Browsing by Author "Karakaş, Alper"
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Bioassay guided fractionation of extracts from flowers of Bellis perennis L. for their anticancer activity
Karakaş, Pehlivan Fatma; Karakaş, Alper; Mshvildadze, V; Legault, J.; Pichette, A.; Türker, Uçar Arzu (Georg Thieme Verlag Kg, 2011)Common daisy (Bellis perennis L.) is a member of the cosmopolitan family Compositae (Asteraceae). It is native to western, central, and northern Europe, but is commonly found as an invasive plant in North America (1). B. ... -
Cytotoxic, anti-inflammatory and antioxidant activities of four different extracts of Galega officinalis L (goat's rue)
Karakaş, Fatma Pehlivan; Türker, Arzu Uçar; Karakaş, Alper; Mshvildadze, Vakhtang (Pharmacotherapy Group, 2016)Purpose: To evaluate the cytotoxic, anti-inflammatory and antioxidant activities of four different solvent extracts obtained from the aerial parts of Galega officinalis L. Methods: The hexane, DCM, methanol and water ... -
Determination of melatonin hormone and neurotransmitters in cerebrospinal fluid: method validation and uncertainty calculations
Çetin, Özge Yetgin; Karadeniz, Hatice; Karakaş, Alper; Karakaş, Serpil Yenisoy (Pleiades Publishing Inc, 2018)The uncertainty of measurement for well-known neurotransmitters like serotonin, noradrenalin and gamma-aminobutyric acid (GABA), glutamate and melatonin hormone with high performance liquid chromatography-fluorescence ... -
Effect of different photoperiods on gonadal maintenance and development in mongolian gerbils (Meriones unguiculatus)
Karakaş, Alper; Gündüz, Bülent (Zoological Soc Japan, 2002)The role of photoperiod in adult testicular maintenance and body weight and juvenile development was assessed in male Mongolian gerbils (Meriones unguiculatus). Gerbils were raised on a 14L (14 hr of light) photoperiod. ... -
The effect of pinealectomy and leptin hormone on the proliferation and apoptosis activation in Syrian hamster testis in different photoperiods
Gündüz, Bülent; Karakaş, Alper; Terzi, Hakan; Öner, Jale; Serin, Erdinç; Kükner, Aysel (Wiley-Blackwell Publishing, Inc, 2009)P>The effects of pinealectomy and leptin hormone on proliferative and apoptotic processes in the epithelia of testicular seminiferous tubules of Syrian hamsters have been investigated. Proliferative and apoptotic processes ... -
The effect of pinealectomy, melatonin and leptin hormones on ovarian follicular development in female Syrian hamsters (Mesocricetus auratus)
Karakaş, Alper; Kaya, Aliye; Gündüz, Bülent (Akademiai Kiado Zrt, 2010)We studied the effects of melatonin and leptin hormones on ovarian follicular development in intact and pinealectomized female Syrian hamsters. We first monitored the oestrous cycle of the hamsters by the vaginal smear ... -
Effects of European mistletoe (Viscum album L. subsp album) extracts on activity rhythms of the Syrian hamsters (Mesocricetus auratus)
Karakaş, Alper; Türker, Arzu Uçar; Gündüz, Bülent (Taylor & Francis Ltd., 2008)Antitumor drugs may have some significant nervous system side-effects such as disrupted sleep, eating and drinking patterns. European Mistletoe has been investigated for many decades for its potential use against cancer. ... -
The effects of leptin hormone on locomotor activity in Syrian Hamsters (Mesocricetus Auratus)
Gündüz, Bülent; Karakaş, Alper (2011)The suprachiasmatic nucleus (SCN) generates and controls the circadian rhythms in mammals including the rhythm of locomotor activity. Leptin is a hormone secreted by adipose tissue that informs the brain about the fat ... -
The effects of mistletoe (Viscum Album L. Subsp. Album) extracts on isolated intestinal contractions
Throughout history folk medicine has served as an alternative or complimentary method of treating disorders like intestinal colic. Mistletoe is a common name for many species of semi-parasitic plants that grow on trees ... -
The effects of mistletoe (Viscum album L.) extracts on isolated ileum contractions
Serin, Erdinç; Karakaş, Alper; Türker, Arzu; Gündüz, Bülent (Amer Assoc Clinical Chemistry, 2006)European mistletoe (Viscum album L, Loranthaceae) is an evergreen, semiparasitic plant normally found growing on a variety of trees. Both in viva and in vitro studies have shown the cytotoxic, cardiotoxic, immunostimulant, ... -
The effects of photoperiod and age on food anticipatory activity in Mongolian gerbils (Meriones unguiculatus)
Karakaş, Alper (Taylor & Francis Ltd, 2011)In many animal models, the circadian rhythm of locomotor activity is regulated by at least two external pacemakers, environmental photoperiod and food availability. Entrainment with food is characterized by an anticipatory ... -
Effects of photoperiod and food availability on growth, leptin, sexual maturation and maintenance in the Mongolian gerbils (Meriones unguiculatus)
Karakaş, Alper; Çamsarı, Çağrı; Serin, Erdinç; Gündüz, Bülent (Zoological Soc Japan, 2005)Reproductive activity of Mongolian gerbils is regulated by photoperiod nevertheless body weight regulation is controlled without ambient photoperiod. Food intake is a major factor affecting rodent reproductive efficiency. ... -
Effects of photoperiod and melatonin infusions on body weight in pinealectomized juvenile siberian hamsters (Phodopus Sungorus)
Gündüz, Bülent; Karakaş, Alper (2001)We examined the effects of daily melatonin (Mel) infusions in pinealectomized prepubertal male Siberian hamsters in three different conditions. In one study we investigated the body weight maturation response to one hour ... -
The effects of pinealectomy and melatonin implants on circadian locomotor activity responses of the Mongolian Gerbils exposed to rapid photoperiodic transitions
Gündüz, Bülent; Karakaş, Alper (2010)Jet-lag sendromu ve vardiyalı çalışma rahatsızlığı fotoperiyoddaki hızlı değişimlerden kaynaklanır ve sıklıkla insanların hayatını olumsuz etkilemektedirler. Bu çalışmada jet-lag ve vardiyalı çalışma simüle edilmek istendi. ... -
The effects of pinealectomy, melatonin injections and implants on the spatial memory performance of male Wistar rats
Karakaş, Alper; Coşkun, Hamit; Kaya, Aliye (Taylor & Francis Ltd, 2011)Melatonin is the main hormone of the pineal gland that informs the body about the environmental light and darkness regimen and is considered to regulate many important physiological and behavioural activities. In the present ... -
The effects of the intraamygdalar melatonin injections on the anxiety like behavior and the spatial memory performance in male Wistar rats
Karakaş, Alper; Coşkun, Hamit; Kaya, Aliye; Küçük, Ayşegül; Gündüz, Bülent (Elsevier, 2011)In the present study, the effects of intraamygdalar administrations of melatonin (1 and 100 mu g/kg), saline and diazepam on the anxiety-like behavior and spatial memory performance in pinealectomized and sham-pinealectomized ... -
The effects of the time of the day and the pinealectomy on anxiety-like behaviour in male Wistar rats
Kaya, Aliye; Karakaş, Alper; Coşkun, Hamit (Taylor & Francis Ltd, 2011)The previous studies on the anxiety-like behaviour in rats by using elevated plus maze and open field have provided rather unequivocal results because they obtained data at different times of the day. These studies have ... -
The effects of the weekend phase delay like shifts on spatial learning performances of the Wistar rats: the sex and generation differences
Coşkun, Hamit; Karakaş, Alper; Kaya, Aliye (Taylor & Francis Ltd, 2012)Many people regularly wake up early in the morning on week days; however, during weekends, they stay awake late into the night and wake up late, thus representing a phase delay in their locomotor activity and sleeping ... -
The evaluation of topical administration of Bellis perennis fraction on circular excision wound healing in Wistar albino rats
Karakaş, Fatma Pehlivan; Karakaş, Alper; Boran, Çetin; Türker, Arzu Uçar; Yalçın, Funda Nuray; Bilensoy, Erem (Taylor & Francis Ltd, 2012)Context: Bellis perennis L. (Asteraceae) has been used traditionally in the treatment of bruises, broken bones, and wounds by European people. Objective: To investigate the wound healing activity of B. perennis flowers in ... -
Food restriction affects locomotor activity in Mongolian Gerbils (Meriones Unguiculatus)
Karakaş, Alper; Serin, Erdinç; Gündüz, Bülent (2006)The circadian rhythm of the locomotor activity is regulated by at least 2 external pacemakers, environmental photoperiod and food availability. In the present study, the effects of short-term (2 weeks) food restriction on ...
