Buğdaycı, GülerPolat, MuallaOğuzman, HamdiÇinpolat, Havva Yasemin2021-06-232021-06-2320160007-50271943-7730https://doi.org/10.1093/labmed/lmw024https://hdl.handle.net/20.500.12491/8731Objectives: The aim of this study was to model the use of reference change values (RCVs) for the follow-up of 4 parameters of patients using oral isotretinoin which is gaining widespread popularity for monitoring the side effects of the treatment. Method: 102 patients received 30 mg/day oral isotretinoin for 24 weeks for the diagnosis of acne vulgaris. Results: Repetitive measurements of the patients were interpreted with RCVs, after comparing the first and second doses based on RCVs: TC, TG, AST and ALT results increased in 12%, 20%, 14% and 12% of the patients respectively. When the first dose was compared with the last dose, the increases were 20%, 29%, 22% and 18% respectively interpreted as significant changes based on laboratory medicine. Conclusions: A more sensitive follow-up is possible in the monitorization of adverse effects by using RCVs method.eninfo:eu-repo/semantics/openAccessIsotretinoinAcne VulgarisReferences ValuesSide EffectsData InterpretationClinical Chemistry TestArticle10.1093/labmed/lmw024473213219273468692-s2.0-85014503557Q3WOS:000381879800008Q4