Uzun, ÖzgeBalbay, ÖnerÇomunoğlu, Nil ÜstündağYavuz, ÖzlemAnnakkaya, Ali NihatGüler, SelverSılan, Coşkun2021-06-232021-06-2320060065-12811618-0372https://doi.org/10.1016/j.acthis.2006.01.001https://hdl.handle.net/20.500.12491/5945Free radical-mediated injury to lung and pulmonary vasculature is an important mechanism in hypoxia-induced lung damage. In this study, we aimed to investigate the potential protective effects of erdosteine as an antioxidant agent on hypobaric hypoxia-induced pulmonary hypertension. Adult mate rats were assigned randomly to three groups. The first group of rats was exposed to hypobaric-hypoxia and the second group was treated with erdosteine (20 mg/kg, daily) for 2 weeks, during which time they were in a hypoxic chamber. These groups were compared with normoxic controls. All. rats were sacrificed after 2 weeks. The hypoxia-induced increase in right ventricle to left ventricle plus septum weight ratio (from 0.20+/-0.01 to 0.26+/-0.01) was reduced significantly in the erdosteine-treated group (0.23+/-0.01). Malondialdehyde levels were elevated (from 0.33+/-0.11 to 0.59+/-0.02) and total antioxidant status was not changed significantly (from 1.77+/-0.42 to 2.61+/-0.23) by hypoxia. In contrast to the hypoxia-exposed group, malondialdehyde levels were significantly decreased in the erdosteine-treated group (0.37+/-0.02). Total antioxidant status (4.03+/-0.22) was significantly higher in erdosteine-treated rats when compared to non-treated rats. Histopathotogical examination demonstrated that erdosteine prevented inflammation and protected lung parenchyma and pulmonary endothelium of hypoxia-exposed rats.eninfo:eu-repo/semantics/closedAccessErdosteinePulmonary HypertensionFree RadicalsLungEndotheliumArticle10.1016/j.acthis.2006.01.00110815968165370872-s2.0-33745499904Q3WOS:000237919500007Q4