Işık, CengizDemirhan, AbdullahYetiş, TevfikÖkmen, KorgünSarman, HakanTekelioğlu, Ümit YaşarDuran, Turan2021-06-232021-06-2320160942-20561433-7347https://doi.org/10.1007/s00167-014-3255-3https://hdl.handle.net/20.500.12491/8611Purpose To evaluate the efficacy of intraarticular injection of ketamine or ketamine plus levobupivacaine on post-operative analgesia in patients undergoing arthroscopic meniscectomy. Methods A prospective, randomized, double-blind study was performed on 60 patients aged 18–65 years who planned to undergo elective arthroscopic meniscectomy. The patients were divided into three groups: the ketamine group (n = 20) received 1.0 mg/kg of intraarticular ketamine in 20 ml of normal saline, the ketamine–levobupivacaine group (n = 20) received 0.5 mg/kg of intraarticular ketamine plus 50.0 mg of 0.25 % levobupivacaine in 20 ml of normal saline, and the control group (n = 20) received 20 ml of intraarticular normal saline. A visual analogue scale (VAS) was used to determine the efficacy of analgesia at 1, 2, 4, 6, 8, 12, and 24 h post-operatively. Results There were statistically significant differences in the median VAS scores among the three groups according to Bonferroni adjustment at all time points (p < 0.01), with the exception of 6 and 24 h post-operatively. The median VAS scores at 1, 2, and 4 h post-operatively were higher in the control group than in the two treatment groups (p < 0.001). The median VAS scores in the control group at 1, 2, 4, 6, 8, and 12 h post-operatively and those in the ketamine group at 4, 8, and 12 h post-operatively were significantly higher than those in the ketamine–levobupivacaine group (p < 0.05). Conclusion Intraarticular ketamine provides effective post-operative analgesia. Addition of intraarticular levobupivacaine to ketamine may provide better amelioration of pain after outpatient arthroscopic meniscectomy. Level of evidence I.eninfo:eu-repo/semantics/openAccessArthroscopic MeniscectomyCorrection10.1007/s00167-014-3255-3241240124012251735062-s2.0-85000360966Q1WOS:000389607500042Q1