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Öğe Effect of epidermal growth factor on rabbit urethral healing(2004) Aǧartan, Canan Aldırmaz; Aktuǧ, Tanju; Güven, Aysel; Demir, Devrim; Öner, Filiz; Çam, MeryemExtensive clinical and laboratory studies have demonstrated epidermal growth factor (EGF) to play an essential role in the regeneration and healing of epithelial surfaces, including respiratory, gastrointestinal and genitourinary tracts. In this study, we evaluated the effects of supplemental EGF on urethral healing using a rabbit preparation. Twenty New Zealand White rabbits were separated into three groups. In group 1 longitudinal urethrotomy and urethral repair were performed (n=8). In group 2 urethrotomy and urethral repair were performed as in group 1 and gelatin gel patches (1.2 × 0.5 × 0.1 cm) were placed between the repaired urethra and the skin (n=6). In group 3 gel patches containing 10 ?g EGF were placed as in group 2 (n=6). Three weeks after surgery all rabbits were examined under anesthesia in order to determine macroscopic urethral fistulae, and the penis was harvested en bloc for histological examination. There was evidence of macroscopic fistulae formation in only one animal in group 3. Histological evaluation revealed no statistically significant difference between the groups (p>0.05). Despite literature suggesting beneficial effects of EGF on wound healing, we found no beneficial effects of EGF on urethral healing.Öğe Effects of melatonin on streptozotocin-induced diabetic liver injury in rats(Elsevier Gmbh, Urban & Fischer Verlag, 2006) Güven, Aysel; Yavuz, Özlem; Çam, Meryem; Ercan, Feriha; Bukan, Neslihan; Çomunoğlu, Cem; Gökçe, FatihThis study investigated the possible protective effects of melatonin as an antioxidant against streptozotocin (STZ)-induced diabetic liver injury in rats. Wistar rats were divided into four groups: untreated control (UC), melatonin-treated control (MC), untreated diabetic (UD), and melatonin-treated diabetic (MD). Experimental diabetes was induced by a single-dose (60 mg/kg, intraperitoneally (ip)) STZ injection, and metatonin was injected (200 wg/kg/day, ip) for 4 weeks. Upon light and electron microscopic examination, we observed that metatonin improved the morphological and histopathological changes of the liver caused by diabetes. Malondialdehyde levels in the liver homogenates of UD rats were higher than those of controls and were markedly reduced after melatonin treatment. Although no significant difference was observed with respect to antioxidant status, the superoxide dismutase activity tended to be higher in the UD rats than in the treated rats. Our findings showed that metatonin administration partially reduced liver injury in STZ-induced diabetic rats.Öğe Melatonin protects against epirubicin-induced cardiotoxicity(Elsevier Gmbh, 2007) Güven, Aysel; Yavuz, Özlem; Çam, Meryem; Ercan, Feriha; Bukan, Neslihan; Çomunoğlu, CemWe investigated the cytoprotective effect of melatonin in epirubicin-induced cardiotoxicity using four experimental groups of mate Wistar rats: untreated control rats, epirubicin-treated rats, epirubicin+melatonin-treated rats, and melatonin-treated rats. We examined the histopathological. and biochemical, effects of melatonin on the epirubicin-induced changes and measured the Levels of the lipid peroxication end-product (malondialdehyde, MDA), an indicator of nitric oxide (NO) synthesis (nitrite/nitrate production), and reduced glutathione (GSH) in the heart. We also studied the extracellular matrix components (fibronectin, laminin) in the heart. Vacuole formation, mitochondrial. deformation and degeneration, and disordered myofibrillary structures were detected ultrastructurally in the epirubicin-treated group. The degeneration was reduced in the heart tissues of the epirubicin+melatonin group. Epirubicin increased the nitrite/nitrate production, but did not change the MDA and GSH levels significantly. Melatonin treatment Lowered the nitrite/nitrate concentrations, while increasing the GSH levels, which exceeded the Levels in epirubicin+melatonin-treated rats. We conclude that the epirubicin increased the nitrozative stress, not the oxidative stress, in heart tissue, and the cardioprotective effect of melatonin was partially attributed to the suppression of epirubicin-induced nitrozative stress. These results suggest that melatonin partially protects against epirubicin-induced cardiotoxicity. (C) 2006 Elsevier GmbH. All rights reserved.Öğe Non-Hodgkin's lymphoma and auricular hypoplasia: associated with juvenile colloid milium or ligneous conjunctivitis?(Blackwell Publishing Ltd, 2005) Kavak, Ayşe; Kaya, Murat; Alper, Murat; Çam, Meryem; Büyükbabani, Nesimi; Bilen, Abdurrahman; Sılan, FatmaThe exact nature of amyloid-like hyaline material deposits in the skin is not well understood in some disorders. Three of those - ligneous conjunctivitis, ligneous periodontitis and colloid milium - have been rarely reported in a same patient. We report a case of mucosal and skin deposits of an amyloid-like homogeneous material associated with non-Hodgkin's lymphoma and congenital auricular hypoplasia. We discussed and reviewed the literature on these unique associations to determine whether these are the same pathological process. We also noted whether this case represents a new syndrome or a coincidental association.Öğe Protective effects of chronic melatonin treatment against renal injury in streptozotocin-induced diabetic rats(Blackwell Munksgaard, 2003) Çam, Meryem; Yavuz, Özlem; Güven, Aysel; Ercan, Feriha; Bukan, Neslihan; Üstündağ, NilThe aim of this study was to investigate the effects of melatonin as an antioxidant, on prevention and treatment of streptozotocin (STZ)induced diabetic renal injury in rats. Male Wistar rats were divided into four groups: ( 1) untreated, ( 2) melatonin-treated, ( 3) untreated diabetic (UD), ( 4) melatonin-treated diabetic ( MD). Experimental diabetes was induced by single dose ( 60 mg/kg, i.p.) STZ injection. For 3 days prior to administration of STZ, melatonin was injected ( 200 mug/kg/day, i.p.); these injections were continued until the end of the study ( 4 weeks). Malondialdehyde (MDA) levels as a marker of lipid peroxidation were significantly increased in the renal homogenates of UD animals and decreased after melatonin administration. The activity of the antioxidative enzyme glutathione peroxidase (GSH-Px) was significantly reduced in UD rats. Melatonin treatment reversed STZ-induced reduction of GSH-Px activity without having an effect on blood glucose. Upon histopathological examination, it was observed that the melatonin treatment prevented the renal morphological damage caused by diabetes. Upon immunohistochemical investigation, glomerular anti-laminin beta1 staining decreased in MD rats. Additionally, no tubular anti-IGF-1 staining was observed in melatonin-treated rats. In conclusion, chronically administered melatonin reduced renal injury in STZ-induced diabetic rats and thus it may provide a useful therapeutic option in humans to reduce oxidative stress and the associated renal injury in patients with diabetes mellitus.
