Bayrak, AbdullahCelebi, SerdalAvcioglu, FatmaAlkan, Yunus2024-09-252024-09-2520240927-39481744-5078https://doi.org/10.1080/09273948.2024.2382928https://hdl.handle.net/20.500.12491/13458PurposeTo compare the effect of different doses of vancomycin on a rabbit model of MRSA keratitis.MethodsTwenty-four eyes of 24 New-Zealand White rabbits were included in the study. MRSA keratitis was applied to 24 left eyes of 24 New Zealand rabbits. Twenty-four hours after MRSA inoculation; 0.5 mg/0.1 mL, 1 mg/0.1 mL, and 2 mg/0.1 mL and balanced salt solution were administered to 6 rabbits in 4 groups, respectively.ResultsThe effect of different doses of vancomycin on reducing bacterial load was found to be statistically significant when each was compared to the control group (p = 0.006). When comparing the dosages with each other, no superiority was shown (p = 0.297, p = 0.749, p = 0.262 respectively). There was a significant increase in the posttreatment total clinical score in the control and 2 mg/0.1 mL groups compared to the pretreatment score (p = 0.001, p = 0.001 respectively).ConclusionIt is emphasized that necessary treatment can be achieved by administering less antibiotic (0.5 mg/0.1 mL) to the corneal intrastromal area.eninfo:eu-repo/semantics/closedAccessCorneal intrastromal therapyfortified topical dropkeratitisMethicillin-resistant Staphylococcus aureus(MRSA)vancomycinArticle10.1080/09273948.2024.2382928391152842-s2.0-85200897459Q1WOS:001286797200001N/A