Ocak, TarıkTekin, ErdalBaştürk, MustafaDuran, ArifSerinken, Mustafa2021-06-232021-06-2320160735-67571532-8171https://doi.org/10.1016/j.ajem.2016.08.002https://hdl.handle.net/20.500.12491/8633Background: There is a lack of specificity of the analgesic agents used to treat headache and underlying acute carbon monoxide poisoning. Objective: To compare effectiveness of "oxygen alone" vs "metoclopramide plus oxygen" vs "metamizole plus oxygen" therapy in treating carbon monoxide-induced headache. Design: A prospective, multicenter, double-blind, controlled trial. Setting: Three emergency departments in Turkey. Population: Adult carbon monoxide poisoning patients with headache. Methods: A total of 117 carbon monoxide-intoxicated patients with headache were randomized into 3 groups and assessed at baseline, 30 minutes, 90 minutes, and 4 hours. Main Outcome Measure: The primary outcomewas patient-reported improvement rates for headache. Secondary end points included nausea, need for rescue medication during treatment, and reduction in carboxyhemoglobin levels. Results: During observation, there was no statistical difference between drug type and visual analog scale score change at 30 minutes, 90 minutes, or 4 hours, for either headache or nausea. No rescue medication was needed during the study period. The reduction in carboxyhemoglobin levels did not differ among the 3 groups. Conclusion: The use of "oxygen alone" is as efficacious as "oxygen plus metoclopramide" or "oxygen plus metamizole sodium" in the treatment of carbon monoxide-induced headache. (C) 2016 Elsevier Inc. All rights reserved.eninfo:eu-repo/semantics/closedAccessCarbon MonoxideClinical TrialArticle10.1016/j.ajem.2016.08.002341121402145275538272-s2.0-84994157132Q1WOS:000389517200016Q2