) of the patients were university graduates, 18% (n=8) had completed high-school education, and 67% (n=29) had completed primary education. No significant difference was observed between the two groups in terms of age, sex, and education level. The mean value of the number of complications that the patients were aware of was 1.17±1.02 and 7.35±1.26 in groups 1 and 2, respectively. We observed a significant difference in the number of complications that the patients were aware of between both groups (p<0.001). Conclusion: The responsibilities of physicians are not solely limited to giving the informed consent form to the patients before LP. Physicians should explain the contents of the form verbally to the patients.
Intravenous Thrombolytic Therapy for Acute Ischemic Stroke:Experiences of a Tertiary Hospital in Turkey
(2021) Yilmaz, Murat; Teker, Handan; Yener, Merve Önerli; Gültekin, Edip; Ögün, Muhammed Nur
Objective: The aim of this study is to retrospectively collect the data of 95 patients with ischemic stroke who received intravenous (IV) tissue plasminogen activator (tPA) therapy between 2015 and 2019 in our clinic, to present the experiences of our clinic. Method: The data of the patients, who applied to our clinic with the diagnosis of acute ischemic stroke between 2015 and 2019, who received thrombolytic therapy, were reviewed retrospectively. General socio-demographic data, clinical features, National Institute Health Scale Scores (NIHSS), Alberta Stroke Program Early Computed Tomography (ASPECT) scores, symptom-to-door, door-to-needle, and symptom-to-needle times, treatment-related complications and Modified Rankin Scores (mRS) at the third month after treatment were evaluated.Results: Procedure-related major or minor bleeding complications developed in 18% of our patients who received tPA therapy. The mortality rate was 15% and 6.3% of these were caused by cerebral hemorrhage due to treatment complications and 8.7% were due to other systemic complications. Logistic regression analysis revealed that only the ASPECT score from factors that we found to be effective on the risk of developing complications was a highly effective factor in the development of complications (p=0.034, OR: 2.131). Conclusions: This study has shown that our results are generally compatible with the literature. Although there is an increase in the number of patients receiving tPA in our clinic every year, we aim to increase awareness of this therapy clinically and to expand the use of IV thrombolytic therapy in selected patients.
Novel mortality markers for critically Ill patients
(Sage Publications Inc, 2020) Yoldaş, Hamit; Karagöz, İbrahim; Ögün, Muhammed Nur; Velioğlu, Yusuf; Yıldız, İsa; Bilgi, Murat; Demirhan, Abdullah
Aim: Inflammatory markers, such as the neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), derived from a complete blood count have recently attracted attention as potential markers of morbidity and mortality in various diseases. The aim of the present study was to assess the usefulness of the NLR and PLR as markers of hospital stay and mortality of patients in intensive care units (ICUs). Methods: Patients treated in the ICU of our institution between October 2016 and August 2017 were enrolled in the study. After obtaining approval from the institutional committee, patient data were sourced from the institution's computerized database and retrospectively analyzed. The patients were assigned to 2 groups according to the outcomes: survivors and deceased. Results: The NLR of survivors and deceased patients was 2.06 (1.18-21.68) and 10.42 (2.85-48.2), respectively. The NLR was significantly elevated in deceased patients as compared with that of survivors (P < .001). Similarly, the median PLR of patients in the deceased group (268.9 [150-3000]) was significantly higher than that of patients in the survivor group (55.7 [11.8-152.5]). The difference in the PLR between groups was significant (P < .001). Conclusion: Both the NLR and PLR, as well as C-reactive protein, predicted mortality in this critically ill population. The PLR and NLR are easy-to-measure, inexpensive markers. Physicians should be aware of elevations in PLR and NLR in patient care in ICUs.
Optical coherence tomography findings in Parkinson's disease
(Wiley, 2018) Türkoğlu, Şule Aydın; Ümit, Doğan; Ögün, Muhammed Nur; Ulaş, Fatih; Keleş, Asena; Yavaş, Nefise Öztürk; Yıldız, Serpil
The aim of this study is to compare optical coherence tomography (OCT) findings of retinal thickness (RT) and retinal nerve fiber layer thickness (RNFLT) of idiopathic Parkinson's disease (IPD) patients to those of healthy subjects, and to investigate whether there is any relationship between the severity of the disease and the RNFLT values. This prospective study was included 25 IPD patients and 29 healthy controls. In the IPD group, the Hoehn and Yahr (H&Y), Unified Parkinson's Disease Rating Scale (UPDRS), and Mini-Mental State Exam (MMSE) were performed. Intraocular pressure (IOP), visual acuity (VA), spherical equivalent, axial length (AL), and central corneal thickness (CCT) were measured using OCT in both groups. The RT was measured in the central retinal (RTc), nasal (RTn), and temporal (RTt) segments. Nasal (RNFLTn), nasal superior (RNFLTns), nasal inferior (RNFLTni), temporal (RNFLTt), temporal superior (RNFLTts), and temporal inferior (RNFLTti) measurements were made and mean RTFLT was calculated (RNFLTg) for each individual. In the patient group, IOP and VA values were statistically significantly lower The RTn and RNFLTg were significantly thinner in the patient group. There was no statistically significant relationship between the severity of IPD and these findings. In our study, RNFLTg and RTn were found to be thinner in the IPD group, which may have caused lower VA scores. The effects of retinal dopamine depletion on RT and RNFLT, and lower IOP values in the non-glaucomatous IPD patients should be further investigated. Copyright (C) 2017, Kaohsiung Medical University. Published by Elsevier Taiwan LLC.
The relationship between total standardized mini mental state examination (SMMSE) and subscores and D vitamin, folate and B12 levels in patients with cognitive dysfunction
(Scientific Publishers of India, 2017) Türkoğlu, Şule Aydın; Ögün, Muhammed Nur; Miçooğulları, Evgin; Gültekin, Edip; Yıldız, Serpil
Introduction: There is evidence that low vitamin levels may be associated with cognitive functions, results from studies on this issue have been incoherent. This study aimed to evaluate whether there is any relationship between the levels of Vitamin D, Folate and B12 and Standardized Mini-Mental Test (SMMT) and subgroups in patients with cognitive dysfunction. Methods: This retrospective study included 184 women and 89 men with cognitive problems and who had SMMSE scores of 24/30 or less. SMMSE scores were prospectively recorded in the patient's file for each patient by an experienced neuropsychologist. SMMSE scores were prospectively recorded in the patient's file for each patient by an experienced neuropsychologist. Vitamin B12, vitamin D and Folate levels were studied from 10:00 am fasting blood samples of each patient and prospectively recorded in patient file. Patient files were retrospectively reviewed and data were recorded. Results: No correlation was found between vitamin D and vitamin B12 levels and SMMSE (total and sub scores) in both sexes. Folate levels were significantly correlated with the SMMSE total (p=0.005, r=0.288), orientation (p=0.004, r=0.290) and registration (p=0.04, r=0.215) scores in females. A positive correlation was found between the folate levels and the SMMSE recall sub score in both sexes (p=0.002, r=0.227). Conclusions: Folate deficiency is an easily treatable condition. Thus it should be considered in the differential diagnosis of cognitive impairment especially in female patients. © 2017, Scientific Publishers of India. All rights reserved.

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